Published in Circulation on February 10, 2011
The immunology of stroke: from mechanisms to translation. Nat Med (2011) 6.53
Time to angiographic reperfusion and clinical outcome after acute ischaemic stroke: an analysis of data from the Interventional Management of Stroke (IMS III) phase 3 trial. Lancet Neurol (2014) 3.61
Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation (2017) 2.76
Reducing door-to-needle times using Toyota's lean manufacturing principles and value stream analysis. Stroke (2012) 2.43
Eligibility for Intravenous Recombinant Tissue-Type Plasminogen Activator Within a Population: The Effect of the European Cooperative Acute Stroke Study (ECASS) III Trial. Stroke (2012) 1.76
Stroke research at a crossroad: asking the brain for directions. Nat Neurosci (2011) 1.68
The neurovascular unit and combination treatment strategies for stroke. Trends Pharmacol Sci (2012) 1.66
A model of cost-effectiveness of tissue plasminogen activator in patient subgroups 3 to 4.5 hours after onset of acute ischemic stroke. Ann Emerg Med (2012) 1.58
Implementation of an institution-wide acute stroke algorithm: Improving stroke quality metrics. Surg Neurol Int (2016) 1.40
Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Prog Neurobiol (2013) 1.33
Facilitating Stroke Management using Modern Information Technology. J Stroke (2013) 1.14
The role of microglia and myeloid immune cells in acute cerebral ischemia. Front Cell Neurosci (2015) 1.12
Stroke Statistics in Korea: Part II Stroke Awareness and Acute Stroke Care, A Report from the Korean Stroke Society and Clinical Research Center For Stroke. J Stroke (2013) 1.11
Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia. Circulation (2012) 1.03
A cluster randomized trial to assess the effect of clinical pathways for patients with stroke: results of the clinical pathways for effective and appropriate care study. BMC Med (2012) 0.99
Evaluation of interval times from onset to reperfusion in patients undergoing endovascular therapy in the Interventional Management of Stroke III trial. Circulation (2014) 0.96
Inducible nitric oxide synthase in neutrophils and endothelium contributes to ischemic brain injury in mice. J Immunol (2014) 0.93
Prehospital stroke care: new prospects for treatment and clinical research. Neurology (2013) 0.92
Organization of a United States county system for comprehensive acute stroke care. Stroke (2012) 0.91
Impact of acute ischemic stroke treatment in patients >80 years of age: the specialized program of translational research in acute stroke (SPOTRIAS) consortium experience. Stroke (2012) 0.90
Neurohospitalists Improve Door-to-Needle Times for Patients With Ischemic Stroke Receiving Intravenous tPA. Neurohospitalist (2012) 0.88
Current perspectives on the use of intravenous recombinant tissue plasminogen activator (tPA) for treatment of acute ischemic stroke. Vasc Health Risk Manag (2014) 0.88
Patterns, predictors, variations, and temporal trends in emergency medical service hospital prenotification for acute ischemic stroke. J Am Heart Assoc (2012) 0.88
Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection. Transl Stroke Res (2015) 0.87
Animal models of ischemic stroke and their application in clinical research. Drug Des Devel Ther (2015) 0.87
Identification of Sleep-Modulated Pathways Involved in Neuroprotection from Stroke. Sleep (2015) 0.84
Intracranial transplantation of human adipose-derived stem cells promotes the expression of neurotrophic factors and nerve repair in rats of cerebral ischemia-reperfusion injury. Int J Clin Exp Pathol (2013) 0.83
Antihypertensive treatment prolongs tissue plasminogen activator door-to-treatment time: secondary analysis of the INSTINCT trial. Stroke (2012) 0.83
Guided antithrombotic therapy: current status and future research direction: report on a National Heart, Lung and Blood Institute working group. Circulation (2012) 0.83
The 2012 Feinberg Lecture: treatment swift and treatment sure. Stroke (2012) 0.83
An automated dispensing system for improving medication timing in the emergency department. World J Emerg Med (2012) 0.83
Process improvement to enhance existing stroke team activity toward more timely thrombolytic treatment. J Clin Neurol (2014) 0.82
Prehospital utility of rapid stroke evaluation using in-ambulance telemedicine: a pilot feasibility study. Stroke (2014) 0.82
Fast neuroprotection (fast-NPRX) for acute ischemic stroke victims: the time for treatment is now. Transl Stroke Res (2013) 0.82
