Published in Mol Endocrinol on October 20, 2005
The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci (2010) 3.38
Function and regulation of the Mediator complex. Curr Opin Genet Dev (2011) 2.51
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev (2009) 1.88
Glucocorticoid receptor phosphorylation differentially affects target gene expression. Mol Endocrinol (2008) 1.81
CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell (2008) 1.66
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect. Proc Natl Acad Sci U S A (2008) 1.54
Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol (2007) 1.50
Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res (2011) 1.40
Complexity in transcription control at the activation domain-mediator interface. Sci Signal (2009) 1.29
Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes. J Steroid Biochem Mol Biol (2008) 1.26
Origins and activity of the Mediator complex. Semin Cell Dev Biol (2011) 1.23
Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling. Mol Cell Biol (2011) 1.19
Chromatin-dependent cooperativity between site-specific transcription factors in vivo. J Biol Chem (2006) 1.19
Molecular mechanisms regulating glucocorticoid sensitivity and resistance. Mol Cell Endocrinol (2008) 1.19
STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. Mol Cell Biol (2006) 1.18
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. J Biol Chem (2008) 1.13
Mediator-dependent nuclear receptor function. Semin Cell Dev Biol (2011) 1.12
Vitamin D in inflammatory diseases. Front Physiol (2014) 1.10
Aberrant regulation of FBW7 in cancer. Oncotarget (2014) 1.08
MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. Mol Cell Biol (2010) 1.06
Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. Br J Pharmacol (2012) 1.01
A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms. Proc Natl Acad Sci U S A (2013) 0.99
A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells. Genome Res (2013) 0.97
Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases. Am J Respir Cell Mol Biol (2012) 0.94
Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges. Mol Endocrinol (2013) 0.94
PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation. J Biol Chem (2012) 0.94
Modulation of transcription parameters in glucocorticoid receptor-mediated repression. Mol Cell Endocrinol (2008) 0.93
Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments. Immunol Res (2009) 0.93
Nicotinamide uncouples hormone-dependent chromatin remodeling from transcription complex assembly. Mol Cell Biol (2007) 0.93
Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. BMC Med Genomics (2011) 0.92
Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1. Br J Pharmacol (2012) 0.91
Vitamin D enhances glucocorticoid action in human monocytes: involvement of granulocyte-macrophage colony-stimulating factor and mediator complex subunit 14. J Biol Chem (2013) 0.91
Conditional ablation of mediator subunit MED1 (MED1/PPARBP) gene in mouse liver attenuates glucocorticoid receptor agonist dexamethasone-induced hepatic steatosis. Gene Expr (2009) 0.91
Regulation of triglyceride metabolism by glucocorticoid receptor. Cell Biosci (2012) 0.91
Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Mol Cell Biol (2013) 0.90
Detection of differentially expressed genes between Erhualian and Large White placentas on day 75 and 90 of gestation. BMC Genomics (2009) 0.89
The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. Nucleic Acids Res (2007) 0.89
Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. Proc Natl Acad Sci U S A (2014) 0.87
Cell cycle phase regulates glucocorticoid receptor function. PLoS One (2011) 0.87
Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction. Mol Cell Endocrinol (2012) 0.86
A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties. J Biol Chem (2013) 0.86
Glucocorticoid-dependent phosphorylation of the transcriptional coregulator GRIP1. Mol Cell Biol (2011) 0.84
Variable steroid receptor responses: Intrinsically disordered AF1 is the key. Mol Cell Endocrinol (2013) 0.84
The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer. J Biol Chem (2014) 0.83
The Mediator Complex and Lipid Metabolism. J Biochem Pharmacol Res (2013) 0.83
Identification of glucocorticoid-induced leucine zipper as a key regulator of tumor cell proliferation in epithelial ovarian cancer. Mol Cancer (2009) 0.83
Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry. Structure (2014) 0.82
A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function. J Cell Sci (2013) 0.81
Basal p38 mitogen-activated protein kinase regulates unliganded glucocorticoid receptor function in airway smooth muscle cells. Am J Respir Cell Mol Biol (2014) 0.81
Pin1 promotes GR transactivation by enhancing recruitment to target genes. Nucleic Acids Res (2013) 0.80
Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. Neuroscience (2015) 0.80
MED25 is a mediator component of HNF4α-driven transcription leading to insulin secretion in pancreatic beta-cells. PLoS One (2012) 0.79
HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter. J Biomed Biotechnol (2010) 0.79
Differential glucocorticoid receptor-mediated transcription mechanisms. J Biol Chem (2010) 0.79
ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Nucleic Acids Res (2013) 0.77
Distress calls of the greater short-nosed fruit bat Cynopterus sphinx activate hypothalamic-pituitary-adrenal (HPA) axis in conspecifics. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2013) 0.77
Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids. Mediators Inflamm (2015) 0.76
Transcriptional regulation of FoxO3 gene by glucocorticoids in murine myotubes. Am J Physiol Endocrinol Metab (2016) 0.75
Glucocorticoid receptor control of transcription: precision and plasticity via allostery. Nat Rev Mol Cell Biol (2017) 0.75
Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK. Mol Endocrinol (2015) 0.75
ETV4 and AP1 transcription factors form multivalent interactions with three sites on the MED25 activator-interacting domain. J Mol Biol (2017) 0.75
Identification and characterization of BATF3 as a context-specific coactivator of the glucocorticoid receptor. PLoS One (2017) 0.75
Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. Genome Res (2009) 3.30
Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc Natl Acad Sci U S A (2003) 2.63
Modulation of glucocorticoid receptor function via phosphorylation. Ann N Y Acad Sci (2004) 1.97
Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo. J Biol Chem (2002) 1.95
Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling. Proc Natl Acad Sci U S A (2009) 1.83
Glucocorticoid receptor phosphorylation differentially affects target gene expression. Mol Endocrinol (2008) 1.81
Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. Am J Pathol (2007) 1.77
Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell (2003) 1.70
Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress. Mol Endocrinol (2007) 1.68
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect. Proc Natl Acad Sci U S A (2008) 1.54
Mifepristone inhibits GRβ coupled prostate cancer cell proliferation. J Urol (2012) 1.51
Cell-specific regulation of androgen receptor phosphorylation in vivo. J Biol Chem (2005) 1.38
Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase. Mol Endocrinol (2006) 1.37
LEF1 in androgen-independent prostate cancer: regulation of androgen receptor expression, prostate cancer growth, and invasion. Cancer Res (2009) 1.34
The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. EMBO J (2005) 1.34
Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes. J Steroid Biochem Mol Biol (2008) 1.26
Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages. PLoS One (2011) 1.25
Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogen-activated protein (MAP) kinase. J Biol Chem (2004) 1.24
Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. Proc Natl Acad Sci U S A (2008) 1.23
ART-27, an androgen receptor coactivator regulated in prostate development and cancer. J Biol Chem (2004) 1.23
Glucocorticoids and the innate immune system: crosstalk with the toll-like receptor signaling network. Mol Cell Endocrinol (2007) 1.19
The type I interferon signaling pathway is a target for glucocorticoid inhibition. Mol Cell Biol (2010) 1.14
BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A (2012) 1.13
Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus. Mol Biol Cell (2002) 1.11
Minireview: Glucocorticoids in autoimmunity: unexpected targets and mechanisms. Mol Endocrinol (2011) 1.11
Regression of atherosclerosis is characterized by broad changes in the plaque macrophage transcriptome. PLoS One (2012) 1.09
Decrease in stromal androgen receptor associates with androgen-independent disease and promotes prostate cancer cell proliferation and invasion. J Cell Mol Med (2008) 1.09
The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes. Mol Cell Biol (2012) 1.06
The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol (2006) 1.02
Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. Mol Cell Biol (2011) 1.02
Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer. Am J Pathol (2010) 1.02
Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids. Proc Natl Acad Sci U S A (2012) 1.01
Inhibition of androgen receptor and β-catenin activity in prostate cancer. Proc Natl Acad Sci U S A (2013) 1.01
The glucocorticoid receptor represses cyclin D1 by targeting the Tcf-beta-catenin complex. J Biol Chem (2006) 1.00
Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages. Mol Cell Biol (2008) 0.99
Genetic dissection of p23, an Hsp90 cochaperone, reveals a distinct surface involved in estrogen receptor signaling. J Biol Chem (2003) 0.98
A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells. Genome Res (2013) 0.97
Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells. Am J Respir Cell Mol Biol (2009) 0.97
Identification of DRIP205 as a coactivator for the Farnesoid X receptor. J Biol Chem (2004) 0.97
High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. Cancer Res (2010) 0.97
Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res (2012) 0.97
LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ Res (2011) 0.96
Regulation of GRIP1 and CBP Coactivator activity by Rho GDI modulates estrogen receptor transcriptional enhancement. J Biol Chem (2002) 0.92
Androgen receptor mutations identified in prostate cancer and androgen insensitivity syndrome display aberrant ART-27 coactivator function. Mol Endocrinol (2005) 0.92
GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression. Proc Natl Acad Sci U S A (2008) 0.91
Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model. J Biol Chem (2014) 0.91
Multivalent peptidomimetic conjugates: a versatile platform for modulating androgen receptor activity. J Am Chem Soc (2012) 0.91
The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors. J Urol (2007) 0.91
Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A (2013) 0.91
Nuclear receptors in inflammation control: repression by GR and beyond. Mol Cell Endocrinol (2013) 0.90
Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells. Cancer Res (2009) 0.90
Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Mol Cell Biol (2013) 0.90
Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasion. J Cell Mol Med (2010) 0.90
Modulation of glucocorticoid receptor transcriptional activation, phosphorylation, and growth inhibition by p27Kip1. J Biol Chem (2003) 0.89
Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages. BMC Genomics (2014) 0.88
Expression and regulation of glucocorticoid receptor in human placental villous fibroblasts. Endocrinology (2005) 0.88
Stabilization of the unliganded glucocorticoid receptor by TSG101. J Biol Chem (2005) 0.86
Research resource: enhanced genome-wide occupancy of estrogen receptor α by the cochaperone p23 in breast cancer cells. Mol Endocrinol (2011) 0.86
Caveolin-1 regulates genomic action of the glucocorticoid receptor in neural stem cells. Mol Cell Biol (2014) 0.84
Glucocorticoid-dependent phosphorylation of the transcriptional coregulator GRIP1. Mol Cell Biol (2011) 0.84
Androgen receptor antagonism by divalent ethisterone conjugates in castrate-resistant prostate cancer cells. ACS Chem Biol (2012) 0.83
Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27. Mol Endocrinol (2007) 0.82
Targeting the androgen receptor with steroid conjugates. J Med Chem (2014) 0.79
RNA polymerase II stalling mediates cytokine gene expression. Cell Cycle (2010) 0.79
Minireview: nuclear receptor coregulators of the p160 family: insights into inflammation and metabolism. Mol Endocrinol (2015) 0.77
Modulation of human estrogen receptor α activity by multivalent estradiol-peptidomimetic conjugates. Mol Biosyst (2011) 0.76
Glucocorticoids in laryngology: a review. Laryngoscope (2014) 0.76
Ligand structural motifs can decouple glucocorticoid receptor transcriptional activation from target promoter occupancy. Biochem Biophys Res Commun (2012) 0.75
Development of phosphorylation site-specific antibodies to nuclear receptors. Methods Mol Biol (2009) 0.75