Published in Dev Biol on February 01, 2011
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol (2011) 1.67
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis. Cell Res (2012) 1.12
Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease. Front Oncol (2012) 1.08
Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis. BMC Genomics (2012) 1.06
CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. Mol Cell (2013) 1.05
Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS One (2012) 1.00
Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer. J Biol Chem (2013) 0.97
A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase. J Biol Chem (2013) 0.93
CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases. Open Biol (2014) 0.92
Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases. Cell Res (2013) 0.87
CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome? Cell Res (2012) 0.82
Age-dependent alterations in spermatogenesis in itchy mice. Spermatogenesis (2012) 0.81
Arabidopsis WD repeat domain55 Interacts with DNA damaged binding protein1 and is required for apical patterning in the embryo. Plant Cell (2012) 0.80
The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis. Semin Cell Dev Biol (2014) 0.80
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B. Gene (2015) 0.79
Crossover localisation is regulated by the neddylation posttranslational regulatory pathway. PLoS Biol (2014) 0.79
CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J Cell Biol (2013) 0.79
Mass spectrometry-based, label-free quantitative proteomics of round spermatids in mice. Mol Med Rep (2014) 0.76
Diagnostic Application of Targeted Next-Generation Sequencing of 80 Genes Associated with Disorders of Sexual Development. Sci Rep (2017) 0.75
Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep (2016) 0.75
MEIOTIC F-BOX Is Essential for Male Meiotic DNA Double-Strand Break Repair in Rice. Plant Cell (2016) 0.75
H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation. Nucleic Acids Res (2016) 0.75
Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell (1997) 10.32
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterization. J Cell Biol (1977) 7.69
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
Recombinational DNA double-strand breaks in mice precede synapsis. Nat Genet (2001) 6.91
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science (2007) 6.70
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science (2007) 5.88
Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet (2004) 4.25
Meiotic sex chromosome inactivation. Development (2007) 4.03
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev (2006) 3.44
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell (2003) 3.42
A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets. Proc Natl Acad Sci U S A (2003) 3.40
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell (2006) 3.39
The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Mol Cell (2000) 3.36
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol (2004) 3.20
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell (2009) 2.79
The PCI domain: a common theme in three multiprotein complexes. Trends Biochem Sci (1998) 2.73
BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol (2004) 2.67
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites. Proc Natl Acad Sci U S A (2006) 2.66
CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem Sci (2009) 2.59
FANCI is a second monoubiquitinated member of the Fanconi anemia pathway. Nat Struct Mol Biol (2007) 2.47
The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. Cancer Res (2007) 2.43
Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. Dev Cell (2006) 2.40
L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. Cell Cycle (2006) 2.37
Chromosome breakage after G2 checkpoint release. J Cell Biol (2007) 2.25
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol Cell Biol (2005) 2.13
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology (2002) 2.05
Cullin 4A associates with the UV-damaged DNA-binding protein DDB. J Biol Chem (1999) 2.04
Sex chromosomes, recombination, and chromatin conformation. Chromosoma (1993) 1.91
The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers. Cancer Res (1998) 1.88
Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J Reprod Fertil (1978) 1.86
The ubiquitin landscape at DNA double-strand breaks. J Cell Biol (2009) 1.86
The XY body: a specialized meiotic chromatin domain. Exp Cell Res (2004) 1.82
Distribution of the Rad51 recombinase in human and mouse spermatocytes. EMBO J (1997) 1.82
Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol (2008) 1.77
SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes. J Cell Sci (2005) 1.73
The behavior of the XY pair in mammals. Int Rev Cytol (1974) 1.69
Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet (2007) 1.68
DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res (2009) 1.60
Histone ubiquitination and chromatin remodeling in mouse spermatogenesis. Dev Biol (1999) 1.60
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. Curr Biol (1997) 1.57
CUL-4A is critical for early embryonic development. Mol Cell Biol (2002) 1.51
FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination. Cell Cycle (2004) 1.42
