Published in Biochem Biophys Res Commun on October 20, 1997
Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci U S A (1998) 4.38
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev (1998) 4.29
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A (1999) 3.91
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev (2004) 3.82
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J (1999) 3.77
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J (1999) 2.80
The paradigm of IL-6: from basic science to medicine. Arthritis Res (2002) 2.34
Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view. Clin Microbiol Rev (2005) 2.33
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc Natl Acad Sci U S A (1998) 2.31
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A (2003) 2.12
Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc Natl Acad Sci U S A (1999) 2.04
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling. Proc Natl Acad Sci U S A (1998) 1.90
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med (2006) 1.84
SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol Cell Biol (1999) 1.69
Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. J Clin Invest (2001) 1.51
Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol Cell Biol (1999) 1.45
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A (2002) 1.42
Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol Cell Biol (2001) 1.41
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc Natl Acad Sci U S A (2001) 1.40
Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction. J Immunol (1999) 1.38
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J (1999) 1.33
SOCS, Inflammation, and Autoimmunity. Front Immunol (2012) 1.32
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol (2002) 1.28
Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism. Proc Natl Acad Sci U S A (2003) 1.26
Negative regulation of FAK signaling by SOCS proteins. EMBO J (2003) 1.26
Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation. Infect Immun (2003) 1.01
Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proc Natl Acad Sci U S A (2003) 1.01
Favorable prognostic value of SOCS2 and IGF-I in breast cancer. BMC Cancer (2007) 1.00
XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway. EMBO J (2007) 0.94
Inhibition of IL-6 family cytokines by SOCS3. Semin Immunol (2014) 0.94
Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3. PLoS One (2010) 0.93
Development of IFN-gamma resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells. Br J Cancer (2007) 0.93
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation. J Biol Chem (2009) 0.90
Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation. Cell Death Differ (2012) 0.89
Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase. Oncol Rep (2011) 0.85
Molecular basis of oncostatin M-induced SOCS-3 expression in astrocytes. Glia (2008) 0.85
Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3). Biochem J (2001) 0.84
Association of CISH -292A/T genetic variant with hepatitis B virus infection. Immunogenetics (2011) 0.83
Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition. PLoS One (2011) 0.83
The role of suppressors of cytokine signalling in human neoplasms. Mol Biol Int (2014) 0.81
Structural and functional analysis of the human TAF1/DYT3 multiple transcript system. Mamm Genome (2007) 0.81
Human primary keratinocytes show restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 protein compared with autologous macrophages. J Biol Chem (2012) 0.80
Gypenoside Attenuates β Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling. Neural Plast (2016) 0.79
Regulation of cytokine-inducible SH2-containing protein (CIS) by ubiquitination and Elongin B/C interaction. Mol Cell Endocrinol (2014) 0.77
SOCS3: A novel therapeutic target for cardioprotection. JAKSTAT (2012) 0.75
Suppressor of cytokine signaling 3 plays an important role in porcine circovirus type 2 subclinical infection by downregulating proinflammatory responses. Sci Rep (2016) 0.75
Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease. J Occup Med Toxicol (2013) 0.75
Resveratrol Attenuates Microglial Activation via SIRT1-SOCS1 Pathway. Evid Based Complement Alternat Med (2017) 0.75
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. Cell Rep (2017) 0.75
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
A new protein containing an SH2 domain that inhibits JAK kinases. Nature (1997) 6.28
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem (1999) 5.81
The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins. J Biol Chem (1987) 5.79
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature (1997) 5.55
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood (2001) 5.17
Electron microscopic observations on the effects of penicillin on the morphology of Chlamydia psittaci. J Bacteriol (1970) 4.96
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol (1999) 4.77
Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis. EMBO J (1988) 4.75
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest (2000) 4.60
Formation and control of optimal trajectory in human multijoint arm movement. Minimum torque-change model. Biol Cybern (1989) 4.17
The mouse homolog of Drosophila Vasa is required for the development of male germ cells. Genes Dev (2000) 3.93
Purification and chemical composition of reticulate bodies of the meningopneumonitis organisms. J Bacteriol (1967) 3.86
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J (1999) 3.77
