Published in MAbs on January 01, 2015
ABodyBuilder: Automated antibody structure prediction with data-driven accuracy estimation. MAbs (2016) 0.79
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo. Sci Rep (2016) 0.77
Prediction and Reduction of the Aggregation of Monoclonal Antibodies. J Mol Biol (2017) 0.75
Rapid and accurate in silico solubility screening of a monoclonal antibody library. Sci Rep (2017) 0.75
Computer-aided drug design at Boehringer Ingelheim. J Comput Aided Mol Des (2016) 0.75
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46
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Scaling and assessment of data quality. Acta Crystallogr D Biol Crystallogr (2005) 61.38
MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36
Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov (2004) 15.57
Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations. J Mol Biol (2002) 9.74
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat Biotechnol (2004) 7.02
ElNemo: a normal mode web server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Res (2004) 5.19
Mechanisms of tryptophan fluorescence shifts in proteins. Biophys J (2001) 4.17
Data processing and analysis with the autoPROC toolbox. Acta Crystallogr D Biol Crystallogr (2011) 3.41
Fluorescence and the location of tryptophan residues in protein molecules. Photochem Photobiol (1973) 3.24
AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides. BMC Bioinformatics (2007) 3.02
Prediction of protein-protein interaction sites using patch analysis. J Mol Biol (1997) 2.91
Role of conformational sampling in computing mutation-induced changes in protein structure and stability. Proteins (2010) 2.56
Prediction of aggregation-prone regions in structured proteins. J Mol Biol (2008) 2.56
Challenges in the development of high protein concentration formulations. J Pharm Sci (2004) 2.52
Protein aggregation and bioprocessing. AAPS J (2006) 2.47
A comparative study of motor-protein motions by using a simple elastic-network model. Proc Natl Acad Sci U S A (2003) 2.17
Design of therapeutic proteins with enhanced stability. Proc Natl Acad Sci U S A (2009) 2.01
Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability. J Mol Biol (2005) 1.90
An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Mol Cell (2009) 1.90
A simple model for proteins with interacting domains. Applications to scanning calorimetry data. Biochemistry (1989) 1.88
Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences. Protein Sci (2005) 1.80
The PASTA server for protein aggregation prediction. Protein Eng Des Sel (2007) 1.76
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies. J Pharm Sci (2008) 1.54
Process economics of industrial monoclonal antibody manufacture. J Chromatogr B Analyt Technol Biomed Life Sci (2006) 1.50
A broad range of Fab stabilities within a host of therapeutic IgGs. Biochem Biophys Res Commun (2007) 1.46
Protein aggregation--pathways and influencing factors. Int J Pharm (2010) 1.44
Principles, approaches, and challenges for predicting protein aggregation rates and shelf life. J Pharm Sci (2009) 1.40
Protein thermostability calculations using alchemical free energy simulations. Biophys J (2010) 1.33
Amyloidogenic determinants are usually not buried. BMC Struct Biol (2009) 1.31
Geometry-based sampling of conformational transitions in proteins. Structure (2007) 1.26
Structure-based engineering of a monoclonal antibody for improved solubility. Protein Eng Des Sel (2010) 1.21
Antibodies to watch in 2014. MAbs (2013) 1.14
A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties. MAbs (2013) 1.11
A rapid, sensitive and economical assessment of monoclonal antibody conformational stability by intrinsic tryptophan fluorescence spectroscopy. Biotechnol J (2008) 0.97
Therapeutic protein aggregation: mechanisms, design, and control. Trends Biotechnol (2014) 0.95
Observation of small cluster formation in concentrated monoclonal antibody solutions and its implications to solution viscosity. Biophys J (2014) 0.94
Characterization and screening of IgG binding to the neonatal Fc receptor. MAbs (2014) 0.93
Dissociation and denaturation equilibria and kinetics of a homogeneous human immunoglobulin Fab fragment. Biochemistry (1976) 0.93
Coarse-grained modeling of the self-association of therapeutic monoclonal antibodies. J Phys Chem B (2012) 0.86
Predicting accelerated aggregation rates for monoclonal antibody formulations, and challenges for low-temperature predictions. J Pharm Sci (2011) 0.85
