MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers.

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Published in Cancer Res on February 07, 2011

Authors

Eduardo Vilar1, Catherine M Bartnik, Stephanie L Stenzel, Leon Raskin, Jaeil Ahn, Victor Moreno, Bhramar Mukherjee, Maria D Iniesta, Meredith A Morgan, Gad Rennert, Stephen B Gruber

Author Affiliations

1: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Associated clinical trials:

Efficacy and Safety of Olaparib in Pretreated Patients With Measurable Colorectal Cancer, Stratified by Microsatellite Instability (MSI) Status | NCT00912743

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