Published in Proteins on December 03, 2010
Computational design of ligand-binding proteins with high affinity and selectivity. Nature (2013) 2.81
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant. Nature (2011) 2.49
Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature (2014) 2.20
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing. Nat Biotechnol (2012) 2.14
Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nat Med (2015) 1.74
mCSM: predicting the effects of mutations in proteins using graph-based signatures. Bioinformatics (2013) 1.69
Scientific benchmarks for guiding macromolecular energy function improvement. Methods Enzymol (2013) 1.59
Amino acid coevolution induces an evolutionary Stokes shift. Proc Natl Acad Sci U S A (2012) 1.35
Mutational effects on stability are largely conserved during protein evolution. Proc Natl Acad Sci U S A (2013) 1.28
Mutations in NOTCH1 cause Adams-Oliver syndrome. Am J Hum Genet (2014) 1.26
Resolution-adapted recombination of structural features significantly improves sampling in restraint-guided structure calculation. Proteins (2012) 1.21
A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain. Curr Biol (2014) 1.19
Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release. Nat Struct Mol Biol (2013) 1.19
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. J Am Chem Soc (2012) 1.08
Biophysics of protein evolution and evolutionary protein biophysics. J R Soc Interface (2014) 1.08
Latent effects of Hsp90 mutants revealed at reduced expression levels. PLoS Genet (2013) 1.07
High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution. Sci Rep (2014) 1.03
Predicting the Impact of Missense Mutations on Protein-Protein Binding Affinity. J Chem Theory Comput (2014) 0.98
Assessing predictors of changes in protein stability upon mutation using self-consistency. PLoS One (2012) 0.96
Site-Specific Amino Acid Preferences Are Mostly Conserved in Two Closely Related Protein Homologs. Mol Biol Evol (2015) 0.95
Structural dynamics flexibility informs function and evolution at a proteome scale. Evol Appl (2013) 0.95
Evolutionary dynamics on protein bi-stability landscapes can potentially resolve adaptive conflicts. PLoS Comput Biol (2012) 0.92
Contingency and entrenchment in protein evolution under purifying selection. Proc Natl Acad Sci U S A (2015) 0.92
Computationally designed libraries for rapid enzyme stabilization. Protein Eng Des Sel (2014) 0.92
Computational protein design with explicit consideration of surface hydrophobic patches. Proteins (2011) 0.92
Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites. Phys Biol (2015) 0.92
The evolution of protein structures and structural ensembles under functional constraint. Genes (Basel) (2011) 0.91
Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy. Eur J Hum Genet (2014) 0.90
Rapid calculation of protein pKa values using Rosetta. Biophys J (2012) 0.90
Hotspot-centric de novo design of protein binders. J Mol Biol (2011) 0.89
C-terminal interactions mediate the quaternary dynamics of αB-crystallin. Philos Trans R Soc Lond B Biol Sci (2013) 0.88
Prediction of mutational tolerance in HIV-1 protease and reverse transcriptase using flexible backbone protein design. PLoS Comput Biol (2012) 0.87
Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions. J Am Chem Soc (2014) 0.87
High-throughput identification of loss-of-function mutations for anti-interferon activity in the influenza A virus NS segment. J Virol (2014) 0.87
Why human disease-associated residues appear as the wild-type in other species: genome-scale structural evidence for the compensation hypothesis. Mol Biol Evol (2014) 0.86
Mining endonuclease cleavage determinants in genomic sequence data. J Biol Chem (2011) 0.86
Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality. PLoS Genet (2015) 0.85
Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds. PLoS One (2012) 0.85
pmx: Automated protein structure and topology generation for alchemical perturbations. J Comput Chem (2014) 0.84
An Integrated Framework Advancing Membrane Protein Modeling and Design. PLoS Comput Biol (2015) 0.84
Functional implications of the binding mode of a human conformation-dependent V2 monoclonal antibody against HIV. J Virol (2014) 0.84
Reprogramming homing endonuclease specificity through computational design and directed evolution. Nucleic Acids Res (2013) 0.84
Boosting antibody developability through rational sequence optimization. MAbs (2015) 0.84
Protein stability: computation, sequence statistics, and new experimental methods. Curr Opin Struct Biol (2015) 0.83
EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib. BMC Bioinformatics (2015) 0.83
A Web Resource for Standardized Benchmark Datasets, Metrics, and Rosetta Protocols for Macromolecular Modeling and Design. PLoS One (2015) 0.82
Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions. PLoS One (2015) 0.82
Adaptation in protein fitness landscapes is facilitated by indirect paths. Elife (2016) 0.82
PROTS-RF: a robust model for predicting mutation-induced protein stability changes. PLoS One (2012) 0.81
Quantification of the transferability of a designed protein specificity switch reveals extensive epistasis in molecular recognition. Proc Natl Acad Sci U S A (2014) 0.81
Engineering a more thermostable blue light photo receptor Bacillus subtilis YtvA LOV domain by a computer aided rational design method. PLoS Comput Biol (2013) 0.81
Allosteric coupling in the bacterial adhesive protein FimH. J Biol Chem (2013) 0.81
A Dynamic molecular basis for malfunction in disease mutants of p97/VCP. Elife (2016) 0.80
Optimization of rotamers prior to template minimization improves stability predictions made by computational protein design. Protein Sci (2015) 0.80
Binding pocket optimization by computational protein design. PLoS One (2012) 0.80
Improved modeling of side-chain--base interactions and plasticity in protein--DNA interface design. J Mol Biol (2012) 0.80
Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting. Elife (2016) 0.79
The linear interaction energy method for the prediction of protein stability changes upon mutation. Proteins (2011) 0.79
Simultaneous Optimization of Biomolecular Energy Functions on Features from Small Molecules and Macromolecules. J Chem Theory Comput (2016) 0.79
FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants. PLoS Comput Biol (2015) 0.78
Genomic architecture of inflammatory bowel disease in five families with multiple affected individuals. Hum Genome Var (2016) 0.78
A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces. Protein Eng Des Sel (2016) 0.78
Engineering of Baeyer-Villiger monooxygenase-based Escherichia coli biocatalyst for large scale biotransformation of ricinoleic acid into (Z)-11-(heptanoyloxy)undec-9-enoic acid. Sci Rep (2016) 0.78
Rational design of temperature-sensitive alleles using computational structure prediction. PLoS One (2011) 0.78
Accurate and Rigorous Prediction of the Changes in Protein Free Energies in a Large-Scale Mutation Scan. Angew Chem Int Ed Engl (2016) 0.78
Missense variant pathogenicity predictors generalize well across a range of function-specific prediction challenges. Hum Mutat (2017) 0.78
Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability. Biochemistry (2016) 0.77
Tools for Predicting the Functional Impact of Nonsynonymous Genetic Variation. Genetics (2016) 0.77
Selection for Protein Kinetic Stability Connects Denaturation Temperatures to Organismal Temperatures and Provides Clues to Archaean Life. PLoS One (2016) 0.77
Mono and dual cofactor dependence of human cystathionine β-synthase enzyme variants in vivo and in vitro. G3 (Bethesda) (2013) 0.77
GNAO1 encephalopathy: further delineation of a severe neurodevelopmental syndrome affecting females. Orphanet J Rare Dis (2016) 0.77
Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16. Antiviral Res (2015) 0.77
Protocols for Molecular Modeling with Rosetta3 and RosettaScripts. Biochemistry (2016) 0.76
Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response. J Comput Biol (2015) 0.76
Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis. Elife (2015) 0.76
Feature-based multiple models improve classification of mutation-induced stability changes. BMC Genomics (2014) 0.76
Structure Based Thermostability Prediction Models for Protein Single Point Mutations with Machine Learning Tools. PLoS One (2015) 0.76
Fast side chain replacement in proteins using a coarse-grained approach for evaluating the effects of mutation during evolution. J Mol Evol (2011) 0.76
Hot or not? Discovery and characterization of a thermostable alditol oxidase from Acidothermus cellulolyticus 11B. Appl Microbiol Biotechnol (2012) 0.76
Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy. Pediatr Nephrol (2012) 0.76
Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor. MAbs (2014) 0.76
A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor. J Biol Chem (2016) 0.76
Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex. J Biol Chem (2016) 0.76
Structure-based predictions broadly link transcription factor mutations to gene expression changes in cancers. Nucleic Acids Res (2014) 0.76
