Published in Proc Natl Acad Sci U S A on October 16, 2006
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell (2008) 3.53
CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol (2010) 2.70
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev (2009) 2.69
Function and regulation of the Mediator complex. Curr Opin Genet Dev (2011) 2.51
The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics (2011) 2.16
The Mediator complex: a central integrator of transcription. Nat Rev Mol Cell Biol (2015) 1.97
Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Nucl Recept Signal (2009) 1.80
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes Dev (2013) 1.79
Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. Proc Natl Acad Sci U S A (2008) 1.77
Malleable machines take shape in eukaryotic transcriptional regulation. Nat Chem Biol (2008) 1.76
Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol (2014) 1.68
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
CDK8: a positive regulator of transcription. Transcription (2012) 1.53
Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J (2008) 1.44
Architecture of the RNA polymerase II-Mediator core initiation complex. Nature (2015) 1.39
Distinct roles for Mediator Cdk8 module subunits in Drosophila development. EMBO J (2007) 1.38
Malleable machines in transcription regulation: the mediator complex. PLoS Comput Biol (2008) 1.35
A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction. Nat Struct Mol Biol (2013) 1.29
CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity (2013) 1.28
The Mediator complex and transcription elongation. Biochim Biophys Acta (2012) 1.24
Origins and activity of the Mediator complex. Semin Cell Dev Biol (2011) 1.23
Brd4-independent transcriptional repression function of the papillomavirus e2 proteins. J Virol (2007) 1.19
Identification, structure, and functional requirement of the Mediator submodule Med7N/31. EMBO J (2008) 1.14
Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast. EMBO J (2011) 1.05
Differential roles of transcriptional mediator subunits in regulation of multidrug resistance gene expression in Saccharomyces cerevisiae. Mol Biol Cell (2010) 1.03
Redefining the modular organization of the core Mediator complex. Cell Res (2014) 1.02
Varicella-zoster virus IE62 protein utilizes the human mediator complex in promoter activation. J Virol (2008) 1.02
Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents. Br J Pharmacol (2009) 1.00
Mediator kinase module and human tumorigenesis. Crit Rev Biochem Mol Biol (2015) 0.98
The Ccr4-not complex regulates Skn7 through Srb10 kinase. Eukaryot Cell (2007) 0.97
Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways. Nucleic Acids Res (2008) 0.96
Preparation and topology of the Mediator middle module. Nucleic Acids Res (2010) 0.95
Targeting cell cycle regulators in hematologic malignancies. Front Cell Dev Biol (2015) 0.92
CDK19 is disrupted in a female patient with bilateral congenital retinal folds, microcephaly and mild mental retardation. Hum Genet (2010) 0.92
Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation. Mol Cell Biol (2010) 0.91
Differential regulation of white-opaque switching by individual subunits of Candida albicans mediator. Eukaryot Cell (2013) 0.90
Mediator complex dependent regulation of cardiac development and disease. Genomics Proteomics Bioinformatics (2013) 0.90
Mediator promotes CENP-a incorporation at fission yeast centromeres. Mol Cell Biol (2012) 0.89
A chromatin-remodeling protein is a component of fission yeast mediator. J Biol Chem (2010) 0.88
CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis. Plant Cell (2014) 0.87
MC EMiNEM maps the interaction landscape of the Mediator. PLoS Comput Biol (2012) 0.87
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Dev Dyn (2011) 0.86
Disordered proteinaceous machines. Chem Rev (2014) 0.86
Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation. Cell Cycle (2016) 0.86
Temporal association of herpes simplex virus ICP4 with cellular complexes functioning at multiple steps in PolII transcription. PLoS One (2013) 0.83
Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes. Biol Direct (2013) 0.83
Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast. Mol Cell Biol (2012) 0.83
Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants. Front Plant Sci (2015) 0.81
Mediator can regulate mitotic entry and direct periodic transcription in fission yeast. Mol Cell Biol (2014) 0.80
Gene repressive activity of RIP140 through direct interaction with CDK8. Mol Endocrinol (2011) 0.80
Mediator Undergoes a Compositional Change during Transcriptional Activation. Mol Cell (2016) 0.79
The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions. Development (2014) 0.79
Mediator regulates non-coding RNA transcription at fission yeast centromeres. Epigenetics Chromatin (2012) 0.79
Structural flexibility and functional interaction of Mediator Cdk8 module. Protein Cell (2013) 0.79
Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene. PLoS One (2013) 0.78
Auxin-dependent compositional change in Mediator in ARF7- and ARF19-mediated transcription. Proc Natl Acad Sci U S A (2016) 0.78
Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas. Br J Cancer (2014) 0.78
Expression of AtMed15 of Arabidopsis in yeast causes flocculation and increases ethanol production in yeast culture. Sci Rep (2016) 0.77
Mediator structure and rearrangements required for holoenzyme formation. Nature (2017) 0.76
mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PLoS One (2015) 0.76
Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells. J Clin Endocrinol Metab (2016) 0.76
A kinase-independent role for CDK19 in p53 response. Mol Cell Biol (2017) 0.75
MED12 mutations in human diseases. Protein Cell (2013) 0.75
Type I interferon inhibits varicella-zoster virus replication by interfering with the dynamic interaction between mediator and IE62 within replication compartments. Cell Biosci (2016) 0.75
A general framework for modeling growth and division of mammalian cells. BMC Syst Biol (2011) 0.75
Mediator redefines itself. Cell Res (2014) 0.75
Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway. Endocrinology (2016) 0.75
Candida albicans Swi/Snf and Mediator Complexes Differentially Regulate Mrr1-induced MDR1 Expression and Fluconazole Resistance. Antimicrob Agents Chemother (2017) 0.75
ScMED7, a sugarcane mediator subunit gene, acts as a regulator of plant immunity and is responsive to diverse stress and hormone treatments. Mol Genet Genomics (2017) 0.75
Functional metabolomics as a tool to analyze Mediator function and structure in plants. PLoS One (2017) 0.75
Sub1/PC4, a multifaceted factor: from transcription to genome stability. Curr Genet (2017) 0.75
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
EMAN: semiautomated software for high-resolution single-particle reconstructions. J Struct Biol (1999) 27.52
Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44
Situs: A package for docking crystal structures into low-resolution maps from electron microscopy. J Struct Biol (1999) 5.71
A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell (1993) 5.35
A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast. Proc Natl Acad Sci U S A (1994) 4.21
Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol Cell (1998) 4.09
Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process. EMBO J (2002) 3.57
Structure, function, and activator-induced conformations of the CRSP coactivator. Science (2002) 3.52
Mediator of transcriptional regulation. Annu Rev Biochem (2000) 3.51
Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II. Genetics (1989) 3.04
The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev (1998) 2.91
TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature (2000) 2.76
Structures of complete RNA polymerase II and its subcomplex, Rpb4/7. J Biol Chem (2004) 2.52
Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction. Mol Cell (2002) 2.32
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res (2004) 2.15
The yeast Mediator complex and its regulation. Trends Biochem Sci (2005) 2.15
Regulatory diversity among metazoan co-activator complexes. Nat Rev Mol Cell Biol (2004) 2.10
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev (2002) 2.02
Conserved structures of mediator and RNA polymerase II holoenzyme. Science (1999) 1.97
A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast. J Biol Chem (2002) 1.84
Structural organization of yeast and mammalian mediator complexes. Proc Natl Acad Sci U S A (2000) 1.76
Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. EMBO Rep (2001) 1.67
Molray--a web interface between O and the POV-Ray ray tracer. Acta Crystallogr D Biol Crystallogr (2001) 1.64
TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution. Proc Natl Acad Sci U S A (2003) 1.33
Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe. J Biol Chem (2000) 1.09
Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro. J Biol Chem (2003) 1.09
Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells. Proc Natl Acad Sci U S A (2001) 1.04
The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator. J Biol Chem (2004) 1.00
Characterization of the Prk1 protein kinase from Schizosaccharomyces pombe. Yeast (1998) 0.93
Strul--a method for 3D alignment of single-particle projections based on common line correlation in Fourier space. Ultramicroscopy (2001) 0.84
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat Genet (2002) 4.48
Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum Mol Genet (2004) 4.11
DNA replication and transcription in mammalian mitochondria. Annu Rev Biochem (2007) 3.74
Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome. Cell Metab (2009) 3.06
RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing. Genes Dev (2005) 2.99
MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell (2007) 2.76
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
The yeast Mediator complex and its regulation. Trends Biochem Sci (2005) 2.15
Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. Proc Natl Acad Sci U S A (2012) 2.10
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med (2012) 2.08
Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA. Mol Cell Biol (2004) 1.97
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J (2011) 1.89
Mitochondrial transcription and its regulation in mammalian cells. Trends Biochem Sci (2007) 1.88
Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions. Mol Cell (2006) 1.86
The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells. EMBO J (2004) 1.81
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab (2011) 1.68
Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro. J Biol Chem (2010) 1.67
ATP-induced conformational dynamics in the AAA+ motor unit of magnesium chelatase. Structure (2010) 1.63
A genome-wide role for CHD remodelling factors and Nap1 in nucleosome disassembly. EMBO J (2007) 1.59
Structural basis for induced formation of the inflammatory mediator prostaglandin E2. Proc Natl Acad Sci U S A (2008) 1.58
