Published in Diabetes on January 12, 2011
Metformin to Treat Obesity in Children With Insulin Resistance | NCT00005669
Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study. Diabetes Care (2012) 1.78
Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study. Obesity (Silver Spring) (2011) 1.07
Metformin in obesity, cancer and aging: addressing controversies. Aging (Albany NY) (2012) 1.04
An evolving scientific basis for the prevention and treatment of pediatric obesity. Int J Obes (Lond) (2014) 1.00
Metformin and its clinical use: new insights for an old drug in clinical practice. Arch Med Sci (2012) 0.96
Treatment of obesity in children and adolescents. J Pediatr Pharmacol Ther (2012) 0.93
Childhood obesity for pediatric gastroenterologists. J Pediatr Gastroenterol Nutr (2013) 0.93
Metformin use in children with obesity and normal glucose tolerance--effects on cardiovascular markers and intrahepatic fat. J Pediatr Endocrinol Metab (2012) 0.87
Pharmacotherapy for childhood obesity: present and future prospects. Int J Obes (Lond) (2012) 0.83
Assessment and management of obesity in childhood and adolescence. Nat Rev Gastroenterol Hepatol (2011) 0.82
Addressing prediabetes in childhood obesity treatment programs: support from research and current practice. Child Obes (2014) 0.82
Pediatric obesity pharmacotherapy: current state of the field, review of the literature and clinical trial considerations. Int J Obes (Lond) (2016) 0.81
Unplanned medication discontinuation as a potential pharmacovigilance signal: a nested young person cohort study. BMC Pharmacol Toxicol (2014) 0.80
Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial. Nutr Diabetes (2016) 0.80
Diabetes, metformin and incidence of and death from invasive cancer in postmenopausal women: Results from the women's health initiative. Int J Cancer (2015) 0.79
Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits. Int J Obes (Lond) (2015) 0.78
Pediatric obesity: etiology and treatment. Pediatr Clin North Am (2011) 0.78
In Vitro and In Vivo Effects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose Tissue. J Diabetes Res (2015) 0.77
Hyperglycemia-Mediated Oxidative Stress Increases Pulmonary Vascular Permeability. Microcirculation (2016) 0.76
Clinical Pharmacokinetics and Pharmacodynamics of Antihyperglycemic Medications in Children and Adolescents with Type 2 Diabetes Mellitus. Clin Pharmacokinet (2016) 0.75
Treatment strategies to prevent renal damage in hypertensive children. Curr Hypertens Rep (2014) 0.75
Pressure To Be Thin and Insulin Sensitivity Among Adolescents. J Adolesc Health (2016) 0.75
Predictors of weight-loss response with glucagon-like peptide-1 receptor agonist treatment among adolescents with severe obesity. Clin Obes (2015) 0.75
Assessment of metformin as an additional treatment to therapeutic lifestyle changes in pediatric patients with metabolic syndrome. Cholesterol (2012) 0.75
Effects of SLC22A1 Polymorphisms on Metformin-Induced Reductions in Adiposity and Metformin Pharmacokinetics in Obese Children With Insulin Resistance. J Clin Pharmacol (2016) 0.75
Commentary: A Randomized, Double-Blind, Placebo-Controlled Trial of Metformin Treatment of Weight Gain Associated with Initiation of Atypical Antipsychotic Therapy in Children and Adolescents. Front Psychiatry (2017) 0.75
Effect of phentermine on weight reduction in a pediatric weight management clinic. Int J Obes (Lond) (2016) 0.75
Obese and overweight children and adolescents: an algorithmic clinical approach. Iran J Pediatr (2013) 0.75
Effect of folic acid and metformin on insulin resistance and inflammatory factors of obese children and adolescents. J Res Med Sci (2016) 0.75
Effects of metformin on energy intake and satiety in obese children. Diabetes Obes Metab (2015) 0.75
A longitudinal study of serum insulin and insulin resistance as predictors of weight and body fat gain in African American and Caucasian children. Int J Obes (Lond) (2016) 0.75
Pharmacotherapy in the Management of Pediatric Obesity. Curr Diab Rep (2017) 0.75
The effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS). Oncotarget (2017) 0.75
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet (1998) 34.34
Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA (2010) 23.45
Obesity and the metabolic syndrome in children and adolescents. N Engl J Med (2004) 13.99
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med (1995) 6.51
Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med (2005) 5.27
Ten-year follow-up of behavioral, family-based treatment for obese children. JAMA (1990) 4.54
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med (1995) 4.29
Effects of a weight management program on body composition and metabolic parameters in overweight children: a randomized controlled trial. JAMA (2007) 4.09
Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med (2006) 4.05
Efficacy of maintenance treatment approaches for childhood overweight: a randomized controlled trial. JAMA (2007) 3.50
Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism. Diabetes Care (2003) 3.25
Addition of metformin to a lifestyle modification program in adolescents with insulin resistance. J Pediatr (2008) 2.69
Metformin extended release treatment of adolescent obesity: a 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up. Arch Pediatr Adolesc Med (2010) 2.68
Increasing fruit and vegetable intake and decreasing fat and sugar intake in families at risk for childhood obesity. Obes Res (2001) 2.60
Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion. J Clin Endocrinol Metab (2008) 2.52
Effects of sibutramine treatment in obese adolescents: a randomized trial. Ann Intern Med (2006) 2.38
Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care (2001) 2.33
Clinical review: treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials. J Clin Endocrinol Metab (2008) 2.21
Meta-analysis: metformin treatment in persons at risk for diabetes mellitus. Am J Med (2008) 2.10
Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes (1995) 2.09
Childhood obesity predicts adult metabolic syndrome: the Fels Longitudinal Study. J Pediatr (2007) 2.07
Family-based treatment of severe pediatric obesity: randomized, controlled trial. Pediatrics (2009) 1.87
The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics (2001) 1.82
Insulin resistance, hyperinsulinemia, and energy intake in overweight children. J Pediatr (2008) 1.59
Do children lose and maintain weight easier than adults: a comparison of child and parent weight changes from six months to ten years. Obes Res (1995) 1.48
Risk factors for developing non-insulin dependent diabetes: a 10 year follow up of men in Uppsala. BMJ (1991) 1.46
Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin. J Clin Endocrinol Metab (2006) 1.45
Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children. J Pediatr (2006) 1.45
The effect of metformin on the metabolic abnormalities associated with upper-body fat distribution. BIGPRO Study Group. Diabetes Care (1996) 1.41
Beneficial effects of metformin in normoglycemic morbidly obese adolescents. Metabolism (2001) 1.39
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. J Clin Endocrinol Metab (1991) 1.38
Use of metformin in obese adolescents with hyperinsulinemia: a 6-month, randomized, double-blind, placebo-controlled clinical trial. J Pediatr Endocrinol Metab (2008) 1.30
Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents. Pediatr Diabetes (2008) 1.25
Metformin decreases food consumption and induces weight loss in subjects with obesity with type II non-insulin-dependent diabetes. Obes Res (1998) 1.25
The stability of metabolic syndrome in children and adolescents. J Clin Endocrinol Metab (2009) 1.23
Metformin for obesity in children and adolescents: a systematic review. Diabetes Care (2009) 1.17
Metformin treatment to prevent early puberty in girls with precocious pubarche. J Clin Endocrinol Metab (2006) 1.10
Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance. Pediatr Diabetes (2008) 1.07
Pharmacotherapy of childhood obesity: an evidence-based, conceptual approach. Diabetes Care (2007) 1.01
Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention. Int J Obes (Lond) (2006) 1.00
Randomized placebo-controlled trial of metformin for adolescents with polycystic ovary syndrome. Arch Pediatr Adolesc Med (2006) 0.96
Childhood overweight status predicts diabetes at age 21 years: a follow-up study. Obesity (Silver Spring) (2009) 0.95
Development of a questionnaire for detecting potential adverse drug reactions. Ann Pharmacother (1992) 0.93
Metformin treatment for four years to reduce total and visceral fat in low birth weight girls with precocious pubarche. J Clin Endocrinol Metab (2008) 0.88
Relative role of major risk factors for Type 2 diabetes development in the historical cohort of the Brisighella Heart Study: an 8-year follow-up. Diabet Med (2005) 0.87
Influence of metformin on metabolic effect of insulin in human adipose tissue in vitro. Diabete Metab (1984) 0.82
Randomized controlled trial evaluating response to metformin versus standard therapy in the treatment of adolescents with polycystic ovary syndrome. J Pediatr Endocrinol Metab (2005) 0.81
Insulin resistance is associated with arterial stiffness independent of obesity in male adolescents. Hypertens Res (2007) 0.81
Effect of biguanide treatment in obese children. Helv Paediatr Acta (1977) 0.81
Weight-reducing effect of diguanides in obese non-diabetic women. Br Med J (1969) 0.80
A better index of body adiposity. Obesity (Silver Spring) (2011) 7.53
