Published in Mol Psychiatry on January 18, 2011
Cellular Aging and Neurobiology of Depression Study (CAN-D) | NCT00285935
Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. Mol Psychiatry (2013) 1.96
Telomeres and early-life stress: an overview. Biol Psychiatry (2012) 1.75
Of sound mind and body: depression, disease, and accelerated aging. Dialogues Clin Neurosci (2011) 1.63
A randomized controlled trial of qigong exercise on fatigue symptoms, functioning, and telomerase activity in persons with chronic fatigue or chronic fatigue syndrome. Ann Behav Med (2012) 1.59
Stress and telomere biology: a lifespan perspective. Psychoneuroendocrinology (2013) 1.46
Launching the 'war on mental illness'. Mol Psychiatry (2014) 1.39
Early life stress and telomere length: investigating the connection and possible mechanisms: a critical survey of the evidence base, research methodology and basic biology. Bioessays (2012) 1.23
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging. Neurosci Biobehav Rev (2015) 1.05
Depressive symptoms are not associated with leukocyte telomere length: findings from the Nova Scotia Health Survey (NSHS95), a population-based study. PLoS One (2012) 1.05
An integrative review of factors associated with telomere length and implications for biobehavioral research. Nurs Res (2013) 0.97
Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres. Transl Psychiatry (2013) 0.96
Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey. Mol Psychiatry (2014) 0.94
Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step. Proc Natl Acad Sci U S A (2011) 0.92
Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass. Mol Psychiatry (2014) 0.91
The age-by-disease interaction hypothesis of late-life depression. Am J Geriatr Psychiatry (2013) 0.91
Telomeres, early-life stress and mental illness. Adv Psychosom Med (2015) 0.90
Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction. Transl Psychiatry (2013) 0.87
Increased telomerase activity and vitamin D supplementation in overweight African Americans. Int J Obes (Lond) (2011) 0.84
An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity. Blood (2014) 0.84
Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults. J Affect Disord (2014) 0.83
Telomeres and epigenetics: potential relevance to chronic pain. Pain (2012) 0.83
Major depressive disorder and measures of cellular aging: an integrative review. Nurs Res Pract (2013) 0.82
Association between informal caregiving and cellular aging in the survey of the health of wisconsin: the role of caregiving characteristics, stress, and strain. Am J Epidemiol (2014) 0.82
Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores. PLoS One (2012) 0.81
Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium. Int J Neuropsychopharmacol (2015) 0.81
Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes. J Immunol Res (2016) 0.80
PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression. Psychiatry Res (2015) 0.78
Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings. Psychiatry Res (2014) 0.77
Telomere length and telomerase in a well-characterized sample of individuals with major depressive disorder compared to controls. Psychoneuroendocrinology (2015) 0.77
Therapeutic Targeting of Telomerase. Genes (Basel) (2016) 0.76
Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study. Transl Psychiatry (2016) 0.76
Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder. Transl Psychiatry (2015) 0.75
Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report. Mol Neuropsychiatry (2016) 0.75
Statistical Analysis Plan for Stage 1 EMBARC (Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care) Study. Contemp Clin Trials Commun (2017) 0.75
Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings. J Psychosom Res (2017) 0.75
A global measure of perceived stress. J Health Soc Behav (1983) 56.90
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet (1997) 25.40
Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol (1967) 22.39
Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A (2004) 12.89
Association between telomere length in blood and mortality in people aged 60 years or older. Lancet (2003) 10.56
Oxidative stress shortens telomeres. Trends Biochem Sci (2002) 9.48
Relationship of subjective and objective social status with psychological and physiological functioning: preliminary data in healthy white women. Health Psychol (2000) 7.85
Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell (1999) 6.98
Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet (2007) 6.57
A molecular and cellular theory of depression. Arch Gen Psychiatry (1997) 6.10
Telomere states and cell fates. Nature (2000) 5.71
Telomere diseases. N Engl J Med (2009) 5.68
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med (2006) 4.61
