Published in Anal Chem on January 18, 2011
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Enumeration of 166 billion organic small molecules in the chemical universe database GDB-17. J Chem Inf Model (2012) 1.39
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Production of a functional catalytic antibody ScFv-NusA fusion protein in bacterial cytoplasm. J Biochem (2003) 1.29
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Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9. Proc Natl Acad Sci U S A (2004) 1.25
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Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc (2013) 1.14
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Functional imaging of legumain in cancer using a new quenched activity-based probe. J Am Chem Soc (2012) 1.05
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Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein. J Neurosci (2011) 0.99
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Highly enantio- and diastereoselective Mannich reactions of glycine Schiff bases with in situ generated N-Boc-imines catalyzed by a cinchona alkaloid thiourea. Org Lett (2010) 0.96
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A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of Pseudomonas aeruginosa biofilms. Angew Chem Int Ed Engl (2011) 0.93
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Classification of organic molecules by molecular quantum numbers. ChemMedChem (2009) 0.92
Use of an inhibitor to identify members of the hormone-sensitive lipase family. Biochemistry (2006) 0.90
A high-throughput, low-volume enzyme assay on solid support. Anal Chem (2005) 0.90
Modular organization of a Cdc6-like protein from the crenarchaeon Sulfolobus solfataricus. Biochem J (2004) 0.90
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A substrate-induced switch in the reaction mechanism of a thermophilic esterase: kinetic evidences and structural basis. J Biol Chem (2003) 0.89
Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation. Nat Commun (2013) 0.89
Bacterial colitis increases susceptibility to oral prion disease. J Infect Dis (2009) 0.89
Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase. Bioresour Technol (2010) 0.89
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Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius. Proteins (2008) 0.88
Visualization and virtual screening of the chemical universe database GDB-17. J Chem Inf Model (2013) 0.88
Crystallization and preliminary X-ray diffraction analysis of the hyperthermophilic Sulfolobus solfataricus phosphotriesterase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.88
SMIfp (SMILES fingerprint) chemical space for virtual screening and visualization of large databases of organic molecules. J Chem Inf Model (2013) 0.87
Discovery of α7-nicotinic receptor ligands by virtual screening of the chemical universe database GDB-13. J Chem Inf Model (2011) 0.87
Denaturing action of urea and guanidine hydrochloride towards two thermophilic esterases. Biochem J (2002) 0.87
Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB). J Med Chem (2010) 0.85
Glycopeptide dendrimers with high affinity for the fucose-binding lectin LecB from Pseudomonas aeruginosa. ChemMedChem (2009) 0.84
Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL. ACS Chem Neurosci (2014) 0.84
Defects in DNA lesion bypass lead to spontaneous chromosomal rearrangements and increased cell death. Eukaryot Cell (2009) 0.84
Visualisation and subsets of the chemical universe database GDB-13 for virtual screening. J Comput Aided Mol Des (2011) 0.84
Visualisation of the chemical space of fragments, lead-like and drug-like molecules in PubChem. J Comput Aided Mol Des (2011) 0.84
Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases. Biochim Biophys Acta (2005) 0.84
Inhibition of mitosis by glycopeptide dendrimer conjugates of colchicine. Chemistry (2005) 0.83
Neoglycopeptide dendrimer libraries as a source of lectin binding ligands. Org Lett (2007) 0.83
Discovery of NMDA glycine site inhibitors from the chemical universe database GDB. ChemMedChem (2008) 0.83
Sgs1 truncations induce genome rearrangements but suppress detrimental effects of BLM overexpression in Saccharomyces cerevisiae. J Mol Biol (2010) 0.83
Low background FRET-substrates for lipases and esterases suitable for high-throughput screening under basic (pH 11) conditions. Org Biomol Chem (2006) 0.83
A combinatorial approach to catalytic peptide dendrimers. Angew Chem Int Ed Engl (2004) 0.82
Atom pair 2D-fingerprints perceive 3D-molecular shape and pharmacophores for very fast virtual screening of ZINC and GDB-17. J Chem Inf Model (2014) 0.82
Electrostatics and flexibility drive membrane recognition and early penetration by the antimicrobial peptide dendrimer bH1. Chem Commun (Camb) (2013) 0.82
Structural and functional analyses reveal that Staphylococcus aureus antibiotic resistance factor HmrA is a zinc-dependent endopeptidase. J Biol Chem (2011) 0.82
The conserved N-terminal helix of acylpeptide hydrolase from archaeon Aeropyrum pernix K1 is important for its hyperthermophilic activity. Biochim Biophys Acta (2008) 0.82
Enzyme activity fingerprinting with substrate cocktails. J Am Chem Soc (2004) 0.82
Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease. Biol Chem (2007) 0.81
A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction. J Am Chem Soc (2004) 0.81
OMA and OPA--software-supported mass spectra analysis of native and modified nucleic acids. J Am Soc Mass Spectrom (2012) 0.81
Dual mechanism of zinc-proline catalyzed aldol reactions in water. Chem Commun (Camb) (2006) 0.81
Comprehensive analysis of surface charged residues involved in thermal stability in Alicyclobacillus acidocaldarius esterase 2. Protein Eng Des Sel (2012) 0.81
Alicyclobacillus acidocaldarius thermophilic esterase EST2's activity in milk and cheese models. Appl Environ Microbiol (2006) 0.81
A catalytically essential motif in external loop 5 of the bacterial oligosaccharyltransferase PglB. J Biol Chem (2013) 0.81
The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family. J Mol Biol (2004) 0.81
On-bead cyclization in a combinatorial library of 15,625 octapeptides. Bioorg Med Chem (2008) 0.81
Peptide dendrimer/lipid hybrid systems are efficient DNA transfection reagents: structure--activity relationships highlight the role of charge distribution across dendrimer generations. ACS Nano (2013) 0.81
A general method for designing combinatorial peptide libraries decodable by amino acid analysis. J Comb Chem (2007) 0.81
A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue. Proc Natl Acad Sci U S A (2002) 0.81
Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells. Chem Commun (Camb) (2014) 0.81
Fluorogenic substrates for lipases, esterases, and acylases using a TIM-mechanism for signal release. Biotechnol J (2007) 0.80