Published in Nucleic Acids Res on July 01, 2001
Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood (2009) 2.26
Regulation of the human catalytic subunit of telomerase (hTERT). Gene (2012) 1.81
Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms. Int J Cancer (2009) 1.26
HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter function. Virology (2008) 1.16
The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation. Circ Res (2008) 1.13
Dmp1 and tumor suppression. Oncogene (2007) 1.10
Transcriptional silencing of a novel hTERT reporter locus during in vitro differentiation of mouse embryonic stem cells. Mol Biol Cell (2006) 1.09
Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene. Protein Cell (2010) 1.07
Expression of Dmp1 in specific differentiated, nonproliferating cells and its regulation by E2Fs. Oncogene (2006) 1.06
Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1. J Biol Chem (2008) 1.02
A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells. Cancer Prev Res (Phila) (2011) 0.97
Purification and identification of a transcription factor, USF-2, binding to E-box element in the promoter of human telomerase reverse transcriptase (hTERT). Proteomics (2010) 0.96
Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells. J Biol Chem (2009) 0.96
Differential repression of human and mouse TERT genes during cell differentiation. Nucleic Acids Res (2009) 0.95
Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells. Proc Natl Acad Sci U S A (2004) 0.92
The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer. Oncotarget (2016) 0.92
p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell (2010) 0.88
Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis. Nucleic Acids Res (2008) 0.86
Repression of androgen receptor transcription through the E2F1/DNMT1 axis. PLoS One (2011) 0.86
Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy? Cell Death Dis (2014) 0.84
Distinct and temporal roles of nucleosomal remodeling and histone deacetylation in the repression of the hTERT gene. Mol Biol Cell (2010) 0.84
Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells. Mol Cell Biol (2012) 0.84
E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells. Oncotarget (2015) 0.83
Signal transduction involving the dmp1 transcription factor and its alteration in human cancer. Clin Med Oncol (2008) 0.82
Transduction of E2F-1 TAT fusion proteins represses expression of hTERT in primary ductal breast carcinoma cell lines. Mol Cancer (2008) 0.82
The regulation of telomerase in oncogenesis. Acta Naturae (2009) 0.81
Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1/Sp3 Binding to the Promoter and a Permissive Chromatin Environment. J Biol Chem (2015) 0.81
IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling. J Immunol (2013) 0.81
Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression. J Biol Chem (2012) 0.80
Telomere dysfunction promotes metastasis in a TERC null mouse model of head and neck cancer. Mol Cancer Res (2011) 0.80
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes (Basel) (2016) 0.79
E2F1: a potential negative regulator of hTERT transcription in normal cells upon activation of oncogenic c-Myc. Med Sci Monit (2012) 0.79
regSNPs: a strategy for prioritizing regulatory single nucleotide substitutions. Bioinformatics (2012) 0.79
Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms. PLoS Comput Biol (2014) 0.78
p63α protein upregulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion. J Biol Chem (2017) 0.78
Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms. Front Genet (2016) 0.77
Alternative lengthening of telomeres in cancer stem cells in vivo. Oncogene (2014) 0.76
Human Specific Regulation of the Telomerase Reverse Transcriptase Gene. Genes (Basel) (2016) 0.75
E2F1 Transcription Factor Regulates O-linked N-acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Expression. J Biol Chem (2015) 0.75
Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes. FASEB J (2016) 0.75
Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC. Front Cell Dev Biol (2017) 0.75
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Cancer cell cycles. Science (1996) 21.29
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Structure and function of telomeres. Nature (1991) 14.82
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34
Telomerase catalytic subunit homologs from fission yeast and human. Science (1997) 12.35
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J (1992) 10.97
The RNA component of human telomerase. Science (1995) 9.86
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74
Control of telomere length by the human telomeric protein TRF1. Nature (1997) 7.62
Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell (1999) 6.98
Telomere loss: mitotic clock or genetic time bomb? Mutat Res (1992) 6.50
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev (2001) 6.13
Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J (1995) 6.03
