Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 3208614)

Published in Am J Respir Cell Mol Biol on January 21, 2011

Authors

Samuel L Collins1, Katharine E Black, Yee Chan-Li, Young-Hoon Ahn, Philip A Cole, Jonathan D Powell, Maureen R Horton

Author Affiliations

1: Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Articles cited by this

Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49

Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature (2002) 6.50

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med (2002) 5.70

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides. Am J Physiol (1993) 5.64

Resolution of lung inflammation by CD44. Science (2002) 4.09

CD44 and its interaction with extracellular matrix. Adv Immunol (1993) 4.04

Transcriptional regulation by cyclic AMP. Annu Rev Biochem (1997) 3.81

Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J Immunol (2006) 3.32

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest (2009) 2.96

Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Invest (1996) 2.86

Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J Exp Med (1994) 2.37

Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells. J Clin Invest (2003) 2.22

Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1. J Immunol (2005) 2.01

Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest (2003) 1.90

Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells. J Immunol (2001) 1.89

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol (2006) 1.79

Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages. J Exp Med (1996) 1.75

Respiratory syncytial virus induces insensitivity to beta-adrenergic agonists in mouse lung epithelium in vivo. Am J Physiol Lung Cell Mol Physiol (2007) 1.74

Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism. J Biol Chem (1997) 1.65

Adenosine A2A receptor activation reduces lung injury in trauma/hemorrhagic shock. Crit Care Med (2006) 1.63

Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient mice. J Immunol (2005) 1.62

Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages. J Immunol (1997) 1.61

Synergy between A2B adenosine receptors and hypoxia in activating human lung fibroblasts. Am J Respir Cell Mol Biol (2004) 1.52

RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy. Proc Natl Acad Sci U S A (2004) 1.52

cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts. Am J Physiol Cell Physiol (2004) 1.47

Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice. J Immunol (2001) 1.47

Adenosine receptors. J Biol Chem (1992) 1.44

Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages. J Biol Chem (1998) 1.43

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury. J Clin Invest (2005) 1.43

Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations. Am J Physiol Lung Cell Mol Physiol (2005) 1.39

CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2. J Biol Chem (2008) 1.32

CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice. Am J Pathol (2002) 1.28

Induction and regulation of macrophage metalloelastase by hyaluronan fragments in mouse macrophages. J Immunol (1999) 1.24

Low molecular weight hyaluronan from stretched lung enhances interleukin-8 expression. Am J Respir Cell Mol Biol (2003) 1.23

Functions of hyaluronan. Ann Rheum Dis (1995) 1.23

Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid. Thorax (1995) 1.14

A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase. Am J Respir Cell Mol Biol (2006) 1.10

Threat matrix: low-molecular-weight hyaluronan (HA) as a danger signal. Immunol Res (2005) 1.09

Effect of adenosine A2A receptor activation in murine models of respiratory disorders. Am J Physiol Lung Cell Mol Physiol (2005) 1.05

Adenosine A2A receptors promote adenosine-stimulated wound healing in bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2005) 0.97

Differential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2006) 0.96

Involvement of hyaluronan in epidermal Langerhans cell maturation and migration in vivo. J Dermatol Sci (2003) 0.95

The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion. Am J Respir Cell Mol Biol (2008) 0.95

Regulation of plasminogen activator inhibitor-1 and urokinase by hyaluronan fragments in mouse macrophages. Am J Physiol Lung Cell Mol Physiol (2000) 0.95

TLR4 is a negative regulator in noninfectious lung inflammation. J Immunol (2010) 0.90

Bronchoalveolar lavage fibronectin in patients with sarcoidosis: correlation to hyaluronan and disease activity. Eur Respir J (1991) 0.87

Articles by these authors

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell (2006) 10.28

HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant (2008) 7.10

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity (2009) 6.86

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol (2011) 5.22

Allogeneic hematopoietic stem-cell transplantation for sickle cell disease. N Engl J Med (2009) 4.59

Role of LAG-3 in regulatory T cells. Immunity (2004) 4.36

Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21

Egr-2 and Egr-3 are negative regulators of T cell activation. Nat Immunol (2005) 3.74

Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol (2004) 3.70

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53

A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol (2006) 3.40

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38

Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J Immunol (2006) 3.32

Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron (2010) 3.15

Regulation of immune responses by mTOR. Annu Rev Immunol (2011) 3.08

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature (2008) 2.83

Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (2008) 2.79

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature (2007) 2.78

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood (2007) 2.69

A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J Immunol (2007) 2.53

Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A (2006) 2.30

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell (2002) 2.29

Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. Biol Blood Marrow Transplant (2010) 2.17

