TRPM2, calcium and neurodegenerative diseases.

Emerging mechanisms of disrupted cellular signaling in brain ischemia. Nat Neurosci (2011) 1.11

trans-Resveratrol protects ischemic PC12 Cells by inhibiting the hypoxia associated transcription factors and increasing the levels of antioxidant defense enzymes. ACS Chem Neurosci (2012) 0.89

White matter changes in patients with amnestic mild cognitive impairment detected by diffusion tensor imaging. PLoS One (2013) 0.88

Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Mol Brain (2011) 0.84

A cell permeable NPE caged ADP-ribose for studying TRPM2. PLoS One (2012) 0.84

Potential role of melastatin-related transient receptor potential cation channel subfamily M gene expression in the pathogenesis of urinary bladder cancer. Oncol Lett (2016) 0.81

Glia and TRPM2 Channels in Plasticity of Central Nervous System and Alzheimer's Diseases. Neural Plast (2016) 0.78

TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli. Curr Neuropharmacol (2015) 0.78

Mechanisms underlying cell death in ischemia-like damage to the rat spinal cord in vitro. Cell Death Dis (2013) 0.76

TRPM7 and its role in neurodegenerative diseases. Channels (Austin) (2015) 0.75

Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat. Arch Med Sci (2016) 0.75

TRP channels as sensors of oxygen availability. Pflugers Arch (2013) 0.75

Effects of a voltage sensitive calcium channel blocker and a sodium-calcium exchanger inhibitor on apoptosis of motor neurons in adult spinal cord slices. Cell J (2012) 0.75

2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist. Nat Chem Biol (2017) 0.75

TRP channels. Annu Rev Biochem (2007) 8.09

Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci (2007) 6.27

Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell (2004) 6.15

Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci (2004) 5.10

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature (2001) 4.75

A key role for TRPM7 channels in anoxic neuronal death. Cell (2003) 4.46

Immunocyte Ca2+ influx system mediated by LTRPC2. Science (2001) 3.64

LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell (2002) 3.36

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem (2007) 3.35

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci (2008) 3.25

Ischemia opens neuronal gap junction hemichannels. Science (2006) 3.00

TRP channels: an overview. Cell Calcium (2005) 2.98

Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem (2003) 2.22

TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21

Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell (2005) 2.15

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem (2004) 2.08

Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem (2002) 2.01

Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol Cell Physiol (2003) 1.69

A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J Biol Chem (2003) 1.63

Tissue distribution profiles of the human TRPM cation channel family. J Recept Signal Transduct Res (2006) 1.62

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production. J Neurosci (2009) 1.47

The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem (2008) 1.45

NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. J Neurosci (2005) 1.44

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate. J Gen Physiol (2009) 1.38

TRP channels in disease. Sci STKE (2005) 1.32

A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci (2006) 1.31

Paradox of Ca2+ signaling, cell death and stroke. Trends Neurosci (2006) 1.30

Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem (2005) 1.30

Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin. J Biol Chem (2006) 1.29

Intracellular calcium activates TRPM2 and its alternative spliced isoforms. Proc Natl Acad Sci U S A (2009) 1.28

The mammalian melastatin-related transient receptor potential cation channels: an overview. Pflugers Arch (2005) 1.28

Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices. Brain Res (2006) 1.28

TRPM2 Ca2+ permeable cation channels: from gene to biological function. Cell Calcium (2003) 1.27

Calcium signaling in neurodegeneration. Mol Neurodegener (2009) 1.27

The effects of amyloid precursor protein on postsynaptic composition and activity. J Biol Chem (2009) 1.25

Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes. Biochem J (2006) 1.21

TRPMs and neuronal cell death. Pflugers Arch (2005) 1.19

Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol (2009) 1.19

NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. J Biol Chem (2002) 1.15

TRPM2. Handb Exp Pharmacol (2007) 1.10

The role of TRPM channels in cell death. Pflugers Arch (2005) 1.09

TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose. Pflugers Arch (2005) 1.08

TRP channels in disease. Subcell Biochem (2007) 1.06

Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. Neurotoxicology (2010) 1.04

Evolutionary determinants of divergent calcium selectivity of TRPM channels. FASEB J (2007) 1.03

Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc Natl Acad Sci U S A (2008) 1.01

TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD? Biochim Biophys Acta (2007) 1.00

Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. Biochem Biophys Res Commun (2005) 0.98

Dysregulation of calcium homeostasis in Alzheimer's disease. Neurochem Res (2009) 0.96

Transient receptor potential channels in Alzheimer's disease. Biochim Biophys Acta (2007) 0.96

Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2. J Biol Chem (2008) 0.95

Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet (2006) 0.95

TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. J Recept Signal Transduct Res (2006) 0.94

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function. Am J Physiol Cell Physiol (2006) 0.93

The transmembrane segment S6 determines cation versus anion selectivity of TRPM2 and TRPM8. J Biol Chem (2007) 0.88

Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein. Expert Rev Neurother (2009) 0.86

Intracellular calcium elevation induced by extracellular application of cyclic-ADP-ribose or oxytocin is temperature-sensitive in rodent NG108-15 neuronal cells with or without exogenous expression of human oxytocin receptors. J Neuroendocrinol (2010) 0.84

TRP channels: functions and involvement in neurologic disease. Neurology (2008) 0.81

Neuroprotective effects of the antifungal drug clotrimazole. Neuroscience (2002) 0.80

Effects of clotrimazole on experimental spinal cord injury. Arch Med Res (2006) 0.76

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A (2004) 3.21

Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science (2008) 2.46

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci (2009) 1.75

Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate. J Neurosci (2006) 1.70

Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors. Crit Rev Neurobiol (2006) 1.46

Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. J Neurosci (2010) 1.43

TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A (2007) 1.37

Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn. J Neurosci (2007) 1.31

Paradox of Ca2+ signaling, cell death and stroke. Trends Neurosci (2006) 1.30

A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission. Neuron (2002) 1.25

Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol (2009) 1.19

Regulation of NMDA receptors by the tyrosine kinase Fyn. FEBS J (2011) 1.17

Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases. EMBO J (2011) 1.13

Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons. J Biol Chem (2003) 1.10

Control of excitatory synaptic transmission by C-terminal Src kinase. J Biol Chem (2008) 1.03

G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus. Biochim Biophys Acta (2006) 0.93

Postsynaptic clustering and activation of Pyk2 by PSD-95. J Neurosci (2010) 0.92

Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission. Hippocampus (2009) 0.91

Effects of repeated prenatal glucocorticoid exposure on long-term potentiation in the juvenile guinea-pig hippocampus. J Physiol (2007) 0.90

Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons. J Biol Chem (2008) 0.88

Isoflurane regulates atypical type-A γ-aminobutyric acid receptors in alveolar type II epithelial cells. Anesthesiology (2013) 0.88

The involvement of PACAP/VIP system in the synaptic transmission in the hippocampus. J Mol Neurosci (2010) 0.87

Fyn, a potential target for Alzheimer's disease. J Alzheimers Dis (2011) 0.87

Insulin increases the potency of glycine at ionotropic glycine receptors. Mol Pharmacol (2007) 0.86

Mechanisms of general anesthesia. Curr Opin Anaesthesiol (2002) 0.86

Loss of endoplasmic reticulum Ca2+ homeostasis: contribution to neuronal cell death during cerebral ischemia. Acta Pharmacol Sin (2012) 0.85

Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation. Proc Natl Acad Sci U S A (2012) 0.85

Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Mol Brain (2011) 0.84

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons. Mol Brain (2012) 0.84

The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations. Mol Brain (2010) 0.84

The negative feedback regulation of microRNA-146a in human periodontal ligament cells after Porphyromonas gingivalis lipopolysaccharide stimulation. Inflamm Res (2015) 0.83

The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity. J Neurosci (2013) 0.83

Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase. Sci Rep (2013) 0.82

Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells. Anticancer Drugs (2014) 0.82

Genistein regulates the IL-1 beta induced activation of MAPKs in human periodontal ligament cells through G protein-coupled receptor 30. Arch Biochem Biophys (2012) 0.81

Acute 5-HT7 receptor activation increases NMDA-evoked currents and differentially alters NMDA receptor subunit phosphorylation and trafficking in hippocampal neurons. Mol Brain (2013) 0.81

Desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors facilitates use-dependent inhibition by pentobarbital. Mol Pharmacol (2003) 0.81

Transient receptor potential channels of the melastatin family and ischemic responses of central neurons. Stroke (2007) 0.80

Weighted least squares fitting with multiple templates for detection of small spontaneous signals. J Neurosci Methods (2007) 0.80

[In vitro and in vivo inhibitory effect of Ad-ING4 gene on proliferation of human prostate cancer PC-3 cells]. Ai Zheng (2009) 0.79

Nonselective cation channels and links to hippocampal ischemia, aging, and dementia. Adv Exp Med Biol (2013) 0.78

Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses. Hippocampus (2010) 0.78

Reciprocal and activity-dependent regulation of surface AMPA and NMDA receptors in cultured neurons. Int J Physiol Pathophysiol Pharmacol (2009) 0.77

Involvement of GABAergic modulation of the nucleus submedius (Sm) morphine-induced antinociception. Pain (2004) 0.77

Tea polyphenol-induced neuron-like differentiation of mouse mesenchymal stem cells. Chin J Physiol (2011) 0.77

An anti-coagulation agent Futhan preferentially targets GABA(A) receptors in lungepithelia: implication in treating asthma. Int J Physiol Pathophysiol Pharmacol (2011) 0.77

Glial implications in transplantation therapy of spinal cord injury. Chin J Traumatol (2009) 0.76

Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. Hippocampus (2014) 0.76

Antitumor and antiangiogenic activities of anti-vascular endothelial growth factor hairpin ribozyme in human hepatocellular carcinoma cell cultures and xenografts. World J Gastroenterol (2007) 0.76

Interaction of acetylcholinesterase with neurexin-1β regulates glutamatergic synaptic stability in hippocampal neurons. Mol Brain (2014) 0.76

Microinjection of morphine into thalamic nucleus submedius depresses bee venom-induced inflammatory pain in the rat. J Pharm Pharmacol (2008) 0.75

Optogenetics and synaptic plasticity. Acta Pharmacol Sin (2013) 0.75

[Construction of adenovirus expressing anti-vascular endothelial growth factor hairpin ribozyme and its inhibition of growth of colorectal cancer HT-29 cells]. Ai Zheng (2009) 0.75

[An experimental study on biocompatibility of Bio-oss collagen with cultured bone marrow stromal cells]. Shanghai Kou Qiang Yi Xue (2008) 0.75

[The study of the growth-suppression and mechanisms of hepatocelluar carcinoma tumor in nude mice]. Sheng Wu Gong Cheng Xue Bao (2006) 0.75

[The effect of oncolytic adenovirus on human umbilical vein endothelial cell]. Sheng Wu Gong Cheng Xue Bao (2006) 0.75

[Effect of electroacupuncture stimulation of "Huantiao" (GB 30) on walking ability and touch sensation in rabbits with lumbar intervertebral disc protrusion]. Zhen Ci Yan Jiu (2013) 0.75