Published in Nature on August 21, 2011
Protein activity regulation by conformational entropy. Nature (2012) 2.53
Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently. Chem Soc Rev (2015) 1.74
NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers. Proc Natl Acad Sci U S A (2013) 1.48
Role of cavities and hydration in the pressure unfolding of T4 lysozyme. Proc Natl Acad Sci U S A (2014) 1.38
Integrative, dynamic structural biology at atomic resolution--it's about time. Nat Methods (2015) 1.36
Allosteric inhibition through suppression of transient conformational states. Nat Chem Biol (2013) 1.33
Chemical exchange in biomacromolecules: past, present, and future. J Magn Reson (2014) 1.24
Effect of freezing conditions on distances and their distributions derived from Double Electron Electron Resonance (DEER): a study of doubly-spin-labeled T4 lysozyme. J Magn Reson (2012) 1.22
Fast and accurate fitting of relaxation dispersion data using the flexible software package GLOVE. J Biomol NMR (2013) 1.09
pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR. Proc Natl Acad Sci U S A (2012) 1.09
A single-molecule dissection of ligand binding to a protein with intrinsic dynamics. Nat Chem Biol (2013) 1.08
Biophysics of protein evolution and evolutionary protein biophysics. J R Soc Interface (2014) 1.08
Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins. Curr Opin Struct Biol (2015) 1.02
A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. J Biol Chem (2014) 1.01
Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling. Proc Natl Acad Sci U S A (2013) 0.99
Transiently populated intermediate functions as a branching point of the FF domain folding pathway. Proc Natl Acad Sci U S A (2012) 0.96
Characterizing the protonation state of cytosine in transient G·C Hoogsteen base pairs in duplex DNA. J Am Chem Soc (2013) 0.94
A designed conformational shift to control protein binding specificity. Angew Chem Int Ed Engl (2014) 0.93
Evolutionary dynamics on protein bi-stability landscapes can potentially resolve adaptive conflicts. PLoS Comput Biol (2012) 0.92
Cavity as a source of conformational fluctuation and high-energy state: high-pressure NMR study of a cavity-enlarged mutant of T4 lysozyme. Biophys J (2015) 0.92
Measurement of histidine pKa values and tautomer populations in invisible protein states. Proc Natl Acad Sci U S A (2014) 0.92
Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants. Proc Natl Acad Sci U S A (2013) 0.90
Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study. Proc Natl Acad Sci U S A (2016) 0.89
Is pressure-induced signal loss in NMR spectra for the Leu99Ala cavity mutant of T4 lysozyme due to unfolding? Proc Natl Acad Sci U S A (2015) 0.89
Flexible backbone sampling methods to model and design protein alternative conformations. Methods Enzymol (2013) 0.89
Probing transient conformational states of proteins by solid-state R(1ρ) relaxation-dispersion NMR spectroscopy. Angew Chem Int Ed Engl (2014) 0.89
From a structural average to the conformational ensemble of a DNA bulge. Proc Natl Acad Sci U S A (2014) 0.88
Protein folding on the ribosome studied using NMR spectroscopy. Prog Nucl Magn Reson Spectrosc (2013) 0.87
Structure of a low-population intermediate state in the release of an enzyme product. Elife (2015) 0.87
Probing slowly exchanging protein systems via ¹³Cα-CEST: monitoring folding of the Im7 protein. J Biomol NMR (2013) 0.87
Interaction Networks in Protein Folding via Atomic-Resolution Experiments and Long-Time-Scale Molecular Dynamics Simulations. J Am Chem Soc (2015) 0.87
Multistate approaches in computational protein design. Protein Sci (2012) 0.86
Characterizing RNA ensembles from NMR data with kinematic models. Nucleic Acids Res (2014) 0.86
Homologous ligands accommodated by discrete conformations of a buried cavity. Proc Natl Acad Sci U S A (2015) 0.85
Loop interactions and dynamics tune the enzymatic activity of the human histone deacetylase 8. J Am Chem Soc (2013) 0.85
Folding of the four-helix bundle FF domain from a compact on-pathway intermediate state is governed predominantly by water motion. Proc Natl Acad Sci U S A (2012) 0.84
Cold denaturation of a protein dimer monitored at atomic resolution. Nat Chem Biol (2013) 0.84
Structures of the excited states of phospholamban and shifts in their populations upon phosphorylation. Biochemistry (2013) 0.84
Defining a length scale for millisecond-timescale protein conformational exchange. Proc Natl Acad Sci U S A (2013) 0.84
Allosteric switch regulates protein-protein binding through collective motion. Proc Natl Acad Sci U S A (2016) 0.83