Conformational stability as a design target to control protein aggregation. Protein Eng Des Sel (2014) 0.84
Development of scoring functions for antibody sequence assessment and optimization. PLoS One (2013) 0.78
A critical evaluation of microcalorimetry as a predictive tool for long term stability of liquid protein formulations: granulocyte colony stimulating factor (GCSF). Eur J Pharm Biopharm (2013) 0.77
High throughput prediction of the long-term stability of pharmaceutical macromolecules from short-term multi-instrument spectroscopic data. J Pharm Sci (2014) 0.76
Different species of alpha-synuclein oligomers induce calcium influx and seeding. J Neurosci (2007) 3.16
A specific antidote for dabigatran: functional and structural characterization. Blood (2013) 2.77
Channelrhodopsin-2 is a leaky proton pump. Proc Natl Acad Sci U S A (2009) 1.87
Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene (2002) 1.62
Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J Clin Invest (2003) 1.59
Cooperative binding of ATP and RNA induces a closed conformation in a DEAD box RNA helicase. Proc Natl Acad Sci U S A (2008) 1.58
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers. J Biol Chem (2008) 1.56
Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation. Mol Microbiol (2008) 1.56
The mechanism of ATP-dependent RNA unwinding by DEAD box proteins. Biol Chem (2009) 1.42
Molecular basis of MAPK-activated protein kinase 2:p38 assembly. Proc Natl Acad Sci U S A (2007) 1.40
Strategies for the assessment of protein aggregates in pharmaceutical biotech product development. Pharm Res (2010) 1.35
Combined participation of hydroxylase active site residues and effector protein binding in a para to ortho modulation of toluene 4-monooxygenase regiospecificity. Biochemistry (2002) 1.29
Structural basis of chemokine sequestration by a herpesvirus decoy receptor. Cell (2002) 1.29
Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem J (2005) 1.28
Substrate binding and active site residues in RNases E and G: role of the 5'-sensor. J Biol Chem (2009) 1.07
Physicochemical properties of bacterial glycopolymers in relation to bioactivity. Carbohydr Res (2003) 1.04
Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides. Biophys J (2011) 1.03
Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins. Eur J Biochem (2002) 1.03
Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis. Biochem J (2007) 1.02
Investigation into the interaction of recombinant human serum albumin with Re-lipopolysaccharide and lipid A. J Endotoxin Res (2002) 1.02
Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide. Biophys J (2004) 0.99
Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide. Eur J Biochem (2004) 0.93
Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. J Biol Chem (2003) 0.91
Thermodynamic analysis of the lipopolysaccharide-dependent resistance of gram-negative bacteria against polymyxin B. Biophys J (2007) 0.91
Transfection efficiency and cytotoxicity of nonviral gene transfer reagents in human smooth muscle and endothelial cells. Pharm Res (2004) 0.91
Mechanisms of endotoxin neutralization by synthetic cationic compounds. J Endotoxin Res (2006) 0.91
Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-x(L) on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media. Biotechnol Bioeng (2002) 0.90
Crystal structures and functional studies of T4moD, the toluene 4-monooxygenase catalytic effector protein. Biochemistry (2005) 0.88
Lysozyme-lysozyme self-interactions as assessed by the osmotic second virial coefficient: impact for physical protein stabilization. Biotechnol J (2009) 0.86
Selection of high-producing CHO cells using NPT selection marker with reduced enzyme activity. Biotechnol Bioeng (2005) 0.86
Insights into protein-polysorbate interactions analysed by means of isothermal titration and differential scanning calorimetry. Eur Biophys J (2009) 0.86
Peptide-based treatment of sepsis. Appl Microbiol Biotechnol (2011) 0.85
A critical evaluation of self-interaction chromatography as a predictive tool for the assessment of protein-protein interactions in protein formulation development: a case study of a therapeutic monoclonal antibody. Eur J Pharm Biopharm (2010) 0.85
Physicochemical characterization of the endotoxins from Coxiella burnetii strain Priscilla in relation to their bioactivities. BMC Biochem (2004) 0.84
Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes. Eur Biophys J (2004) 0.83
Conformational analysis of protein secondary structure during spray-drying of antibody/mannitol formulations. Eur J Pharm Biopharm (2006) 0.83
