Published in Mamm Genome on August 29, 2012
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47
Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis. Mol Metab (2013) 1.00
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res (2014) 0.98
Chromosome substitution strains: gene discovery, functional analysis, and systems studies. Mamm Genome (2012) 0.93
Peroxidasin is essential for eye development in the mouse. Hum Mol Genet (2014) 0.87
Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice. PLoS One (2013) 0.80
A robust and reliable non-invasive test for stress responsivity in mice. Front Behav Neurosci (2014) 0.79
Novel small-eye allele in paired box gene 6 (Pax6) is caused by a point mutation in intron 7 and creates a new exon. Mol Vis (2013) 0.78
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Retinal proteome alterations in a mouse model of type 2 diabetes. Diabetologia (2014) 0.77
Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice. J Biomed Sci (2014) 0.77
Longitudinal fundus and retinal studies with SD-OCT: a comparison of five mouse inbred strains. Mamm Genome (2013) 0.76
Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice. PLoS One (2016) 0.76
Long-term experiment to study the development, interaction, and influencing factors of DEXA parameters. Mamm Genome (2013) 0.76
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations. G3 (Bethesda) (2016) 0.75
INFRAFRONTIER: a European resource for studying the functional basis of human disease. Mamm Genome (2016) 0.75
Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol (2015) 0.75
Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines. PLoS One (2015) 0.75
Viable Ednra (Y129F) mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation. Mamm Genome (2016) 0.75
Network Modules of the Cross-Species Genotype-Phenotype Map Reflect the Clinical Severity of Human Diseases. PLoS One (2015) 0.75
Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 (I27N) mutant mice. J Biomed Sci (2017) 0.75
A forkhead-domain gene is mutated in a severe speech and language disorder. Nature (2001) 9.25
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell (2009) 3.63
Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. Am J Hum Genet (2005) 3.50
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol (2010) 2.72
EMPReSS: standardized phenotype screens for functional annotation of the mouse genome. Nat Genet (2005) 2.71
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Mouse phenotyping. Methods (2010) 1.43
Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci (2011) 1.24
Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells. Nat Commun (2011) 1.12
Uromodulin biology and pathophysiology--an update. Kidney Blood Press Res (2010) 1.11
MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma. Oncogene (2011) 1.10
Systematic gene expression profiling of mouse model series reveals coexpressed genes. Proteomics (2008) 1.06
Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism. Am J Physiol Renal Physiol (2009) 1.02
Uromodulin and chronic kidney disease. Kidney Blood Press Res (2010) 1.00
Gene or size: metabolic rate and body temperature in obese growth hormone-deficient dwarf mice. Obes Res (2004) 1.00
MTSS1 overexpression correlates with poor prognosis in colorectal cancer. J Gastrointest Surg (2011) 1.00
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One (2010) 0.97
Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease. Neurobiol Aging (2009) 0.96
PITX3 polymorphism is associated with early onset Parkinson's disease. Neurobiol Aging (2008) 0.96
The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance. J Transl Med (2011) 0.94
PITX3 gene polymorphism is associated with Parkinson's disease in Chinese population. Brain Res (2011) 0.94
EMMA--the European mouse mutant archive. Brief Funct Genomic Proteomic (2007) 0.94
Mutation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia. Am J Physiol Renal Physiol (2010) 0.93
Expanding the body mass range: associations between BMR and tissue morphology in wild type and mutant dwarf mice (David mice). J Comp Physiol B (2006) 0.93
Systematic, standardized and comprehensive neurological phenotyping of inbred mice strains in the German Mouse Clinic. J Neurosci Methods (2006) 0.92
Murine missing in metastasis (MIM) mediates cell polarity and regulates the motility response to growth factors. PLoS One (2011) 0.92
MausDB: an open source application for phenotype data and mouse colony management in large-scale mouse phenotyping projects. BMC Bioinformatics (2008) 0.91
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mamm Genome (2009) 0.89
Metastasis suppressor-1, MTSS1, acts as a putative tumour suppressor in human bladder cancer. Anticancer Res (2011) 0.88
The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease. Curr Top Med Chem (2009) 0.85
Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets. Part Fibre Toxicol (2011) 0.82
Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med (2009) 18.03
A mouse for all reasons. Cell (2007) 9.01
The knockout mouse project. Nat Genet (2004) 7.80
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science (2006) 7.35
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet (2006) 6.52
Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol (2004) 5.79
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet (2008) 5.23
A genome-wide perspective of genetic variation in human metabolism. Nat Genet (2009) 5.00
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc Natl Acad Sci U S A (2004) 4.93
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest (2005) 4.81
Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron (2006) 4.80
OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation (2010) 4.60
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell (2007) 4.56
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial. Lancet Oncol (2007) 4.03
A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci U S A (2010) 3.90
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets. Immunity (2007) 3.83
Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol (2002) 3.82
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell (2009) 3.63
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med (2007) 3.61
Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect (2005) 3.57
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab (2008) 3.52
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science (2004) 3.38
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest (2009) 3.33
Transcatheter aortic valve replacement for degenerative bioprosthetic surgical valves: results from the global valve-in-valve registry. Circulation (2012) 3.30
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet (2010) 3.21
Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PLoS One (2013) 3.19
New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing. Nat Commun (2012) 3.18
Phenotypic spectrum associated with mutations of the mitochondrial polymerase gamma gene. Brain (2006) 3.16
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A (2003) 3.05
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature (2005) 3.02
Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2010) 3.02
Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. Lancet (2010) 2.98
The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS One (2008) 2.94
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science (2010) 2.93
Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma. Clin Cancer Res (2006) 2.88
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One (2010) 2.84
EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell (2007) 2.81
Disparate individual fates compose robust CD8+ T cell immunity. Science (2013) 2.80
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci (2003) 2.79
Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med (2008) 2.78
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res (2009) 2.72
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol (2010) 2.72
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. Am J Hum Genet (2011) 2.71
Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet (2011) 2.68
MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo. Nat Immunol (2002) 2.66
The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome (2012) 2.65
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci U S A (2013) 2.63
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes (2012) 2.62
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A (2004) 2.57
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J Biol Chem (2007) 2.55
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis (2009) 2.54
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci (2011) 2.52
Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell (2005) 2.52
Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice. Environ Health Perspect (2006) 2.51
Targeted next generation sequencing as a diagnostic tool in epileptic disorders. Epilepsia (2012) 2.45
Uncoupling protein 1 expression and high-fat diets. Am J Physiol Regul Integr Comp Physiol (2010) 2.42
Knowledge discovery by automated identification and ranking of implicit relationships. Bioinformatics (2004) 2.42
Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol (2012) 2.39
Regulatory context is a crucial part of gene function. Trends Genet (2002) 2.37