Anergic T cells are metabolically anergic. J Immunol (2009) 2.12

Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12

High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood (2010) 1.99

Chemical rescue of a mutant enzyme in living cells. Science (2006) 1.95

Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nat Struct Mol Biol (2008) 1.89

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A (2011) 1.86

mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol Rev (2012) 1.74

Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr Opin Struct Biol (2008) 1.72

Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science (2011) 1.70

Structural basis for the recognition of c-Src by its inactivator Csk. Cell (2008) 1.66

A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription. EMBO J (2003) 1.65

The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity (2010) 1.64

RNA-selective, live cell imaging probes for studying nuclear structure and function. Chem Biol (2006) 1.63

The chemical biology of protein phosphorylation. Annu Rev Biochem (2009) 1.59

Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol (2007) 1.59

Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol (2007) 1.58

A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity (2011) 1.58

Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J (2010) 1.58

Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes. Cancer Res (2002) 1.53

Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol (2005) 1.52

LSD1 and the chemistry of histone demethylation. Curr Opin Chem Biol (2007) 1.52

Reading and function of a histone code involved in targeting corepressor complexes for repression. Mol Cell Biol (2005) 1.52

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science (2011) 1.49

Quantification of fragments of human serum inter-alpha-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption/ionization-based immunoassay. Clin Chem (2006) 1.45

Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation. J Immunol (2009) 1.45

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry (2007) 1.44

A mechanism-based inactivator for histone demethylase LSD1. J Am Chem Soc (2006) 1.43

A clinician's guide to the diagnosis and treatment of interstitial lung diseases. South Med J (2007) 1.43

Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell (2003) 1.42

Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell (2013) 1.40

Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines. Mol Cancer Ther (2011) 1.39

TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci U S A (2007) 1.39

mTOR: taking cues from the immune microenvironment. Immunology (2009) 1.38

Electrophilic tuning of the chemoprotective natural product sulforaphane. Proc Natl Acad Sci U S A (2010) 1.37

Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur J Immunol (2008) 1.35

The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation. J Biol Chem (2002) 1.34

Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A (2011) 1.30

Csk, a critical link of g protein signals to actin cytoskeletal reorganization. Dev Cell (2002) 1.30

Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J Am Chem Soc (2010) 1.29

Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. J Biol Chem (2006) 1.26

p300/CBP-associated factor drives DEK into interchromatin granule clusters. J Biol Chem (2005) 1.24

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nat Chem Biol (2012) 1.24

MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms. FASEB J (2012) 1.24

Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proc Natl Acad Sci U S A (2002) 1.22

Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nat Struct Mol Biol (2011) 1.21

Investigation of the roles of catalytic residues in serotonin N-acetyltransferase. J Biol Chem (2002) 1.20

Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry (2007) 1.20

mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation. J Clin Invest (2015) 1.18

Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205. J Biol Chem (2005) 1.17

Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Chem Biol (2011) 1.16

Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor. Cancer Immunol Immunother (2011) 1.16

In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry (2009) 1.16

Ascertainment of collagen vascular disease in patients presenting with interstitial lung disease. Respir Med (2009) 1.15

Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. J Am Chem Soc (2010) 1.15

Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template. Mol Cell Biol (2002) 1.14

Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor. J Am Chem Soc (2005) 1.14

The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. J Biol Chem (2006) 1.14

Protein semisynthesis and expressed protein ligation: chasing a protein's tail. Curr Opin Chem Biol (2005) 1.11

Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent. Mol Cell Biol (2003) 1.09

Sleep quality and health-related quality of life in idiopathic pulmonary fibrosis. Chest (2008) 1.09

Retracted Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat Immunol (2013) 1.09

Threat matrix: low-molecular-weight hyaluronan (HA) as a danger signal. Immunol Res (2005) 1.09

X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition. J Mol Biol (2002) 1.09

Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells. J Immunol (2012) 1.08

The novel cyclophilin binding compound, sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction. J Immunol (2004) 1.08

Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors. Cancer Cell (2003) 1.08

Advanced visualization of airways with 64-MDCT: 3D mapping and virtual bronchoscopy. AJR Am J Roentgenol (2007) 1.07

Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation. Structure (2011) 1.07

Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms. Cancer Res (2002) 1.07