Published in Oncol Rep on January 13, 2011
Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription. Cell Signal (2011) 0.86
Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric cancer patients. J Cancer Res Clin Oncol (2014) 0.83
Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells. Biochem Biophys Res Commun (2012) 0.82
Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene. Biochem Biophys Res Commun (2011) 0.79
Nuclear lymphocyte-specific protein tyrosine kinase and its interaction with CR6-interacting factor 1 promote the survival of human leukemic T cells. Oncol Rep (2015) 0.75
Protein degradation machinery is present broadly during early development in the sea urchin. Gene Expr Patterns (2014) 0.75
The STATs of cancer--new molecular targets come of age. Nat Rev Cancer (2004) 13.07
SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol (2007) 6.89
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J (1999) 3.77
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05
Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol (2002) 3.00
Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation. Nature (1996) 2.94
Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts. Proc Natl Acad Sci U S A (1988) 2.60
Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun (1997) 2.51
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells (1999) 2.28
T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunol Rev (2009) 2.23
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A (2003) 2.12
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem (2000) 1.97
Thymic tumorigenesis induced by overexpression of p56lck. Proc Natl Acad Sci U S A (1991) 1.93
Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines. Br J Haematol (2004) 1.70
SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition. Oncogene (2005) 1.55
The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol Rev (2003) 1.52
Identification of STAT3 as a specific substrate of breast tumor kinase. Oncogene (2006) 1.40
The tumor suppressor activity of SOCS-1. Oncogene (2002) 1.29
Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase. J Immunol (1997) 1.28
Negative regulation of FAK signaling by SOCS proteins. EMBO J (2003) 1.26
The lck tyrosine protein kinase. Oncogene (1991) 1.21
Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia. Mol Cell Biol (1994) 1.19
A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation. Mol Cancer Res (2006) 1.05
Regulation of the Src family kinase Lck by Hsp90 and ubiquitination. Mol Cell Biol (2004) 1.04
Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation. Int J Oncol (2010) 0.93
The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation. Oncogene (2000) 0.91
Dysregulation of the protein tyrosine kinase LCK in lymphoproliferative disorders and in other neoplasias. Leuk Lymphoma (1999) 0.89
Characterization of STAT5B phosphorylation correlating with expression of cytokine-inducible SH2-containing protein (CIS). Cell Signal (2005) 0.85
A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation. Mol Cancer Res (2006) 1.05
Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells. Biochem Biophys Res Commun (2010) 0.98
Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation. Int J Oncol (2010) 0.93
Metabolic response to endotoxin in vivo in the conscious mouse: role of interleukin-6. Metabolism (2010) 0.90
Effect of anti-IL-2Ralpha antibody on IL-2-induced Jak/STAT signaling. Am J Transplant (2002) 0.88
Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription. Cell Signal (2011) 0.86
Characterization of STAT5B phosphorylation correlating with expression of cytokine-inducible SH2-containing protein (CIS). Cell Signal (2005) 0.85
Fratricide of CD8+ cytotoxic T lymphocytes is dependent on cellular activation and perforin-mediated killing. Eur J Immunol (2004) 0.85
Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes. Metabolomics (2009) 0.84
Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells. Biochem Biophys Res Commun (2012) 0.82
Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene. Biochem Biophys Res Commun (2011) 0.79
Evaluation of antinociceptive, anti-inflammatory and antipyretic effects of Strobilanthes cusia leaf extract in male mice and rats. Am J Chin Med (2003) 0.78
Mouse LSTRA leukemia as a model of human natural killer T cell and highly aggressive lymphoid malignancies. Leuk Lymphoma (2013) 0.78