Published in J Physiol on January 05, 2009
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
TRPM2: a multifunctional ion channel for calcium signalling. J Physiol (2010) 1.51
A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet (2010) 1.42
Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations. Nat Rev Neurosci (2014) 1.20
Emerging mechanisms of disrupted cellular signaling in brain ischemia. Nat Neurosci (2011) 1.11
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release. FASEB J (2011) 1.04
TRPM2, calcium and neurodegenerative diseases. Int J Physiol Pathophysiol Pharmacol (2010) 0.95
Flufenamic acid as an ion channel modulator. Pharmacol Ther (2013) 0.94
State-dependent inhibition of TRPM2 channel by acidic pH. J Biol Chem (2010) 0.94
Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+). Biochem Biophys Res Commun (2010) 0.93
Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore. J Biol Chem (2011) 0.92
TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death. Neurosci Lett (2012) 0.92
TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation. PLoS One (2012) 0.90
Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate. J Gen Physiol (2015) 0.87
Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury. J Cereb Blood Flow Metab (2013) 0.87
Sexually dimorphic response of TRPM2 inhibition following cardiac arrest-induced global cerebral ischemia in mice. J Mol Neurosci (2013) 0.85
Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Mol Brain (2011) 0.84
Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons. Mol Brain (2012) 0.84
TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia. Cell Death Dis (2014) 0.82
Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels. Br J Pharmacol (2012) 0.81
Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media. PLoS One (2012) 0.80
TR(I)Pping towards treatment for ischemia. Nat Neurosci (2009) 0.78
A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles. Sci Rep (2015) 0.76
Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat. Arch Med Sci (2016) 0.75
The overexpressed functional transient receptor potential channel TRPM2 in oral squamous cell carcinoma. Sci Rep (2016) 0.75
TRP channels as sensors of oxygen availability. Pflugers Arch (2013) 0.75
Ovariectomy-Induced Mitochondrial Oxidative Stress, Apoptosis, and Calcium Ion Influx Through TRPA1, TRPM2, and TRPV1 Are Prevented by 17β-Estradiol, Tamoxifen, and Raloxifene in the Hippocampus and Dorsal Root Ganglion of Rats. Mol Neurobiol (2016) 0.75
Ischemic cell death in brain neurons. Physiol Rev (1999) 8.01
Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J Physiol (1987) 6.72
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature (2001) 4.75
Immunocyte Ca2+ influx system mediated by LTRPC2. Science (2001) 3.64
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell (2002) 3.36
Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science (1999) 3.23
Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem (2003) 2.22
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem (2004) 2.08
Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem (2002) 2.01
Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurones in culture. J Physiol (1989) 1.88
Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. Genomics (1998) 1.80
Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol Cell Physiol (2003) 1.69
A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J Biol Chem (2003) 1.63
Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture. Proc Natl Acad Sci U S A (1993) 1.63
Tissue distribution profiles of the human TRPM cation channel family. J Recept Signal Transduct Res (2006) 1.62
Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J Neurotrauma (2002) 1.45
Ischemic delayed neuronal death. A mitochondrial hypothesis. Stroke (1995) 1.32
A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci (2006) 1.31
Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol (2008) 1.30
The mammalian melastatin-related transient receptor potential cation channels: an overview. Pflugers Arch (2005) 1.28
TRPM2 Ca2+ permeable cation channels: from gene to biological function. Cell Calcium (2003) 1.27
Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes. Biochem J (2006) 1.21
The characterization and localization of the glutamate receptor subunit GluR1 in the rat brain. J Neurosci (1991) 1.21
Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol (2004) 1.15
Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology (2005) 1.11
Molecular mechanisms underlying specificity of excitotoxic signaling in neurons. Curr Mol Med (2004) 1.11
TRPM2. Handb Exp Pharmacol (2007) 1.10
Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel. J Physiol (2003) 1.09
Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K+ channels. J Neurophysiol (2005) 1.00
Different mechanisms of Ca2+ transport in NMDA and Ca2+-permeable AMPA glutamate receptor channels. J Gen Physiol (1998) 0.98
TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors. Pflugers Arch (2005) 0.95
GABA neurons survive focal ischemic injury. Neuroscience (2004) 0.94
N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev (2007) 0.94
AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity. J Neurosci (1995) 0.91
Regulation of KCa-channel activity by cyclic ADP-ribose and ADP-ribose in coronary arterial smooth muscle. Am J Physiol (1998) 0.86
Survival of parvalbumin-immunoreactive neurons in the gerbil hippocampus following transient forebrain ischemia does not depend on HSP-70 protein induction. Brain Res (1995) 0.86
Effect of transient cerebral ischemia on gamma-aminobutyric acidA receptor alpha 1-subunit-immunoreactive interneurons in the gerbil CA1 hippocampus. Hippocampus (1997) 0.81
Force-clamp spectroscopy monitors the folding trajectory of a single protein. Science (2004) 6.82
Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell (2004) 6.15
The mechanical stability of ubiquitin is linkage dependent. Nat Struct Biol (2003) 4.66
A key role for TRPM7 channels in anoxic neuronal death. Cell (2003) 4.46
Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron (2002) 4.18
Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain. Nature (2012) 4.04
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science (2002) 3.98
Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol (2006) 3.66
Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2006) 3.47
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci (2007) 3.44
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell (2002) 3.36
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A (2004) 3.21
The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques. Proc Natl Acad Sci U S A (2004) 3.18
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Evidence on the impact of sustained exposure to air pollution on life expectancy from China's Huai River policy. Proc Natl Acad Sci U S A (2013) 2.89
Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch (2010) 2.83
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell (2011) 2.62
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev (2006) 2.62
Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity (2011) 2.60
Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science (2008) 2.46
Calcium, ischemia and excitotoxicity. Cell Calcium (2010) 2.38
Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol (2012) 2.34
TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J (2006) 2.28
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium (2003) 2.21
TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A (2009) 2.20
Upregulation of TRPC1 in the development of cardiac hypertrophy. J Mol Cell Cardiol (2006) 2.17
Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. Neuron (2003) 2.16
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A (2009) 2.08
Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet (2004) 1.98
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci (2007) 1.95
Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol (2004) 1.91
Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. Biophys J (2006) 1.82
Designed biomaterials to mimic the mechanical properties of muscles. Nature (2010) 1.80
Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies. Antioxid Redox Signal (2007) 1.80
Intracranial aneurysms: from vessel wall pathology to therapeutic approach. Nat Rev Neurol (2011) 1.77
The prognostic role of circulating tumor cells (CTCs) detected by RT-PCR in breast cancer: a meta-analysis of published literature. Breast Cancer Res Treat (2011) 1.76
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci (2009) 1.75
Steal physiology is spatially associated with cortical thinning. J Neurol Neurosurg Psychiatry (2010) 1.73
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal (2009) 1.71
STIM protein coupling in the activation of Orai channels. Proc Natl Acad Sci U S A (2009) 1.70
The natural history and predictive features of hemorrhage from brain arteriovenous malformations. Stroke (2008) 1.67
Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA. Mol Pharmacol (2003) 1.65
Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury. J Neurosci (2006) 1.63
PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci (2007) 1.62
Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke. Trends Pharmacol Sci (2008) 1.62
FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood (2009) 1.59
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels (Austin) (2008) 1.59
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. J Neurosci (2008) 1.58
Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci (2004) 1.56
Distinctive rheumatic manifestations in 98 patients with human immunodeficiency virus infection in China. J Rheumatol (2007) 1.56
Impaired peri-nidal cerebrovascular reserve in seizure patients with brain arteriovenous malformations. Brain (2010) 1.56
Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proc Natl Acad Sci U S A (2006) 1.55
The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J Mol Biol (2006) 1.54
Polyprotein of GB1 is an ideal artificial elastomeric protein. Nat Mater (2007) 1.54
Long-term low-dose spironolactone therapy is safe in oligoanuric hemodialysis patients. Cardiology (2009) 1.49
PEVK domain of titin: an entropic spring with actin-binding properties. J Struct Biol (2002) 1.49
TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol (2011) 1.47
Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors. Crit Rev Neurobiol (2006) 1.46
Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci Signal (2010) 1.44
Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. J Neurosci (2010) 1.43
Sub-angstrom conformational changes of a single molecule captured by AFM variance analysis. Biophys J (2006) 1.42
Priority setting in neurosurgery as exemplified by an everyday challenge. Can J Neurol Sci (2013) 1.39
TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A (2007) 1.37
Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. J Immunol (2008) 1.32
TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun (2013) 1.32
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat. Stroke (2008) 1.31
A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci (2006) 1.31
Dosimetry based on EPR spectral analysis of fingernail clippings. Health Phys (2010) 1.31
Atomic force microscopy reveals parallel mechanical unfolding pathways of T4 lysozyme: evidence for a kinetic partitioning mechanism. Proc Natl Acad Sci U S A (2008) 1.30
Paradox of Ca2+ signaling, cell death and stroke. Trends Neurosci (2006) 1.30
Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes (2010) 1.29
Randomized placebo-controlled trial of the bradykinin B₂ receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial. Ann Allergy Asthma Immunol (2011) 1.28
Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM. Proc Natl Acad Sci U S A (2002) 1.27
Roles of TRPM2 in oxidative stress. Cell Calcium (2011) 1.26
Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus. J Virol (2013) 1.26
Nonmechanical protein can have significant mechanical stability. Angew Chem Int Ed Engl (2006) 1.25
Intravenously administered bone marrow cells migrate to damaged brain tissue and improve neural function in ischemic rats. Cell Transplant (2008) 1.25
A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission. Neuron (2002) 1.25
Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells. Nat Methods (2013) 1.25
Site-specific discrimination by cyanovirin-N for alpha-linked trisaccharides comprising the three arms of Man(8) and Man(9). J Mol Biol (2002) 1.24