Castleman's disease: from basic mechanisms to molecular therapeutics.

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Published in Oncologist on March 25, 2011

Authors

Hazem E El-Osta1, Razelle Kurzrock

Author Affiliations

1: Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), MD Anderson Cancer Center, Unit 455, P.O. Box 301402, Houston, Texas 77030, USA.

Associated clinical trials:

A Study to Evaluate the Efficacy and Safety of CNTO328 Plus Best Supportive Care in Multicentric Castleman's Disease | NCT01024036

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Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science (1994) 39.60

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Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol (2009) 14.33

Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med (1999) 11.27

G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature (1998) 5.24

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Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood (1989) 4.17

Interleukin 6: from bench to bedside. Nat Clin Pract Rheumatol (2006) 4.10

Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem (1996) 3.57

Proteasome inhibition as a novel therapeutic target in human cancer. J Clin Oncol (2005) 3.43

The management of unicentric and multicentric Castleman's disease: a report of 16 cases and a review of the literature. Cancer (1999) 2.90

The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol (2005) 2.75

A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: clinical findings and clinicopathologic correlations in 15 patients. J Clin Oncol (1985) 2.67

Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood (1999) 2.65

Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer (2007) 2.62

Treatment of unicentric and multicentric Castleman disease and the role of radiotherapy. Cancer (2001) 2.59

The clinical behavior of localized and multicentric Castleman disease. Ann Intern Med (1998) 2.57

Human herpesvirus 8 encodes a homolog of interleukin-6. J Virol (1997) 2.56

Remission of HHV-8 and HIV-associated multicentric Castleman disease with ganciclovir treatment. Blood (2003) 2.41

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest (1990) 2.37

Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood (2000) 2.31

Multicentric Castleman's disease in HIV infection: a clinical and pathological study of 20 patients. AIDS (1996) 2.28

High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease. Blood (2002) 2.26

Brief report: alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody. N Engl J Med (1994) 2.13

KSHV vFLIP binds to IKK-gamma to activate IKK. J Cell Sci (2003) 2.04

Case records of the Massachusetts General Hospital; weekly clinicopathological exercises; founded by Richard C. Cabot. N Engl J Med (1954) 1.85

Multicentric angiofollicular lymph node hyperplasia: a clinicopathologic study of 16 cases. Hum Pathol (1985) 1.79

Fifty years of multicentric Castleman's disease. Acta Oncol (2004) 1.65

Brief communication: rituximab in HIV-associated multicentric Castleman disease. Ann Intern Med (2007) 1.54

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The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem (2003) 1.42

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Epidemiology of regular prescribed opioid use: results from a national, population-based survey. J Pain Symptom Manage (2008) 1.24

Antiviral drug susceptibility of human herpesvirus 8. Antimicrob Agents Chemother (1997) 1.23

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[Castleman's disease]. Rev Med Interne (1996) 0.98

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Alpha-interferon in angioimmunoblastic lymphadenopathy. Ann Intern Med (1988) 0.87

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Signal transduction targets in Kaposi's sarcoma. Curr Opin Oncol (2006) 0.83

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Aggressive angiofollicular lymph node hyperplasia (Castleman's disease) treated with high dose melphalan and autologous bone marrow transplantation. Hematol Oncol (1986) 0.81

Is interferon-a an active agent in Castleman's disease? Ann Oncol (1992) 0.81

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Low dose interferon-alpha therapy for HIV-associated multicentric Castleman's disease. Int J STD AIDS (2003) 0.80

Castleman's disease, plasma-cell type. Diagnosis of central nervous system involvement by cerebrospinal fluid cytology. Acta Cytol (1986) 0.80

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Multicentric Castleman disease complicated by tumor lysis syndrome after systemic chemotherapy. Leuk Res (2009) 0.78

Near-total resolution of multicentric Castleman disease by prolonged treatment with thalidomide. Am J Hematol (2006) 0.77

Alpha-interferon therapy in refractory angioimmunoblastic lymphadenopathy. Eur J Haematol (1987) 0.77

2-Chloro-deoxyadenosine therapy for giant lymph node hyperplasia. Br J Haematol (1995) 0.77

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