Correlated positions in protein evolution and engineering. J Ind Microbiol Biotechnol (2016) 0.76
Predicting the effects of amino acid replacements in peptide hormones on their binding affinities for class B GPCRs and application to the design of secretin receptor antagonists. J Comput Aided Mol Des (2012) 0.75
Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach. Cancer Inform (2016) 0.75
Identifying EGFR mutation-induced drug resistance based on alpha shape model analysis of the dynamics. Proteome Sci (2016) 0.75
Two strategies to engineer flexible loops for improved enzyme thermostability. Sci Rep (2017) 0.75
Introduction to the Rosetta Special Collection. PLoS One (2015) 0.75
Computational Redesign of Thioredoxin Is Hypersensitive toward Minor Conformational Changes in the Backbone Template. J Mol Biol (2016) 0.75
Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis. MBio (2016) 0.75
Crucial roles of single residues in binding affinity, specificity, and promiscuity in the cellulosomal cohesin-dockerin interface. J Biol Chem (2015) 0.75
Prediction of protein relative enthalpic stability from molecular dynamics simulations of the folded and unfolded states. Biophys J (2012) 0.75
Localized structural frustration for evaluating the impact of sequence variants. Nucleic Acids Res (2016) 0.75
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning. Proc Natl Acad Sci U S A (2017) 0.75
Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family. J R Soc Interface (2017) 0.75
High-throughput identification of protein mutant stability computed from a double mutant fitness landscape. Protein Sci (2015) 0.75
Kinetic Characterization of 100 Glycoside Hydrolase Mutants Enables the Discovery of Structural Features Correlated with Kinetic Constants. PLoS One (2016) 0.75
Computational prediction of the tolerance to amino-acid deletion in green-fluorescent protein. PLoS One (2017) 0.75
Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations. J Mol Biol (2002) 9.74
Effective energy function for proteins in solution. Proteins (1999) 9.44
Macromolecular modeling with rosetta. Annu Rev Biochem (2008) 8.32
Native protein sequences are close to optimal for their structures. Proc Natl Acad Sci U S A (2000) 7.99
High-resolution structure prediction and the crystallographic phase problem. Nature (2007) 7.67
A simple physical model for binding energy hot spots in protein-protein complexes. Proc Natl Acad Sci U S A (2002) 6.18
The backrub motion: how protein backbone shrugs when a sidechain dances. Structure (2006) 5.71
Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease. Biochemistry (1990) 3.29
ProTherm and ProNIT: thermodynamic databases for proteins and protein-nucleic acid interactions. Nucleic Acids Res (2006) 2.81
Eris: an automated estimator of protein stability. Nat Methods (2007) 2.78
Predicting protein stability changes upon mutation using database-derived potentials: solvent accessibility determines the importance of local versus non-local interactions along the sequence. J Mol Biol (1997) 2.38
Backrub-like backbone simulation recapitulates natural protein conformational variability and improves mutant side-chain prediction. J Mol Biol (2008) 2.27
Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details. Protein Eng Des Sel (2009) 2.25
Predicting free energy changes using structural ensembles. Nat Methods (2009) 1.93
Residual structure in large fragments of staphylococcal nuclease: effects of amino acid substitutions. Biochemistry (1989) 1.87
Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state. Biochemistry (1992) 1.75
A potential smoothing algorithm accurately predicts transmembrane helix packing. Nat Struct Biol (1999) 1.68
A "solvated rotamer" approach to modeling water-mediated hydrogen bonds at protein-protein interfaces. Proteins (2005) 1.62
High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. J Mol Biol (2006) 1.49
Contributions of the ionizable amino acids to the stability of staphylococcal nuclease. Biochemistry (1996) 1.38
Large-scale prediction of protein geometry and stability changes for arbitrary single point mutations. Proteins (2004) 1.29
Energetic contribution of side chain hydrogen bonding to the stability of staphylococcal nuclease. Biochemistry (1995) 1.14
Energetic and structural analysis of the role of tryptophan 59 in FKBP12. Biochemistry (2003) 0.98
A single-point mutation in the extreme heat- and pressure-resistant sso7d protein from sulfolobus solfataricus leads to a major rearrangement of the hydrophobic core. Biochemistry (1999) 0.88
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res (2007) 37.31
