Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

PubWeight™: 2.37‹?› | Rank: Top 2%

🔗 View Article (PMC 296765)

Published in J Clin Invest on August 01, 1990

Authors

S J Brandt1, D M Bodine, C E Dunbar, A W Nienhuis

Author Affiliations

1: Clinical Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.

Associated clinical trials:

Tocilizumab for KSHV-Associated Multicentric Castleman Disease | NCT01441063

Articles citing this

A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A (1998) 6.76

Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proc Natl Acad Sci U S A (1999) 4.52

Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med (2009) 4.03

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice. EMBO J (1995) 3.48

Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood (2009) 2.68

Iron sequestration and anemia of inflammation. Semin Hematol (2009) 1.85

Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component. J Exp Med (1998) 1.78

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus. J Exp Med (1992) 1.74

Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman's disease. Am J Pathol (1997) 1.72

An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease. Clin Infect Dis (2010) 1.70

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J Exp Med (1996) 1.65

Role of retinoic acid in the imprinting of gut-homing IgA-secreting cells. Semin Immunol (2008) 1.51

Castleman's disease: from basic mechanisms to molecular therapeutics. Oncologist (2011) 1.40

Iron homeostasis and the inflammatory response. Annu Rev Nutr (2010) 1.40

Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci U S A (1992) 1.37

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice. Elife (2013) 1.36

Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases. Int J Biol Sci (2012) 1.27

Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV-MCD) and the KSHV Inflammatory Cytokine Syndrome. Front Microbiol (2012) 1.25

Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease. Blood (2013) 1.23

Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies. Cancer Manag Res (2011) 1.23

Transgenic mouse model of AA amyloidosis. Am J Pathol (1999) 1.21

KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation. J Clin Invest (2011) 1.21

HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood (2012) 1.14

Impact of interleukin-6 in hematological malignancies. Transfus Med Hemother (2013) 1.11

Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice. J Exp Med (1996) 1.08

New approaches to the treatment of human herpesvirus 8-associated disease. Rev Med Virol (2008) 1.07

Cytokines in systemic lupus erythematosus. Curr Mol Med (2009) 1.03

Interleukin-6, but not interleukin-4, is expressed by Reed-Sternberg cells in Hodgkin's disease with or without histologic features of Castleman's disease. Am J Pathol (1992) 0.99

Castleman disease. Korean J Hematol (2012) 0.96

Castleman's disease in childhood: report of three cases and review of the literature. Ital J Pediatr (2011) 0.96

Update and new approaches in the treatment of Castleman disease. J Blood Med (2016) 0.93

Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. J Exp Med (1992) 0.92

Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A. Virology (2012) 0.90

Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome. World J Surg Oncol (2007) 0.89

Possible roles of Epstein-Barr virus in Castleman disease. J Cardiothorac Surg (2009) 0.86

Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras. J Exp Med (1993) 0.85

Interleukin-6 blockade in ocular inflammatory diseases. Clin Exp Immunol (2014) 0.84

Sequence analysis of Kaposi sarcoma-associated herpesvirus (KSHV) microRNAs in patients with multicentric Castleman disease and KSHV-associated inflammatory cytokine syndrome. J Infect Dis (2012) 0.84

Unicentric mixed variant Castleman disease associated with intrabronchial plasmacytoma. Diagn Pathol (2014) 0.84

A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica. Case Rep Nephrol Urol (2012) 0.83

Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy. J Clin Invest (1996) 0.83

Astrocytic alterations in interleukin-6/Soluble interleukin-6 receptor alpha double-transgenic mice. Am J Pathol (2000) 0.83

Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice. Am J Pathol (1994) 0.82

Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate. Clin Rheumatol (2006) 0.81

Transgenic mice in the study of cytokine function. Int J Exp Pathol (1993) 0.81

Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes. Int J Exp Pathol (2004) 0.79

T-cell-dependent immunity and thrombocytopenia in rats infected with Plasmodium chabaudi. Infect Immun (1992) 0.76

Kaposi sarcoma herpes virus-associated hemophagocytic syndrome complicated by multicentric castleman disease and kaposi sarcoma in a HIV-negative immunocompetent patient: an autopsy case. J Korean Med Sci (2009) 0.76

Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation. J Virol (2015) 0.76

Tocilizumab-induced remission of nephrotic syndrome accompanied by secondary amyloidosis and glomerulonephritis in a patient with rheumatoid arthritis. CEN Case Rep (2014) 0.75

Functional heterogeneity and pathogenic significance of interleukin-6 in B-cell lymphomas. Am J Pathol (1992) 0.75