Structural investigations into the interaction of hemoglobin and part structures with bacterial endotoxins. Innate Immun (2008) 0.83
Stabilized nonviral formulations for the delivery of MCP-1 gene into cells of the vasculoendothelial system. Pharm Res (2004) 0.82
Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines. Curr Drug Targets (2012) 0.82
Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin. Innate Immun (2010) 0.82
Effects of the nonsteroidal anti-inflammatory drug naproxen on human erythrocytes and on cell membrane molecular models. Biophys Chem (2010) 0.80
p27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHO-DUKX adapted for growth in suspension and serum-free media. Biotechnol Bioeng (2002) 0.80
The membrane-activity of Ibuprofen, Diclofenac, and Naproxen: a physico-chemical study with lecithin phospholipids. Biochim Biophys Acta (2009) 0.80
The expression of endotoxic activity in the Limulus test as compared to cytokine production in immune cells. Curr Med Chem (2009) 0.80
Thermodynamics of demicellization of mixed micelles composed of sodium oleate and bile salts. Langmuir (2004) 0.80
Solubilization of negatively charged DPPC/DPPG liposomes by bile salts. J Colloid Interface Sci (2004) 0.79
Resolving power of dynamic light scattering for protein and polystyrene nanoparticles. Pharm Dev Technol (2014) 0.79
Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects. Curr Drug Targets (2012) 0.79
Investigation into the interaction of the phosphoporin PhoE with outer membrane lipids: physicochemical characterization and biological activity. Med Chem (2005) 0.79
Physicochemical characterization and biological activity of lipooligosaccharides and lipid A from Neisseria meningitidis. J Endotoxin Res (2007) 0.79
Structural polymorphism of hydrated monoacylated maltose glycolipids. Chem Phys Lipids (2008) 0.78
Molecular basis for endotoxin neutralization by amphipathic peptides derived from the alpha-helical cationic core-region of NK-lysin. Biophys Chem (2010) 0.78
Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI). J Med Chem (2010) 0.78
Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins, part 2: stability during storage at elevated temperatures. J Pharm Sci (2012) 0.78
Fully human antibodies against the Protease-Activated Receptor-2 (PAR-2) with anti-inflammatory activity. Hum Antibodies (2011) 0.78
Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines. Open Biochem J (2013) 0.77
Human cells and cell membrane molecular models are affected in vitro by the nonsteroidal anti-inflammatory drug ibuprofen. Biochim Biophys Acta (2011) 0.77
Hydrophobic interactions are the driving force for the binding of peptide mimotopes and Staphylococcal protein A to recombinant human IgG1. Eur Biophys J (2007) 0.76
Crystallization and preliminary analysis of xenobiotic reductase A and ligand complexes from Pseudomonas putida II-B. Acta Crystallogr D Biol Crystallogr (2004) 0.76
Buffer capacity of biologics--from buffer salts to buffering by antibodies. Biotechnol Prog (2013) 0.76
Viscosity measurements of antibody solutions by photon correlation spectroscopy: an indirect approach - limitations and applicability for high-concentration liquid protein solutions. Pharm Dev Technol (2012) 0.76
Correlation of protein-protein interactions as assessed by affinity chromatography with colloidal protein stability: a case study with lysozyme. Pharm Dev Technol (2010) 0.76
Structure-guided residence time optimization of a dabigatran reversal agent. MAbs (2015) 0.75
Crystallization and preliminary analysis of native and N-terminal truncated isoforms of toluene-4-monooxygenase catalytic effector protein. Acta Crystallogr D Biol Crystallogr (2003) 0.75
Large-scale production of lipoplexes with long shelf-life. Eur J Pharm Biopharm (2005) 0.75
Buffer-free therapeutic antibody preparations provide a viable alternative to conventionally buffered solutions: from protein buffer capacity prediction to bioprocess applications. Biotechnol J (2015) 0.75
Comparative SAXS and DSC study on stratum corneum structural organization in an epidermal cell culture model (ROC): impact of cultivation time. Eur J Pharm Sci (2013) 0.75
An infrared reflection-absorption spectroscopic (IRRAS) study of the interaction of lipid A and lipopolysaccharide Re with endotoxin-binding proteins. Med Chem (2009) 0.75
Membrane interacting peptides--towards the understanding of biological membranes. Biophys Chem (2010) 0.75