Evaluation of the implementation of a rapid response treatment protocol for patients with acute onset stroke: can we increase the number of patients treated and shorten the time needed? Cerebrovasc Dis Extra (2014) 0.82
Differences in process management and in-hospital delays in treatment with iv thrombolysis. PLoS One (2013) 0.81
Blood pressure management in stroke: Five new things. Neurol Clin Pract (2014) 0.81
Geographic and sociodemographic disparities in drive times to Joint Commission-certified primary stroke centers in North Carolina, South Carolina, and Georgia. Prev Chronic Dis (2011) 0.81
Hip Hop Stroke: Study Protocol for a Randomized Controlled Trial to Address Stroke Literacy. J Clin Trials (2015) 0.81
Health promotion interventions for increasing stroke awareness in ethnic minorities: a systematic review of the literature. BMC Public Health (2014) 0.81
24/7 Neurocritical Care Nurse Practitioner Coverage Reduced Door-to-Needle Time in Stroke Patients Treated with Tissue Plasminogen Activator. J Stroke Cerebrovasc Dis (2016) 0.81
Focal embolic cerebral ischemia in the rat. Nat Protoc (2015) 0.80
Long-term functional recovery and compensation after cerebral ischemia in rats. Behav Brain Res (2014) 0.79
Generalization of the Right Acute Stroke Prevention Strategies in Reducing in-Hospital Delays. PLoS One (2016) 0.79
Apigenin-7-O-β-D-(-6''-p-coumaroyl)-Glucopyranoside Treatment Elicits Neuroprotective Effect against Experimental Ischemic Stroke. Int J Biol Sci (2016) 0.78
Neuroprotective action of acute estrogens: animal models of brain ischemia and clinical implications. Steroids (2013) 0.78
Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia. F1000Res (2014) 0.78
Contemporary trends and predictors of postacute service use and routine discharge home after stroke. J Am Heart Assoc (2015) 0.78
Spatial distribution of insulin-like growth factor binding protein-2 following hypoxic-ischemic injury. BMC Neurosci (2013) 0.78
Stroke code improves intravenous thrombolysis administration in acute ischemic stroke. PLoS One (2014) 0.78
YiQiFuMai powder injection ameliorates blood-brain barrier dysfunction and brain edema after focal cerebral ischemia-reperfusion injury in mice. Drug Des Devel Ther (2016) 0.78
Association between i.v. thrombolysis volume and door-to-needle times in acute ischemic stroke. J Neurol (2016) 0.77
Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke. Ann Clin Transl Neurol (2017) 0.77
Short Door-to-Needle Times in Acute Ischemic Stroke and Prospective Identification of Its Delaying Factors. Cerebrovasc Dis Extra (2015) 0.76
In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment. Brain Res (2015) 0.76
Recombinant tissue plasminogen activator for the treatment of acute ischemic stroke. Proc (Bayl Univ Med Cent) (2011) 0.76
Effects of pretreatment with a combination of melatonin and electroacupuncture in a rat model of transient focal cerebral ischemia. Evid Based Complement Alternat Med (2013) 0.76
The Yin and Yang of innate immunity in stroke. Biomed Res Int (2014) 0.76
Simple In-Hospital Interventions to Reduce Door-to-CT Time in Acute Stroke. Int J Vasc Med (2016) 0.76
PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window. Autophagy (2017) 0.75
Problems and limitations in thrombolysis of acute stroke patients at a tertiary care center. Indian J Crit Care Med (2015) 0.75
Main Trunk and Division Middle Cerebral Artery Occlusions: Differences in Recanalization Times, Number of Stent Retriever Passes and Clinical Outcomes: A Single-Center Experience. Interv Neurol (2015) 0.75
Quality Improvement in Acute Ischemic Stroke Care in Taiwan: The Breakthrough Collaborative in Stroke. PLoS One (2016) 0.75
No space left for intravenous thrombolysis in acute stroke: CONS. Intern Emerg Med (2016) 0.75
Effect of prehospital notification on acute stroke care: a multicenter study. Scand J Trauma Resusc Emerg Med (2016) 0.75
Prehospital and intra-hospital time delays in posterior circulation stroke: results from the Austrian Stroke Unit Registry. J Neurol (2016) 0.75
More Wake, Less Stroke. Sleep (2015) 0.75
Imaging of prehospital stroke therapeutics. Expert Rev Cardiovasc Ther (2015) 0.75
Perception Versus Actual Performance in Timely Tissue Plasminogen Activation Administration in the Management of Acute Ischemic Stroke. J Am Heart Assoc (2015) 0.75