[Castleman disease: unusual location of the chest]. Pan Afr Med J (2012) 0.75

A rare case of renal thrombotic microangiopathy associated with Castleman's disease. BMC Nephrol (2017) 0.75

Emerging treatments in Castleman disease - a critical appraisal of siltuximab. Biologics (2016) 0.75

Treatment of Kaposi Sarcoma Herpesvirus-Associated Multicentric Castleman Disease. Hematol Oncol Clin North Am (2018) 0.75

A case of Takayasu arteritis complicated by Castleman's disease. Clin Rheumatol (2008) 0.75

[Castleman's disease]. Mund Kiefer Gesichtschir (2005) 0.75

Autoimmune findings resembling connective tissue disease in a patient with Castleman's disease. Clin Rheumatol (1997) 0.75

IgG4-related disease involving polyserous effusions with elevated serum interleukin-6 levels: a case report and literature review. Immunol Res (2017) 0.75

Portal hypertension and refractory ascites associated with multicentric Castleman's disease. Dig Dis Sci (2000) 0.75

Articles cited by this

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem (1983) 206.01

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95

A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol (1986) 16.65

Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer (1957) 9.27

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome. J Exp Med (1989) 6.99

The biology of interleukin-6. Blood (1989) 6.65

Effect of internal viral sequences on the utility of retroviral vectors. J Virol (1987) 6.06

Rapid cell culture assay technic for murine leukaemia viruses. Nature (1971) 5.87

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A (1984) 5.81

Induction of beta 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell (1986) 5.79

Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum (1988) 4.60

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med (1988) 4.31

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol (1988) 4.20

Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood (1989) 4.17

IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1989) 4.03

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci U S A (1987) 3.92

Increased plasma levels of interleukin-6 in sepsis. Blood (1989) 3.92

A macrophage-derived factor required by plasmacytomas for survival and proliferation in vitro. Science (1986) 3.28

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci U S A (1989) 2.87

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest (1989) 2.83

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood (1989) 2.78

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc Natl Acad Sci U S A (1987) 2.76

A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: clinical findings and clinicopathologic correlations in 15 patients. J Clin Oncol (1985) 2.67

Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine. Biochem Genet (1978) 2.55

Castleman's disease and related disorders. Semin Diagn Pathol (1988) 2.47

Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas. FEBS Lett (1989) 2.43

Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett (1988) 2.39

Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc Natl Acad Sci U S A (1988) 2.37

Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV. J Immunol (1989) 2.27

Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines. J Immunol (1988) 2.24

B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. J Immunol (1988) 2.20

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. J Immunol (1988) 1.92

Involvement of IL-6 in mesangial proliferative glomerulonephritis. J Immunol (1989) 1.89

Regulation of the acute phase and immune responses in viral disease. Enhanced expression of the beta 2-interferon/hepatocyte-stimulating factor/interleukin 6 gene in virus-infected human fibroblasts. J Exp Med (1988) 1.74

Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro. Proc Natl Acad Sci U S A (1989) 1.69

A systemic lymphoproliferative disorder with morphologic features of Castleman's disease. Pathological findings in 15 patients. Am J Surg Pathol (1983) 1.58

Stimulation of murine hemopoietic colony formation by human IL-6. J Immunol (1988) 1.54

IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. J Immunol (1989) 1.47

Interleukin-6 is a potent thrombopoietic factor in vivo in mice. Blood (1989) 1.40

The acute phase nature of interleukin 6: studies in Kawasaki disease and other febrile illnesses. Clin Exp Immunol (1989) 1.36

Retroviral transfer and expression of the interleukin-3 gene in hemopoietic cells. Genes Dev (1987) 1.21

Synergism of BSF-2/interleukin 6 and interleukin 3 on development of multipotential hemopoietic progenitors in serum-free culture. J Exp Med (1988) 1.20

Effect of B cell differentiation factor (BCDF) on biosynthesis and secretion of immunoglobulin molecules in human B cell lines. J Immunol (1985) 1.15

REFRACTORY ANEMIA WITH ABNORMAL IRON METABOLISM: ITS REMISSION AFTER RESECTION OF HYPERPLASTIC MEDIASTINAL LYMPH NODES. N Engl J Med (1965) 1.13

A possible autocrine role for interleukin-6 in two lymphoma cell lines. Blood (1989) 1.09

Interleukin-6 enhances growth factor-dependent proliferation of the blast cells of acute myeloblastic leukemia. Blood (1988) 0.96

