Early life stress and telomere length: investigating the connection and possible mechanisms: a critical survey of the evidence base, research methodology and basic biology.

PubWeight™: 1.23‹?› | Rank: Top 10%

🔗 View Article (PMC 3557830)

Published in Bioessays on September 19, 2012

Authors

Idan Shalev1

Author Affiliations

1: Department of Psychology and Neuroscience, Duke University, Durham, NC, USA. idan.shalev@duke.edu

Articles citing this

Social disadvantage, genetic sensitivity, and children's telomere length. Proc Natl Acad Sci U S A (2014) 1.64

Is chronic asthma associated with shorter leukocyte telomere length at midlife? Am J Respir Crit Care Med (2014) 1.55

Stress and telomere biology: a lifespan perspective. Psychoneuroendocrinology (2013) 1.46

Stress exposure in early post-natal life reduces telomere length: an experimental demonstration in a long-lived seabird. Proc Biol Sci (2014) 1.38

Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. Mol Psychiatry (2014) 1.21

The association of telomere length with family violence and disruption. Pediatrics (2014) 1.13

The long-term impact of adverse caregiving environments on epigenetic modifications and telomeres. Front Behav Neurosci (2015) 0.89

Lifelong leukocyte telomere dynamics and survival in a free-living mammal. Aging Cell (2015) 0.84

Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults. J Affect Disord (2014) 0.83

Influence of diet on leukocyte telomere length, markers of inflammation and oxidative stress in individuals with varied glucose tolerance: a Chinese population study. Nutr J (2016) 0.81

Early adversity, elevated stress physiology, accelerated sexual maturation, and poor health in females. Dev Psychol (2015) 0.81

Against all odds: genocidal trauma is associated with longer life-expectancy of the survivors. PLoS One (2013) 0.80

Drug addiction is associated with leukocyte telomere length. Sci Rep (2013) 0.80

Cortisol is not associated with telomere shortening or chromosomal instability in human lymphocytes cultured under low and high folate conditions. PLoS One (2015) 0.80

Child and family health in the era of prevention: new opportunities and challenges. J Behav Med (2016) 0.79

Childhood sexual abuse and posttraumatic stress disorder among pregnant and postpartum women: review of the literature. Arch Womens Ment Health (2014) 0.79

High sodium intake is associated with short leukocyte telomere length in overweight and obese adolescents. Int J Obes (Lond) (2015) 0.76

Interaction between Obstructive Sleep Apnea and Shortened Telomere Length on Brain White Matter Abnormality. Sleep (2016) 0.76

Accelerated telomere shortening: Tracking the lasting impact of early institutional care at the cellular level. Psychiatry Res (2016) 0.75

Detecting telomere elongation in longitudinal datasets: analysis of a proposal by Simons, Stulp and Nakagawa. PeerJ (2017) 0.75

Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder. Transl Psychiatry (2015) 0.75

Emotions and family interactions in childhood: Associations with leukocyte telomere length emotions, family interactions, and telomere length. Psychoneuroendocrinology (2015) 0.75

Risky Family Processes Prospectively Forecast Shorter Telomere Length Mediated Through Negative Emotions. Health Psychol (2016) 0.75

Association of Average Telomere Length with Body-Mass Index and Vitamin D Status in Juvenile Population with Type 1 Diabetes. Zdr Varst (2015) 0.75

Sex-Specific Effects of Combined Exposure to Chemical and Non-chemical Stressors on Neuroendocrine Development: a Review of Recent Findings and Putative Mechanisms. Curr Environ Health Rep (2017) 0.75

Articles cited by this

(truncated to the top 100)

The serial cultivation of human diploid cell strains. Exp Cell Res (1961) 25.11

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97

Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation (2003) 23.97

ON THE PERMANENT LIFE OF TISSUES OUTSIDE OF THE ORGANISM. J Exp Med (1912) 21.31

Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48

Aging: a theory based on free radical and radiation chemistry. J Gerontol (1956) 20.39

Telomere measurement by quantitative PCR. Nucleic Acids Res (2002) 18.69

The Stability of Broken Ends of Chromosomes in Zea Mays. Genetics (1941) 16.95

From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci (2008) 15.90

Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A (2004) 12.89

Association between telomere length in blood and mortality in people aged 60 years or older. Lancet (2003) 10.56

Oxidative stress shortens telomeres. Trends Biochem Sci (2002) 9.48

Origin of concatemeric T7 DNA. Nat New Biol (1972) 9.08

Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74

Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet (1994) 7.04

Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet (2005) 6.85

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J Mol Biol (1978) 6.45

Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36

Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res (1989) 4.72

Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol (1998) 4.68

Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci U S A (2007) 4.58

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature (2010) 4.36

Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull (2011) 4.27

Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med (1999) 4.27

Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet (2010) 4.26

Conservation of the human telomere sequence (TTAGGG)n among vertebrates. Proc Natl Acad Sci U S A (1989) 4.08

Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet (2003) 3.77

The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med (2008) 3.68

Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatry (2006) 3.33

Rise in insulin resistance is associated with escalated telomere attrition. Circulation (2005) 3.27

Telomere length in the newborn. Pediatr Res (2002) 3.26

Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet (2006) 3.25

Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients. J Immunol (2007) 3.20

Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav (2011) 3.04

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J Immunol (1996) 3.03

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol (2012) 3.03

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J (2002) 2.96

Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. Nucleic Acids Res (2011) 2.92

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun (2012) 2.90

Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay. Int J Epidemiol (2009) 2.87

Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol (2008) 2.86

Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging. Biol Psychiatry (2006) 2.85

Telomere length in early life predicts lifespan. Proc Natl Acad Sci U S A (2012) 2.74

Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry (2012) 2.67

Telomere position effect in human cells. Science (2001) 2.61

Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis (2005) 2.47

Telomere length in different tissues of elderly patients. Mech Ageing Dev (2000) 2.45

A meta-analytic review of the effects of childhood abuse on medical outcomes in adulthood. Psychosom Med (2009) 2.41

Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. Mol Psychiatry (2012) 2.37

Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet (2007) 2.37

Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study. Psychoneuroendocrinology (2011) 2.37

The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY) (2008) 2.35

[Principle of marginotomy in template synthesis of polynucleotides]. Dokl Akad Nauk SSSR (1971) 2.26

Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging. Biol Psychiatry (2009) 2.20

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radic Biol Med (2000) 2.19

The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet (2009) 2.17

Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci (2004) 2.10

Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. PLoS One (2010) 2.10

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell (2011) 2.07

Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosom Med (2010) 2.06

Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLoS One (2010) 2.03

Telomere length and early severe social deprivation: linking early adversity and cellular aging. Mol Psychiatry (2011) 2.01

Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96

Telomerase and cancer: revisiting the telomere hypothesis. Trends Biochem Sci (1996) 1.93

Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci (2009) 1.90

Telomere length, current perceived stress, and urinary stress hormones in women. Cancer Epidemiol Biomarkers Prev (2009) 1.88

Commentary: Raising the bar on telomere epidemiology. Int J Epidemiol (2009) 1.84

Reduced telomerase activity in human T lymphocytes exposed to cortisol. Brain Behav Immun (2008) 1.82

Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biol Psychiatry (2011) 1.81

Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79

Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One (2011) 1.78

The power of exercise: buffering the effect of chronic stress on telomere length. PLoS One (2010) 1.78

Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology (2010) 1.73

Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule. J Gerontol A Biol Sci Med Sci (2011) 1.72

Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mech Ageing Dev (2008) 1.69

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med (2012) 1.66

Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromes. Aging (Albany NY) (2010) 1.62

Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. PLoS Genet (2012) 1.57

Multivitamin use and telomere length in women. Am J Clin Nutr (2009) 1.54

A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol (2009) 1.51

Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr (2007) 1.47

Blood cell telomere length is a dynamic feature. PLoS One (2011) 1.41

Comparison of chromosome telomere integrity in multiple tissues from subjects at different ages. Cancer Genet Cytogenet (1998) 1.39

Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response. Mol Psychiatry (2011) 1.36

Rapid telomere shortening in children. Blood (1999) 1.35

Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children. Psychosom Med (2011) 1.34

Diet, nutrition and telomere length. J Nutr Biochem (2011) 1.33

An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects. Am J Hum Biol (2010) 1.32

Telomere length in human natural killer cell subsets. Ann N Y Acad Sci (2007) 1.25

Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro. Endocrinology (1997) 1.23

Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci (1998) 1.23

Telomeres, immune aging and autoimmunity. Exp Gerontol (2006) 1.17

Short telomeres in patients with chronic schizophrenia who show a poor response to treatment. J Psychiatry Neurosci (2008) 1.08

No correlation between childhood maltreatment and telomere length. Biol Psychiatry (2010) 1.07

Investigation of telomere lengths measurement by quantitative real-time PCR to predict age. Leg Med (Tokyo) (2008) 1.05

Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence. Nucleic Acids Res (2012) 1.03

Quantitative fluorescence in situ hybridization (Q-FISH). Curr Protoc Cell Biol (2001) 1.02

Measuring vertebrate telomeres: applications and limitations. Mol Ecol (2004) 0.98