Published in Curr Opin Genet Dev on February 15, 2011
Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell (2013) 9.55
Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell (2013) 8.37
The many faces and functions of β-catenin. EMBO J (2012) 3.85
Transcriptional regulation and its misregulation in disease. Cell (2013) 2.92
Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage. Cell Stem Cell (2011) 2.80
A downy mildew effector attenuates salicylic acid-triggered immunity in Arabidopsis by interacting with the host mediator complex. PLoS Biol (2013) 2.44
A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell (2012) 2.29
Drugging Wnt signalling in cancer. EMBO J (2012) 1.63
TFIIH: when transcription met DNA repair. Nat Rev Mol Cell Biol (2012) 1.63
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell (2013) 1.58
The ancient and evolving roles of cohesin in gene expression and DNA repair. Curr Biol (2012) 1.49
Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature (2016) 1.43
CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila. PLoS Biol (2015) 1.41
RNA polymerase II C-terminal domain: Tethering transcription to transcript and template. Chem Rev (2013) 1.35
The Arabidopsis mediator subunit MED25 differentially regulates jasmonate and abscisic acid signaling through interacting with the MYC2 and ABI5 transcription factors. Plant Cell (2012) 1.27
MED12 alterations in both human benign and malignant uterine soft tissue tumors. PLoS One (2012) 1.26
Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II. Proc Natl Acad Sci U S A (2012) 1.23
Origins and activity of the Mediator complex. Semin Cell Dev Biol (2011) 1.23
Mutations in MED12 cause X-linked Ohdo syndrome. Am J Hum Genet (2013) 1.20
Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity. Cell Rep (2014) 1.14
Mediator and human disease. Semin Cell Dev Biol (2011) 1.10
How salicylic acid takes transcriptional control over jasmonic acid signaling. Front Plant Sci (2015) 1.10
Aberrant regulation of FBW7 in cancer. Oncotarget (2014) 1.08
Diversity, classification and function of the plant protein kinase superfamily. Philos Trans R Soc Lond B Biol Sci (2012) 1.08
Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: emerging preclinical and clinical evidence. Ther Adv Hematol (2015) 1.06
Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast. EMBO J (2011) 1.05
Indole Glucosinolate Biosynthesis Limits Phenylpropanoid Accumulation in Arabidopsis thaliana. Plant Cell (2015) 1.05
Dosage changes of MED13L further delineate its role in congenital heart defects and intellectual disability. Eur J Hum Genet (2013) 1.04
Integrator regulates transcriptional initiation and pause release following activation. Mol Cell (2014) 1.04
The Arabidopsis mediator complex subunit16 positively regulates salicylate-mediated systemic acquired resistance and jasmonate/ethylene-induced defense pathways. Plant Cell (2012) 1.02
Redefining the modular organization of the core Mediator complex. Cell Res (2014) 1.02
Enhancers: multi-dimensional signal integrators. Transcription (2012) 1.02
The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression. PLoS Genet (2012) 0.99
Multidrug resistance in fungi: regulation of transporter-encoding gene expression. Front Physiol (2014) 0.98
An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation. RNA (2012) 0.98
MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. EMBO Mol Med (2014) 0.98
Mediator kinase module and human tumorigenesis. Crit Rev Biochem Mol Biol (2015) 0.98
Enhancer identification in mouse embryonic stem cells using integrative modeling of chromatin and genomic features. BMC Genomics (2012) 0.96
Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes. J Biol Chem (2013) 0.95
The Tlo proteins are stoichiometric components of Candida albicans mediator anchored via the Med3 subunit. Eukaryot Cell (2012) 0.95
Bacterial control of host gene expression through RNA polymerase II. J Clin Invest (2013) 0.95
Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Proc Natl Acad Sci U S A (2014) 0.94
Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. Transcription (2013) 0.92
Oxidative-stress-induced nuclear to cytoplasmic relocalization is required for Not4-dependent cyclin C destruction. J Cell Sci (2012) 0.91
The conserved Mediator subunit MDT-15 is required for oxidative stress responses in Caenorhabditis elegans. Aging Cell (2013) 0.91
Differential regulation of white-opaque switching by individual subunits of Candida albicans mediator. Eukaryot Cell (2013) 0.90
Tumor-suppressive effects of CDK8 in endometrial cancer cells. Cell Cycle (2013) 0.90
Mediator complex dependent regulation of cardiac development and disease. Genomics Proteomics Bioinformatics (2013) 0.90
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat Chem Biol (2015) 0.90
Analysis of Candida albicans mutants defective in the Cdk8 module of mediator reveal links between metabolism and biofilm formation. PLoS Genet (2014) 0.90
The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes. Plant Cell (2014) 0.89
Molecular mechanisms of regulation of sulfate assimilation: first steps on a long road. Front Plant Sci (2014) 0.89
Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis. PLoS One (2013) 0.88
Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression. Retrovirology (2012) 0.88
NuMA is required for the selective induction of p53 target genes. Mol Cell Biol (2013) 0.88
Med5(Nut1) and Med17(Srb4) are direct targets of mediator histone H4 tail interactions. PLoS One (2012) 0.88
Hox regulation of transcription: more complex(es). Dev Dyn (2013) 0.88
Regulation of Ace2-dependent genes requires components of the PBF complex in Schizosaccharomyces pombe. Cell Cycle (2015) 0.87