An exact solution for R2,eff in CPMG experiments in the case of two site chemical exchange. J Magn Reson (2014) 0.83
Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin. Proc Natl Acad Sci U S A (2013) 0.83
Internal protein dynamics on ps to μs timescales as studied by multi-frequency (15)N solid-state NMR relaxation. J Biomol NMR (2013) 0.83
Measuring hydrogen exchange rates in invisible protein excited states. Proc Natl Acad Sci U S A (2014) 0.82
Measurement of the signs of methyl 13C chemical shift differences between interconverting ground and excited protein states by R(1ρ): an application to αB-crystallin. J Biomol NMR (2012) 0.81
Quantum chemical calculations of amide-15N chemical shift anisotropy tensors for a membrane-bound cytochrome-b5. J Phys Chem B (2013) 0.81
Substrate dynamics in enzyme action: rotations of monosaccharide subunits in the binding groove are essential for pectin methylesterase processivity. Biophys J (2013) 0.80
Celebrating structural biology. Nat Struct Mol Biol (2011) 0.80
Mechanisms of amyloid formation revealed by solution NMR. Prog Nucl Magn Reson Spectrosc (2015) 0.80
Characterization of the conformational fluctuations in the Josephin domain of ataxin-3. Biophys J (2014) 0.79
Heteronuclear Adiabatic Relaxation Dispersion (HARD) for quantitative analysis of conformational dynamics in proteins. J Magn Reson (2012) 0.79
Dynamics of the His79-heme alkaline transition of yeast iso-1-cytochrome c probed by conformationally gated electron transfer with Co(II)bis(terpyridine). J Am Chem Soc (2013) 0.79
Exposing the Moving Parts of Proteins with NMR Spectroscopy. J Phys Chem Lett (2012) 0.79
Evaluating the uncertainty in exchange parameters determined from off-resonance R1ρ relaxation dispersion for systems in fast exchange. J Magn Reson (2014) 0.78
Detecting O2 binding sites in protein cavities. Sci Rep (2016) 0.78
Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis. Cell Rep (2015) 0.78
Predicting Binding Free Energies. Annu Rev Biophys (2017) 0.78
Fractional enrichment of proteins using [2-(13)C]-glycerol as the carbon source facilitates measurement of excited state 13Cα chemical shifts with improved sensitivity. J Biomol NMR (2015) 0.77
Identification and characterization of a multispecific monoclonal antibody G2 against chicken prion protein. Protein Sci (2014) 0.77
A minor conformation of a lanthanide tag on adenylate kinase characterized by paramagnetic relaxation dispersion NMR spectroscopy. J Biomol NMR (2015) 0.77
(S)Pinning down protein interactions by NMR. Protein Sci (2016) 0.77
Predicting protein backbone chemical shifts from Cα coordinates: extracting high resolution experimental observables from low resolution models. J Chem Theory Comput (2015) 0.77
A personal perspective on chemistry-driven RNA research. Biopolymers (2013) 0.76
Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy. Proc Natl Acad Sci U S A (2016) 0.76
Geometric analysis characterizes molecular rigidity in generic and non-generic protein configurations. J Mech Phys Solids (2015) 0.76
Reply to Kitahara and Mulder: An ensemble view of protein stability best explains pressure effects in a T4 lysozyme cavity mutant. Proc Natl Acad Sci U S A (2015) 0.76
Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure. Proc Natl Acad Sci U S A (2015) 0.76
Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses. Nat Commun (2017) 0.75
Protein dynamics: Catch them if you can. Nat Chem Biol (2013) 0.75
Atomistic structural ensemble refinement reveals non-native structure stabilizes a sub-millisecond folding intermediate of CheY. Sci Rep (2017) 0.75
Capturing Invisible Motions in the Transition from Ground to Rare Excited States of T4 Lysozyme L99A. Biophys J (2016) 0.75
Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches. PLoS Comput Biol (2016) 0.75
The ribosome's energy landscape: Recent insights from computation. Biophys Rev (2015) 0.75
Mapping transiently formed and sparsely populated conformations on a complex energy landscape. Elife (2016) 0.75
Protein dynamics elucidated by NMR technique. Protein Cell (2013) 0.75
Modeling Protein Excited-state Structures from "Over-length" Chemical Cross-links. J Biol Chem (2016) 0.75
Binding affinities controlled by shifting conformational equilibria: opportunities and limitations. Biophys J (2015) 0.75
Probing conformational dynamics in biomolecules via chemical exchange saturation transfer: a primer. J Biomol NMR (2017) 0.75
Rational design of proteins that exchange on functional timescales. Nat Chem Biol (2017) 0.75
(13)C-NMR studies on disulfide bond isomerization in bovine pancreatic trypsin inhibitor (BPTI). J Biomol NMR (2016) 0.75
