Cancer epigenetics reaches mainstream oncology.

Non-coding RNAs in human disease. Nat Rev Genet (2011) 11.40

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature (2011) 8.29

Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13

Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A (2012) 4.26

Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell (2012) 3.65

DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet (2012) 3.33

Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer (2013) 3.23

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet (2012) 3.08

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med (2012) 2.86

Wnt signaling in cancer. Cold Spring Harb Perspect Biol (2012) 2.75

Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer (2013) 2.41

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. Cell Stem Cell (2013) 2.33

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell (2015) 2.20

Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins. Nat Chem (2015) 2.17

Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res (2012) 2.10

Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu Rev Immunol (2012) 2.06

Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol (2013) 1.95

Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin Cancer Res (2013) 1.84

Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis Rheumatol (2014) 1.77

DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene (2011) 1.76

Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed. Future Med Chem (2012) 1.74

Epigenetic mechanisms in neurological disease. Nat Med (2012) 1.74

Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing. Genome Res (2013) 1.67

Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation. Genome Med (2012) 1.65

Epigenetic disruption of the PIWI pathway in human spermatogenic disorders. PLoS One (2012) 1.64

Emerging targeted agents in metastatic breast cancer. Nat Rev Clin Oncol (2013) 1.59

Epigenetic modifications in cancer. Clin Genet (2011) 1.53

Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties. PLoS One (2013) 1.50

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome Res (2012) 1.47

miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer. Cancer Res (2012) 1.46

Chromatin Accessibility Landscape of Cutaneous T Cell Lymphoma and Dynamic Response to HDAC Inhibitors. Cancer Cell (2017) 1.39

ATAC-king the complexity of SAGA during evolution. Genes Dev (2012) 1.36

Targeting tumor cell motility to prevent metastasis. Adv Drug Deliv Rev (2011) 1.32

Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression. Proc Natl Acad Sci U S A (2011) 1.26

Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis. Oncogene (2013) 1.25

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers. Gastroenterology (2015) 1.24

KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. J Clin Invest (2013) 1.21

BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models. PLoS One (2013) 1.19

Human papillomavirus DNA methylation as a potential biomarker for cervical cancer. Cancer Epidemiol Biomarkers Prev (2012) 1.19

Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress. Transl Psychiatry (2012) 1.17

Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med (2013) 1.17

Regulation of DNA methylation in rheumatoid arthritis synoviocytes. J Immunol (2012) 1.16

Alcohol, DNA methylation, and cancer. Alcohol Res (2013) 1.14

Drugging the undruggable: transcription therapy for cancer. Biochim Biophys Acta (2012) 1.14

Epigenetic disruption of cadherin-11 in human cancer metastasis. J Pathol (2012) 1.14

Regulation of microRNAs by epigenetics and their interplay involved in cancer. J Exp Clin Cancer Res (2013) 1.14

DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer. Biochem Biophys Res Commun (2014) 1.12

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer (2015) 1.12

Specific glycosylation of membrane proteins in epithelial ovarian cancer cell lines: glycan structures reflect gene expression and DNA methylation status. Mol Cell Proteomics (2014) 1.11

Interactions between epigenetics and metabolism in cancers. Front Oncol (2012) 1.11

Cancer development, progression, and therapy: an epigenetic overview. Int J Mol Sci (2013) 1.10

Functional DNA demethylation is accompanied by chromatin accessibility. Nucleic Acids Res (2013) 1.09

Epigenetics in the human brain. Neuropsychopharmacology (2012) 1.08

Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life. Epigenetics (2012) 1.08

Epigenetic inheritance of disease and disease risk. Neuropsychopharmacology (2012) 1.07

Epigenetics of the antibody response. Trends Immunol (2013) 1.06

Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas. Cell Res (2016) 1.06

Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization. Nucleic Acids Res (2012) 1.05

Mapping the new molecular landscape: social dimensions of epigenetics. New Genet Soc (2013) 1.04

Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep (2014) 1.04

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. Blood (2014) 1.03

Epigenetic control of epithelial-mesenchymal-transition in human cancer. Mol Clin Oncol (2012) 1.03

The role of redox signaling in epigenetics and cardiovascular disease. Antioxid Redox Signal (2013) 1.03

Methylcap-seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese population. PLoS One (2012) 1.03

Interplay between Epigenetics and Genetics in Cancer. Genomics Inform (2013) 1.03

Increased mitochondrial DNA copy number in occupations associated with low-dose benzene exposure. Environ Health Perspect (2011) 1.02

Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. Cancer Lett (2012) 1.02

DNMT1 is regulated by ATP-citrate lyase and maintains methylation patterns during adipocyte differentiation. Mol Cell Biol (2013) 1.01

Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity. Nat Commun (2014) 1.00

miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways. Clin Cancer Res (2012) 1.00

CG methylation. Epigenomics (2012) 0.99

Multifaceted role of EZH2 in breast and prostate tumorigenesis: epigenetics and beyond. Epigenetics (2013) 0.99

Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats. PLoS One (2012) 0.99

Somatic variation and cancer: therapies lost in the mix. Hum Genet (2011) 0.99

DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma. World J Gastroenterol (2014) 0.99

DNA methylation as clinically useful biomarkers-light at the end of the tunnel. Pharmaceuticals (Basel) (2012) 0.99

Promoter hypomethylation of EpCAM-regulated bone morphogenetic protein gene family in recurrent endometrial cancer. Clin Cancer Res (2013) 0.99

Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. Clin Epigenetics (2015) 0.99

Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas. EMBO Mol Med (2013) 0.98

Epigenetic regulation in human melanoma: past and future. Epigenetics (2015) 0.98

The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. J Biol Chem (2013) 0.97

Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas. Genome Biol (2013) 0.97

DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract. Epigenetics (2012) 0.97

From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity. Oncotarget (2015) 0.96

Cancer Epigenetics for the 21st Century: What's Next? Genes Cancer (2011) 0.96

CpG island structure and trithorax/polycomb chromatin domains in human cells. Genomics (2012) 0.96

Epigenetic treatment of solid tumours: a review of clinical trials. Clin Epigenetics (2015) 0.96

Targeting EZH2 and PRC2 dependence as novel anticancer therapy. Exp Hematol (2015) 0.95

LINE-1 hypomethylation in gastric cancer, detected by bisulfite pyrosequencing, is associated with poor prognosis. Gastric Cancer (2012) 0.95

Histone target selection within chromatin: an exemplary case of teamwork. Genes Dev (2014) 0.95

Methylome analysis reveals an important role for epigenetic changes in the regulation of the Arabidopsis response to phosphate starvation. Proc Natl Acad Sci U S A (2015) 0.94

Long interspersed nuclear element-1 hypomethylation and oxidative stress: correlation and bladder cancer diagnostic potential. PLoS One (2012) 0.94

Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics. Front Genet (2012) 0.94

Methylation levels of LINE-1 in primary lesion and matched metastatic lesions of colorectal cancer. Br J Cancer (2013) 0.93

From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms. Genome Med (2012) 0.93

CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer. RNA Biol (2012) 0.92

Review of the alterations in DNA methylation in esophageal squamous cell carcinoma. Surg Today (2013) 0.92

MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation. PLoS One (2013) 0.92

Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study. Gut (2014) 0.92

CpG methylation recruits sequence specific transcription factors essential for tissue specific gene expression. Biochim Biophys Acta (2012) 0.91

Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46

The Polycomb group protein EZH2 directly controls DNA methylation. Nature (2005) 13.67

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics (2011) 7.38

Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29

A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A (2008) 7.14

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res (2002) 7.09

The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci (2003) 6.24

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res (2007) 5.62

DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol (2006) 4.38

A role for RNAi in the selective correction of DNA methylation defects. Science (2009) 4.30

Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A (2012) 4.26

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol Cell Biol (2004) 4.15

Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res (2009) 3.81

Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. Lancet Oncol (2008) 3.60

DNA methylation and cancer. Adv Genet (2010) 3.50

Epigenetics and aging: the targets and the marks. Trends Genet (2007) 3.44

DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet (2012) 3.33

BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol (2009) 3.05

Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology (2008) 2.91

Low-level microsatellite instability in most colorectal carcinomas. Cancer Res (2002) 2.87

Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell (2010) 2.86

A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell (2010) 2.78

A systematic profile of DNA methylation in human cancer cell lines. Cancer Res (2003) 2.75

DNA methylation: a profile of methods and applications. Biotechniques (2002) 2.74

The role of histone deacetylases (HDACs) in human cancer. Mol Oncol (2007) 2.72

Notch signaling is essential for ventricular chamber development. Dev Cell (2007) 2.53

GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol (2003) 2.42

The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. Nucleic Acids Res (2003) 2.41

Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes. EMBO J (2002) 2.40

SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood (2002) 2.34

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat Genet (2006) 2.33

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol (2005) 2.27

Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J (2007) 2.21

Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. EMBO J (2003) 2.21

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A (2011) 2.21

A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics (2009) 2.21

BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors. J Clin Oncol (2010) 2.18

Cross-talk between aging and cancer: the epigenetic language. Ann N Y Acad Sci (2007) 2.17

A DNA methylation fingerprint of 1628 human samples. Genome Res (2011) 2.16

Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res (2006) 2.15

CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle (2007) 2.12

Cancer epigenomics: beyond genomics. Curr Opin Genet Dev (2012) 2.11

Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma. J Natl Cancer Inst (2004) 2.08

Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res (2003) 2.03

New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood (2008) 1.97

Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. Hum Mol Genet (2003) 1.93

CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas. Clin Cancer Res (2004) 1.92

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Res (2009) 1.87

DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E. J Biol Chem (2004) 1.82

Methyl-DNA immunoprecipitation (MeDIP): hunting down the DNA methylome. Biotechniques (2008) 1.81

Dysregulation of microRNAs in cancer: playing with fire. FEBS Lett (2010) 1.79

Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet (2003) 1.77

E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription. EMBO J (2005) 1.76

Cis-acting noncoding RNAs: friends and foes. Nat Struct Mol Biol (2012) 1.73

A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer (2004) 1.72

Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells. Cancer Res (2007) 1.71

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70

Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients. Cancer Res (2004) 1.66

DNA methylation contributes to natural human variation. Genome Res (2013) 1.66

Epigenetic disruption of the PIWI pathway in human spermatogenic disorders. PLoS One (2012) 1.64

Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment. Genome Res (2014) 1.64

Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern. J Biol Chem (2004) 1.64

Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. Hum Mol Genet (2004) 1.60

Breast cancer epigenetics: from DNA methylation to microRNAs. J Mammary Gland Biol Neoplasia (2010) 1.58

Epigenetic biomarkers for human cancer: the time is now. Crit Rev Oncol Hematol (2008) 1.57

Histone deacetylase inhibitors: understanding a new wave of anticancer agents. Int J Cancer (2004) 1.57

Intronic RNAs mediate EZH2 regulation of epigenetic targets. Nat Struct Mol Biol (2012) 1.56

The epigenetic face of systemic lupus erythematosus. J Immunol (2006) 1.55

MicroRNAs and cancer epigenetics: a macrorevolution. Curr Opin Oncol (2010) 1.49

Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proc Natl Acad Sci U S A (2010) 1.48

A prognostic DNA methylation signature for stage I non-small-cell lung cancer. J Clin Oncol (2013) 1.47

CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia. J Exp Med (2009) 1.47

Abnormalities of the APC/beta-catenin pathway in endometrial cancer. Oncogene (2002) 1.46

Mecp2-null mice provide new neuronal targets for Rett syndrome. PLoS One (2008) 1.45

A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res (2004) 1.44

Aberrant regulation of messenger RNA 3'-untranslated region in human cancer. Cell Oncol (2007) 1.44

Towards the human cancer epigenome: a first draft of histone modifications. Cell Cycle (2005) 1.44

Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer. Int J Cancer (2002) 1.44

Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. Int J Cancer (2003) 1.43

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells. Nucleic Acids Res (2007) 1.42

High-performance capillary electrophoretic method for the quantification of 5-methyl 2'-deoxycytidine in genomic DNA: application to plant, animal and human cancer tissues. Electrophoresis (2002) 1.42

How epigenetics can explain human metastasis: a new role for microRNAs. Cell Cycle (2009) 1.41

DNA methylomes, histone codes and miRNAs: tying it all together. Int J Biochem Cell Biol (2008) 1.40

Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers. Cancer Res (2003) 1.39

Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. PLoS One (2012) 1.38

A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation. Clin Cancer Res (2005) 1.38

Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res (2002) 1.37

EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma. Cancer Res (2005) 1.37

MGMT hypermethylation: a prognostic foe, a predictive friend. DNA Repair (Amst) (2007) 1.33

The epigenetic basis of twin discordance in age-related diseases. Pediatr Res (2007) 1.32

Cancer epigenetics and methylation. Science (2002) 1.31

A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer. Cancer Res (2006) 1.29

Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma. J Clin Oncol (2005) 1.28

The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Carcinogenesis (2007) 1.27

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc Natl Acad Sci U S A (2009) 1.27

Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors. Genes Chromosomes Cancer (2004) 1.27

Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome. Epigenetics (2010) 1.26