Published in Br J Haematol on February 20, 2011
Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1. Haematologica (2013) 0.96
Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome. Blood (2014) 0.88
Physiology and pathophysiology of iron in hemoglobin-associated diseases. Free Radic Biol Med (2014) 0.85
Iron dosing in kidney disease: inconsistency of evidence and clinical practice. Nephrol Dial Transplant (2014) 0.81
Efficacy and safety of deferasirox in non-thalassemic patients with elevated ferritin levels after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant (2015) 0.77
Erythropoietic drive is the strongest predictor of hepcidin level in adults with sickle cell disease. Blood Cells Mol Dis (2015) 0.77
Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in long-term iron loading β-thalassemic mice. Asian Pac J Trop Biomed (2014) 0.77
Effects of Pregnancy and Lactation on Iron Metabolism in Rats. Biomed Res Int (2015) 0.76
Deferasirox in a refractory anemia after other treatment options: case report and literature review. Clin Case Rep (2015) 0.75
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest (2004) 11.05
Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med (2002) 9.01
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood (2002) 7.58
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet (2003) 5.82
Immunoassay for human serum hepcidin. Blood (2008) 5.32
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med (2007) 5.18
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05
Regulation of iron metabolism by hepcidin. Annu Rev Nutr (2006) 3.96
Hepcidin is decreased in TFR2 hemochromatosis. Blood (2004) 3.46
Defensins of vertebrate animals. Curr Opin Immunol (2002) 3.41
Suppression of hepcidin during anemia requires erythropoietic activity. Blood (2006) 3.32
Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol (2002) 3.13
The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica (2008) 2.92
Hepcidin in iron overload disorders. Blood (2005) 2.88
Systemic iron homeostasis. Physiol Rev (2013) 2.69
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood (2005) 2.66
Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood (2009) 2.65
Hepcidin--a potential novel biomarker for iron status in chronic kidney disease. Clin J Am Soc Nephrol (2009) 2.61
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A (2005) 2.60
Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica (2007) 2.52
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood (2007) 2.51
Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran. Thromb Haemost (2006) 2.27
Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis. Br J Haematol (2008) 2.25
Retracted The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab (2008) 2.25
Proinflammatory state, hepcidin, and anemia in older persons. Blood (2010) 2.19
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J Clin Invest (2010) 2.18
Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol (2002) 2.17
The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A (2005) 2.10
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood (2005) 2.08
In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood (2010) 2.03
Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol (2007) 2.02
Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Genomics (2005) 1.97
Detection, evaluation, and management of iron-restricted erythropoiesis. Blood (2010) 1.93
The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem (2002) 1.89
The hypercoagulable state in thalassemia. Blood (2002) 1.88
The role of hepcidin in iron metabolism. Acta Haematol (2009) 1.88
Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol (2003) 1.88
Cathelicidins: a family of endogenous antimicrobial peptides. Curr Opin Hematol (2002) 1.86
Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology (2011) 1.82
Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol (2003) 1.82
Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women. Am J Clin Nutr (2008) 1.79
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood (2007) 1.78
Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis (2007) 1.76
Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest (2007) 1.72
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia. Blood (2008) 1.72
Antimicrobial components of vaginal fluid. Am J Obstet Gynecol (2002) 1.67
Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene. Blood (2004) 1.64
Addition of fresh frozen plasma as a source of complement to rituximab in advanced chronic lymphocytic leukaemia. Lancet Oncol (2007) 1.63
Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. BMC Infect Dis (2004) 1.63
The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood (2005) 1.60
Flow cytometry measurement of the labile iron pool in human hematopoietic cells. Cytometry A (2008) 1.59
Cerebrovascular accident in beta-thalassemia major (beta-TM) and beta-thalassemia intermedia (beta-TI). Am J Hematol (2008) 1.59
Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer (2007) 1.58
Cationic polypeptides are required for antibacterial activity of human airway fluid. J Immunol (2002) 1.58
Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. Anesthesiology (2010) 1.58
Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res (2008) 1.57
Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol (2006) 1.55
By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J Immunol (2003) 1.54
The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood (2009) 1.51
Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica (2009) 1.51
Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood (2012) 1.51
Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. J Clin Endocrinol Metab (2010) 1.50
Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest (2011) 1.49
Hepcidin and iron-loading anemias. Haematologica (2006) 1.49
Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol (2009) 1.48
Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability. Br J Haematol (2007) 1.45
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood (2004) 1.44
Magnetic resonance imaging to determine the incidence of brain ischaemia in patients with beta-thalassaemia intermedia. Thromb Haemost (2010) 1.44
Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation. Phytother Res (2010) 1.42
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab (2012) 1.42
Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol (2005) 1.41
Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun (2005) 1.41
Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis (2007) 1.40
Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun (2006) 1.40
Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood (2005) 1.38
Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood (2010) 1.37
Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol (2002) 1.35
Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency. Blood (2008) 1.35
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood (2013) 1.34
Red blood cells, platelets and polymorphonuclear neutrophils of patients with sickle cell disease exhibit oxidative stress that can be ameliorated by antioxidants. Br J Haematol (2006) 1.33
Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biol Reprod (2003) 1.32
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood (2012) 1.32
TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol (2005) 1.31
Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J Clin Invest (2006) 1.30
Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica (2006) 1.23
Non-transfusion-dependent thalassemias. Haematologica (2013) 1.21
Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica (2011) 1.21
Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells Mol Dis (2007) 1.20
N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Free Radic Biol Med (2005) 1.20
Changes in parameters of oxidative stress and free iron biomarkers during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndromes. Haematologica (2010) 1.19
Oxidative stress in red blood cells, platelets and polymorphonuclear leukocytes from patients with myelodysplastic syndrome. Eur J Haematol (2007) 1.18