Telomere diseases.

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Published in N Engl J Med on December 10, 2009

Authors

Rodrigo T Calado1, Neal S Young

Author Affiliations

1: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. calador@nhlbi.nih.gov

Associated clinical trials:

Nandrolone Decanoate in the Treatment of Telomeropathies | NCT02055456

Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial. | NCT03018236

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T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy. Blood (2010) 1.09

Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine. Haematologica (2010) 1.09

Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria. Br J Haematol (2004) 1.09

Perforin gene mutations in patients with acquired aplastic anemia. Blood (2007) 1.07

CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins. Blood (2006) 1.07

Gene expression profiling in CD34 cells to identify differences between aplastic anemia patients and healthy volunteers. Blood (2003) 1.06

Fas-mediated apoptosis is important in regulating cell replication and death in trisomy 8 hematopoietic cells but not in cells with other cytogenetic abnormalities. Blood (2002) 1.05

Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1. J Infect Dis (2003) 1.05

Mitochondrial DNA mutations in patients with myelodysplastic syndromes. Blood (2002) 1.05

Mitochondrial DNA sequence variation in single cells from leukemia patients. Blood (2006) 1.05

External contamination in single cell mtDNA analysis. PLoS One (2007) 1.04

Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia. Blood (2011) 1.04

Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry. Blood (2002) 1.03

Effect of anticoagulants on multiplexed measurement of cytokine/chemokines in healthy subjects. Cytokine (2012) 1.03

Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemia. Exp Hematol (2006) 1.03

Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppression. Clin Gastroenterol Hepatol (2009) 1.02

Mitochondrial DNA sequence heterogeneity in circulating normal human CD34 cells and granulocytes. Blood (2004) 1.02

Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens. Blood (2002) 1.01

Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation. Blood (2012) 1.01

Molecular analysis of TCR clonotypes in LGL: a clonal model for polyclonal responses. J Immunol (2004) 0.98

Late complications following treatment for severe aplastic anemia (SAA) with high-dose cyclophosphamide (Cy): follow-up of a randomized trial. Blood (2002) 0.96

Relative incidence of agranulocytosis and aplastic anemia. Am J Hematol (2006) 0.96

A pilot study of the recombinant soluble human tumour necrosis factor receptor (p75)-Fc fusion protein in patients with myelodysplastic syndrome. Br J Haematol (2002) 0.96

VP1u phospholipase activity is critical for infectivity of full-length parvovirus B19 genomic clones. Virology (2008) 0.96

Recombinant humanized anti-IL-2 receptor antibody (daclizumab) produces responses in patients with moderate aplastic anemia. Blood (2003) 0.96

Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background. Hum Mol Genet (2006) 0.95

The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure. Blood (2009) 0.95

Neutrophil count in African Americans: lowering the target cutoff to initiate or resume chemotherapy? J Clin Oncol (2010) 0.94

Cytogenetic abnormalities in paroxysmal nocturnal haemoglobinuria usually occur in haematopoietic cells that are glycosylphosphatidylinositol-anchored protein (GPI-AP) positive. Br J Haematol (2003) 0.92

Selective reduction of natural killer T cells in the bone marrow of aplastic anaemia. Br J Haematol (2002) 0.92