Tumor induction and tissue atrophy in mice lacking E2F-1. Cell (1996) 4.80
A human telomeric protein. Science (1995) 4.77
A mammalian telomerase-associated protein. Science (1997) 4.37
Runaway telomere elongation caused by telomerase RNA gene mutations. Nature (1995) 4.34
Telomeres: beginning to understand the end. Science (1995) 4.13
Myc activates telomerase. Genes Dev (1998) 3.74
Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med (1995) 3.74
Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature (1996) 3.61
Functional characterization and developmental regulation of mouse telomerase RNA. Science (1995) 3.26
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res (1999) 2.74
The catalytic subunit of yeast telomerase. Proc Natl Acad Sci U S A (1997) 2.72
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res (2000) 2.54
Estrogen activates telomerase. Cancer Res (1999) 2.41
Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci U S A (1995) 2.40
Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res (1999) 2.32
Telomeres: no end in sight. Cell (1994) 2.31
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Genet (1996) 2.18
Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci U S A (1996) 2.05
Regulation of telomerase activity in immortal cell lines. Mol Cell Biol (1996) 1.82
Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Biol Cell (1996) 1.71
Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev (1997) 1.59
Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc Natl Acad Sci U S A (1996) 1.42
Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids. EMBO J (1996) 1.23
The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene. J Biol Chem (1999) 1.16
Pocket protein-independent repression of urokinase-type plasminogen activator and plasminogen activator inhibitor 1 gene expression by E2F1. Mol Cell Biol (2000) 1.14
Telomerase activity is associated with cell cycle deregulation in human breast cancer. Cancer Res (1997) 1.09
Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines. Cancer Res (1996) 1.04
Telomerase activity in head and neck tumors after introduction of wild-type p53, p21, p16, and E2F-1 genes by means of recombinant adenovirus. Head Neck (2000) 0.92
Intact functional domains of the retinoblastoma gene product (pRb) are required for downregulation of telomerase activity. Biochim Biophys Acta (1999) 0.83
Of telomeres and tumors. Nat Med (1996) 0.82
Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem (1994) 2.82
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res (1999) 2.74
Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res (1998) 2.08
Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents. Proc Natl Acad Sci U S A (1984) 1.87
Escherichia coli gene induction by alkylation treatment. Genetics (1986) 1.71
Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites. J Virol (2001) 1.54
Inferior vena cava occlusion catheter for pediatric patients with heart disease: for more detailed cardiovascular assessments. Catheter Cardiovasc Interv (2001) 1.39
Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Cancer Res (2000) 1.37
Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription. Clin Cancer Res (2000) 1.32
The development of real-time two-dimensional Doppler echocardiography and its clinical significance in acquired valvular diseases. With special reference to the evaluation of valvular regurgitation. Jpn Heart J (1984) 1.30
Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer. Clin Cancer Res (1998) 1.24
Telomerase activation by histone deacetylase inhibitor in normal cells. Nucleic Acids Res (2001) 1.22
hTERT is a critical determinant of telomerase activity in renal-cell carcinoma. Int J Cancer (1998) 1.19
Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT. Nucleic Acids Res (2000) 1.12
Coexpression of the c-kit receptor and the stem cell factor in gynecological tumors. Cancer Res (1994) 1.12
Intraoperative color flow mapping by real-time two-dimensional Doppler echocardiography for evaluation of valvular and congenital heart disease and vascular disease. J Thorac Cardiovasc Surg (1985) 1.09
Jun N-terminal kinase 1 mediates transcriptional induction of matrix metalloproteinase 9 expression. Neoplasia (2001) 1.07
Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter. Cancer Res (2001) 1.07
Expression of telomerase activity in human endometrium is localized to epithelial glandular cells and regulated in a menstrual phase-dependent manner correlated with cell proliferation. Am J Pathol (1998) 1.07
The 5' region of the human papillomavirus type 31 upstream regulatory region acts as an enhancer which augments viral early expression through the action of YY1. Virology (1997) 1.05
A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter. Hum Gene Ther (2000) 1.05
Relative probability of mutagenic translesion synthesis on the leading and lagging strands during replication of UV-irradiated DNA in a human cell extract. Biochemistry (1993) 1.02
