Published in Lancet on July 06, 2002
A Trial of the Ideal Protein System Versus Low Fat Diet for Weight Loss (RENEWAL) | NCT03515889
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest (2006) 9.49
Lipid-induced insulin resistance: unravelling the mechanism. Lancet (2010) 4.88
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) (2008) 3.17
Adipokines and insulin resistance. Mol Med (2008) 2.97
Fetuin-A and incident diabetes mellitus in older persons. JAMA (2008) 2.92
Adiponectin as an anti-inflammatory factor. Clin Chim Acta (2007) 2.56
Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes (2008) 2.41
Adiponectin in insulin resistance: lessons from translational research. Am J Clin Nutr (2009) 2.22
Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann N Y Acad Sci (2010) 2.16
Role of adiponectin in human skeletal muscle bioenergetics. Cell Metab (2006) 2.09
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09
Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women. Ann Intern Med (2008) 2.01
Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis. Diabetologia (2009) 1.96
Adiponectin actions in the cardiovascular system. Cardiovasc Res (2006) 1.92
Cardioprotection by adiponectin. Trends Cardiovasc Med (2006) 1.86
Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program. Diabetes (2008) 1.78
Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. Proc Natl Acad Sci U S A (2004) 1.61
Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study. Diabetologia (2007) 1.59
Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study. Diabetes Care (2008) 1.51
Circulating adiponectin concentrations in patients with congestive heart failure. Heart (2006) 1.47
(n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Adv Nutr (2011) 1.39
Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes (2007) 1.35
High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study. J Clin Endocrinol Metab (2010) 1.29
Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies. J Clin Endocrinol Metab (2010) 1.29
Novel biomarkers for predicting preeclampsia. Trends Cardiovasc Med (2008) 1.20
Macrophage adiponectin expression improves insulin sensitivity and protects against inflammation and atherosclerosis. Diabetes (2010) 1.19
Pathophysiological significance of adiponectin. Med Mol Morphol (2007) 1.18
Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.17
Adipokines and incident type 2 diabetes in an Aboriginal Canadian [corrected] population: the Sandy Lake Health and Diabetes Project. Diabetes Care (2008) 1.14
Inflammatory concepts of obesity. Int J Inflam (2011) 1.14
Transforming growth factor-beta1 and incident type 2 diabetes: results from the MONICA/KORA case-cohort study, 1984-2002. Diabetes Care (2009) 1.13
Adiponectin and type 2 diabetes in Samoan adults. Am J Hum Biol (2009) 1.13
Total and high molecular weight adiponectin have similar utility for the identification of insulin resistance. Cardiovasc Diabetol (2010) 1.12
Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. Diabetes Metab Res Rev (2007) 1.11
CRP and adiponectin and its oligomers in the metabolic syndrome: evaluation of new laboratory-based biomarkers. Am J Clin Pathol (2008) 1.10
Declining beta-cell compensation for insulin resistance in Hispanic women with recent gestational diabetes mellitus: association with changes in weight, adiponectin, and C-reactive protein. Diabetes Care (2009) 1.09
Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp Gerontol (2007) 1.07
Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance. Diabetes (2012) 1.07
Cyanidin-3-O-β-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes. Diabetes (2011) 1.05
Duration of lactation and maternal adipokines at 3 years postpartum. Diabetes (2011) 1.04
Adiponectin signaling and function in insulin target tissues. J Mol Cell Biol (2016) 1.03
Adiponectin: Probe of the molecular paradigm associating diabetes and obesity. World J Diabetes (2015) 1.01
Adiponectin in cardiovascular inflammation and obesity. Int J Inflam (2011) 1.01
Genes, diet and type 2 diabetes mellitus: a review. Rev Diabet Stud (2007) 1.01
The usefulness of circulating adipokine levels for the assessment of obesity-related health problems. Int J Med Sci (2008) 0.99
Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages. Atherosclerosis (2013) 0.98
Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression (POWER) study. J Clin Psychiatry (2010) 0.96
Adiponectin and energy homeostasis. Rev Endocr Metab Disord (2014) 0.96
The adiponectin receptor homologs in C. elegans promote energy utilization and homeostasis. PLoS One (2011) 0.96
Plasma adiponectin does not correlate with insulin resistance and cardiometabolic variables in nondiabetic Asian Indian teenagers. Diabetes Care (2008) 0.95
Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology (2008) 0.95
Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. Metabolism (2009) 0.94
Maternal serum adiponectin multimers in gestational diabetes. J Perinat Med (2009) 0.94
Plasma resistin, adiponectin, and risk of incident atrial fibrillation: the Framingham Offspring Study. Am Heart J (2011) 0.94
