Published in Anesthesiology on April 01, 2011
Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function | NCT02469077
Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci (2013) 2.24
A meta-analytic review of the hypoalgesic effects of exercise. J Pain (2012) 1.24
Regular physical activity prevents development of chronic pain and activation of central neurons. J Appl Physiol (1985) (2012) 1.09
Self-reported physical activity predicts pain inhibitory and facilitatory function. Med Sci Sports Exerc (2014) 0.93
Alleviation of chronic neuropathic pain by environmental enrichment in mice well after the establishment of chronic pain. Behav Brain Funct (2013) 0.92
The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis: a knowledge translation randomized controlled trial: part II: clinical outcomes. BMC Public Health (2012) 0.89
Intensity thresholds for aerobic exercise-induced hypoalgesia. Med Sci Sports Exerc (2014) 0.89
Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice. Pain (2015) 0.89
Exercise training attenuates acute hyperalgesia in streptozotocin-induced diabetic female rats. Clinics (Sao Paulo) (2011) 0.88
Novel multi-system functional gains via task specific training in spinal cord injured male rats. J Neurotrauma (2014) 0.87
Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain. J Pain (2013) 0.87
Exercise-mediated improvements in painful neuropathy associated with prediabetes in mice. Pain (2013) 0.86
Home cage wheel running is an objective and clinically relevant method to assess inflammatory pain in male and female rats. J Neurosci Methods (2016) 0.86
Benefits of exercise intervention in reducing neuropathic pain. Front Cell Neurosci (2014) 0.85
Prior voluntary wheel running attenuates neuropathic pain. Pain (2016) 0.83
The use of functional neuroimaging to evaluate psychological and other non-pharmacological treatments for clinical pain. Neurosci Lett (2012) 0.82
Isometric exercise as a test of pain modulation: effects of experimental pain test, psychological variables, and sex. Pain Med (2013) 0.81
What do plasma beta-endorphin levels reveal about endogenous opioid analgesic function? Eur J Pain (2011) 0.80
Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States. PLoS One (2015) 0.80
Exercise prevents development of autonomic dysregulation and hyperalgesia in a mouse model of chronic muscle pain. Pain (2016) 0.79
Voluntary and forced exercises prevent the development of tolerance to analgesic effects of morphine in rats. Iran J Basic Med Sci (2014) 0.79
Exercise-induced modulation of pain in adults with and without painful diabetic neuropathy. J Pain (2014) 0.79
Effect of Exercise on µ-Opioid Receptor Expression in the Rostral Ventromedial Medulla in Neuropathic Pain Rat Model. Ann Rehabil Med (2015) 0.78
Effect of environment on the long-term consequences of chronic pain. Pain (2015) 0.77
The neural mobilization technique modulates the expression of endogenous opioids in the periaqueductal gray and improves muscle strength and mobility in rats with neuropathic pain. Behav Brain Funct (2014) 0.76
Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain. Front Neurosci (2016) 0.76
Delayed Exercise Is Ineffective at Reversing Aberrant Nociceptive Afferent Plasticity or Neuropathic Pain After Spinal Cord Injury in Rats. Neurorehabil Neural Repair (2015) 0.76
Impact of physical activity on pain perception in an animal model of endometriosis. J Endometr Pelvic Pain Disord (2015) 0.76
The Rationale for Exercise in the Management of Pain in Parkinson's Disease. J Parkinsons Dis (2015) 0.75
Effects of treadmill exercise on advanced osteoarthritis pain in rats. Arthritis Rheumatol (2017) 0.75
Role of lateral parabrachial opioid receptors in exercise-induced modulation of the hypotensive hemorrhage response in conscious male rats. Behav Brain Res (2011) 0.75
Reduced Modulation of Pain in Older Adults After Isometric and Aerobic Exercise. J Pain (2016) 0.75
Improvements in impaired GABA and GAD65/67 production in the spinal dorsal horn contribute to exercise-induced hypoalgesia in a mouse model of neuropathic pain. Mol Pain (2016) 0.75
The pain-relieving qualities of exercise in knee osteoarthritis. Open Access Rheumatol (2013) 0.75
Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews. Cochrane Database Syst Rev (2017) 0.75
How does physical activity modulate pain? Pain (2017) 0.75
Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise. Pain Res Manag (2016) 0.75
High-Intensity Swimming Exercise Decreases Glutamate-Induced Nociception by Activation of G-Protein-Coupled Receptors Inhibiting Phosphorylated Protein Kinase A. Mol Neurobiol (2016) 0.75
Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms. Pain (2017) 0.75
Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis. Life Sci (2017) 0.75
Comparative effectiveness of two stabilization exercise positions on pain and functional disability of patients with low back pain. J Exerc Rehabil (2017) 0.75
Altered Gene Expression of RNF34 and PACAP Possibly Involved in Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in Rats. Int J Mol Sci (2017) 0.75