Retracted Circulating matrix metalloproteinases and their inhibitors in patients with Kawasaki disease. Circulation (2001) 1.02
Autocrine transforming growth factor beta suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells. Cell Growth Differ (2001) 1.00
Intravascular ultrasound assessment of regional aortic wall stiffness, distensibility, and compliance in patients with coarctation of the aorta. Am Heart J (1997) 0.99
Conservative management and vaginal delivery following ruptured renal angiomyolipoma. Obstet Gynecol (2001) 0.96
Evaluation of biplane color Doppler transesophageal echocardiography in 200 consecutive patients. Circulation (1992) 0.96
Comparative study of the primary structures of cytochrome b5 from four species. Proc Natl Acad Sci U S A (1970) 0.95
Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway. Cancer Res (2000) 0.93
Creation of immortalised epithelial cells from ovarian endometrioma. Br J Cancer (2012) 0.93
Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide. Br J Cancer (2003) 0.92
Hemodynamic infarction of the spinal cord: involvement of the gray matter plus the border-zone between the central and peripheral arteries. Spinal Cord (2005) 0.92
Assessment of cardiovascular dynamics by pressure-area relations in pediatric patients with congenital heart disease. J Thorac Cardiovasc Surg (2001) 0.92
Intraperitoneal administration of telomerase-specific oncolytic adenovirus sensitizes ovarian cancer cells to cisplatin and affects survival in a xenograft model with peritoneal dissemination. Cancer Gene Ther (2010) 0.90
Induction of the alkylation-inducible aidB gene of Escherichia coli by anaerobiosis. J Bacteriol (1989) 0.90
Demethylating reagent 5-azacytidine inhibits telomerase activity in human prostate cancer cells through transcriptional repression of hTERT. Clin Cancer Res (2000) 0.90
Usefulness of a prototype intravascular ultrasound imaging in evaluation of aortic dissection and comparison with angiographic study, transesophageal echocardiography, computed tomography, and magnetic resonance imaging. Am J Cardiol (1995) 0.89
Ovarian endometrioid adenocarcinoma with ectopic production of alpha-fetoprotein. Gynecol Oncol (1998) 0.89
N-hexane polyneuropathy--a case report with a review of the literature. Med J Osaka Univ (1977) 0.87
A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy. Oncogene (2009) 0.87
Pseudoaneurysm after heart transplantation with history of LVAD driveline infection. Ann Thorac Surg (2001) 0.87
Bi-plane color transesophageal Doppler echocardiography (color TEE): its advantages and limitations. Int J Card Imaging (1989) 0.86
Detection of human telomerase reverse transcriptase messenger RNA in voided urine samples as a useful diagnostic tool for bladder cancer. Clin Cancer Res (1998) 0.85
Global myocardial ischemia as a complication of an acute type A aortic dissection--rapid diagnosis of a case by transesophageal echocardiography. Jpn Circ J (2000) 0.85
[Clinical result of left ventricular free wall rupture resulting from acute myocardial infarction]. Kyobu Geka (1995) 0.85
Rb and E2F-1 regulate telomerase activity in human cancer cells. Biochim Biophys Acta (2001) 0.85
Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. Biochim Biophys Acta (2001) 0.85
Incidence of febrile convulsions in children with congenital hypothyroidism. Acta Paediatr (1998) 0.84
Arterial haemodynamics in patients after repair of tetralogy of Fallot: influence on left ventricular after load and aortic dilatation. Heart (2007) 0.84
Creation of tumorigenic human endometrial epithelial cells with intact chromosomes by introducing defined genetic elements. Oncogene (2006) 0.83
Circulating tumour cells detected by a novel adenovirus-mediated system may be a potent therapeutic marker in gynaecological cancers. Br J Cancer (2012) 0.83
Postanginal septicaemia with external jugular venous thrombosis: case report. Br J Oral Maxillofac Surg (1999) 0.82
FADD gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo. Anticancer Res (2001) 0.82
[Coronary malperfusion due to acute type A aortic dissection; surgical strategy and results]. Kyobu Geka (2007) 0.82
A tubule cell line established from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene. Jpn J Cancer Res (1991) 0.82
Redo without transfusion in a patient with idiopathic thrombocytopenic purpura. Ann Thorac Surg (2000) 0.82
Cilia-associated respiratory bacillus infection in rabbits. Lab Anim Sci (1990) 0.82
[Single-dose and high-volume Bretschneider cardioplegic solution for congenital heart surgery]. Kyobu Geka (1999) 0.82
Correlation between tumorigenicity and expression levels or splicing patterns of transcripts of the human papillomavirus type 16 E6 gene. Jpn J Cancer Res (1994) 0.82
Fatal intraoperative dissection of the innominate artery due to perfusion through the right axillary artery. J Thorac Cardiovasc Surg (2000) 0.82