Role of Gut-Related Peptides and Other Hormones in the Amelioration of Type 2 Diabetes after Roux-en-Y Gastric Bypass Surgery. ISRN Endocrinol (2012) 0.94
Major depressive disorder is a risk factor for low bone mass, central obesity, and other medical conditions. Dialogues Clin Neurosci (2011) 0.94
Blood-Based Indicators of Insulin Resistance and Metabolic Syndrome in Bottlenose Dolphins (Tursiops truncatus). Front Endocrinol (Lausanne) (2013) 0.94
Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes. Aging (Albany NY) (2013) 0.94
Body composition is related to increase in plasma adiponectin levels rather than training in young obese men. Eur J Appl Physiol (2005) 0.92
Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population. PLoS One (2013) 0.92
Hypoadiponectinemia in obese subjects with type II diabetes: A close association with central obesity indices. J Res Med Sci (2011) 0.92
Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice. Endocrinology (2014) 0.92
Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years. Diabetologia (2011) 0.91
Small, dense LDL particles predict changes in intima media thickness and insulin resistance in men with type 2 diabetes and prediabetes--a prospective cohort study. PLoS One (2013) 0.91
Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men. Atherosclerosis (2012) 0.91
A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus--a randomized controlled trial START-J study. Cardiovasc Diabetol (2014) 0.90
Cardiometabolic risk factors related to vitamin d and adiponectin in obese children and adolescents. Int J Endocrinol (2013) 0.90
PAQR-2 may be a regulator of membrane fluidity during cold adaptation. Worm (2013) 0.90
Association of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and type 2 diabetes mellitus. Diabetol Metab Syndr (2014) 0.90
Hypoadiponectinaemia in diabetes mellitus type 2: molecular mechanisms and clinical significance. Clin Exp Pharmacol Physiol (2011) 0.89
Neck circumference is a predictor of metabolic syndrome and obstructive sleep apnea in short-sleeping obese men and women. Metab Syndr Relat Disord (2014) 0.88
Adiponectin trajectories before type 2 diabetes diagnosis: Whitehall II study. Diabetes Care (2012) 0.88
A cluster randomised school-based lifestyle intervention programme for the prevention of childhood obesity and related early cardiovascular disease (JuvenTUM 3). BMC Public Health (2011) 0.88
Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction. PLoS One (2012) 0.87
Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits. Diabetes (2014) 0.86
The burden of type 2 diabetes: strategies to prevent or delay onset. Vasc Health Risk Manag (2007) 0.86
Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates. J Clin Endocrinol Metab (2006) 0.86
Systems biology of meridians, acupoints, and chinese herbs in disease. Evid Based Complement Alternat Med (2012) 0.85
Role of adipokines and other inflammatory mediators in gestational diabetes mellitus and previous gestational diabetes mellitus. Int J Endocrinol (2012) 0.85
Multiple biomarker prediction of type 2 diabetes. Diabetes Care (2009) 0.85
Hypertension in metabolic syndrome: vascular pathophysiology. Int J Hypertens (2013) 0.84
Biomarkers in nonalcoholic fatty liver disease. Can J Gastroenterol Hepatol (2014) 0.84
Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Eur J Hum Genet (2010) 0.84
Low serum apolipoprotein A1/B ratio is associated with proliferative diabetic retinopathy in type 2 diabetes. Graefes Arch Clin Exp Ophthalmol (2012) 0.83
Insulin promotes macrophage foam cell formation: potential implications in diabetes-related atherosclerosis. Lab Invest (2012) 0.83
Salivary pH as a marker of plasma adiponectin concentrations in Women. Diabetol Metab Syndr (2012) 0.83
Adiponectin as a biomarker of osteoporosis in postmenopausal women: controversies. Dis Markers (2014) 0.83
Association of genetic variants in the adiponectin gene with metabolic syndrome: a case-control study and a systematic meta-analysis in the Chinese population. PLoS One (2013) 0.83
Role of serum vaspin in progression of type 2 diabetes: a 2-year cohort study. PLoS One (2014) 0.83
Serum adiponectin and bone mineral density in male hemodialysis patients. Osteoporos Int (2011) 0.82
C-reactive protein, high-molecular-weight adiponectin and development of metabolic syndrome in the Japanese general population: a longitudinal cohort study. PLoS One (2013) 0.82
Adiponectin and lipid profiles compared with insulins in relation to early growth of British South Asian and European children: the Manchester children's growth and vascular health study. J Clin Endocrinol Metab (2011) 0.82
Vascular complications and changes in body mass index in Japanese type 2 diabetic patients with abdominal obesity. Cardiovasc Diabetol (2013) 0.82
Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. Ther Adv Endocrinol Metab (2011) 0.81
Do circulating blood cell types correlate with modifiable risk factors and outcomes in patients with acute coronary syndrome (ACS)? Indian Heart J (2015) 0.81
Serum total adiponectin is associated with impaired glucose tolerance in Asian Indian females but not in males. J Diabetes Sci Technol (2010) 0.81