A multispecific monoclonal antibody G2 recognizes at least three completely different epitope sequences with high affinity. Protein Sci (2017) 0.75
Probing slow timescale dynamics in proteins using methyl (1)H CEST. J Biomol NMR (2017) 0.75
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94
TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts. J Biomol NMR (2009) 16.09
The CCPN data model for NMR spectroscopy: development of a software pipeline. Proteins (2005) 13.03
The dynamic energy landscape of dihydrofolate reductase catalysis. Science (2006) 7.55
Enzyme recruitment in evolution of new function. Annu Rev Microbiol (1976) 6.95
Consistent blind protein structure generation from NMR chemical shift data. Proc Natl Acad Sci U S A (2008) 6.76
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. Science (1992) 6.51
Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules. Methods Enzymol (2001) 5.58
Intrinsic motions along an enzymatic reaction trajectory. Nature (2007) 5.53
Molecular dynamics and protein function. Proc Natl Acad Sci U S A (2005) 4.70
Protein-protein docking with backbone flexibility. J Mol Biol (2007) 4.32
Studying excited states of proteins by NMR spectroscopy. Nat Struct Biol (2001) 4.07
Protein structure determination from NMR chemical shifts. Proc Natl Acad Sci U S A (2007) 3.96
Protein dynamism and evolvability. Science (2009) 3.57
Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR. Nature (2007) 3.21
A simple method to predict protein flexibility using secondary chemical shifts. J Am Chem Soc (2005) 3.15
A heteronuclear correlation experiment for simultaneous determination of 15N longitudinal decay and chemical exchange rates of systems in slow equilibrium. J Biomol NMR (1994) 3.14
A transient and low-populated protein-folding intermediate at atomic resolution. Science (2010) 3.08
Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA. Science (2006) 2.88
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR. Nature (2004) 2.84
Role of conformational sampling in computing mutation-induced changes in protein structure and stability. Proteins (2010) 2.56
Probing invisible, low-populated States of protein molecules by relaxation dispersion NMR spectroscopy: an application to protein folding. Acc Chem Res (2008) 2.15
A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene. Nature (1992) 2.10
Lessons from the lysozyme of phage T4. Protein Sci (2010) 1.85
Dynamic regulation of archaeal proteasome gate opening as studied by TROSY NMR. Science (2010) 1.69
Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product release. Proc Natl Acad Sci U S A (2005) 1.68
Reconstructing NMR spectra of "invisible" excited protein states using HSQC and HMQC experiments. J Am Chem Soc (2002) 1.66
Probing chemical shifts of invisible states of proteins with relaxation dispersion NMR spectroscopy: how well can we do? J Am Chem Soc (2008) 1.64
Measurement of bond vector orientations in invisible excited states of proteins. Proc Natl Acad Sci U S A (2007) 1.52
Structures of invisible, excited protein states by relaxation dispersion NMR spectroscopy. Proc Natl Acad Sci U S A (2008) 1.49
Flexibility and ligand exchange in a buried cavity mutant of T4 lysozyme studied by multinuclear NMR. Biochemistry (2000) 1.30
Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states. J Biomol NMR (2008) 1.23
Access of ligands to cavities within the core of a protein is rapid. Nat Struct Biol (1996) 1.18
Analysis of the effectiveness of proline substitutions and glycine replacements in increasing the stability of phage T4 lysozyme. Biopolymers (1992) 1.09
Double- and zero-quantum NMR relaxation dispersion experiments sampling millisecond time scale dynamics in proteins. J Am Chem Soc (2004) 1.04
Halogenated benzenes bound within a non-polar cavity in T4 lysozyme provide examples of I...S and I...Se halogen-bonding. J Mol Biol (2008) 0.96
Isotope labeling methods for studies of excited protein states by relaxation dispersion NMR spectroscopy. Nat Protoc (2009) 0.93
A simple method for measuring signs of (1)H (N) chemical shift differences between ground and excited protein states. J Biomol NMR (2010) 0.92
CPMG relaxation dispersion NMR experiments measuring glycine 1H alpha and 13C alpha chemical shifts in the 'invisible' excited states of proteins. J Biomol NMR (2009) 0.89
Using chemical exchange to assign non-covalent protein complexes in slow exchange with the free state: enhanced resolution and efficient signal editing. J Biomol NMR (2004) 0.85
Design of a novel globular protein fold with atomic-level accuracy. Science (2003) 13.06