Interleukin-1 and interleukin-6 stimulate acute-phase protein production in primary mouse hepatocytes. J Leukoc Biol (1989) 0.94

Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus. Am J Pathol (1988) 0.89

Molecular genetic and immunohistochemical analyses of a case of multicentric Castleman's disease. Jpn J Clin Oncol (1988) 0.79

Articles by these authors

Bone marrow cells regenerate infarcted myocardium. Nature (2001) 21.24

Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A (2001) 7.19

Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med (1994) 4.86

An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation. Mol Cell Biol (1988) 4.08

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev (1990) 4.07

A family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene. Nucleic Acids Res (1980) 3.91

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc Natl Acad Sci U S A (1986) 3.71

5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. N Engl J Med (1982) 3.29

The functional human dihydrofolate reductase gene. J Biol Chem (1984) 3.28

RNA processing errors in patients with beta-thalassemia. Proc Natl Acad Sci U S A (1982) 2.99

Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism. Proc Natl Acad Sci U S A (1984) 2.99

Differences in human alpha-, beta- and delta-globin gene expression in monkey kidney cells. Cell (1982) 2.78

High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial. Lancet (2000) 2.75

Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease. N Engl J Med (1993) 2.50

Continuous subcutaenous administration of deferoxamine in patients with iron overload. N Engl J Med (1977) 2.31

Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell (1985) 2.28

Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity (1997) 2.27

Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability. Blood (1984) 2.17

Transplanted adult bone marrow cells repair myocardial infarcts in mice. Ann N Y Acad Sci (2001) 2.17

Developmental regulation of human globin genes. Annu Rev Biochem (1985) 2.16

Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis. Blood (1999) 2.14

Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Mol Cell Biol (1993) 2.05

Cloning and characterization of DNA sequences surrounding the human gamma-, delta-, and beta-globin genes. Proc Natl Acad Sci U S A (1980) 2.04

Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein. Nucleic Acids Res (1990) 2.01

Beta Thalassemia: mutations which affect processing of the beta-Globin mRNA precursor. Cell (1980) 1.98

Hepatitis-associated aplastic anemia. N Engl J Med (1997) 1.98

Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. Blood (1997) 1.88

Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy. N Engl J Med (1989) 1.85

Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells. Proc Natl Acad Sci U S A (1989) 1.84

Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector. Proc Natl Acad Sci U S A (1992) 1.82

Expression of the human c-fms proto-oncogene product (colony-stimulating factor-1 receptor) on peripheral blood mononuclear cells and choriocarcinoma cell lines. J Clin Invest (1986) 1.77

Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes. Cell (1984) 1.77

Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol (1993) 1.76

Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells. Blood (1994) 1.75

Translation of rabbit haemoglobin messenger RNA by thalassaemic and non-thalassaemic ribosomes. Nat New Biol (1971) 1.75

Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. Blood (2001) 1.74

Isolation and translation of hemoglobin messenger RNA from thalassemia, sickle cell anemia, and normal human reticulocytes. J Clin Invest (1971) 1.74

Intronless human dihydrofolate reductase genes are derived from processed RNA molecules. Proc Natl Acad Sci U S A (1982) 1.69

Mechanism of DNase I hypersensitive site formation within the human globin locus control region. Proc Natl Acad Sci U S A (1992) 1.67

Identification of a stage selector element in the human gamma-globin gene promoter that fosters preferential interaction with the 5' HS2 enhancer when in competition with the beta-promoter. EMBO J (1992) 1.65

The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q. Proc Natl Acad Sci U S A (1987) 1.64

Targeted and highly efficient gene transfer into CD4+ cells by a recombinant human immunodeficiency virus retroviral vector. J Clin Invest (1991) 1.64

Active conformation of the globin genes in uninduced and induced mouse erythroleukemia cells. Cell (1978) 1.64

Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea. N Engl J Med (1990) 1.63

Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor. Blood (1993) 1.62

5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia. Blood (1983) 1.61

Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells. Proc Natl Acad Sci U S A (1990) 1.59

Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7. Proc Natl Acad Sci U S A (1995) 1.58

Selective activation of human beta-but not gamma-globin gene in human fibroblast x mouse erythroleukaemia cell hybrids. Nature (1979) 1.58

Cyclosporine therapy of aplastic anaemia, congenital and acquired red cell aplasia. Br J Haematol (1989) 1.56

Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood (1996) 1.56

Isolation and characterization of a 15-kilobase genomic sequence coding for part of the Pro alpha 2 chain of sheep type I collagen. J Biol Chem (1980) 1.53

Advances in thalassemia research. Blood (1984) 1.52

Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate. Exp Hematol (1992) 1.50