Association of human papillomavirus with malignant and premalignant lesions of the uterine endometrium. Hum Pathol (1995) 0.82
Outcome of Stanford type B acute aortic dissection. Circulation (1992) 0.81
Intraoperative transesophageal echocardiography in pediatric patients. J Thorac Cardiovasc Surg (1990) 0.81
A novel treatment of human malignant gliomas in vitro and in vivo: FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter. Int J Oncol (2001) 0.81
Early growth response-1 mediates up-regulation of telomerase in placenta. Placenta (2007) 0.80
Distinct telomere length regulation in premalignant cervical and endometrial lesions: implications for the roles of telomeres in uterine carcinogenesis. J Pathol (2006) 0.80
Giant cell formation in cells exposed to 740 nm and 760 nm optical traps. Lasers Surg Med (1997) 0.80
Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer. Br J Cancer (2010) 0.80
Krüppel-like factor 4 mediates anti-proliferative effects of progesterone with G₀/G₁ arrest in human endometrial epithelial cells. J Endocrinol Invest (2010) 0.80
Subcellular phototoxicity of 5-aminolaevulinic acid (ALA). Lasers Surg Med (1998) 0.80
Ventricular energetics in Fontan circulation: evaluation with a theoretical model. Pediatr Int (2000) 0.79
[A surgical case of quadricuspid aortic valve associated aortic regurgitation and severe mitral regurgitation due to infective endocarditis]. Kyobu Geka (1998) 0.79
Dispensability of p53 degradation for tumorigenicity and decreased serum requirement of human papillomavirus type 16 E6. Mol Carcinog (1998) 0.79
Doppler ultrasound examination of prosthetic function and ventricular blood flow after mitral valve replacement. Herz (1986) 0.79
[Advantages of transesophageal color Doppler echocardiography in the diagnosis and surgical treatment of cardiac masses]. J Cardiol (1990) 0.79
Efficacy and safety of torasemide in children with heart failure. Arch Dis Child (2008) 0.78
Severe diffuse atherosclerotic lesions of right gastroepiploic artery graft. Ann Thorac Surg (1999) 0.78
[High pressure occlusion of leukocyte depletion arterial line filter in patients with cardio-pulmonary bypass surgery]. Kyobu Geka (2001) 0.78
New direction of biplane transesophageal echocardiography with special emphasis on real-time biplane imaging and matrix phased-array biplane transducer. Echocardiography (1990) 0.78
Transvascular intracardiac applications of a miniaturized phased-array ultrasonic endoscope. Initial experience with intracardiac imaging in piglets. Circulation (1991) 0.78
A case of renal transplantation received from a living donor with second-generation anti-hepatitis C virus antibody positive into an anti-hepatitis C virus antibody negative recipient. Transplant Proc (2000) 0.78
Receptor selective synthetic retinoids as potential cancer chemotherapy agents. Curr Cancer Drug Targets (2002) 0.77
Utility of 10 MHz ultrasound catheters in the intraaortic assessment of coronary artery ostial stenoses. Am J Cardiol (1996) 0.77
Utility of biplane transesophageal echocardiography in left ventricular wall motion analysis. J Cardiothorac Vasc Anesth (1991) 0.77
Improved survival in patients with continuous-flow ventricular assist device for bridge to heart transplantation. Transplant Proc (2013) 0.76
Role of pituitary adenylate cyclase-activating polypeptide in modulating hypothalamus-pituitary neuroendocrine functions in mouse cell models. J Neuroendocrinol (2015) 0.76
[Ventricular septal perforation due to weak blunt chest trauma; report of a case]. Kyobu Geka (2007) 0.76
Early diagnosis and surgical intervention of acute aortic dissection by transesophageal color flow mapping. Circulation (1990) 0.76
Development and clinical application of minimally invasive cardiac surgery using percutaneous cardiopulmonary support. Jpn J Thorac Cardiovasc Surg (2000) 0.76
Amino acid sequence of Salmonella typhimurium branched-chain amino acid aminotransferase. Biochemistry (1989) 0.75
Variomatrix--a newly developed transesophageal echocardiography probe with a rotating matrix biplane transducer. Technological aspects and initial clinical experience. Echocardiography (1993) 0.75
[The effect of milrinone for the shock patients after cardiac surgery]. Kyobu Geka (1999) 0.75
Clinical experience of milrinone as a pharmacological bridge to heart transplantation. Jpn J Thorac Cardiovasc Surg (2000) 0.75
[Usefulness of intracardiac echocardiography for guidance of transseptal puncture procedure]. J Cardiol (1995) 0.75
Thermocardiography in the ischemic heart. Heart Vessels (1985) 0.75
[A case of Hashimoto's thyroiditis, myasthenia gravis and pernicious anemia (author's transl)]. Rinsho Ketsueki (1980) 0.75
[Observation of lesions in uterine cervix with videomacroscope]. Nihon Sanka Fujinka Gakkai Zasshi (1990) 0.75
[Changes in serum creatine phosphokinase and MB-CPK isoenzyme activities following cardiac surgery (author's transl)]. Nihon Kyobu Geka Gakkai Zasshi (1981) 0.75