The Inventory for Depressive Symptomatology (IDS): preliminary findings. Psychiatry Res (1986) 4.16
A survey for assessing physical activity among older adults. Med Sci Sports Exerc (1993) 4.08
Telomere shortening in atherosclerosis. Lancet (2001) 3.65
Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol (2008) 3.57
Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients. J Immunol (2007) 3.20
Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology (2005) 3.08
Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging. Biol Psychiatry (2006) 2.85
Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods (2009) 2.78
Psychological and metabolic stress: a recipe for accelerated cellular aging? Hormones (Athens) (2009) 2.61
Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres. EMBO Rep (2001) 2.59
Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging (2002) 2.46
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY) (2008) 2.35
Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings. PLoS One (2011) 2.30
Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med (2005) 2.30
Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging. Biol Psychiatry (2009) 2.20
Telomere length homeostasis. Chromosoma (2006) 2.12
Telomerase, mitochondria and oxidative stress. Exp Gerontol (2009) 2.05
Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLoS One (2010) 2.03
Telomere biology and cardiovascular disease. Circ Res (2006) 1.96
Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data from the Heart and Soul Study. Arterioscler Thromb Vasc Biol (2008) 1.92
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci (2008) 1.91
Telomere length, current perceived stress, and urinary stress hormones in women. Cancer Epidemiol Biomarkers Prev (2009) 1.88
Telomeres and cardiovascular disease: does size matter? Circ Res (2004) 1.83
Telomeres and human somatic fitness. J Gerontol A Biol Sci Med Sci (2006) 1.82
Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications. Ann N Y Acad Sci (2006) 1.80
Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology (2010) 1.73
Dynamics of telomerase activity in response to acute psychological stress. Brain Behav Immun (2009) 1.68
Cytokines modulate telomerase activity in a human multiple myeloma cell line. Cancer Res (2002) 1.64
Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation (2009) 1.63
Depression gets old fast: do stress and depression accelerate cell aging? Depress Anxiety (2010) 1.58
Relationship between physical activity level, telomere length, and telomerase activity. Med Sci Sports Exerc (2008) 1.55
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis. Osteoporos Int (2007) 1.55
Stress impacts telomere dynamics. Biol Lett (2007) 1.48
Telomere shortening occurs in Asian Indian Type 2 diabetic patients. Diabet Med (2005) 1.46
Genetic pathway of major depressive disorder in shortening telomeric length. Psychiatr Genet (2007) 1.31
A natural product telomerase activator as part of a health maintenance program. Rejuvenation Res (2010) 1.30
Telomerase induction in T cells: a cure for aging and disease? Exp Gerontol (2006) 1.25
DNA damage responses in neural cells: Focus on the telomere. Neuroscience (2007) 1.23
The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis. J Neurochem (2000) 1.23
Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. PLoS One (2008) 1.20
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J Neurosci (2004) 1.17
Telomerase therapeutics for degenerative diseases. Curr Mol Med (2005) 1.07
Short telomeres are preferentially elongated by telomerase in human cells. FEBS Lett (2009) 1.07
Signal transduction and genes-to-behaviors pathways in psychiatric diseases. Sci STKE (2003) 1.06
Kleemeier Award Lecture 2008--the canary in the coal mine: telomeres and human healthspan. J Gerontol A Biol Sci Med Sci (2009) 1.00
Novel roles for telomerase in aging. Mech Ageing Dev (2006) 0.96
Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation. Liver Int (2008) 0.95
Telomere dysfunction of lymphocytes in patients with Alzheimer disease. Cogn Behav Neurol (2003) 0.92
Pharmacological intervention strategies for affecting telomerase activity: future prospects to treat cancer and degenerative disease. Biochimie (2007) 0.91
The pleiotropy of telomerase against cell death. Mol Cells (2005) 0.91
The emerging role of telomere biology in cardiovascular disease. Front Biosci (Landmark Ed) (2010) 0.89
Telomerase induction in astrocytes of Sprague-Dawley rat after ischemic brain injury. Neurosci Lett (2004) 0.88
Telomerase as a growth-promoting factor. Cell Cycle (2003) 0.88
Serum oxidized low-density lipoprotein is inversely correlated to telomerase activity in peripheral blood mononuclear cells of haemodialysis patients. Nephrology (Carlton) (2006) 0.87
Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. Mech Ageing Dev (2001) 0.86
Telomerase: not just for the elongation of telomeres. Bioessays (2006) 0.85
Clinical outcome and tolerability of sertraline in major depression: a study with plasma levels. Prog Neuropsychopharmacol Biol Psychiatry (2002) 0.84
Expression of telomerase activity and oxidative stress in human hepatocellular carcinoma with cirrhosis. World J Gastroenterol (2003) 0.80
Telomere dysfunction and telomerase activation in cancer--a pathological paradox? Cytogenet Genome Res (2007) 0.79
Quantitative measurement of telomerase activity and localization of its catalytic subunit (hTERT) in chronic inflammation of capsule formation around various model implants and in sarcomas in a rat model. J Biomed Mater Res A (2008) 0.77
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature (2001) 23.49
Structure and function of telomeres. Nature (1991) 14.82
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature (1989) 13.18
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell (1987) 8.32
Relationship of subjective and objective social status with psychological and physiological functioning: preliminary data in healthy white women. Health Psychol (2000) 7.85
The molecular structure of centromeres and telomeres. Annu Rev Biochem (1984) 7.51
An alternative pathway for yeast telomere maintenance rescues est1- senescence. Cell (1993) 6.89
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature (1990) 6.82
DNA sequences of telomeres maintained in yeast. Nature (1984) 6.52
A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J Mol Biol (1978) 6.45
Cloning yeast telomeres on linear plasmid vectors. Cell (1982) 6.39
A scale of valuations of states of illness: is there a social consensus? Int J Epidemiol (1978) 5.82
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature (2000) 5.55
The nucleotide sequence of the cloned rpoD gene for the RNA polymerase sigma subunit from E coli K12. Nucleic Acids Res (1981) 5.52
Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs. Cell (1987) 4.85
Crystal structure of TFIID TATA-box binding protein. Nature (1992) 4.85
Telomeres and their control. Annu Rev Genet (2000) 4.74
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell (2001) 4.58
A conserved secondary structure for telomerase RNA. Cell (1991) 4.52
Runaway telomere elongation caused by telomerase RNA gene mutations. Nature (1995) 4.34
The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A (1998) 4.17
Obesity-related glomerulopathy: an emerging epidemic. Kidney Int (2001) 3.98
Functional evidence for an RNA template in telomerase. Science (1990) 3.88
An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem (2000) 3.44
Telomerase in yeast. Science (1995) 3.38
The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res Brain Res Rev (1997) 3.23
Developmentally programmed healing of chromosomes by telomerase in Tetrahymena. Cell (1991) 3.21
Phenotypic diversity and ecosystem functioning in changing environments: a theoretical framework. Proc Natl Acad Sci U S A (2001) 3.13
The stationary-phase sigma factor sigma S (RpoS) is required for a sustained acid tolerance response in virulent Salmonella typhimurium. Mol Microbiol (1995) 3.11
Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest (1992) 3.05
The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin. J Biol Chem (1985) 3.04
Radioimmunoassay of an antibiotic: gentamicin. Nat New Biol (1972) 3.02
Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network. J Cell Biol (1994) 2.95
Identification of a telomeric DNA sequence in Trypanosoma brucei. Cell (1984) 2.89
Signal transduction by the TCR for antigen. Curr Opin Immunol (2000) 2.87
Cognitive effects of corticosteroids. Am J Psychiatry (1990) 2.85
An overhanging 3' terminus is a conserved feature of telomeres. Mol Cell Biol (1989) 2.85
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol (1996) 2.78
Nortriptyline and cognitive-behavioral therapy in the treatment of cigarette smoking. Arch Gen Psychiatry (1998) 2.77
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev (1996) 2.76
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. Genes Dev (1997) 2.73
Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration. Cell (1997) 2.71
The dynamics of cocirculating influenza strains conferring partial cross-immunity. J Math Biol (1997) 2.69
Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med (1993) 2.69
Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry (1998) 2.69
A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science (1995) 2.68
Block in anaphase chromosome separation caused by a telomerase template mutation. Science (1997) 2.65
Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins (2005) 2.59