Phenotype and course of Hutchinson-Gilford progeria syndrome. N Engl J Med (2008) 5.34
Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr (2011) 4.60
Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet (2002) 3.68
Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring) (2011) 3.62
Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review. Ann Intern Med (2012) 3.04
Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: a systematic review and meta-analysis. Ann Intern Med (2014) 2.82
Long-term treatment of hypoparathyroidism: a randomized controlled study comparing parathyroid hormone-(1-34) versus calcitriol and calcium. J Clin Endocrinol Metab (2003) 2.53
Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression. Sci Transl Med (2013) 2.39
A prospective study of psychological predictors of body fat gain among children at high risk for adult obesity. Pediatrics (2006) 2.28
A randomized trial of a low-carbohydrate diet vs orlistat plus a low-fat diet for weight loss. Arch Intern Med (2010) 2.25
Orthopedic complications of overweight in children and adolescents. Pediatrics (2006) 2.25
Hypo-functional SLC26A4 variants associated with nonsyndromic hearing loss and enlargement of the vestibular aqueduct: genotype-phenotype correlation or coincidental polymorphisms? Hum Mutat (2009) 2.25
Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement: a systematic review. Ann Intern Med (2013) 2.15
Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA (2006) 2.07
Childhood predictors of young-onset type 2 diabetes. Diabetes (2007) 2.06
A 3-year randomized therapeutic trial of nitisinone in alkaptonuria. Mol Genet Metab (2011) 1.98
The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr (2009) 1.88
Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. J Am Diet Assoc (2008) 1.77
Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency. J Clin Endocrinol Metab (2004) 1.73
Loss of control over eating, adiposity, and psychopathology in overweight children. Int J Eat Disord (2002) 1.71
Dry eye signs and symptoms in women with premature ovarian failure. Arch Ophthalmol (2004) 1.69
Impact of computer-aided detection in a regional screening mammography program. AJR Am J Roentgenol (2005) 1.67
Laboratory assessment of the food intake of children and adolescents with loss of control eating. Am J Clin Nutr (2009) 1.64
Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: impact on bone mineral density in HIV-infected children. Pediatrics (2006) 1.63
Health-related quality of life in overweight and nonoverweight black and white adolescents. J Pediatr (2005) 1.60
Insulin resistance, hyperinsulinemia, and energy intake in overweight children. J Pediatr (2008) 1.59
Changing patterns of type 2 diabetes incidence among Pima Indians. Diabetes Care (2007) 1.55
Bone mineral density and fractures in Turner syndrome. Am J Med (2003) 1.51
The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. Clin Endocrinol (Oxf) (2006) 1.50
The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr Metab (Lond) (2008) 1.49
Determining the waist circumference in african americans which best predicts insulin resistance. Obesity (Silver Spring) (2008) 1.44
Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in african americans. Obes Res (2004) 1.43
Disordered-eating attitudes in relation to bone mineral density and markers of bone turnover in overweight adolescents. J Adolesc Health (2009) 1.42
Low bone mass in premenopausal women with depression. Arch Intern Med (2007) 1.38
The 24-h carbohydrate oxidation rate in a human respiratory chamber predicts ad libitum food intake. Am J Clin Nutr (2007) 1.37
Clinical characteristics of a cohort of 244 patients with congenital adrenal hyperplasia. J Clin Endocrinol Metab (2012) 1.36
Sex differences in visceral adipose tissue volume among African Americans. Am J Clin Nutr (2002) 1.35
Three-month tolerability of orlistat in adolescents with obesity-related comorbid conditions. Obes Res (2002) 1.34
Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes. J Clin Endocrinol Metab (2004) 1.34
Bone mineral density in estrogen-deficient young women. J Clin Endocrinol Metab (2009) 1.33
Preventing excessive weight gain in adolescents: interpersonal psychotherapy for binge eating. Obesity (Silver Spring) (2007) 1.33
Endothelial function, but not carotid intima-media thickness, is affected early in menopause and is associated with severity of hot flushes. J Clin Endocrinol Metab (2010) 1.32
Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvement. J Bone Miner Res (2005) 1.30
Effects of binge eating on satiation, satiety, and energy intake of overweight children. Am J Clin Nutr (2006) 1.30
Influence of excess adiposity on exercise fitness and performance in overweight children and adolescents. Pediatrics (2005) 1.29
Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians. Diabetes (2008) 1.29
Prospective study of thymic carcinoids in patients with multiple endocrine neoplasia type 1. J Clin Endocrinol Metab (2003) 1.28
Less activation of the left dorsolateral prefrontal cortex in response to a meal: a feature of obesity. Am J Clin Nutr (2006) 1.27
Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure. Fertil Steril (2005) 1.26
The stability of metabolic syndrome in children and adolescents. J Clin Endocrinol Metab (2009) 1.23
Eating in the absence of hunger in adolescents: intake after a large-array meal compared with that after a standardized meal. Am J Clin Nutr (2010) 1.21
Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity. Diabetes (2005) 1.21
Functional imaging of SDHx-related head and neck paragangliomas: comparison of 18F-fluorodihydroxyphenylalanine, 18F-fluorodopamine, 18F-fluoro-2-deoxy-D-glucose PET, 123I-metaiodobenzylguanidine scintigraphy, and 111In-pentetreotide scintigraphy. J Clin Endocrinol Metab (2011) 1.19
Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes (2003) 1.19
Impaired endothelial function in young women with premature ovarian failure: normalization with hormone therapy. J Clin Endocrinol Metab (2004) 1.19
Decreased bone mineral density with off-label use of tenofovir in children and adolescents infected with human immunodeficiency virus. J Pediatr (2008) 1.17
A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (Chronocort) vs. conventional hydrocortisone (Cortef) in the treatment of congenital adrenal hyperplasia. Clin Endocrinol (Oxf) (2009) 1.17
Longitudinal adherence to fecal occult blood testing impacts colorectal cancer screening quality. Am J Gastroenterol (2011) 1.16
Longitudinal studies of incidence and progression of diabetic retinopathy assessed by retinal photography in pima indians. Diabetes Care (2003) 1.16
Early growth in offspring of diabetic mothers. Diabetes Care (2005) 1.15
Higher fasting plasma concentrations of glucagon-like peptide 1 are associated with higher resting energy expenditure and fat oxidation rates in humans. Am J Clin Nutr (2006) 1.14
Lower energy expenditure predicts long-term increases in weight and fat mass. J Clin Endocrinol Metab (2013) 1.14
Children's descriptions of the foods consumed during loss of control eating episodes. Eat Behav (2006) 1.14
Nighttime eating: commonly observed and related to weight gain in an inpatient food intake study. Am J Clin Nutr (2008) 1.13
Adiposity and human regional body temperature. Am J Clin Nutr (2009) 1.12
Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals. Am J Clin Nutr (2008) 1.12
Relationships between plasma leptin concentrations and human brain structure: a voxel-based morphometric study. Neurosci Lett (2006) 1.12
Comparison of methods to assess change in children's body composition. Am J Clin Nutr (2004) 1.11
An instrument to measure skeletal burden and predict functional outcome in fibrous dysplasia of bone. J Bone Miner Res (2004) 1.11
Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. Diabetes Metab Res Rev (2007) 1.11
Less activation in the left dorsolateral prefrontal cortex in the reanalysis of the response to a meal in obese than in lean women and its association with successful weight loss. Am J Clin Nutr (2007) 1.10
Electronic Interventions for Alcohol Misuse and Alcohol Use Disorders: A Systematic Review. Ann Intern Med (2015) 1.06
A pilot study of interpersonal psychotherapy for preventing excess weight gain in adolescent girls at-risk for obesity. Int J Eat Disord (2010) 1.06
Younger, premenopausal women with major depressive disorder have more abdominal fat and increased serum levels of prothrombotic factors: implications for greater cardiovascular risk. Metabolism (2005) 1.06
Postprandial glucagon-like peptide-1 (GLP-1) response is positively associated with changes in neuronal activity of brain areas implicated in satiety and food intake regulation in humans. Neuroimage (2007) 1.05
Daily parathyroid hormone 1-34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure. J Bone Miner Res (2012) 1.04
Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. J Clin Endocrinol Metab (2011) 1.04
Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor. Am J Clin Nutr (2009) 1.03
The menstrual cycle: a biological marker of general health in adolescents. Ann N Y Acad Sci (2008) 1.03
Quality of life and pain in premenopausal women with major depressive disorder: the POWER Study. Health Qual Life Outcomes (2006) 1.02
Neurotrophin-3 improves functional constipation. Am J Gastroenterol (2003) 1.02
Positive linear growth and bone responses to growth hormone treatment in children with types III and IV osteogenesis imperfecta: high predictive value of the carboxyterminal propeptide of type I procollagen. J Bone Miner Res (2003) 1.02