Published in Proc Natl Acad Sci U S A on July 01, 2002
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat Struct Mol Biol (2005) 2.50
Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR. Proc Natl Acad Sci U S A (2011) 0.83
Self-assembled gold nanocrystal micelles act as an excellent artificial nanozyme with ribonuclease activity. J Biol Inorg Chem (2009) 0.78
A role for hydrophobicity in a Diels-Alder reaction catalyzed by pyridyl-modified RNA. Nucleic Acids Res (2009) 0.76
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. Biochem J (1959) 31.27
Shape complementarity at protein/protein interfaces. J Mol Biol (1993) 10.40
Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci U S A (1991) 5.94
At the crossroads of chemistry and immunology: catalytic antibodies. Science (1991) 3.06
From molecular diversity to catalysis: lessons from the immune system. Science (1995) 1.97
The interdependence of protein surface topography and bound water molecules revealed by surface accessibility and fractal density measures. J Mol Biol (1992) 1.39
Immunological origins of binding and catalysis in a Diels-Alderase antibody. Science (1998) 1.28
Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis. Science (1993) 1.26
Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies. Chem Rev (1997) 1.15
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. Science (1999) 1.15
An antibody exo Diels-Alderase inhibitor complex at 1.95 angstrom resolution. Science (1998) 1.07
Transition states and mechanisms of the hetero-Diels-Alder reactions of hyponitrous acid, nitrosoalkanes, nitrosoarenes, and nitrosocarbonyl compounds. J Org Chem (2001) 1.01
Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution. Proc Natl Acad Sci U S A (1996) 0.86
Catalytic antibodies and other biomimetic catalysts. Nat Prod Rep (2000) 0.85
Regioselectivity and enantioselectivity in an antibody catalyzed hetero Diels-Alder reaction. Bioorg Med Chem (1996) 0.85
Mode of binding of anti-P-glycoprotein antibody MRK-16 to its antigen. A crystallographic and molecular modeling study. J Biol Chem (1998) 0.83
Extending the chemistry of enzymes and abzymes. Trends Biotechnol (1991) 0.78
Catalytic antibodies: the rerouting of chemical reactions. Towards electrophilic aromatic substitution by carbon dioxide. Ann N Y Acad Sci (1996) 0.78
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53
An efficient one-step site-directed and site-saturation mutagenesis protocol. Nucleic Acids Res (2004) 6.42
The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood (2007) 4.14
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy. Gastroenterology (2012) 3.28
ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. J Immunol (2006) 2.99
Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries. Medicine (Baltimore) (2010) 2.33
Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions. Proc Natl Acad Sci U S A (2008) 2.24
C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease. J Clin Invest (2002) 2.11
Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee. J Pediatr Gastroenterol Nutr (2012) 1.91
Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery. J Chem Inf Model (2007) 1.81
Immunologic and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin preparations. Blood (2006) 1.80
The molecular architecture of the metalloprotease FtsH. Proc Natl Acad Sci U S A (2006) 1.74
A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfecta. PLoS Genet (2009) 1.68
970 million druglike small molecules for virtual screening in the chemical universe database GDB-13. J Am Chem Soc (2009) 1.64
Virtual exploration of the small-molecule chemical universe below 160 Daltons. Angew Chem Int Ed Engl (2005) 1.57
The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein. J Mol Biol (2003) 1.54
Endocrine and bone metabolic complications in chronic liver disease and after liver transplantation in children. J Pediatr Gastroenterol Nutr (2012) 1.49
Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility. PLoS Pathog (2012) 1.48
Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice. Infect Immun (2006) 1.45
Multivalent glycoconjugates as anti-pathogenic agents. Chem Soc Rev (2012) 1.41
