Published in Hum Mol Genet on February 25, 2011
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HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation. Brain (2014) 1.13
Mutant huntingtin impairs immune cell migration in Huntington disease. J Clin Invest (2012) 1.11
The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal. Hum Mol Genet (2013) 1.07
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Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1. J Huntingtons Dis (2012) 0.91
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Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A (2014) 0.80
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A multifunctional, multi-pathway intracellular localization signal in Huntingtin. Commun Integr Biol (2013) 0.79
A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease. Hum Mol Genet (2014) 0.79
A study of molecular changes relating to energy metabolism and cellular stress in people with Huntington's disease: looking for biomarkers. J Bioenerg Biomembr (2012) 0.78
Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideum. J Biomed Sci (2012) 0.78
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F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics. PLoS One (2010) 0.90
Increased levels of gamma-glutamylamines in Huntington disease CSF. J Neurochem (2008) 0.90
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Mapping the interaction of cofilin with subdomain 2 on actin. Biochemistry (2007) 0.85
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ADF/cofilin controls cell polarity during fibroblast migration. Curr Biol (2003) 2.78
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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One (2008) 2.33
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Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. EMBO J (2005) 2.02
Disease-associated prion protein oligomers inhibit the 26S proteasome. Mol Cell (2007) 2.01
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Microglial activation in presymptomatic Huntington's disease gene carriers. Brain (2007) 1.93
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Actin-binding proteins take the reins in growth cones. Nat Rev Neurosci (2008) 1.73
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BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol (2007) 1.66
Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates. J Proteome Res (2007) 1.59
Specification of actin filament function and molecular composition by tropomyosin isoforms. Mol Biol Cell (2003) 1.51
Gene expression in Huntington's disease skeletal muscle: a potential biomarker. Hum Mol Genet (2005) 1.51
Xenopus actin-interacting protein 1 (XAip1) enhances cofilin fragmentation of filaments by capping filament ends. J Biol Chem (2002) 1.50
White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington's disease. Brain (2007) 1.47
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Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis. J Biol Chem (2005) 1.42
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Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease. Hum Brain Mapp (2011) 1.39
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Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood. Proc Natl Acad Sci U S A (2007) 1.35
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Regulation of growth cone actin dynamics by ADF/cofilin. J Histochem Cytochem (2003) 1.32
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Growth cone-like waves transport actin and promote axonogenesis and neurite branching. Dev Neurobiol (2009) 1.28
Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin. J Biol Chem (2005) 1.28
Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease. Hum Mol Genet (2011) 1.25
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RNA association and nucleocytoplasmic shuttling by ataxin-1. J Cell Sci (2005) 1.21
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ADF/cofilin regulates actomyosin assembly through competitive inhibition of myosin II binding to F-actin. Dev Cell (2012) 1.20
Brain-derived neurotrophic factor regulation of retinal growth cone filopodial dynamics is mediated through actin depolymerizing factor/cofilin. J Neurosci (2004) 1.20
Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking. Nat Neurosci (2009) 1.18
ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain. Neuron (2012) 1.17
Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation. Dev Cell (2008) 1.17
Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice. Proc Natl Acad Sci U S A (2012) 1.17
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Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease. Hum Mol Genet (2006) 1.15
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Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease. Mov Disord (2009) 1.14
Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression. J Clin Invest (2012) 1.14
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Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. EMBO J (2011) 1.13
Abnormal peripheral chemokine profile in Huntington's disease. PLoS Curr (2011) 1.12
Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease. Prog Neurobiol (2007) 1.12
Imaging microglial activation in Huntington's disease. Brain Res Bull (2006) 1.12
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Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy. Hum Brain Mapp (2011) 1.05
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Early atrophy of pallidum and accumbens nucleus in Huntington's disease. J Neurol (2010) 1.04
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