Published in Cancer Prev Res (Phila) on March 16, 2011
Regulation of the human catalytic subunit of telomerase (hTERT). Gene (2012) 1.81
Epigenetic diet: impact on the epigenome and cancer. Epigenomics (2011) 1.33
Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. Mol Cancer (2013) 1.17
Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications. PLoS One (2012) 1.02
Going Green: The Role of the Green Tea Component EGCG in Chemoprevention. J Carcinog Mutagen (2013) 0.93
Phytochemical antioxidants modulate mammalian cellular epigenome: implications in health and disease. Antioxid Redox Signal (2012) 0.89
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Epigenetic effects of green tea polyphenols in cancer. Epigenomics (2013) 0.87
Plant phytochemicals as epigenetic modulators: role in cancer chemoprevention. AAPS J (2013) 0.86
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Pharmaceutical regulation of telomerase and its clinical potential. J Cell Mol Med (2012) 0.83
Therapeutic targeting of replicative immortality. Semin Cancer Biol (2015) 0.83
Impact of Epigenetic Dietary Components on Cancer through Histone Modifications. Curr Med Chem (2015) 0.82
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes (Basel) (2016) 0.79
Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clin Epigenetics (2015) 0.78
Effects of physiological levels of the green tea extract epigallocatechin-3-gallate on breast cancer cells. Front Endocrinol (Lausanne) (2014) 0.78
Induction of Apoptosis in Pancreatic Cancer Cells by CDDO-Me Involves Repression of Telomerase through Epigenetic Pathways. J Carcinog Mutagen (2014) 0.77
Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms. Front Genet (2016) 0.77
Reducing Breast Cancer Recurrence: The Role of Dietary Polyphenolics. Nutrients (2016) 0.77
Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells. Mol Cell Endocrinol (2015) 0.77
Therapeutic Targeting of Telomerase. Genes (Basel) (2016) 0.76
Homeostatic imbalance and colon cancer: the dynamic epigenetic interplay of inflammation, environmental toxins, and chemopreventive plant compounds. Front Oncol (2012) 0.76
Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells. Oncotarget (2016) 0.75
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res (2003) 3.72
Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res (2006) 3.17
Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters. Mol Cell (2006) 2.48
Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J Natl Cancer Inst (1997) 2.39
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci U S A (2001) 2.33
The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma. Oncogene (2000) 2.15
Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers. Cancer Sci (2008) 2.13
Dietary polyphenols may affect DNA methylation. J Nutr (2007) 1.96
Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols. PLoS One (2010) 1.77
hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site. Cancer Res (2007) 1.77
Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res (2000) 1.64
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One (2010) 1.61
Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol (2000) 1.60
A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent. Cancer Res (2007) 1.59
Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene. Nucleic Acids Res (2007) 1.59
Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification. Cancer Res (2008) 1.58
Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation. Mol Endocrinol (2007) 1.55
Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. J Biol Chem (2000) 1.49
Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res (2009) 1.48
Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. Int J Cancer (2008) 1.45
Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG. J Cell Biochem (2008) 1.39
TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Mol Carcinog (2008) 1.39
Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation. Toxicol Appl Pharmacol (2008) 1.36
E2F-1 represses transcription of the human telomerase reverse transcriptase gene. Nucleic Acids Res (2001) 1.35
Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms. Int J Cancer (2009) 1.26
Genetic and epigenetic modulation of telomerase activity in development and disease. Gene (2004) 1.25
Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Cancer Res (2003) 1.24
Identification of Mad as a repressor of the human telomerase (hTERT) gene. Oncogene (2000) 1.23
A potential prodrug for a green tea polyphenol proteasome inhibitor: evaluation of the peracetate ester of (-)-epigallocatechin gallate [(-)-EGCG]. Bioorg Med Chem (2004) 1.20
Epigallocatechin-3-gallate induces apoptosis in estrogen receptor-negative human breast carcinoma cells via modulation in protein expression of p53 and Bax and caspase-3 activation. Mol Cancer Ther (2005) 1.15
Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate. Clin Cancer Res (2004) 1.15
EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Int J Oncol (2004) 1.15
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins. Biochem Biophys Res Commun (1998) 1.15
Signaling through estrogen receptors modulates telomerase activity in human prostate cancer. J Clin Invest (2002) 1.14
Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate. Drug Metab Dispos (2006) 1.14
Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo. BMC Cancer (2010) 1.13
The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells. Biochem Biophys Res Commun (2007) 1.06
Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res (2010) 1.03
Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. FASEB J (2009) 1.00
Cancer chemoprevention by tea polyphenols. Proc Natl Sci Counc Repub China B (2000) 0.90
Growth factors and chemotherapeutic modulation of breast cancer cells. J Pharm Pharmacol (2003) 0.89
Telomerase inhibition in cancer therapeutics: molecular-based approaches. Curr Med Chem (2006) 0.87
EGCG inhibits growth and induces apoptosis in renal cell carcinoma through TFPI-2 overexpression. Oncol Rep (2009) 0.85
Antitumor activity of novel fluoro-substituted (-)-epigallocatechin-3-gallate analogs. Cancer Lett (2009) 0.85
Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the growth of breast cancer. Eur J Cancer (2008) 0.85
Regulation of the human catalytic subunit of telomerase (hTERT). Gene (2012) 1.81
The impact of metabolism on DNA methylation. Hum Mol Genet (2005) 1.66
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One (2010) 1.61
Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis. Am J Respir Cell Mol Biol (2008) 1.58
Aging, cancer and nutrition: the DNA methylation connection. Mech Ageing Dev (2003) 1.53
Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts. Mol Cell Biochem (2003) 1.45
Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG. J Cell Biochem (2008) 1.39
Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin Epigenetics (2010) 1.33
Epigenetic diet: impact on the epigenome and cancer. Epigenomics (2011) 1.33
Gene-environment interactions and epigenetic basis of human diseases. Curr Issues Mol Biol (2008) 1.31
Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. Am J Respir Cell Mol Biol (2010) 1.29
Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms. Int J Cancer (2009) 1.26
Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design. Proteins (2004) 1.26
Genetic and epigenetic modulation of telomerase activity in development and disease. Gene (2004) 1.25
Analysis of telomerase activity and detection of its catalytic subunit, hTERT. Anal Biochem (2003) 1.23
Synthetic analogs of green tea polyphenols as proteasome inhibitors. Mol Med (2002) 1.22
DNA methylation impacts on learning and memory in aging. Neurobiol Aging (2007) 1.20
Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation. Genes Chromosomes Cancer (2004) 1.19
Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. Mol Cancer (2013) 1.17
EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Int J Oncol (2004) 1.15
Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J (2009) 1.14
Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. Mol Cancer (2010) 1.11
Telomerase inhibition by retinoids precedes cytodifferentiation of leukemia cells and may contribute to terminal differentiation. Mol Cancer Ther (2004) 1.10
Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice. Carcinogenesis (2010) 1.07
Polyphenols and aging. Curr Aging Sci (2010) 1.06
Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements. Gene (2003) 1.06
Assessment of telomere length and factors that contribute to its stability. Eur J Biochem (2003) 1.04
Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications. PLoS One (2012) 1.02
DNA methylation detection: bisulfite genomic sequencing analysis. Methods Mol Biol (2011) 1.02
Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. Biochem Biophys Res Commun (2003) 1.01
Structure-activity relationships of synthetic analogs of (-)-epigallocatechin-3-gallate as proteasome inhibitors. Anticancer Res (2004) 1.00
Effect of a prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate on the growth of androgen-independent prostate cancer in vivo. Nutr Cancer (2008) 1.00
Epigenetic regulation of caloric restriction in aging. BMC Med (2011) 0.99
Regioselective Acylation of Hexopyranosides with Pivaloyl Chloride. J Org Chem (1998) 0.99
EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase. Biochem Biophys Res Commun (2008) 0.99
Mitochondrial regulation of epigenetics and its role in human diseases. Epigenetics (2012) 0.98
