Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 3766488)

Published in Mov Disord on April 29, 2013

Authors

Pablo R Moya1, Jens R Wendland, Liza M Rubenstein, Kiara R Timpano, Gary A Heiman, Jay A Tischfield, Robert A King, Anne M Andrews, Samanda Ramamoorthy, Francis J McMahon, Dennis L Murphy

Author Affiliations

1: National Institute of Mental Health-Intramural Research Program, Bethesda, MD, USA. moyap@mail.nih.gov

Articles cited by this

A map of human genome variation from population-scale sequencing. Nature (2010) 121.13

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (2003) 28.61

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (1996) 16.04

Population stratification and spurious allelic association. Lancet (2003) 10.53

The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry (1989) 6.98

The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry (2011) 6.66

Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27

Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry (2010) 6.15

Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry (2009) 3.97

The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry (2010) 2.82

miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science (2010) 2.75

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med (2010) 2.75

Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Am J Hum Genet (2005) 2.44

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J Neurosci (2007) 2.33

Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci (2008) 2.21

A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol (2003) 2.15

Recent advances in Tourette syndrome research. Trends Neurosci (2006) 2.13

Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry (2003) 2.12

Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol Interv (2004) 1.89

A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci U S A (1999) 1.86

Tourette syndrome: evolving concepts. Mov Disord (2011) 1.84

Gilles de la Tourette's syndrome and obsessive-compulsive disorder. Evidence supporting a genetic relationship. Arch Gen Psychiatry (1986) 1.83

Dopaminergic dsyfunction in Tourette syndrome. Ann Neurol (1982) 1.79

Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest (2008) 1.57

The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions. Mol Psychiatry (2006) 1.53

Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Proc Natl Acad Sci U S A (2005) 1.53

Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc Natl Acad Sci U S A (2012) 1.48

The genetics of Tourette syndrome: a review. J Psychosom Res (2009) 1.46

Serotonin and blood pressure regulation. Pharmacol Rev (2012) 1.41

A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet (2007) 1.39

Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET. Neuropsychopharmacology (2007) 1.30

Serotonergic transcriptional networks and potential importance to mental health. Nat Neurosci (2012) 1.28

Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective. Psychol Med (2011) 1.25

Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder. Mol Psychiatry (2006) 1.23

Recent advances in Tourette syndrome. Curr Opin Neurol (2011) 1.13

The genetics of Tourette syndrome. Nat Rev Neurol (2012) 1.13

Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies. Cell Mol Neurobiol (2006) 1.09

A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder. Neuropsychopharmacology (2007) 1.07

Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, Tourette's syndrome, and healthy controls. Neuropsychopharmacology (1995) 1.05

Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease. Curr Opin Pharmacol (2011) 1.04

Neurobiology of tourette syndrome: current status and need for further investigation. J Neurosci (2011) 1.02

Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder. Mol Psychiatry (1999) 1.00

The genetics of Tourette disorder. Curr Opin Genet Dev (2011) 0.99

Extrastriatal dopaminergic dysfunction in tourette syndrome. Ann Neurol (2010) 0.99

Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? PLoS One (2010) 0.98

Support for the association between the rare functional variant I425V of the serotonin transporter gene and susceptibility to obsessive compulsive disorder. Mol Psychiatry (2005) 0.97

Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder. J Neurosci (2007) 0.95

miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells. Int J Neuropsychopharmacol (2012) 0.94

Diagnostic interview assessed neuropsychiatric disorder comorbidity in 334 individuals with obsessive-compulsive disorder. Depress Anxiety (2004) 0.93

Characterization of a putative intrarenal serotonergic system. Am J Physiol Renal Physiol (2007) 0.92

Central biogenic amine metabolism in children with the syndrome of chronic multiple tics of Gilles de la Tourette: norepinephrine, serotonin, and dopamine. J Am Acad Child Psychiatry (1979) 0.92

Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study. Mol Psychiatry (2009) 0.92

Chronic, multiple tics of Gilles de la Tourette's disease. CSF acid monoamine metabolites after probenecid administration. Arch Gen Psychiatry (1978) 0.91

SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder. Psychiatr Genet (2008) 0.91

Clinical phenomenology and phenotype variability in Tourette syndrome. J Psychosom Res (2009) 0.90

An international multicenter association study of the serotonin transporter gene in persistent ADHD. Genes Brain Behav (2010) 0.87

An association study between 5-HTTLPR polymorphism, COMT polymorphism, and Tourette's syndrome. Psychiatry Res (2000) 0.85

Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome. Pharmacol Biochem Behav (2005) 0.83

A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings. Biol Psychiatry (2011) 0.83

Natural and engineered coding variation in antidepressant-sensitive serotonin transporters. Neuroscience (2011) 0.83

Psychopathology and personality characteristics in relation to blood serotonin in Tourette's syndrome and obsessive-compulsive disorder. J Psychopharmacol (2001) 0.82

Influence of serotonin on the human ureter: an in vitro pharmacological study. Urol Int (1995) 0.81

A clinical comparison of pathologic skin picking and obsessive-compulsive disorder. Compr Psychiatry (2009) 0.80

Whole blood serotonin and tryptophan levels in Tourette's disorder: effects of acute and chronic clonidine treatment. Life Sci (1984) 0.79

Skin picking and trichotillomania in adults with obsessive-compulsive disorder. Compr Psychiatry (2011) 0.79

The genetics of obsessive-compulsive disorder and Tourette's syndrome: what are the common factors? Curr Psychiatry Rep (2009) 0.79

