PubRank

Ronald A DePinho

Author PubWeight™ 481.58‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 International network of cancer genome projects. Nature 2010 20.35
2 Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 2007 17.20
3 FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007 12.33
4 The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 2004 12.30
5 Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 2007 10.60
6 Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 2009 10.21
7 Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006 10.05
8 Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 2006 9.20
9 FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007 8.94
10 Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 2003 8.27
11 Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 2004 8.16
12 Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet 2009 7.81
13 The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004 7.77
14 Pancreatic cancer biology and genetics. Nat Rev Cancer 2002 7.36
15 Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012 7.36
16 HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009 6.96
17 Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 2013 6.53
18 Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011 6.36
19 Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 2002 6.10
20 How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 2007 5.80
21 Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 2007 5.65
22 Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 2006 5.53
23 Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002 5.11
24 Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 2010 5.08
25 Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 2004 5.00
26 p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 2008 5.00
27 Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res 2006 4.80
28 Connecting chromosomes, crisis, and cancer. Science 2002 4.69
29 SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature 2011 4.57
30 PI3 kinase signals BCR-dependent mature B cell survival. Cell 2009 4.43
31 Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 2003 4.32
32 Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol 2009 4.31
33 Telomeres and telomerase in cancer. Carcinogenesis 2009 4.28
34 The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 2007 3.76
35 High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci U S A 2004 3.75
36 SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 2011 3.69
37 Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest 2005 3.66
38 IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 2011 3.61
39 FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 2009 3.37
40 Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell 2009 3.37
41 Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab 2008 3.22
42 Passenger deletions generate therapeutic vulnerabilities in cancer. Nature 2012 3.11
43 Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2002 3.06
44 Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol 2010 3.05
45 Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 2003 2.92
46 Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev 2004 2.91
47 Stromal biology of pancreatic cancer. J Cell Biochem 2007 2.88
48 Telomeres, stem cells, senescence, and cancer. J Clin Invest 2004 2.87
49 Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 2004 2.83
50 AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell 2011 2.77
51 STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 2002 2.77
52 Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet 2012 2.75
53 PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 2010 2.68
54 Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis. Nat Med 2002 2.58
55 A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest 2007 2.57
56 Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet 2002 2.53
57 Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol 2008 2.50
58 mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A 2008 2.48
59 FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest 2009 2.46
60 Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev 2003 2.38
61 PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell 2013 2.38
62 Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol 2009 2.32
63 A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med 2008 2.31
64 SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol 2008 2.29
65 LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol 2003 2.24
66 Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med 2010 2.17
67 The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene 2004 2.14
68 PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. Cancer Discov 2011 2.14
69 p53: good cop/bad cop. Cell 2002 2.11
70 p16(Ink4a) in melanocyte senescence and differentiation. J Natl Cancer Inst 2002 2.09
71 Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 2011 2.07
72 Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci U S A 2002 2.03
73 FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem 2010 2.00
74 Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol 2004 1.99
75 Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Cancer Cell 2011 1.99
76 SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J Biol Chem 2002 1.99
77 Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci U S A 2008 1.92
78 Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 2012 1.91
79 Cancer: crime and punishment. Nature 2005 1.91
80 Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev 2005 1.84
81 Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Mol Cell Biol 2005 1.78
82 Molecular diversity of astrocytes with implications for neurological disorders. Proc Natl Acad Sci U S A 2004 1.76
83 Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell 2012 1.75
84 Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol 2012 1.74
85 From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A 2013 1.71
86 Towards patient-based cancer therapeutics. Nat Biotechnol 2010 1.63
87 Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res 2007 1.60
88 FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 2010 1.58
89 Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. Mol Cell Biol 2002 1.56
90 Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma. Cancer Res 2003 1.55
91 The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med 2009 1.55
