|
1
|
Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.
|
Cancer Res
|
2007
|
1.56
|
|
2
|
PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas.
|
J Invest Dermatol
|
2010
|
1.46
|
|
3
|
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer.
|
Cancer Res
|
2008
|
1.39
|
|
4
|
Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3.
|
Cancer Res
|
2007
|
1.31
|
|
5
|
A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer.
|
Cancer Prev Res (Phila)
|
2010
|
1.21
|
|
6
|
Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.
|
Cancer Res
|
2003
|
1.15
|
|
7
|
Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas.
|
Cancer Res
|
2004
|
1.15
|
|
8
|
Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer.
|
Mol Carcinog
|
2007
|
1.12
|
|
9
|
Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma.
|
Cancer Res
|
2011
|
0.98
|
|
10
|
Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model.
|
Mol Oncol
|
2012
|
0.94
|
|
11
|
Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism.
|
Photochem Photobiol
|
2005
|
0.91
|
|
12
|
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas.
|
Carcinogenesis
|
2011
|
0.90
|
|
13
|
Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, Stat3 and neuroendocrine markers.
|
Carcinogenesis
|
2012
|
0.88
|
|
14
|
Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease.
|
Am J Pathol
|
2005
|
0.85
|
|
15
|
Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2.
|
Cancer Res
|
2006
|
0.82
|
|
16
|
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.
|
Toxicol Pathol
|
2005
|
0.81
|
|
17
|
Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.
|
Oncogene
|
2002
|
0.80
|
|
18
|
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
|
Cancer Res
|
2003
|
0.80
|
|
19
|
Protein Kinase C ε , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells.
|
J Skin Cancer
|
2013
|
0.77
|
|
20
|
Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice.
|
Toxicol Pathol
|
2007
|
0.76
|
|
21
|
Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid.
|
Life Sci
|
2002
|
0.76
|
|
22
|
Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals.
|
Carcinogenesis
|
2015
|
0.75
|
|
23
|
Mouse models of the skin: models to define mechanisms of skin carcinogenesis.
|
J Skin Cancer
|
2013
|
0.75
|