Single-particle cryoelectron microscopy analysis reveals the HIV-1 spike as a tripod structure. Proc Natl Acad Sci U S A (2010) 1.54
Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. Mol Cell (2010) 1.53
Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro. Proc Natl Acad Sci U S A (2008) 1.52
Structural basis for detoxification and oxidative stress protection in membranes. J Mol Biol (2006) 1.49
The transcription machinery in mammalian mitochondria. Biochim Biophys Acta (2004) 1.41
Conserved sequence box II directs transcription termination and primer formation in mitochondria. J Biol Chem (2006) 1.40
Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem (2003) 1.39
Mammalian transcription factor A is a core component of the mitochondrial transcription machinery. Proc Natl Acad Sci U S A (2012) 1.37
TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution. Proc Natl Acad Sci U S A (2003) 1.33
A family of putative transcription termination factors shared amongst metazoans and plants. Curr Genet (2005) 1.33
The structures of frataxin oligomers reveal the mechanism for the delivery and detoxification of iron. Structure (2006) 1.31
G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation. Proc Natl Acad Sci U S A (2010) 1.21
Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target. Angew Chem Int Ed Engl (2010) 1.19
Molecular phylogenetics of ascomycotal adhesins--a novel family of putative cell-surface adhesive proteins in fission yeasts. Fungal Genet Biol (2007) 1.16
A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop. Nucleic Acids Res (2012) 1.15
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. Am J Hum Genet (2011) 1.14
Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1. Biochemistry (2004) 1.13
The structural and functional role of Med5 in the yeast Mediator tail module. J Biol Chem (2005) 1.10
Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro. J Biol Chem (2003) 1.09
MTERF2 is a nucleoid component in mammalian mitochondria. Biochim Biophys Acta (2009) 1.09
Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A. Nat Commun (2012) 1.07
In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication. EMBO Rep (2012) 1.06
The multitalented Mediator complex. Trends Biochem Sci (2013) 1.04
LRPPRC is a mitochondrial matrix protein that is conserved in metazoans. Biochem Biophys Res Commun (2010) 1.03
MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Cell Metab (2013) 1.03
Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase-1. J Biol Chem (2010) 1.02
The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form. J Biol Chem (2005) 1.00
The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator. J Biol Chem (2004) 1.00
A new cryo-EM single-particle ab initio reconstruction method visualizes secondary structure elements in an ATP-fueled AAA+ motor. J Mol Biol (2007) 0.99
Magnetite nanoparticles can be coupled to microbubbles to support multimodal imaging. Biomacromolecules (2012) 0.99
Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer. Biochemistry (2008) 0.98
Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome. J Biol Chem (2011) 0.98
Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S. Pflugers Arch (2012) 0.97
Structure of mitochondrial transcription termination factor 3 reveals a novel nucleic acid-binding domain. Biochem Biophys Res Commun (2010) 0.96
The classical srb4-138 mutant allele causes dissociation of yeast Mediator. Biochem Biophys Res Commun (2006) 0.96
Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis. Proc Natl Acad Sci U S A (2012) 0.96
Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription. Nucleic Acids Res (2010) 0.96
Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways. Nucleic Acids Res (2008) 0.96
Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid. Proc Natl Acad Sci U S A (2004) 0.95
The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis. Nucleic Acids Res (2011) 0.94
Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1. Biochemistry (2007) 0.94
Histone modifications influence mediator interactions with chromatin. Nucleic Acids Res (2011) 0.94
Turning of the receptor-binding domains opens up the murine leukaemia virus Env for membrane fusion. EMBO J (2008) 0.93
Neither Reb1p nor poly(dA*T) elements are responsible for the highly specific chromatin organization at the ILV1 promoter. J Biol Chem (2001) 0.93
tmRNA.SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes. J Struct Biol (2009) 0.92
Mediator influences telomeric silencing and cellular life span. Mol Cell Biol (2011) 0.92
Exploring the activity of tobacco etch virus protease in detergent solutions. Anal Biochem (2008) 0.92
The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation. Nucleic Acids Res (2014) 0.92
Projection structure at 8 A resolution of the melibiose permease, an Na-sugar co-transporter from Escherichia coli. EMBO J (2002) 0.90
Distinct differences in chromatin structure at subtelomeric X and Y' elements in budding yeast. PLoS One (2009) 0.90
Liposome and protein based stealth nanoparticles. Faraday Discuss (2013) 0.90
Mediator promotes CENP-a incorporation at fission yeast centromeres. Mol Cell Biol (2012) 0.89
Three-dimensional structure of the sugar symporter melibiose permease from cryo-electron microscopy. J Struct Biol (2005) 0.89
Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID. Structure (2009) 0.88
A chromatin-remodeling protein is a component of fission yeast mediator. J Biol Chem (2010) 0.88
Subunit arrangement in the dodecameric chloroplast small heat shock protein Hsp21. Protein Sci (2010) 0.87