Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.

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Published in Lancet Oncol on July 16, 2012

Authors

Gerald S Falchook1, Karl D Lewis, Jeffrey R Infante, Michael S Gordon, Nicholas J Vogelzang, Douglas J DeMarini, Peng Sun, Christopher Moy, Stephen A Szabo, Lori T Roadcap, Vijay G R Peddareddigari, Peter F Lebowitz, Ngocdiep T Le, Howard A Burris, Wells A Messersmith, Peter J O'Dwyer, Kevin B Kim, Keith Flaherty, Johanna C Bendell, Rene Gonzalez, Razelle Kurzrock, Leslie A Fecher

Author Affiliations

1: Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA. gfalchoo@mdanderson.org

Associated clinical trials:

Open-label Study to Investigate the Safety, PK, and Pharmacodynamics of GSK1120212 in Subjects With Solid Tumors or Lymphoma | NCT00687622

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