Unmasking the tonic-aversive state in neuropathic pain. Nat Neurosci (2009) 2.77
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A (2005) 2.36
Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes (2003) 2.36
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A (2003) 2.29
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain (2002) 2.24
Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nat Neurosci (2006) 2.23
A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther (2004) 2.21
Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem (2004) 2.17
Central modulation of pain. J Clin Invest (2010) 2.12
Multiple actions of systemic artemin in experimental neuropathy. Nat Med (2003) 2.12
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther (2004) 2.08
Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci (2002) 2.00
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology (2007) 1.96
Antinociceptive and nociceptive actions of opioids. J Neurobiol (2004) 1.93
Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol (2004) 1.93
Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. J Neurosci (2003) 1.89
Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain (2007) 1.88
Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers (2005) 1.83
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain (2011) 1.82
Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance? Neurosignals (2005) 1.80
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70
Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. Anesthesiology (2002) 1.63
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology (2003) 1.60
The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain (2006) 1.59
Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. J Neurosci (2002) 1.58
Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain (2010) 1.58
Peripheral mechanisms of pain and analgesia. Brain Res Rev (2008) 1.55
Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues. Biopolymers (2005) 1.54
Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance. Anesth Analg (2005) 1.53
An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Mol Pain (2005) 1.49
Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain (2005) 1.49
Medullary pain facilitating neurons mediate allodynia in headache-related pain. Ann Neurol (2009) 1.48
CB2 cannabinoid receptor mediation of antinociception. Pain (2006) 1.47
Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nat Neurosci (2008) 1.47
Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain (2003) 1.46
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proc Natl Acad Sci U S A (2012) 1.44
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem (2006) 1.40
CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? Curr Opin Pharmacol (2003) 1.39
Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. J Neurosci (2006) 1.37
Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. J Clin Invest (2007) 1.37
Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy. Pain (2011) 1.37
Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology (2006) 1.34
The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model. PLoS One (2008) 1.31
A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain. Bone (2009) 1.31
Descending pain modulation and chronification of pain. Curr Opin Support Palliat Care (2014) 1.30
Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization. J Neurosci (2011) 1.30
Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. J Neurosci (2005) 1.29
Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle. Am J Physiol Endocrinol Metab (2005) 1.28
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorg Med Chem (2009) 1.28
The metabolic syndrome: role of skeletal muscle metabolism. Ann Med (2006) 1.28
Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorg Med Chem Lett (2006) 1.23
Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors. Brain Res (2009) 1.22
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. J Med Chem (2007) 1.21
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. J Med Chem (2007) 1.21
Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. Anesthesiology (2011) 1.21
Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem (2007) 1.19
Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y. J Neurosci (2002) 1.18
Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem (2006) 1.16
Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Mol Pain (2011) 1.15
Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorg Med Chem Lett (2007) 1.15
Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain (2006) 1.15
Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache. Pain (2010) 1.13
Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neurosci Lett (2005) 1.13
Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. J Neurosci (2004) 1.13
Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain (2008) 1.13
Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity. Pain (2011) 1.12
Inhibition of pain responses by activation of CB(2) cannabinoid receptors. Chem Phys Lipids (2002) 1.12