Dynamic histone modifications mark sex chromosome inactivation and reactivation during mammalian spermatogenesis. Proc Natl Acad Sci U S A (2004) 1.41
Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am J Hum Genet (2007) 1.41
Identification of two major components of the lateral elements of synaptonemal complexes of the rat. Eur J Cell Biol (1987) 1.35
Comparative genomic hybridization of squamous cell carcinoma of the esophagus: the possible involvement of the DPI gene in the 13q34 amplicon. Genes Chromosomes Cancer (1999) 1.33
Identification of novel amplification gene targets in mouse and human breast cancer at a syntenic cluster mapping to mouse ch8A1 and human ch13q34. Cancer Res (2007) 1.27
Adrenocortical carcinoma is characterized by a high frequency of chromosomal gains and high-level amplifications. Genes Chromosomes Cancer (2000) 1.23
Overexpression of the human homologue for Caenorhabditis elegans cul-4 gene is associated with poor outcome in node-negative breast cancer. Anticancer Res (2007) 1.22
Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'. Hum Reprod Update (2009) 1.22
SUMO modified proteins localize to the XY body of pachytene spermatocytes. Chromosoma (2004) 1.18
Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse. J Androl (1994) 1.14
Genetic alterations in childhood medulloblastoma analyzed by comparative genomic hybridization. J Pediatr Hematol Oncol (2002) 1.12
DNA double-strand breaks in meiosis: checking their formation, processing and repair. DNA Repair (Amst) (2009) 1.12
A study of intercellular bridges during spermatogenesis in the rat. Am J Anat (1987) 1.11
DNA polymerase beta is critical for mouse meiotic synapsis. EMBO J (2009) 1.09
M31 and macroH2A1.2 colocalise at the pseudoautosomal region during mouse meiosis. J Cell Sci (2001) 1.07
Proliferation defects and genome instability in cells lacking Cul4A. Oncogene (2009) 1.05
Correlation of meiotic events in testis sections and microspreads of mouse spermatocytes relative to the mid-pachytene checkpoint. Chromosoma (2004) 0.97
Extensive pairing of the XY bivalent in mouse spermatocytes as visualized by whole-mount electron microscopy. J Cell Sci (1977) 0.94
Thyroid hormones and testis development: a model system for increasing testis growth and sperm production. Ann N Y Acad Sci (1991) 0.83
Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev (2004) 3.91
ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature (2005) 2.58
FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J (2009) 2.11
Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol (2006) 2.11
Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes. Biol Reprod (2008) 1.89
FoxM1 mediates resistance to herceptin and paclitaxel. Cancer Res (2010) 1.78
Localization of androgen and estrogen receptors in adult male mouse reproductive tract. J Androl (2002) 1.69
Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. Mol Cell Biol (2006) 1.62
Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration. J Lipid Res (2009) 1.59
Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc. J Biol Chem (2004) 1.58
FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. J Biol Chem (2008) 1.58
Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med (2010) 1.43
Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase. Mol Cell Biol (2008) 1.42
Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res (2004) 1.40
Proteasome activator PA200 is required for normal spermatogenesis. Mol Cell Biol (2006) 1.38
Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A (2012) 1.32
Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility. Proc Natl Acad Sci U S A (2007) 1.29
The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase. J Virol (2004) 1.25
FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. J Biol Chem (2007) 1.25
The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1. Mol Cell Biol (2007) 1.25
New and unexpected: forkhead meets ARF. Curr Opin Genet Dev (2005) 1.25
Ddb1 is required for the proteolysis of the Schizosaccharomyces pombe replication inhibitor Spd1 during S phase and after DNA damage. J Biol Chem (2003) 1.24
Oestrogens and spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.23
Differential regulation of E2F1, DP1, and the E2F1/DP1 complex by ARF. Mol Cell Biol (2002) 1.23
DDB2 decides cell fate following DNA damage. Proc Natl Acad Sci U S A (2009) 1.22
A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1. J Biol Chem (2009) 1.17
FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors. Cancer Res (2011) 1.15
Blood-tissue barriers: morphofunctional and immunological aspects of the blood-testis and blood-epididymal barriers. Adv Exp Med Biol (2012) 1.13
Tumor-prone phenotype of the DDB2-deficient mice. Oncogene (2005) 1.13
Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A (2013) 1.12
Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice. Biol Reprod (2007) 1.12
Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells. Mol Oncol (2010) 1.11
The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. Hepatology (2010) 1.09
Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites. Nucleic Acids Res (2003) 1.09
FoxM1 regulates mammary luminal cell fate. Cell Rep (2012) 1.08