Dynamics of telomere length variation in Tetrahymena thermophila. Cell (1987) 2.56
Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene (1994) 2.47
Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol Med (1995) 2.44
Shotgun optical maps of the whole Escherichia coli O157:H7 genome. Genome Res (2001) 2.43
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A (1999) 2.42
Developmentally controlled telomere addition in wild-type and mutant paramecia. Mol Cell Biol (1988) 2.41
Competitive binding of alpha-actinin and calmodulin to the NMDA receptor. Nature (1997) 2.41
Template boundary in a yeast telomerase specified by RNA structure. Science (2000) 2.39
Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev (1997) 2.37
Ku is associated with the telomere in mammals. Proc Natl Acad Sci U S A (1999) 2.36
Comparative mapping in grasses. Wheat relationships. Mol Gen Genet (1995) 2.33
Immunogenicity and smoking-cessation outcomes for a novel nicotine immunotherapeutic. Clin Pharmacol Ther (2011) 2.33
Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1988) 2.32
Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element. Cell (1986) 2.29
Advanced backcross QTL analysis: a method for the simultaneous discovery and transfer of valuable QTLs from unadapted germplasm into elite breeding lines. Theor Appl Genet (1996) 2.29
Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappa. J Virol (1995) 2.25
Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene (2001) 2.25
Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature (1996) 2.24
PartsList: a web-based system for dynamically ranking protein folds based on disparate attributes, including whole-genome expression and interaction information. Nucleic Acids Res (2001) 2.23
Vasopressin administration facilitates fluid removal during hemodialysis. Kidney Int (2006) 2.23
Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers. Mol Cell Biol (1989) 2.21
Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes (2001) 2.19
Neurosteroids: biosynthesis and function of these novel neuromodulators. Front Neuroendocrinol (2000) 2.17
DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study. Neurology (2003) 2.14
Completely diverted tube ileostomy compared with loop ileostomy for protection of low colorectal anastomosis: a pilot study. Colorectal Dis (2014) 2.06
A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. QJM (1995) 2.05
Differences in preconceptional and prenatal behaviors in women with intended and unintended pregnancies. Am J Public Health (1998) 2.05
Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress. Neuroscience (1997) 2.03
Beyond synexpression relationships: local clustering of time-shifted and inverted gene expression profiles identifies new, biologically relevant interactions. J Mol Biol (2001) 2.03
Cognitive-behavioral intervention increases abstinence rates for depressive-history smokers. J Consult Clin Psychol (1994) 2.03
An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy. Science (2000) 2.03
Evaluation of three hollow-fiber membrane oxygenators without integrated arterial filters for neonatal cardiopulmonary bypass. Perfusion (2011) 2.02
Psychosis and anti-tuberculosis therapy. Lancet (1989) 2.02
Thromboprophylaxis rates in US medical centers: success or failure? J Thromb Haemost (2007) 2.02
Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med (1991) 2.00
The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa). J Virol (1996) 1.97
Mood management and nicotine gum in smoking treatment: a therapeutic contact and placebo-controlled study. J Consult Clin Psychol (1996) 1.96
Telomeres: do the ends justify the means? Cell (1984) 1.95
The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother. Am J Hum Genet (1999) 1.94
Sequence-specific DNA primer effects on telomerase polymerization activity. Mol Cell Biol (1993) 1.92
Polyneuronal innervation of spiny stellate neurons in cat visual cortex. J Comp Neurol (1994) 1.92
Altering specific telomerase RNA template residues affects active site function. Genes Dev (1995) 1.92
Injecting drug use and HIV infection in southwest China. AIDS (1994) 1.91
Seizures associated with antidepressants: a review. J Clin Psychiatry (1993) 1.91
Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr Biol (2001) 1.89
The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process. Cell (1996) 1.88
Architecture of telomerase RNA. EMBO J (1994) 1.88
Genomic reorganization in ciliated protozoans. Annu Rev Genet (1986) 1.86
Molecular-genetic maps for group 1 chromosomes of Triticeae species and their relation to chromosomes in rice and oat. Genome (1995) 1.85
The Texas Medication Algorithm Project: report of the Texas Consensus Conference Panel on Medication Treatment of Major Depressive Disorder. J Clin Psychiatry (1999) 1.84