Predictors of diagnostic neuroimaging delays among adults presenting with symptoms suggestive of acute stroke in Ontario: a prospective cohort study. CMAJ Open (2016) 0.75
Pharmacist Impact on Ischemic Stroke Care in the Emergency Department. J Emerg Med (2015) 0.75
Impact of Day of the Week and Time of Arrival on Ischemic Stroke Management. P R Health Sci J (2015) 0.75
Intranasal Delivery of Exendin-4 Confers Neuroprotective Effect Against Cerebral Ischemia in Mice. AAPS J (2015) 0.75
Outcome determinants of stroke in a brazilian primary stroke center. Stroke Res Treat (2014) 0.75
Intravenous recombinant tissue plasminogen activator for acute ischemic stroke: a feasibility and safety study. Int J Gen Med (2016) 0.75
Stroke thrombolysis given by emergency physicians cuts in-hospital delays significantly immediately after implementing a new treatment protocol. Scand J Trauma Resusc Emerg Med (2016) 0.75
Utilization of emergency medical service increases chance of thrombolytic therapy in patients with acute ischemic stroke. J Formos Med Assoc (2013) 0.75
Intravenous Tissue Plasminogen Activator Can Be Safely Given without Complete Blood Count Results Back. PLoS One (2015) 0.75
Increase in national intravenous thrombolysis rates for ischaemic stroke between 2005 and 2012: is bigger better? BMC Neurol (2016) 0.75
Centralising and optimising decentralised stroke care systems: a simulation study on short-term costs and effects. BMC Med Res Methodol (2017) 0.75
How a CT-Direct Protocol at an American Comprehensive Stroke Center Led to Door-to-Needle Times Less Than 30 Minutes. Neurohospitalist (2016) 0.75
Intravenous thrombolysis for ischemic stroke in the golden hour: propensity-matched analysis from the SITS-EAST registry. J Neurol (2017) 0.75
New standardized nursing cooperation workflow to reduce stroke thrombolysis delays in patients with acute ischemic stroke. Neuropsychiatr Dis Treat (2017) 0.75
Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids. Aging Dis (2017) 0.75
The American Heart Association's Get With the Guidelines (GWTG)-Stroke development and impact on stroke care. Stroke Vasc Neurol (2017) 0.75
A resident boot camp for reducing door-to-needle times at academic medical centers. Neurol Clin Pract (2017) 0.75
Disparities and Trends in Door-to-Needle Time: The FL-PR CReSD Study (Florida-Puerto Rico Collaboration to Reduce Stroke Disparities). Stroke (2017) 0.75
Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation (2014) 22.74
Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med (2012) 13.59
Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation (2010) 13.28
Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med (2015) 12.70
Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med (2011) 11.99
Ethical and scientific implications of the globalization of clinical research. N Engl J Med (2009) 11.42
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med (2013) 11.34
Bariatric surgery versus intensive medical therapy for diabetes--3-year outcomes. N Engl J Med (2014) 10.66
Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation (2015) 10.14
A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med (2013) 9.97
Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med (2015) 9.70
Low diagnostic yield of elective coronary angiography. N Engl J Med (2010) 9.38
Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med (2015) 8.69
Ultrafiltration in decompensated heart failure with cardiorenal syndrome. N Engl J Med (2012) 8.28
Application of new cholesterol guidelines to a population-based sample. N Engl J Med (2014) 8.22
Door-to-balloon time and mortality among patients undergoing primary PCI. N Engl J Med (2013) 8.08
The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke (2007) 8.06
Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke (2005) 8.05
Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature (2007) 8.03
Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. JAMA (2006) 7.81
Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA (2009) 7.78
Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med (2011) 7.30
Closure of patent foramen ovale versus medical therapy after cryptogenic stroke. N Engl J Med (2013) 7.00
Relationship between early physician follow-up and 30-day readmission among Medicare beneficiaries hospitalized for heart failure. JAMA (2010) 6.91
Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation (2011) 6.36
Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves. N Engl J Med (2015) 6.28