Protein structure prediction using Rosetta. Methods Enzymol (2004) 12.05
Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol Cell Proteomics (2005) 10.60
Predicting protein structures with a multiplayer online game. Nature (2010) 9.95
Toward high-resolution de novo structure prediction for small proteins. Science (2005) 9.18
Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations. J Mol Biol (2003) 8.35
Macromolecular modeling with rosetta. Annu Rev Biochem (2008) 8.32
Kemp elimination catalysts by computational enzyme design. Nature (2008) 8.19
Evaluation of structural and evolutionary contributions to deleterious mutation prediction. J Mol Biol (2002) 7.79
High-resolution structure prediction and the crystallographic phase problem. Nature (2007) 7.67
De novo computational design of retro-aldol enzymes. Science (2008) 7.62
Protein structure prediction and analysis using the Robetta server. Nucleic Acids Res (2004) 7.39
ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods Enzymol (2011) 7.33
Intrinsic dynamics of an enzyme underlies catalysis. Nature (2005) 7.32
Consistent blind protein structure generation from NMR chemical shift data. Proc Natl Acad Sci U S A (2008) 6.76
A simple physical model for binding energy hot spots in protein-protein complexes. Proc Natl Acad Sci U S A (2002) 6.18
Higher-energy C-trap dissociation for peptide modification analysis. Nat Methods (2007) 5.04
Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nat Struct Mol Biol (2011) 5.02
A dual pressure linear ion trap Orbitrap instrument with very high sequencing speed. Mol Cell Proteomics (2009) 4.75
Towards robust regional estimates of CO2 sources and sinks using atmospheric transport models. Nature (2002) 4.71
New tools provide new insights in NMR studies of protein dynamics. Science (2006) 4.64
An orientation-dependent hydrogen bonding potential improves prediction of specificity and structure for proteins and protein-protein complexes. J Mol Biol (2003) 4.63
Assigning function to yeast proteins by integration of technologies. Mol Cell (2003) 4.58
Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs. Chem Biol (2006) 4.52
Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science (2011) 4.42
Protein-protein docking with backbone flexibility. J Mol Biol (2007) 4.32
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science (2010) 4.32
Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8. Proteins (2009) 4.27
Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer. Anal Chem (2006) 4.10
Computational redesign of endonuclease DNA binding and cleavage specificity. Nature (2006) 4.06
Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature (2010) 4.04
Automated de novo prediction of native-like RNA tertiary structures. Proc Natl Acad Sci U S A (2007) 3.87
Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer. Mol Cell Proteomics (2011) 3.75
Algorithm discovery by protein folding game players. Proc Natl Acad Sci U S A (2011) 3.74
Computational redesign of protein-protein interaction specificity. Nat Struct Mol Biol (2004) 3.66
Modeling structurally variable regions in homologous proteins with rosetta. Proteins (2004) 3.64
Structure prediction for CASP8 with all-atom refinement using Rosetta. Proteins (2009) 3.64
Quantitative dynamics and binding studies of the 20S proteasome by NMR. Nature (2007) 3.63
ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility. Proteins (2006) 3.60
Rational HIV immunogen design to target specific germline B cell receptors. Science (2013) 3.55
High-resolution mapping of protein sequence-function relationships. Nat Methods (2010) 3.47
Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature (2006) 3.45
Computational alanine scanning of protein-protein interfaces. Sci STKE (2004) 3.41
Automated prediction of CASP-5 structures using the Robetta server. Proteins (2003) 3.41
New algorithms and an in silico benchmark for computational enzyme design. Protein Sci (2006) 3.40
Simplification of antiretroviral therapy with tenofovir-emtricitabine or abacavir-Lamivudine: a randomized, 96-week trial. Clin Infect Dis (2009) 3.32
Inflammation in neurodegenerative diseases. Immunology (2010) 3.22
An engineered microbial platform for direct biofuel production from brown macroalgae. Science (2012) 3.20
Isotope labeling strategies for the study of high-molecular-weight proteins by solution NMR spectroscopy. Nat Protoc (2006) 3.14
A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins. J Mol Biol (2003) 3.08
A transient and low-populated protein-folding intermediate at atomic resolution. Science (2010) 3.08