Treatment of Diamond-Blackfan anaemia with haematopoietic growth factors, granulocyte-macrophage colony stimulating factor and interleukin 3: sustained remissions following IL-3. Br J Haematol (1991) 1.50

Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science (1992) 1.49

Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability. Blood (1998) 1.48

Brief report: treatment with azacitidine of patients with end-stage beta-thalassemia. N Engl J Med (1993) 1.48

Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood (1993) 1.48

Promoter sequences required for function of the human gamma globin gene in erythroid cells. EMBO J (1986) 1.47

Contribution of promoter to tissue-specific expression of the mouse immunoglobulin kappa gene. Science (1985) 1.44

Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector. J Clin Invest (1994) 1.39

An array of murine leukemia virus-related elements is transmitted and expressed in a primate recipient of retroviral gene transfer. J Virol (1996) 1.38

Inducible, high-level production of infectious murine leukemia retroviral vector particles pseudotyped with vesicular stomatitis virus G envelope protein. Hum Gene Ther (1995) 1.37

Relative stability of alpha- and beta-globin messenger RNAs in homozygous beta+ thalassemia. Proc Natl Acad Sci U S A (1977) 1.36

Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice. Proc Natl Acad Sci U S A (1988) 1.36

Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells. Mol Cell Biol (1987) 1.35

Retroviral-mediated transfer of genomic globin genes leads to regulated production of RNA and protein. Proc Natl Acad Sci U S A (1987) 1.34

Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder. Mol Cell Biol (1989) 1.34

Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. J Clin Invest (1987) 1.33

Periodic microcirculatory flow in patients with sickle-cell disease. N Engl J Med (1984) 1.32

Hemoglobin messenger RNA from human bone marrow. Isolation and translation in homozygous and heterozygous beta-thalassemia. J Clin Invest (1973) 1.32

Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. EMBO J (1995) 1.30

Evidence of genetic heterogeneity in five kindreds with familial hypertrophic cardiomyopathy. Circulation (1992) 1.29

An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells. Genomics (1999) 1.28

Regulation of hemoglobin synthesis during the development of the red cell (third of three parts). N Engl J Med (1977) 1.28

Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells. Proc Natl Acad Sci U S A (1994) 1.28

Epitheliocystis, a new infectious disease of the bluegill (Lepomis macrochirus). Antonie Van Leeuwenhoek (1969) 1.28

Cell-free hemoglobin synthesis in beta-thalassemia. Proc Natl Acad Sci U S A (1970) 1.28

Efficient gene transfer into human cord blood CD34+ cells and the CD34+CD38- subset using highly purified recombinant adeno-associated viral vector preparations that are free of helper virus and wild-type AAV. Gene Ther (2000) 1.28

Characterization of replication-competent retroviruses from nonhuman primates with virus-induced T-cell lymphomas and observations regarding the mechanism of oncogenesis. J Virol (1994) 1.28

COOH-terminal-modified interleukin-3 is retained intracellularly and stimulates autocrine growth. Science (1989) 1.27

Prolonged high-level detection of retrovirally marked hematopoietic cells in nonhuman primates after transduction of CD34+ progenitors using clinically feasible methods. Mol Ther (2000) 1.26

Functional requirements for phenotypic correction of murine beta-thalassemia: implications for human gene therapy. Blood (2001) 1.26

Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells. Exp Hematol (1993) 1.26

Many multipotential gene-marked progenitor or stem cell clones contribute to hematopoiesis in nonhuman primates. Blood (2000) 1.25

"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA. Proc Natl Acad Sci U S A (1983) 1.25

Therapeutic approaches to hemoglobin switching in treatment of hemoglobinopathies. Annu Rev Med (1992) 1.24

Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer. Br J Cancer (2010) 1.23

Retroviral transfer and expression of the interleukin-3 gene in hemopoietic cells. Genes Dev (1987) 1.21

A beta-globin gene, inactive in the K562 leukemic cell, functions normally in a heterologous expression system. Proc Natl Acad Sci U S A (1984) 1.21

Update on the use of nonhuman primate models for preclinical testing of gene therapy approaches targeting hematopoietic cells. Hum Gene Ther (2001) 1.21

Recombinant adeno-associated virus-mediated high-efficiency, transient expression of the murine cationic amino acid transporter (ecotropic retroviral receptor) permits stable transduction of human HeLa cells by ecotropic retroviral vectors. J Virol (1996) 1.20

A weak upstream promoter gives rise to long human beta-globin RNA molecules. Biochem Biophys Res Commun (1983) 1.20