Estrogen, efferent ductules, and the epididymis. Biol Reprod (2010) 1.07
Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice. J Lipid Res (2009) 1.06
Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis. Biol Reprod (2009) 1.05
The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. BMC Dev Biol (2010) 1.03
Retracted DDB2, an essential mediator of premature senescence. Mol Cell Biol (2010) 1.03
Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation. Cancer Res (2009) 1.02
Aquaporin-1 and -9 are differentially regulated by oestrogen in the efferent ductule epithelium and initial segment of the epididymis. Biol Cell (2005) 1.02
Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers. Stem Cells (2009) 1.01
Claudin and occludin expression and function in the seminiferous epithelium. Philos Trans R Soc Lond B Biol Sci (2010) 1.01
Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs. Dev Cell (2013) 1.01
Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferation. Biol Reprod (2005) 1.00
Study of C reactive protein as a prognostic marker in malaria from Eastern India. Adv Biomed Res (2012) 1.00
ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF. Mol Cell Biol (2005) 0.99
Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance. Exp Cell Res (2007) 0.99
ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells (2010) 0.98
Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein. J Virol (2006) 0.98
Assessment of spermatogenesis through staging of seminiferous tubules. Methods Mol Biol (2013) 0.97
Tumor suppression by ARF: gatekeeper and caretaker. Cell Cycle (2010) 0.96
Differential expression of estrogen receptors alpha and beta in the reproductive tracts of adult male dogs and cats. Biol Reprod (2002) 0.96
Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function. Biol Reprod (2009) 0.96
Schizosaccharomyces pombe Ddb1 is functionally linked to the replication checkpoint pathway. J Biol Chem (2003) 0.95
The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules. Reprod Biol Endocrinol (2003) 0.94
The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability. Biol Reprod (2009) 0.94
DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response. Cell Cycle (2009) 0.94
PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer. Cancer Res (2013) 0.92
Effects of depletion of CREB-binding protein on c-Myc regulation and cell cycle G1-S transition. J Biol Chem (2004) 0.92
Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice. Genesis (2010) 0.92
ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4. EMBO Rep (2009) 0.92
ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege. Ann N Y Acad Sci (2007) 0.91
Effects of 3-beta-diol, an androgen metabolite with intrinsic estrogen-like effects, in modulating the aquaporin-9 expression in the rat efferent ductules. Reprod Biol Endocrinol (2006) 0.91
A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes. Exp Cell Res (2006) 0.90
Expression of aquaporins in the efferent ductules, sperm counts, and sperm motility in estrogen receptor-alpha deficient mice fed lab chow versus casein. Mol Reprod Dev (2006) 0.90
p21 cooperates with DDB2 protein in suppression of ultraviolet ray-induced skin malignancies. J Biol Chem (2011) 0.90
Absence of estrogen receptor alpha leads to physiological alterations in the mouse epididymis and consequent defects in sperm function. Biol Reprod (2010) 0.90
Epididymal hypo-osmolality induces abnormal sperm morphology and function in the estrogen receptor alpha knockout mouse. Biol Reprod (2010) 0.90
Ectopic pregnancy--an analysis of 180 cases. J Indian Med Assoc (2007) 0.90
Immunofluorescence reveals ubiquitination of retained distal cytoplasmic droplets on ejaculated porcine spermatozoa. J Androl (2004) 0.89
ER function in the adult male rat: short- and long-term effects of the antiestrogen ICI 182,780 on the testis and efferent ductules, without changes in testosterone. Endocrinology (2002) 0.89
Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin. Cancer Biol Ther (2010) 0.88
Differential hormonal regulation of estrogen receptors ERalpha and ERbeta and androgen receptor expression in rat efferent ductules. Reproduction (2004) 0.88
DDB2 suppresses epithelial-to-mesenchymal transition in colon cancer. Cancer Res (2013) 0.88
Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer. Cancer Res (2012) 0.88
Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. Biol Reprod (2011) 0.87
Melphalan-induced up-regulation of B7-1 surface expression on normal splenic B cells. Cancer Immunol Immunother (2003) 0.85
The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy. Reprod Biol Endocrinol (2003) 0.85
Tslc1 (nectin-like molecule-2) is essential for spermatozoa motility and male fertility. J Androl (2006) 0.85
Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis. Virology (2009) 0.84
Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage. Cell Div (2010) 0.84
Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). Endocrinology (2007) 0.84
Microtubules of the mouse testis exhibit differential sensitivity to the microtubule disruptors Carbendazim and colchicine. Toxicol Sci (2002) 0.83
P19ARF inhibits the functions of the HPV16 E7 oncoprotein. Oncogene (2003) 0.83