Design of a novel globular protein fold with atomic-level accuracy. Science (2003) 13.06
Protein structure prediction using Rosetta. Methods Enzymol (2004) 12.05
Predicting protein structures with a multiplayer online game. Nature (2010) 9.95
Toward high-resolution de novo structure prediction for small proteins. Science (2005) 9.18
Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations. J Mol Biol (2003) 8.35
Macromolecular modeling with rosetta. Annu Rev Biochem (2008) 8.32
Kemp elimination catalysts by computational enzyme design. Nature (2008) 8.19
Evaluation of structural and evolutionary contributions to deleterious mutation prediction. J Mol Biol (2002) 7.79
High-resolution structure prediction and the crystallographic phase problem. Nature (2007) 7.67
De novo computational design of retro-aldol enzymes. Science (2008) 7.62
Protein structure prediction and analysis using the Robetta server. Nucleic Acids Res (2004) 7.39
ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods Enzymol (2011) 7.33
Consistent blind protein structure generation from NMR chemical shift data. Proc Natl Acad Sci U S A (2008) 6.76
A simple physical model for binding energy hot spots in protein-protein complexes. Proc Natl Acad Sci U S A (2002) 6.18
Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nat Struct Mol Biol (2011) 5.02
Towards robust regional estimates of CO2 sources and sinks using atmospheric transport models. Nature (2002) 4.71
An orientation-dependent hydrogen bonding potential improves prediction of specificity and structure for proteins and protein-protein complexes. J Mol Biol (2003) 4.63
Assigning function to yeast proteins by integration of technologies. Mol Cell (2003) 4.58
Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs. Chem Biol (2006) 4.52
Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science (2011) 4.42
Protein-protein docking with backbone flexibility. J Mol Biol (2007) 4.32
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science (2010) 4.32
Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8. Proteins (2009) 4.27
Computational redesign of endonuclease DNA binding and cleavage specificity. Nature (2006) 4.06
Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature (2010) 4.04
Automated de novo prediction of native-like RNA tertiary structures. Proc Natl Acad Sci U S A (2007) 3.87
Algorithm discovery by protein folding game players. Proc Natl Acad Sci U S A (2011) 3.74
Computational redesign of protein-protein interaction specificity. Nat Struct Mol Biol (2004) 3.66
Modeling structurally variable regions in homologous proteins with rosetta. Proteins (2004) 3.64
Structure prediction for CASP8 with all-atom refinement using Rosetta. Proteins (2009) 3.64
ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility. Proteins (2006) 3.60
Rational HIV immunogen design to target specific germline B cell receptors. Science (2013) 3.55
High-resolution mapping of protein sequence-function relationships. Nat Methods (2010) 3.47
Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature (2006) 3.45
Computational alanine scanning of protein-protein interfaces. Sci STKE (2004) 3.41
Automated prediction of CASP-5 structures using the Robetta server. Proteins (2003) 3.41
New algorithms and an in silico benchmark for computational enzyme design. Protein Sci (2006) 3.40
Simplification of antiretroviral therapy with tenofovir-emtricitabine or abacavir-Lamivudine: a randomized, 96-week trial. Clin Infect Dis (2009) 3.32
Inflammation in neurodegenerative diseases. Immunology (2010) 3.22
An engineered microbial platform for direct biofuel production from brown macroalgae. Science (2012) 3.20
A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins. J Mol Biol (2003) 3.08
Atomic accuracy in predicting and designing noncanonical RNA structure. Nat Methods (2010) 3.07
Progress in modeling of protein structures and interactions. Science (2005) 3.05
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci U S A (2009) 3.01
Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home. Proteins (2007) 3.01
NMR structure determination for larger proteins using backbone-only data. Science (2010) 3.00
Refinement of protein structures into low-resolution density maps using rosetta. J Mol Biol (2009) 2.94
The 3D profile method for identifying fibril-forming segments of proteins. Proc Natl Acad Sci U S A (2006) 2.88
De novo prediction of three-dimensional structures for major protein families. J Mol Biol (2002) 2.88
RosettaLigand docking with full ligand and receptor flexibility. J Mol Biol (2008) 2.86
Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc Natl Acad Sci U S A (2006) 2.81
Multipass membrane protein structure prediction using Rosetta. Proteins (2006) 2.79
Computational thermostabilization of an enzyme. Science (2005) 2.79
Rosetta predictions in CASP5: successes, failures, and prospects for complete automation. Proteins (2003) 2.77
Improved molecular replacement by density- and energy-guided protein structure optimization. Nature (2011) 2.74
Improved side-chain modeling for protein-protein docking. Protein Sci (2005) 2.72
Close agreement between the orientation dependence of hydrogen bonds observed in protein structures and quantum mechanical calculations. Proc Natl Acad Sci U S A (2004) 2.71
Elicitation of structure-specific antibodies by epitope scaffolds. Proc Natl Acad Sci U S A (2010) 2.68
CASD-NMR: critical assessment of automated structure determination by NMR. Nat Methods (2009) 2.50
A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell (2007) 2.50
Principles for designing ideal protein structures. Nature (2012) 2.50
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant. Nature (2011) 2.49
Physically realistic homology models built with ROSETTA can be more accurate than their templates. Proc Natl Acad Sci U S A (2006) 2.47
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature (2011) 2.46
Protein-DNA binding specificity predictions with structural models. Nucleic Acids Res (2005) 2.45
De novo protein structure generation from incomplete chemical shift assignments. J Biomol NMR (2008) 2.43
No effect of rosiglitazone for treatment of HIV-1 lipoatrophy: randomised, double-blind, placebo-controlled trial. Lancet (2004) 2.43
Assessing the utility of coevolution-based residue-residue contact predictions in a sequence- and structure-rich era. Proc Natl Acad Sci U S A (2013) 2.43
Computational design of protein-protein interactions. Curr Opin Chem Biol (2004) 2.39
Contact order revisited: influence of protein size on the folding rate. Protein Sci (2003) 2.37
Prediction of the structure of symmetrical protein assemblies. Proc Natl Acad Sci U S A (2007) 2.35
Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science (2012) 2.33
Progress and challenges in high-resolution refinement of protein structure models. Proteins (2005) 2.28
Design, activity, and structure of a highly specific artificial endonuclease. Mol Cell (2002) 2.25
RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite. PLoS One (2011) 2.21
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature (2011) 2.20
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players. Nat Biotechnol (2012) 2.19
Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold. Science (2011) 2.17
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing. Nat Biotechnol (2012) 2.14
De novo determination of protein backbone structure from residual dipolar couplings using Rosetta. J Am Chem Soc (2002) 2.12
Dissecting the genome of the polyploid crop oilseed rape by transcriptome sequencing. Nat Biotechnol (2011) 2.12
Free modeling with Rosetta in CASP6. Proteins (2005) 2.10
Improved beta-protein structure prediction by multilevel optimization of nonlocal strand pairings and local backbone conformation. Proteins (2006) 2.07
Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus. Proc Natl Acad Sci U S A (2011) 2.03
Atomic model of the type III secretion system needle. Nature (2012) 2.02
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system. Nat Struct Mol Biol (2009) 2.02
Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging. PLoS Biol (2006) 1.99
High-resolution comparative modeling with RosettaCM. Structure (2013) 1.96
RosettaHoles: rapid assessment of protein core packing for structure prediction, refinement, design, and validation. Protein Sci (2009) 1.96
Homology modeling using parametric alignment ensemble generation with consensus and energy-based model selection. Nucleic Acids Res (2006) 1.96
An improved protein decoy set for testing energy functions for protein structure prediction. Proteins (2003) 1.94
Prediction of CASP6 structures using automated Robetta protocols. Proteins (2005) 1.94
Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface. J Mol Biol (2006) 1.93
Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope. Structure (2010) 1.91
Alternate states of proteins revealed by detailed energy landscape mapping. J Mol Biol (2010) 1.90
A simple physical model for the prediction and design of protein-DNA interactions. J Mol Biol (2004) 1.90
Coupled prediction of protein secondary and tertiary structure. Proc Natl Acad Sci U S A (2003) 1.90