Epigenetic control of telomerase and modes of telomere maintenance in aging and abnormal systems. Front Biosci (2005) 0.98
Profiling DNA methylation by bisulfite genomic sequencing: problems and solutions. Methods Mol Biol (2004) 0.96
MicroRNAs: an emerging science in cancer epigenetics. J Clin Bioinforma (2013) 0.94
p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms. PLoS One (2011) 0.94
Strategies targeting telomerase inhibition. Mol Biotechnol (2008) 0.94
Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells. Anticancer Res (2009) 0.92
The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells. Int J Oncol (2007) 0.92
Insufficient DNA methylation affects healthy aging and promotes age-related health problems. Clin Epigenetics (2011) 0.90
Epigallocatechin gallate and sulforaphane combination treatment induce apoptosis in paclitaxel-resistant ovarian cancer cells through hTERT and Bcl-2 down-regulation. Exp Cell Res (2013) 0.90
Epigenomics of ovarian cancer and its chemoprevention. Front Genet (2011) 0.89
2D difference gel electrophoresis analysis of different time points during the course of neoplastic transformation of human mammary epithelial cells. J Proteome Res (2010) 0.89
Epigenetic regulation of telomerase in retinoid-induced differentiation of human leukemia cells. Int J Oncol (2008) 0.88
An overview of epigenetic assays. Mol Biotechnol (2007) 0.87
Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein. PLoS One (2013) 0.87
The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells. Transl Oncol (2008) 0.87
Telomerase, telomerase inhibition, and cancer. J Anti Aging Med (2003) 0.86
Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop. Exp Cell Res (2006) 0.86
Pathway modulations and epigenetic alterations in ovarian tumorbiogenesis. J Cell Physiol (2014) 0.84
Combined chromatin immunoprecipitation and bisulfite methylation sequencing analysis. Methods Mol Biol (2011) 0.84
Identification of a new class of FtsZ inhibitors by structure-based design and in vitro screening. J Chem Inf Model (2013) 0.84
Methylation of green tea polyphenols affects their binding to and inhibitory poses of the proteasome beta5 subunit. Int J Mol Med (2006) 0.84
Aging cell culture: methods and observations. Methods Mol Biol (2007) 0.83
Impact of epigenetic dietary compounds on transgenerational prevention of human diseases. AAPS J (2013) 0.81
Retinoid-induced histone deacetylation inhibits telomerase activity in estrogen receptor-negative breast cancer cells. Anticancer Res (2009) 0.81
Aerobic and electrochemical oxidative cross-dehydrogenative-coupling (CDC) reaction in an imidazolium-based ionic liquid. Chemistry (2010) 0.81
RNA interference using a plasmid construct expressing short-hairpin RNA. Methods Mol Biol (2007) 0.80
A method to study the expression of DNA methyltransferases in aging systems in vitro. Methods Mol Biol (2007) 0.80
A novel approach to oligonucleotide synthesis using an imidazolium ion tag as a soluble support. J Org Chem (2006) 0.79
Retrovirus-mediated RNA interference. Targeting hTERT through stable expression of short-hairpin RNA. Methods Mol Biol (2007) 0.78
hTERT knockdown in human embryonic kidney cells using double-stranded RNA. Methods Mol Biol (2007) 0.78
Cell senescence culturing methods. Methods Mol Biol (2013) 0.78
Ionic-liquid-supported peptide synthesis demonstrated by the synthesis of Leu(5)-enkephalin. J Org Chem (2005) 0.78
Real-time methylomic aberrations during initiation and progression of induced human mammary epithelial cell tumorigenesis. Epigenomics (2013) 0.77
Differential expression of epigenetic modulators during human embryonic stem cell differentiation. Mol Biotechnol (2008) 0.77
The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes. J Oncol (2011) 0.77
Novel epigallocatechin gallate analogs as potential anticancer agents: a patent review (2009 - present). Expert Opin Ther Pat (2012) 0.76
Validation of the AmpC β-lactamase binding site and identification of inhibitors with novel scaffolds. J Chem Inf Model (2012) 0.76
Methylated-CpG Island Recovery Assay. Methods Mol Biol (2011) 0.76
Methods of telomerase inhibition. Methods Mol Biol (2007) 0.76
A method to detect DNA methyltransferase I gene transcription in vitro in aging systems. Methods Mol Biol (2007) 0.76
The transposon-driven evolutionary origin and basis of histone deacetylase functions and limitations in disease prevention. Clin Epigenetics (2011) 0.75
Analysis of biomarkers of caloric restriction in aging cells. Methods Mol Biol (2013) 0.75
Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics. Anticancer Agents Med Chem (2015) 0.75
Collision-induced dissociation of sulfur-containing imidazolium ionic liquids. J Mass Spectrom (2008) 0.75
Oligonucleotide synthesis using ionic liquids as soluble supports. Nucleosides Nucleotides Nucleic Acids (2007) 0.75