The three clades of the telomere-associated TLO gene family of Candida albicans have different splicing, localization, and expression features. Eukaryot Cell (2012) 0.87
Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes. Nucleic Acids Res (2012) 0.87
Computational schemes for the prediction and annotation of enhancers from epigenomic assays. Methods (2014) 0.85
Vitamin D receptor gene (VDR) transcripts in bone, cartilage, muscles and blood and microarray analysis of vitamin D responsive genes expression in paravertebral muscles of juvenile and adolescent idiopathic scoliosis patients. BMC Musculoskelet Disord (2012) 0.85
The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification. PLoS Pathog (2014) 0.84
Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res (2014) 0.84
Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes. J Biol Chem (2012) 0.84
Non-mRNA 3' end formation: how the other half lives. Wiley Interdiscip Rev RNA (2013) 0.84
A genetic screen for functional partners of condensin in fission yeast. G3 (Bethesda) (2014) 0.83
Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast. Mol Cell Biol (2012) 0.83
The emerging roles of eRNAs in transcriptional regulatory networks. RNA Biol (2014) 0.83
Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes. Biol Direct (2013) 0.83
Microbial effectors target multiple steps in the salicylic acid production and signaling pathway. Front Plant Sci (2015) 0.82
The function of the Mediator complex in plant immunity. Plant Signal Behav (2013) 0.81
Transcriptional complexity and roles of Fra-1/AP-1 at the uPA/Plau locus in aggressive breast cancer. Nucleic Acids Res (2014) 0.81
Med13p prevents mitochondrial fission and programmed cell death in yeast through nuclear retention of cyclin C. Mol Biol Cell (2014) 0.81
Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants. Front Plant Sci (2015) 0.81
TAF7: traffic controller in transcription initiation. Transcription (2013) 0.81
The Arabidopsis Mediator Complex Subunit16 Is a Key Component of Basal Resistance against the Necrotrophic Fungal Pathogen Sclerotinia sclerotiorum. Plant Physiol (2015) 0.81
The MAPKKKs Ste11 and Bck1 jointly transduce the high oxidative stress signal through the cell wall integrity MAP kinase pathway. Microb Cell (2015) 0.81
Mediator can regulate mitotic entry and direct periodic transcription in fission yeast. Mol Cell Biol (2014) 0.80
Using microRNA as an alternative treatment for hyperlipidemia and cardiovascular disease: cardio-miRs in the pipeline. J Cardiovasc Pharmacol (2013) 0.80
The Mediator complex of Caenorhabditis elegans: insights into the developmental and physiological roles of a conserved transcriptional coregulator. Nucleic Acids Res (2015) 0.80
Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. Mol Cell Proteomics (2012) 0.80
A functional portrait of Med7 and the mediator complex in Candida albicans. PLoS Genet (2014) 0.80
Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila. J Biol Chem (2014) 0.80
Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines. PLoS One (2012) 0.80
How Microbes Twist Jasmonate Signaling around Their Little Fingers. Plants (Basel) (2016) 0.80
Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12. PLoS Genet (2016) 0.80
Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α. J Biol Chem (2013) 0.79
MED25 is a mediator component of HNF4α-driven transcription leading to insulin secretion in pancreatic beta-cells. PLoS One (2012) 0.79
A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31. Curr Biol (2012) 0.79
Structural flexibility and functional interaction of Mediator Cdk8 module. Protein Cell (2013) 0.79
Gdown1: making a link between mediator and RNA polymerase II elongation control. Transcription (2012) 0.78
Cyclin C mediates stress-induced mitochondrial fission and apoptosis. Mol Biol Cell (2015) 0.78
Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene. PLoS One (2013) 0.78
Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency. PLoS One (2015) 0.77
Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1. Proc Natl Acad Sci U S A (2015) 0.77
Protein and DNA modifications: evolutionary imprints of bacterial biochemical diversification and geochemistry on the provenance of eukaryotic epigenetics. Cold Spring Harb Perspect Biol (2014) 0.77
Complex disease interventions from a network model for type 2 diabetes. PLoS One (2013) 0.77
What's new in estrogen receptor action in the female reproductive tract. J Mol Endocrinol (2016) 0.77
ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Nucleic Acids Res (2013) 0.77
Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62
Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 4.81
Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci (2005) 4.37
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell (2008) 3.53
Structure, function, and activator-induced conformations of the CRSP coactivator. Science (2002) 3.52
Mediator of transcriptional regulation. Annu Rev Biochem (2000) 3.51
The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci (2010) 3.38
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol Cell (2004) 3.34
The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem Sci (2005) 3.25
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature (2008) 3.24
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature (2006) 3.23
A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome. Genome Res (2009) 2.89
CDK8 is a stimulus-specific positive coregulator of p53 target genes. Mol Cell (2007) 2.88
General requirement for RNA polymerase II holoenzymes in vivo. Proc Natl Acad Sci U S A (1995) 2.88
TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature (2000) 2.76
CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol (2010) 2.70
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev (2009) 2.69
Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex. Nucleic Acids Res (2008) 2.32
Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction. Mol Cell (2002) 2.32
The TRAP/SMCC/Mediator complex and thyroid hormone receptor function. Trends Endocrinol Metab (2001) 2.26
Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA. Mol Cell (2006) 2.16
Mediator structural conservation and implications for the regulation mechanism. Structure (2009) 2.08
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev (2002) 2.02
Ras induces mediator complex exchange on C/EBP beta. Mol Cell (2004) 1.98
The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II. Proc Natl Acad Sci U S A (2006) 1.91
Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions. Mol Cell (2006) 1.86
Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86
Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Mol Cell (2007) 1.84
A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature (2002) 1.82
A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J (2003) 1.78
Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. Proc Natl Acad Sci U S A (2008) 1.77
MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor. Mol Endocrinol (2005) 1.76
Structural organization of yeast and mammalian mediator complexes. Proc Natl Acad Sci U S A (2000) 1.76
Head module control of mediator interactions. Mol Cell (2006) 1.72
The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. Proc Natl Acad Sci U S A (2004) 1.70
Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. EMBO Rep (2001) 1.67
The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. Mol Cell (2000) 1.65
Mediator head module structure and functional interactions. Nat Struct Mol Biol (2010) 1.36
TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution. Proc Natl Acad Sci U S A (2003) 1.33
Complexity in transcription control at the activation domain-mediator interface. Sci Signal (2009) 1.29
The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. PLoS Genet (2008) 1.29
Mediator complex association with constitutively transcribed genes in yeast. Proc Natl Acad Sci U S A (2009) 1.22
Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p. J Biol Chem (2008) 1.20
Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation. Mol Cell Biol (2010) 1.18
Role for Med12 in regulation of Nanog and Nanog target genes. J Biol Chem (2008) 1.16
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. J Biol Chem (2008) 1.13
The VP16 activation domain establishes an active mediator lacking CDK8 in vivo. J Biol Chem (2006) 1.10
Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro. J Biol Chem (2003) 1.09
MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. Mol Cell Biol (2010) 1.06
Differential roles of transcriptional mediator subunits in regulation of multidrug resistance gene expression in Saccharomyces cerevisiae. Mol Biol Cell (2010) 1.03
A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila. Mol Cell Biol (2010) 1.01
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev (2004) 3.82
Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors. Proc Natl Acad Sci U S A (2006) 3.71
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol Cell (2004) 3.34
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14
Emerging roles of ubiquitin in transcription regulation. Science (2002) 2.92
The RNA polymerase II elongation complex. Annu Rev Biochem (2003) 2.76
Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. J Biol Chem (2003) 2.36
A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. J Biol Chem (2005) 2.10
The INO80 chromatin remodeling complex in transcription, replication and repair. Trends Biochem Sci (2008) 1.96
The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. J Biol Chem (2005) 1.93
Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Biochemistry (2006) 1.81
In and out: histone variant exchange in chromatin. Trends Biochem Sci (2005) 1.81
ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A (2005) 1.69
Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. Mol Cell Biol (2004) 1.48
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43
Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. Dev Cell (2004) 1.27
Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. J Biol Chem (2011) 1.27
The Mediator complex and transcription elongation. Biochim Biophys Acta (2012) 1.24
Origins and activity of the Mediator complex. Semin Cell Dev Biol (2011) 1.23
In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development. Mol Cell Biol (2004) 1.01
Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. J Biol Chem (2003) 1.01
A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. J Biol Chem (2003) 0.96
A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. J Biol Chem (2003) 0.94
Identification of Elongin C and Skp1 sequences that determine Cullin selection. J Biol Chem (2004) 0.85
Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes. J Biol Chem (2012) 0.84
TFIIS and GreB: two like-minded transcription elongation factors with sticky fingers. Cell (2003) 0.83
Mediator comes out from the shadows. Structure (2009) 0.80
Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α. J Biol Chem (2013) 0.79
Assays for investigating the mechanism of promoter escape by RNA polymerase II. Methods Enzymol (2003) 0.77
Preparation and assay of RNA polymerase II elongation factors elongin and ELL. Methods Enzymol (2003) 0.77
New clues to actin function in chromatin regulation. Nat Struct Mol Biol (2008) 0.75