New Jersey Center for Tourette Syndrome sharing repository: methods and sample description. BMC Med Genomics (2008) 0.78

An association analysis between 5-HTTLPR polymorphism and obsessive-compulsive disorder, Tourette syndrome in a Chinese Han population. CNS Neurosci Ther (2011) 0.77

Articles by these authors

Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron (2011) 10.61

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry (2008) 6.73

Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27

Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13

A genome-wide association study of alcohol dependence. Proc Natl Acad Sci U S A (2010) 4.94

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother (2013) 4.80

Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73

Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet (2005) 3.24

High frequencies of de novo CNVs in bipolar disorder and schizophrenia. Neuron (2011) 3.08

Description of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single-nucleotide polymorphism genotyping for Genetic Analysis Workshop 14. BMC Genet (2005) 3.04

Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet (2003) 3.02

Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res (2010) 2.99

L-histidine decarboxylase and Tourette's syndrome. N Engl J Med (2010) 2.92

Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry (2007) 2.87

Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Am J Psychiatry (2007) 2.84

Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. Am J Psychiatry (2007) 2.83

Nanotools for neuroscience and brain activity mapping. ACS Nano (2013) 2.74

Attention training for generalized social anxiety disorder. J Abnorm Psychol (2009) 2.62

Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet (2003) 2.55

Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. Proc Natl Acad Sci U S A (2002) 2.47

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nat Genet (2010) 2.46

Basal Ganglia volumes in patients with Gilles de la Tourette syndrome. Arch Gen Psychiatry (2003) 2.33

Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biol Psychiatry (2011) 2.28

Mutations in THAP1 (DYT6) in early-onset dystonia: a genetic screening study. Lancet Neurol (2009) 2.24

Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc Natl Acad Sci U S A (2002) 2.17

A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol (2003) 2.15

Hair apparent: Rapunzel syndrome. Am J Psychiatry (2005) 1.98

CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell (2012) 1.97

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90

Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort. Am J Psychiatry (2007) 1.88

The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. Biol Psychiatry (2008) 1.86

Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry (2010) 1.85

G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Biol Psychiatry (2006) 1.85

Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33. Am J Psychiatry (2007) 1.85

Contemporary assessment and pharmacotherapy of Tourette syndrome. NeuroRx (2006) 1.82

Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys. Biol Psychiatry (2005) 1.81

Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition. Int J Psychophysiol (2004) 1.79

Nano in the brain: nano-neuroscience. ACS Nano (2012) 1.74

Contribution of common genetic variants to antidepressant response. Biol Psychiatry (2012) 1.73

Gene expression and genetic variation data implicate PCLO in bipolar disorder. Biol Psychiatry (2010) 1.70

Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment. J Am Acad Child Adolesc Psychiatry (2003) 1.69

Defining the phenotype in human genetic studies: forward genetics and reverse phenotyping. Hum Hered (2004) 1.68

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68

Tourette syndrome: the self under siege. J Child Neurol (2006) 1.67

The Netherlands Twin Register biobank: a resource for genetic epidemiological studies. Twin Res Hum Genet (2010) 1.65

Familiality of polarity at illness onset in bipolar affective disorder. Am J Psychiatry (2006) 1.64

Non-replication of association studies: "pseudo-failures" to replicate? Genet Med (2007) 1.62

Subtractive patterning via chemical lift-off lithography. Science (2012) 1.62

Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods (2004) 1.59

A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. J Cereb Blood Flow Metab (2012) 1.59

Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry (2003) 1.58

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease. Brain (2013) 1.57

Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest (2008) 1.57

How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology (2008) 1.56

Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories. Psychiatry Res (2008) 1.54

Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression. Arch Gen Psychiatry (2007) 1.53

A new statistic to evaluate imputation reliability. PLoS One (2010) 1.50

Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence. Alcohol Clin Exp Res (2012) 1.50

Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am J Hum Genet (2005) 1.49

Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees. Biol Psychiatry (2003) 1.49

Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cereb Cortex (2009) 1.48

Psychiatric symptoms associated with focal hand dystonia. Mov Disord (2010) 1.47

Atomoxetine and tics in ADHD. J Am Acad Child Adolesc Psychiatry (2004) 1.43

Diagnostic reliability of bipolar II disorder. Arch Gen Psychiatry (2002) 1.42

Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Behav Res Ther (2006) 1.41

Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology (2004) 1.41

The bipolar disorder phenome database: a resource for genetic studies. Am J Psychiatry (2007) 1.41

A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet (2007) 1.39

Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology (2002) 1.39

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks. Nucleic Acids Res (2008) 1.37

Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder. Am J Psychiatry (2003) 1.36

Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology (2003) 1.36

Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet B Neuropsychiatr Genet (2008) 1.35

Tourette syndrome and tic disorders: a decade of progress. J Am Acad Child Adolesc Psychiatry (2007) 1.33

Centralizing the non-central chi-square: A new method to correct for population stratification in genetic case-control association studies. Genet Epidemiol (2006) 1.33

Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity. Psychiatry Res (2005) 1.31

Examining the unique relationships between anxiety disorders and childhood physical and sexual abuse in the National Comorbidity Survey-Replication. Psychiatry Res (2010) 1.31

Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.31

Family accommodation in pediatric anxiety disorders. Depress Anxiety (2012) 1.31

Familial variation in episode frequency in bipolar affective disorder. Am J Psychiatry (2005) 1.30

Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients. Biol Psychiatry (2012) 1.29

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev (2013) 1.29

SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. Nucleic Acids Res (2010) 1.29