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. J Exp Med (2013) 1.39
Enumeration of 166 billion organic small molecules in the chemical universe database GDB-17. J Chem Inf Model (2012) 1.39
Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome. J Allergy Clin Immunol (2010) 1.36
Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB. Chem Biol (2008) 1.34
Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. J Allergy Clin Immunol (2007) 1.32
Production of a functional catalytic antibody ScFv-NusA fusion protein in bacterial cytoplasm. J Biochem (2003) 1.29
Expression improvement and mechanistic study of the retro-Diels-Alderase catalytic antibody 10F11 by site-directed mutagenesis. J Mol Biol (2004) 1.26
Enzyme assays for high-throughput screening. Curr Opin Biotechnol (2004) 1.25
Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9. Proc Natl Acad Sci U S A (2004) 1.25
Recent advances in enzyme assays. Trends Biotechnol (2004) 1.25
Crystal structure of a dodecameric tetrahedral-shaped aminopeptidase. J Biol Chem (2004) 1.16
Structure and function of the bacterial AAA protease FtsH. Biochim Biophys Acta (2011) 1.15
The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5. J Mol Biol (2006) 1.12
Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis. J Biol Chem (2013) 1.05
A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase. Proc Natl Acad Sci U S A (2003) 1.04
Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition. Proc Natl Acad Sci U S A (2012) 1.04
Prebiotic carbohydrate synthesis: zinc-proline catalyzes direct aqueous aldol reactions of alpha-hydroxy aldehydes and ketones. Org Biomol Chem (2005) 1.03
Crystal structure of the human supernatant protein factor. Structure (2002) 1.03
Crystal structure of the Citrobacter freundii dihydroxyacetone kinase reveals an eight-stranded alpha-helical barrel ATP-binding domain. J Biol Chem (2003) 1.03
Crystal structure of the phosphoenolpyruvate-binding enzyme I-domain from the Thermoanaerobacter tengcongensis PEP: sugar phosphotransferase system (PTS). J Mol Biol (2004) 1.03
Mucosal immunity and nasal influenza vaccination. Expert Rev Vaccines (2012) 1.03
Recombinant Lactobacillus johnsonii as a mucosal vaccine delivery vehicle. Vaccine (2002) 1.02
Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. J Invest Dermatol (2006) 1.00
Application and limitations of transient liver elastography in children. J Pediatr Gastroenterol Nutr (2013) 0.99
Crystal structure of enzyme I of the phosphoenolpyruvate sugar phosphotransferase system in the dephosphorylated state. J Biol Chem (2009) 0.98
A searchable map of PubChem. J Chem Inf Model (2010) 0.97
Regulation of the Dha operon of Lactococcus lactis: a deviation from the rule followed by the Tetr family of transcription regulators. J Biol Chem (2006) 0.97
Removal of metabolites, cytokines and hepatic growth factors by extracorporeal liver support in children. J Pediatr Gastroenterol Nutr (2005) 0.97
Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. J Biol Chem (2004) 0.97
DARPins as bispecific receptor antagonists analyzed for immunoglobulin E receptor blockage. J Mol Biol (2009) 0.96
Kinetics of IgM and IgA antibody response to 23-valent pneumococcal polysaccharide vaccination in healthy subjects. J Clin Immunol (2012) 0.96
Central venous pressure and impaired renal function in patients with acute heart failure. Eur J Heart Fail (2010) 0.96
A calcium-gated lid and a large beta-roll sandwich are revealed by the crystal structure of extracellular lipase from Serratia marcescens. J Biol Chem (2007) 0.93
A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of Pseudomonas aeruginosa biofilms. Angew Chem Int Ed Engl (2011) 0.93
Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor. Nature (2012) 0.93
DARPins against a functional IgE epitope. Immunol Lett (2010) 0.93
Classification of organic molecules by molecular quantum numbers. ChemMedChem (2009) 0.92
X-ray structures of the three Lactococcus lactis dihydroxyacetone kinase subunits and of a transient intersubunit complex. J Biol Chem (2008) 0.92
Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis. J Mol Biol (2003) 0.92
Peptide dendrimers as artificial enzymes, receptors, and drug-delivery agents. Acc Chem Res (2006) 0.92
Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr (2017) 0.91
A high-throughput, low-volume enzyme assay on solid support. Anal Chem (2005) 0.90
MQN-mapplet: visualization of chemical space with interactive maps of DrugBank, ChEMBL, PubChem, GDB-11, and GDB-13. J Chem Inf Model (2013) 0.90
Mucosal vaccination with a recombinant OprF-I vaccine of Pseudomonas aeruginosa in healthy volunteers: comparison of a systemic vs. a mucosal booster schedule. FEMS Immunol Med Microbiol (2003) 0.90
Characteristics of early and late PTLD development in pediatric solid organ transplant recipients. Transplantation (2013) 0.89
Indications and limitations of bariatric intervention in severely obese children and adolescents with and without nonalcoholic steatohepatitis: ESPGHAN Hepatology Committee Position Statement. J Pediatr Gastroenterol Nutr (2015) 0.89
Oxidative changes of bronchoalveolar proteins in cystic fibrosis. Chest (2006) 0.89
Chemical space travel. ChemMedChem (2007) 0.89
Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation. Nat Commun (2013) 0.89
Molecular analysis of ulilysin, the structural prototype of a new family of metzincin metalloproteases. J Biol Chem (2006) 0.89
A low background high-throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone. Bioorg Med Chem Lett (2003) 0.88
Visualization and virtual screening of the chemical universe database GDB-17. J Chem Inf Model (2013) 0.88
Phosphoenolpyruvate: sugar phosphotransferase system from the hyperthermophilic Thermoanaerobacter tengcongensis. Biochemistry (2011) 0.88
SMIfp (SMILES fingerprint) chemical space for virtual screening and visualization of large databases of organic molecules. J Chem Inf Model (2013) 0.87
Discovery of α7-nicotinic receptor ligands by virtual screening of the chemical universe database GDB-13. J Chem Inf Model (2011) 0.87
Phosphoenolpyruvate- and ATP-dependent dihydroxyacetone kinases: covalent substrate-binding and kinetic mechanism. Biochemistry (2004) 0.86
On the relevance of the Met-turn methionine in metzincins. J Biol Chem (2010) 0.86
Intravenous immunoglobulin (IVIG)-mediated neutralisation of C5a: a direct mechanism of IVIG in the maintenance of a high Fc gammaRIIB to Fc gammaRIII expression ratio on macrophages. Br J Haematol (2006) 0.85
Systemic, nasal and oral live vaccines against Pseudomonas aeruginosa: a clinical trial of immunogenicity in lower airways of human volunteers. Vaccine (2009) 0.85
Autophagy-enhancing drug carbamazepine diminishes hepatocellular death in fibrinogen storage disease. J Hepatol (2013) 0.85
Immune responses in the airways by nasal vaccination with systemic boosting against Pseudomonas aeruginosa in chronic lung disease. Vaccine (2009) 0.85
Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB). J Med Chem (2010) 0.85
Internal images: human anti-idiotypic Fab antibodies mimic the IgE epitopes of grass pollen allergen Phl p 5a. Mol Immunol (2006) 0.85
Glycopeptide dendrimers with high affinity for the fucose-binding lectin LecB from Pseudomonas aeruginosa. ChemMedChem (2009) 0.84
Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL. ACS Chem Neurosci (2014) 0.84
Visualisation of the chemical space of fragments, lead-like and drug-like molecules in PubChem. J Comput Aided Mol Des (2011) 0.84
Visualisation and subsets of the chemical universe database GDB-13 for virtual screening. J Comput Aided Mol Des (2011) 0.84
Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex. Arch Biochem Biophys (2006) 0.84
Pd(II)-catalyzed cascade Wacker-Heck reaction: chemoselective coupling of two electron-deficient reactants. J Org Chem (2006) 0.84
Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother (2008) 0.84
Whole-body diffusion-weighted MRI in a case of Rosai-Dorfman disease with exclusive multifocal skeletal involvement. Skeletal Radiol (2011) 0.84
Inhibition of mitosis by glycopeptide dendrimer conjugates of colchicine. Chemistry (2005) 0.83
Lung function and inflammation during murine Pseudomonas aeruginosa airway infection. Immunobiology (2011) 0.83
The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem (2009) 0.83
Molecular aspects of allergy. Mol Aspects Med (2002) 0.83