Atomic accuracy in predicting and designing noncanonical RNA structure. Nat Methods (2010) 3.07
Progress in modeling of protein structures and interactions. Science (2005) 3.05
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci U S A (2009) 3.01
Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home. Proteins (2007) 3.01
NMR structure determination for larger proteins using backbone-only data. Science (2010) 3.00
NMR spectroscopy brings invisible protein states into focus. Nat Chem Biol (2009) 3.00
Cross-correlated relaxation enhanced 1H[bond]13C NMR spectroscopy of methyl groups in very high molecular weight proteins and protein complexes. J Am Chem Soc (2003) 2.99
Refinement of protein structures into low-resolution density maps using rosetta. J Mol Biol (2009) 2.94
The 3D profile method for identifying fibril-forming segments of proteins. Proc Natl Acad Sci U S A (2006) 2.88
De novo prediction of three-dimensional structures for major protein families. J Mol Biol (2002) 2.88
RosettaLigand docking with full ligand and receptor flexibility. J Mol Biol (2008) 2.86
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR. Nature (2004) 2.84
Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc Natl Acad Sci U S A (2006) 2.81
Multipass membrane protein structure prediction using Rosetta. Proteins (2006) 2.79
Computational thermostabilization of an enzyme. Science (2005) 2.79
Rosetta predictions in CASP5: successes, failures, and prospects for complete automation. Proteins (2003) 2.77
Improved molecular replacement by density- and energy-guided protein structure optimization. Nature (2011) 2.74
Improved side-chain modeling for protein-protein docking. Protein Sci (2005) 2.72
Close agreement between the orientation dependence of hydrogen bonds observed in protein structures and quantum mechanical calculations. Proc Natl Acad Sci U S A (2004) 2.71
Elicitation of structure-specific antibodies by epitope scaffolds. Proc Natl Acad Sci U S A (2010) 2.68
Three-dimensional triple-resonance NMR Spectroscopy of isotopically enriched proteins. 1990. J Magn Reson (2011) 2.58
Role of conformational sampling in computing mutation-induced changes in protein structure and stability. Proteins (2010) 2.56
CASD-NMR: critical assessment of automated structure determination by NMR. Nat Methods (2009) 2.50
A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell (2007) 2.50
Principles for designing ideal protein structures. Nature (2012) 2.50
Physically realistic homology models built with ROSETTA can be more accurate than their templates. Proc Natl Acad Sci U S A (2006) 2.47
Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science (2005) 2.47
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell (2008) 2.46
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature (2011) 2.46
Protein-DNA binding specificity predictions with structural models. Nucleic Acids Res (2005) 2.45
De novo protein structure generation from incomplete chemical shift assignments. J Biomol NMR (2008) 2.43
Assessing the utility of coevolution-based residue-residue contact predictions in a sequence- and structure-rich era. Proc Natl Acad Sci U S A (2013) 2.43
No effect of rosiglitazone for treatment of HIV-1 lipoatrophy: randomised, double-blind, placebo-controlled trial. Lancet (2004) 2.43
Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci U S A (2002) 2.39
Computational design of protein-protein interactions. Curr Opin Chem Biol (2004) 2.39
Contact order revisited: influence of protein size on the folding rate. Protein Sci (2003) 2.37
Prediction of the structure of symmetrical protein assemblies. Proc Natl Acad Sci U S A (2007) 2.35
Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science (2012) 2.33
Protein dynamics and conformational disorder in molecular recognition. J Mol Recognit (2010) 2.31
Progress and challenges in high-resolution refinement of protein structure models. Proteins (2005) 2.28
Design, activity, and structure of a highly specific artificial endonuclease. Mol Cell (2002) 2.25
Structure of an intermediate state in protein folding and aggregation. Science (2012) 2.24
RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite. PLoS One (2011) 2.21
Ile, Leu, and Val methyl assignments of the 723-residue malate synthase G using a new labeling strategy and novel NMR methods. J Am Chem Soc (2003) 2.20
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature (2011) 2.20
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players. Nat Biotechnol (2012) 2.19
Observing biological dynamics at atomic resolution using NMR. Trends Biochem Sci (2009) 2.19