Effects of macrophage-specific adiponectin expression on lipid metabolism in vivo. Am J Physiol Endocrinol Metab (2011) 0.81
Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care (2003) 29.49
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med (2013) 15.58
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet (2009) 15.00
Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care (2007) 14.35
Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control Clin Trials (2003) 9.97
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet (2007) 9.56
MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet (2008) 9.50
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med (2002) 8.95
Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med (2010) 8.70
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med (2006) 7.75
Retracted Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science (2004) 7.21
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes (2007) 6.81
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med (2005) 6.04
Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care (2011) 5.50
Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts. Kidney Int (2011) 5.47
Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol (2003) 4.86
Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin. Diabetes (2005) 4.81
Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr (2011) 4.60
Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem (2003) 4.38
Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med (2004) 4.05
The Diabetes Prevention Program: recruitment methods and results. Control Clin Trials (2002) 4.03
Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol (2003) 3.89
Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem (2003) 3.86
Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation (2002) 3.81
Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol (2003) 3.78
Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation (2003) 3.73
Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring) (2011) 3.62
A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping. Am J Hum Genet (2007) 3.39
Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes (2003) 3.28
Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res (2004) 3.16
Components of the "metabolic syndrome" and incidence of type 2 diabetes. Diabetes (2002) 3.14
Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem (2002) 3.05
Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem (2004) 3.01
High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes (2002) 2.98
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A (2004) 2.85
The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb (2005) 2.77
Effect of a diabetic environment in utero on predisposition to type 2 diabetes. Lancet (2003) 2.74
A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array. Diabetes (2007) 2.67
Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res (2007) 2.66
Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension (2004) 2.65
Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation (2004) 2.58
Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program. Am J Clin Nutr (2008) 2.55
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. Gastroenterology (2003) 2.53
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes (2002) 2.49
Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. J Am Soc Nephrol (2002) 2.46
Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program. Diabetes Care (2007) 2.42
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation (2002) 2.40
High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes (2002) 2.36
Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res (2003) 2.35
Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension (2003) 2.32
Adiponectin: a key adipocytokine in metabolic syndrome. Clin Sci (Lond) (2006) 2.31
Ethnic-difference markers for use in mapping by admixture linkage disequilibrium. Am J Hum Genet (2002) 2.29
Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res (2005) 2.28
Mexican American ancestry-informative markers: examination of population structure and marker characteristics in European Americans, Mexican Americans, Amerindians and Asians. Hum Genet (2003) 2.27
The prevention of type 2 diabetes. Nat Clin Pract Endocrinol Metab (2008) 2.27
Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care (2004) 2.24
Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension (2006) 2.24
Adiponectin as a biomarker of the metabolic syndrome. Circ J (2004) 2.22
Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring. Diabetes (2006) 2.21
Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program. Diabetes (2011) 2.17
Preventive effects of eicosapentaenoic acid on coronary artery disease in patients with peripheral artery disease. Circ J (2010) 2.13
Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA (2006) 2.07
Childhood predictors of young-onset type 2 diabetes. Diabetes (2007) 2.06
Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian. Diabetes Care (2003) 2.05