Published in Proc Natl Acad Sci U S A on June 01, 1988
Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. Proc Natl Acad Sci U S A (1989) 2.99
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci U S A (1989) 2.80
Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc Natl Acad Sci U S A (1989) 2.70
Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells. EMBO J (1988) 2.28
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Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase. Mol Cell Biol (1994) 1.26
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Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Mol Cell Biol (1992) 1.20
Delayed thymocyte development induced by augmented expression of p56lck. J Exp Med (1991) 1.20
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Transformation of NIH 3T3 fibroblasts by an activated form of p59hck. Mol Cell Biol (1989) 1.17
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p56Lck anchors CD4 to distinct microdomains on microvilli. Proc Natl Acad Sci U S A (2002) 1.10
Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells. Mol Cell Biol (1992) 1.10
Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation. Mol Cell Biol (1994) 1.04
Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen. J Virol (1991) 1.03
The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site. Mol Cell Biol (1993) 1.03
Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity. Mol Cell Biol (1996) 1.03
Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system. Proc Natl Acad Sci U S A (1991) 1.01
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Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response. J Exp Med (2002) 0.99
Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia. J Exp Med (1991) 0.98
Removal of C-terminal SRC kinase from the immune synapse by a new binding protein. Mol Cell Biol (2005) 0.97
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Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling. J Virol (2011) 0.97
The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells. PLoS Pathog (2011) 0.96
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Purification and characterization of a higher-molecular-mass form of protein phosphotyrosine phosphatase (PTP 1B) from placental membranes. Biochem J (1991) 0.90
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Lyn kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib. J Cell Biochem (2010) 0.88
Herpes simplex virus requires VP11/12 to induce phosphorylation of the activation loop tyrosine (Y394) of the Src family kinase Lck in T lymphocytes. J Virol (2009) 0.87
The protein tyrosine kinase p56lck regulates cell adhesion mediated by CD4 and major histocompatibility complex class II proteins. J Exp Med (1994) 0.86
T cell signal regulation by the actin cytoskeleton. J Biol Chem (2010) 0.86
Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase. Oncol Rep (2011) 0.85
The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]. J Exp Med (1993) 0.84
Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase. J Virol (1992) 0.84
Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts. J Biol Chem (2008) 0.84
Tyrosine kinase activity of CD4-associated p56lck may not be required for CD4-dependent T-cell activation. Proc Natl Acad Sci U S A (1993) 0.84
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Reassessment of the v-fms sequence: threonine phosphorylation of the COOH-terminal domain. J Virol (1991) 0.80
The Src homology 2 domain of the protein-tyrosine kinase p56lck mediates both intermolecular and intramolecular interactions. Proc Natl Acad Sci U S A (1993) 0.80
Haemin enhancement of glucose transport in human lymphocytes: stimulation of protein tyrosine phosphatase and activation of p56lck tyrosine kinase. Biochem J (1993) 0.80
Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene. Biochem Biophys Res Commun (2011) 0.79
Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus. Biochem J (1991) 0.78
Human c-fgr induces a monocyte-specific enzyme in NIH 3T3 cells. Mol Cell Biol (1991) 0.77
Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells. Immunology (2004) 0.76
Inhibition of interleukin-2-mediated DNA synthesis in activated human T-lymphoblasts by okadaic acid is accompanied by hyperphosphorylation of lck. Biochem J (1995) 0.75
Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells. Proc Natl Acad Sci U S A (1994) 0.75
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New procedure for DNA transfection with polycation and dimethyl sulfoxide. Mol Cell Biol (1984) 8.63
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell (1987) 6.91
Characterization of Rous sarcoma virus src gene products synthesized in vitro. J Virol (1978) 6.39
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell (1987) 5.84
Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo. J Virol (1978) 5.30
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell (1985) 5.21
Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation. EMBO J (1985) 5.14
Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science (1986) 4.99
Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain. Cell (1987) 4.63
Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine. Oncogene (1988) 4.25
Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src. Mol Cell Biol (1986) 3.99
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Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion. Nature (1986) 3.00
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol Cell Biol (1988) 2.80
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. EMBO J (1987) 2.67
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. Mol Cell Biol (1987) 2.59
Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Mol Cell Biol (1987) 2.52
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol (1987) 2.44
Isolation and oncogenic potential of a novel human src-like gene. Mol Cell Biol (1986) 2.31
Characterization of cDNA clones for the human c-yes gene. Mol Cell Biol (1987) 2.11
Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells. Mol Cell Biol (1984) 1.92
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A lymphoma cell line expressing elevated levels of tyrosine protein kinase activity. J Biol Chem (1983) 1.45
Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo. Mol Cell Biol (1986) 1.45
Two lck transcripts containing different 5' untranslated regions are present in T cells. Mol Cell Biol (1987) 1.37
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A lymphoma protein with an in vitro site of tyrosine phosphorylation homologous to that in pp60src. J Biol Chem (1982) 1.15
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cDNA cloning with a retrovirus expression vector: generation of a pp60c-src cDNA clone. J Virol (1987) 0.93
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Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo. J Virol (1978) 5.30
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Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine. Oncogene (1988) 4.25
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Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. Proc Natl Acad Sci U S A (1989) 2.99
Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein. Mol Cell Biol (1984) 2.98
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Direct identification of palmitic acid as the lipid attached to p21ras. Mol Cell Biol (1986) 2.02
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Measurement of stoichiometry of protein phosphorylation by biosynthetic labeling. Methods Enzymol (1991) 0.84
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