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol (2013) 6.18
Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes. N Engl J Med (2015) 5.81
One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA (2007) 5.61
Comparative effectiveness of revascularization strategies. N Engl J Med (2012) 5.49
Endoscopic versus open vein-graft harvesting in coronary-artery bypass surgery. N Engl J Med (2009) 5.19
Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ (2013) 5.08
Non-evidence-based ICD implantations in the United States. JAMA (2011) 5.05
Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke. JAMA (2013) 5.05
Transient ischemic attack--proposal for a new definition. N Engl J Med (2002) 4.94
β-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA (2012) 4.92
Sex and racial differences in the use of implantable cardioverter-defibrillators among patients hospitalized with heart failure. JAMA (2007) 4.89
Comparison of MRI and CT for detection of acute intracerebral hemorrhage. JAMA (2004) 4.82
Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med (2011) 4.81
Effects of CYP2C19 genotype on outcomes of clopidogrel treatment. N Engl J Med (2010) 4.73
Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Lancet (2010) 4.72
2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2014) 4.57
Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. N Engl J Med (2012) 4.49
Impact of medication therapy discontinuation on mortality after myocardial infarction. Arch Intern Med (2006) 4.44
The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 1--coronary artery bypass grafting surgery. Ann Thorac Surg (2009) 4.39
Compliance with results reporting at ClinicalTrials.gov. N Engl J Med (2015) 4.17
Variation in use of blood transfusion in coronary artery bypass graft surgery. JAMA (2010) 4.13
Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol (2006) 4.11
An empirically based tool for analyzing mortality associated with congenital heart surgery. J Thorac Cardiovasc Surg (2009) 4.10
Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke (2008) 4.06
Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome. JAMA (2008) 4.06
Get With the Guidelines-Stroke is associated with sustained improvement in care for patients hospitalized with acute stroke or transient ischemic attack. Circulation (2008) 4.00
Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol (2008) 3.98
Validation of European System for Cardiac Operative Risk Evaluation (EuroSCORE) in North American cardiac surgery. Eur J Cardiothorac Surg (2002) 3.86
Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II. Ann Intern Med (2005) 3.83
Pay for performance, quality of care, and outcomes in acute myocardial infarction. JAMA (2007) 3.79
Economic analysis of influenza vaccination and antiviral treatment for healthy working adults. Ann Intern Med (2002) 3.77
Recommendations for the establishment of stroke systems of care: recommendations from the American Stroke Association's Task Force on the Development of Stroke Systems. Stroke (2005) 3.74
Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes. JAMA (2005) 3.72
Conversion of cardiovascular conference abstracts to publications. Circulation (2012) 3.71
Association between stroke center hospitalization for acute ischemic stroke and mortality. JAMA (2011) 3.68
Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality. JAMA (2012) 3.66
An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2013) 3.60
Linking inpatient clinical registry data to Medicare claims data using indirect identifiers. Am Heart J (2009) 3.57
Comparative efficacy of dronedarone and amiodarone for the maintenance of sinus rhythm in patients with atrial fibrillation. J Am Coll Cardiol (2009) 3.54
Statistical analysis of the primary outcome in acute stroke trials. Stroke (2012) 3.52
Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registry. Circulation (2006) 3.45
The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 2--isolated valve surgery. Ann Thorac Surg (2009) 3.45
Racial and ethnic differences in time to acute reperfusion therapy for patients hospitalized with myocardial infarction. JAMA (2004) 3.45
Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction. JAMA (2011) 3.44
Bare metal stent restenosis is not a benign clinical entity. Am Heart J (2006) 3.39
Bedside tool for predicting the risk of postoperative dialysis in patients undergoing cardiac surgery. Circulation (2006) 3.38