A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat Genet (1994) 3.70
Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein. Nature (1999) 3.51
Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res (1995) 3.23
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell (1999) 3.15
CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood (1997) 3.08
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes (2000) 3.01
MDM2 interacts with MDMX through their RING finger domains. FEBS Lett (1999) 2.98
Negative regulation of cytokine signaling pathways. Annu Rev Immunol (2000) 2.98
High-resolution structure of the oligomerization domain of p53 by multidimensional NMR. Science (1994) 2.98
cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc Natl Acad Sci U S A (1987) 2.97
Rice gibberellin-insensitive dwarf mutant gene Dwarf 1 encodes the alpha-subunit of GTP-binding protein. Proc Natl Acad Sci U S A (1999) 2.97
A link between cyclin A expression and adhesion-dependent cell cycle progression. Science (1993) 2.96
Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript. Nature (1990) 2.95
Radical surgery for gastric cancer. A review of the Japanese experience. Cancer (1989) 2.91
Spred is a Sprouty-related suppressor of Ras signalling. Nature (2001) 2.87
Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila. Science (1991) 2.87
Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J (1991) 2.86
Electron microscopic observations on the structure of the envelopes of mature elementary bodies and developmental reticulate forms of Chlamydia psittaci. J Bacteriol (1971) 2.86
The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains. Mol Cell Biol (1991) 2.77
Pulsed-field gel electrophoretic analysis of Campylobacter jejuni DNA for use in epidemiological studies. J Infect (1993) 2.75
Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature (2000) 2.73
Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production. J Immunol (1983) 2.72
Dual enzyme activities of cell wall peptidoglycan synthesis, peptidoglycan transglycosylase and penicillin-sensitive transpeptidase, in purified preparations of Escherichia coli penicillin-binding protein 1A. Biochem Biophys Res Commun (1980) 2.69
Construction of a novel database containing aberrant splicing mutations of mammalian genes. Gene (1994) 2.68
Successful en-bloc resection of large superficial tumors in the stomach and colon using sodium hyaluronate and small-caliber-tip transparent hood. Endoscopy (2003) 2.67
Pathogenesis of Chiari malformation: a morphometric study of the posterior cranial fossa. J Neurosurg (1997) 2.60
Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. Development (1999) 2.57
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J Cell Biol (1996) 2.56
A hierarchical neural-network model for control and learning of voluntary movement. Biol Cybern (1987) 2.52
An autolysin ring associated with cell separation of Staphylococcus aureus. J Bacteriol (1996) 2.52
The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J Immunol (1999) 2.44
Infectious cell entry mechanism of influenza virus. J Virol (1982) 2.41
Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. Proc Natl Acad Sci U S A (1987) 2.34
Sarcoplasmic reticulum Ca2+ release is not a dominating factor in sinoatrial node pacemaker activity. Circ Res (2003) 2.32
'Small worlds' and the evolution of virulence: infection occurs locally and at a distance. Proc Biol Sci (1999) 2.31
Homodimerization and constitutive activation of the erythropoietin receptor. Proc Natl Acad Sci U S A (1992) 2.29
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J Biol Chem (2001) 2.29
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells (1999) 2.28
Uncoating of influenza virus in endosomes. J Virol (1984) 2.26
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J Biol Chem (1999) 2.21
SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell (1999) 2.19
The gene for Machado-Joseph disease maps to human chromosome 14q. Nat Genet (1993) 2.18
Inhibition of LDL oxidation by cocoa. Lancet (1996) 2.16
Characterization of pseudotype VSV possessing HCV envelope proteins. Virology (2001) 2.15
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J Clin Invest (2001) 2.15
A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection. J Exp Med (1997) 2.09
Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein. Nat Genet (1996) 2.06
Pathogen invasion and host extinction in lattice structured populations. J Math Biol (1994) 2.05
Preferential excision of the 5' proximal intron from mRNA precursors with two introns as mediated by the cap structure. Proc Natl Acad Sci U S A (1987) 2.04
The Dictyostelium developmental cDNA project: generation and analysis of expressed sequence tags from the first-finger stage of development. DNA Res (1998) 2.03
Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model. Kidney Int (1992) 2.02
Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. Oncogene (1988) 1.99
Continuous ambulatory radionuclide monitoring of left ventricular function: effect of body position during ergometer exercise. J Nucl Med (1997) 1.99
K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes. Proc Natl Acad Sci U S A (1990) 1.99
Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med (1992) 1.98
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem (2000) 1.97
Evolutionarily stable mutation rate in a periodically changing environment. Genetics (1989) 1.96