92 A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res 2006 1.54
93 Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Proc Natl Acad Sci U S A 2008 1.52
94 PCAF modulates PTEN activity. J Biol Chem 2006 1.52
95 Codependent activators direct myoblast-specific MyoD transcription. Dev Cell 2008 1.52
96 Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. EMBO J 2010 1.47
97 LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat Genet 2008 1.46
98 FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab 2012 1.46
99 mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes Dev 2003 1.44
100 Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer. Cancer Res 2009 1.40
101 DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol 2006 1.39
102 mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle 2009 1.39
103 Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev 2007 1.38
104 Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci U S A 2010 1.38
105 Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med 2007 1.37
106 The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. J Clin Invest 2010 1.35
107 Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes Dev 2008 1.34
108 Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. J Biol Chem 2011 1.31
109 Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci U S A 2002 1.30
110 Cancer chromosomes in crisis. Nat Genet 2004 1.30
111 Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia. Mol Cell Biol 2002 1.28
112 Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. PLoS One 2010 1.27
113 Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes 2008 1.26
114 Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis. Cancer Res 2002 1.24
115 Cancer research: past, present and future. Nat Rev Cancer 2011 1.24
116 Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice. Proc Natl Acad Sci U S A 2009 1.23
117 FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription. Mol Cell Biol 2007 1.21
118 Telomerase extracurricular activities. Proc Natl Acad Sci U S A 2002 1.20
119 Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab 2013 1.19
120 Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Res 2006 1.17
121 Brain metastasis: opportunities in basic and translational research. Cancer Res 2009 1.17
122 Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A 2012 1.15
123 Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. J Neurosci 2003 1.14
124 The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J Biol Chem 2012 1.14
125 Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. Cancer Res 2007 1.13
126 FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation. Gastroenterology 2009 1.11
127 Telomeres and the DNA damage response: why the fox is guarding the henhouse. DNA Repair (Amst) 2004 1.10
128 What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator. Cell Cycle 2008 1.08
129 Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nat Cell Biol 2013 1.07
130 Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle 2011 1.06
131 Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell 2006 1.03
132 Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis. PLoS One 2013 1.02
133 Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood 2011 1.00
134 Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. Cancer Res 2003 1.00
135 Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells. Diabetes 2009 0.98
136 Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 2013 0.98
137 Telomeres and mitochondria in the aging heart. Circ Res 2012 0.98
138 Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle. Angiogenesis 2013 0.97
139 p16(INK4a) and p53 deficiency cooperate in tumorigenesis. Cancer Res 2002 0.96
140 Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. Cancer Res 2014 0.93
141 FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem 2013 0.93
142 Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. J Natl Cancer Inst 2004 0.93
143 The genetic and environmental basis of hepatocellular carcinoma. Discov Med 2006 0.92
144 Cancer biology: gone but not forgotten. Nature 2007 0.92
145 Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell 2007 0.92
146 The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. Cancer Res 2003 0.91
147 Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjug Chem 2012 0.90
148 PTEN: a novel anti-oncogenic function independent of phosphatase activity. Cell Cycle 2005 0.89
149 Take care of your chromosomes lest cancer take care of you. Cancer Cell 2003 0.89
150 Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood 2013 0.89
151 mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases. Sci Signal 2014 0.88
152 FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. J Clin Invest 2012 0.88
153 Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells. Cancer Res 2007 0.86
154 A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. Oncogene 2002 0.86
155 Conquering the complexity of p53. Nat Genet 2004 0.85
156 PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Rep 2013 0.85
157 Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis. Liver Int 2013 0.84
158 A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis. FASEB J 2010 0.84
159 p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis. J Virol 2004 0.84
160 Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. Dev Biol 2012 0.83
161 Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes Dev 2013 0.83
162 Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J Biol Chem 2004 0.82
163 Keeping telomerase in its place. Nat Med 2002 0.82
164 Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2. J Cell Sci 2012 0.82
165 How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer. Cell Cycle 2005 0.80
166 Walking the telomere plank into cancer. J Natl Cancer Inst 2003 0.80
167 Transcription factor FoxO1 is essential for enamel biomineralization. PLoS One 2012 0.78
168 Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes. Cancer Cell 2004 0.78
169 Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer. Nature 2015 0.75
170 Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature 2017 0.75
171 Cancer prevention in developing countries: a vision for preserving health in Mexico. Salud Publica Mex 2016 0.75
172 Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181. J Immunol 2016 0.75
173 Erratum: FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nat Commun 2015 0.75