PubRank

Rohit N Kulkarni

Author PubWeight™ 117.94‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008 6.82
2 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 2003 5.25
3 Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 2005 3.52
4 cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev 2003 3.32
5 TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 2006 3.26
6 Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest 2007 3.02
7 Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab 2009 2.83
8 Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A 2007 2.48
9 Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet 2006 2.21
10 Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol 2006 2.09
11 Insulin resistance alters islet morphology in nondiabetic humans. Diabetes 2013 2.01
12 Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest 2007 1.99
13 Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest 2003 1.83
14 Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states. Cell Rep 2013 1.75
15 Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest 2010 1.70
16 Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology 2004 1.69
17 Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 2003 1.68
18 Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol 2009 1.66
19 The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest 2010 1.61
20 Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 2003 1.60
21 Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes 2008 1.55
22 Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev 2002 1.52
23 Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A 2011 1.50
24 Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab 2005 1.48
25 Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes 2014 1.37
26 Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf) 2002 1.32
27 Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A 2011 1.28
28 Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab 2008 1.28
29 Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells. Diabetes 2011 1.26
30 RNA-binding protein HuD controls insulin translation. Mol Cell 2012 1.25
31 Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci U S A 2010 1.25
32 Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes 2008 1.25
33 High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J 2009 1.25
34 Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues. J Proteome Res 2008 1.23
35 Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes 2010 1.23
36 Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol 2006 1.21
37 Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A 2009 1.17
38 Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes 2008 1.16
39 Soluble factors secreted by T cells promote β-cell proliferation. Diabetes 2013 1.14
40 Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 2003 1.10
41 Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem 2003 1.09
42 Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes 2008 1.08
43 Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus. PLoS One 2011 1.07
44 Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem 2013 1.06
45 Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression. J Biol Chem 2010 1.06
46 Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metab 2010 1.05
47 Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans. Diabetes 2012 1.04
48 Near-infrared fluorescent probe for imaging of pancreatic beta cells. Bioconjug Chem 2010 1.04
49 Molecular approaches to study control of glucose homeostasis. ILAR J 2006 1.03
50 Retracted Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol 2006 1.03
51 Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One 2009 1.03
52 Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med 2013 1.02
53 Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes 2007 0.98
54 Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation. Sci Signal 2012 0.97
55 Loss of glucagon-like peptide-2-induced proliferation following intestinal epithelial insulin-like growth factor-1-receptor deletion. Gastroenterology 2011 0.97
56 Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun 2013 0.97
57 X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function. Diabetes 2013 0.96
58 Pancreatic function in carboxyl-ester lipase knockout mice. Pancreatology 2010 0.94
59 Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci U S A 2012 0.92
60 Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arterioscler Thromb Vasc Biol 2011 0.91
61 Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome. J Proteome Res 2009 0.91
62 New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metab 2013 0.90
63 Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Diabetes 2013 0.90
64 SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. J Biol Chem 2013 0.89
65 A patient with type B insulin resistance syndrome, responsive to immune therapy. Nat Clin Pract Endocrinol Metab 2007 0.89
66 Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol 2007 0.89
67 Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes 2010 0.88
68 Quantitative site-specific reactivity profiling of S-nitrosylation in mouse skeletal muscle using cysteinyl peptide enrichment coupled with mass spectrometry. Free Radic Biol Med 2012 0.88
69 Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab 2005 0.87
70 Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice. Diabetes 2011 0.87
71 Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids. J Clin Endocrinol Metab 2011 0.87
72 The regulation of pre- and post-maturational plasticity of mammalian islet cell mass. Diabetologia 2014 0.83
73 Enhanced GLP-1- and sulfonylurea-induced insulin secretion in islets lacking leptin signaling. Mol Endocrinol 2012 0.83
74 p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A 2014 0.82
75 Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young). PLoS One 2013 0.81
76 GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation. Mol Cell Endocrinol 2013 0.80
77 Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. Adv Exp Med Biol 2010 0.80
78 Unraveling pancreatic islet biology by quantitative proteomics. Expert Rev Proteomics 2011 0.80
79 Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets. Endocrinology 2012 0.79
80 Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function. Endocrinology 2014 0.78
81 GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochim Biophys Acta 2012 0.78
82 Insulin modulation of glucagon secretion: the role of insulin and other factors in the regulation of glucagon secretion. Islets 2010 0.78
83 Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice. Diabetologia 2014 0.76
84 Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells. Diabetes 2002 0.76
85 Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. EMBO J 2012 0.75
86 Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep 2016 0.75