Published in J Neurosci on March 30, 2011
Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes. J Leukoc Biol (2013) 1.51
Paracrine signaling through plasma membrane hemichannels. Biochim Biophys Acta (2012) 1.28
Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. J Physiol (2012) 1.17
The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol (2012) 1.13
Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels. Glia (2011) 1.11
Insights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y). J Gen Physiol (2013) 1.06
Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder? Am J Cardiovasc Dis (2013) 1.05
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol (2013) 1.02
Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation. Basic Res Cardiol (2012) 0.97
Cardiac to cancer: connecting connexins to clinical opportunity. FEBS Lett (2014) 0.96
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci (2014) 0.95
Elusive roles for reactive astrocytes in neurodegenerative diseases. Front Cell Neurosci (2015) 0.95
Restraint stress increases hemichannel activity in hippocampal glial cells and neurons. Front Cell Neurosci (2015) 0.93
Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation. Neural Dev (2012) 0.93
Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases. Front Cell Neurosci (2014) 0.91
Astrocytes conspire with neurons during progression of neurological disease. Curr Opin Neurobiol (2012) 0.90
Hemichannels: new roles in astroglial function. Front Physiol (2014) 0.89
ATP is required and advances cytokine-induced gap junction formation in microglia in vitro. Mediators Inflamm (2013) 0.88
Connexin 43 channels protect osteocytes against oxidative stress-induced cell death. J Bone Miner Res (2013) 0.87
Intracellular Cleavage of the Cx43 C-Terminal Domain by Matrix-Metalloproteases: A Novel Contributor to Inflammation? Mediators Inflamm (2015) 0.85
Protein-mediated interactions of pancreatic islet cells. Scientifica (Cairo) (2013) 0.85
Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin. PLoS One (2015) 0.84
Diseases associated with leaky hemichannels. Front Cell Neurosci (2015) 0.84
Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells. Mediators Inflamm (2014) 0.83
Dynamic micro-organization of P2X7 receptors revealed by PALM based single particle tracking. Front Cell Neurosci (2013) 0.83
Hemichannels in neurodegenerative diseases: is there a link to pathology? Front Cell Neurosci (2014) 0.83
Regulation of gap junction channels by infectious agents and inflammation in the CNS. Front Cell Neurosci (2014) 0.83
FGF-1 Triggers Pannexin-1 Hemichannel Opening in Spinal Astrocytes of Rodents and Promotes Inflammatory Responses in Acute Spinal Cord Slices. J Neurosci (2016) 0.83
Connexin and pannexin signaling in gastrointestinal and liver disease. Transl Res (2015) 0.83
Activation, permeability, and inhibition of astrocytic and neuronal large pore (hemi)channels. J Biol Chem (2014) 0.83
Evidence for aberrant astrocyte hemichannel activity in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL). PLoS One (2014) 0.82
Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation. Mediators Inflamm (2013) 0.81
Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death. PLoS One (2012) 0.81
Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia (2016) 0.79
Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death. Channels (Austin) (2014) 0.79
IL-1RI (interleukin-1 receptor type I) signalling is essential for host defence and hemichannel activity during acute central nervous system bacterial infection. ASN Neuro (2012) 0.79
Antibodies targeting extracellular domain of connexins for studies of hemichannels. Neuropharmacology (2013) 0.79
Connexin: a potential novel target for protecting the central nervous system? Neural Regen Res (2015) 0.78
Astrocytes and lysosomal storage diseases. Neuroscience (2015) 0.78
Possible role of hemichannels in cancer. Front Physiol (2014) 0.78
Purinergic signaling in early inflammatory events of the foreign body response: modulating extracellular ATP as an enabling technology for engineered implants and tissues. Tissue Eng Part B Rev (2014) 0.78
Specific binding and characteristics of 18β-glycyrrhetinic acid in rat brain. PLoS One (2014) 0.78
Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet. Front Cell Neurosci (2014) 0.78
Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice. PLoS One (2013) 0.78
Connexins: substrates and regulators of autophagy. BMC Cell Biol (2016) 0.78
Connexins and their channels in inflammation. Crit Rev Biochem Mol Biol (2016) 0.77
Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer's disease. Cell Death Differ (2016) 0.77
Extracellular Cysteine in Connexins: Role as Redox Sensors. Front Physiol (2016) 0.77
Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible Role in the Progression of Metabolic Syndrome: A New Hypothesis. Front Physiol (2015) 0.77
Osteocytic connexin hemichannels suppress breast cancer growth and bone metastasis. Oncogene (2016) 0.77
The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia. Clin Dev Immunol (2013) 0.77
Therapeutic potential of mGluR5 targeting in Alzheimer's disease. Front Neurosci (2015) 0.77
Antidepressants Impact Connexin 43 Channel Functions in Astrocytes. Front Cell Neurosci (2016) 0.76
Engram formation in psychiatric disorders. Front Neurosci (2014) 0.76
Boldine prevents renal alterations in diabetic rats. J Diabetes Res (2013) 0.76
Neuron-astrocyte interactions in neurodegenerative diseases: Role of neuroinflammation. Clin Exp Neuroimmunol (2015) 0.76
Neuroinflammatory paradigms in lysosomal storage diseases. Front Neurosci (2015) 0.76
Connexins and pannexins in liver damage. EXCLI J (2016) 0.76
Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease. BMC Cell Biol (2017) 0.75
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases. Front Integr Neurosci (2016) 0.75
The acute inhibition of enteric glial metabolism with fluoroacetate alters calcium signaling, hemichannel function and the expression of key proteins. J Neurophysiol (2016) 0.75
New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis. Front Cell Neurosci (2017) 0.75
Role of gap junctions and hemichannels in parasitic infections. Biomed Res Int (2013) 0.75
Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions. Front Mol Neurosci (2016) 0.75
Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease. J Neurochem (2015) 0.75
Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer's disease. PLoS One (2017) 0.75
Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain. Neurochem Res (2017) 0.75
Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells. J Cell Mol Med (2017) 0.75
Nutrient Starvation Decreases Cx43 Levels and Limits Intercellular Communication in Primary Bovine Corneal Endothelial Cells. J Membr Biol (2016) 0.75
The role of Pannexin gene variants in schizophrenia: systematic analysis of phenotypes. Eur Arch Psychiatry Clin Neurosci (2015) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics. Neurochem Res (2017) 0.75
Connexin Hemichannels: Methods for Dye Uptake and Leakage. J Membr Biol (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Astroglial metabolic networks sustain hippocampal synaptic transmission. Science (2008) 3.49
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci U S A (2001) 3.17
Gating and regulation of connexin 43 (Cx43) hemichannels. Proc Natl Acad Sci U S A (2003) 2.79
Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell (2005) 2.75
New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci (2003) 2.25
Astrocyte calcium waves: what they are and what they do. Glia (2006) 2.17
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci (2007) 2.06
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proc Natl Acad Sci U S A (2006) 1.74
Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Cancer Res (2007) 1.70
Intracellular calcium changes trigger connexin 32 hemichannel opening. EMBO J (2005) 1.69
Astroglial networks scale synaptic activity and plasticity. Proc Natl Acad Sci U S A (2011) 1.56
CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. J Biol Chem (2004) 1.56
Gap junction hemichannels contribute to the generation of diarrhoea during infectious enteric disease. Gut (2009) 1.56
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev (2004) 1.54
Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading. J Biol Chem (2008) 1.52
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J Neurochem (2011) 1.52
Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways. J Bone Miner Res (2010) 1.47
TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunol (2003) 1.46
Biological role of connexin intercellular channels and hemichannels. Arch Biochem Biophys (2012) 1.45
Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor. J Biol Chem (2003) 1.39
Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A (2012) 1.38
Control and plasticity of intercellular calcium waves in astrocytes: a modeling approach. J Neurosci (2002) 1.37
Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal (2009) 1.34
Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp Cell Res (2010) 1.34
Deletion of astroglial connexins weakens the blood-brain barrier. J Cereb Blood Flow Metab (2012) 1.30
Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proc Natl Acad Sci U S A (2007) 1.30
FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels. Proc Natl Acad Sci U S A (2010) 1.30
Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor. Mol Biol Cell (2006) 1.30
Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels. Proc Natl Acad Sci U S A (2010) 1.30
Glucocorticoid-induced autophagy in osteocytes. J Bone Miner Res (2010) 1.29
Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by beta-amyloid. FASEB J (2006) 1.28
Electrical and chemical transmission between striatal GABAergic output neurones in rat brain slices. J Physiol (2004) 1.25
Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling. Mol Cell Biol (2010) 1.24
Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration. J Neurosci (2009) 1.23
Gap junction-mediated astrocytic networks in the mouse barrel cortex. J Neurosci (2008) 1.21
Ca(2+) regulation of connexin 43 hemichannels in C6 glioma and glial cells. Cell Calcium (2009) 1.20
Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J Cell Sci (2004) 1.19
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J (2012) 1.17
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol (2012) 1.17
Developmental regulation of the direct interaction between the intracellular loop of connexin 45.6 and the C terminus of major intrinsic protein (aquaporin-0). J Biol Chem (2005) 1.17
A role of the (pro)renin receptor in neuronal cell differentiation. Am J Physiol Regul Integr Comp Physiol (2009) 1.16
Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Mol Biol Cell (2008) 1.15
Currently used methods for identification and characterization of hemichannels. Cell Commun Adhes (2008) 1.13
The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol (2012) 1.13
Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci (2010) 1.12
Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels. Glia (2011) 1.11
Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Brain Res (2012) 1.10
Gap junctions and hemichannels in signal transmission, function and development of bone. Biochim Biophys Acta (2011) 1.08
Aquaporin 0 enhances gap junction coupling via its cell adhesion function and interaction with connexin 50. J Cell Sci (2010) 1.07
Interaction of major intrinsic protein (aquaporin-0) with fiber connexins in lens development. J Cell Sci (2004) 1.07
S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK. Eur J Neurosci (2006) 1.07
Glucocorticoid dose determines osteocyte cell fate. FASEB J (2011) 1.06
Gap junctions and neuronal injury: protectants or executioners? Neuroscientist (2003) 1.05
Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization. Am J Physiol Cell Physiol (2010) 1.05
Gap junction and hemichannel functions in osteocytes. Bone (2012) 1.04
Epileptiform activity in hippocampal slice cultures exposed chronically to bicuculline: increased gap junctional function and expression. J Neurochem (2003) 1.04
The carboxy-terminal tail of connexin43 gap junction protein is sufficient to mediate cytoskeleton changes in human glioma cells. J Cell Biochem (2010) 1.04
Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model. Clin Sci (Lond) (2011) 1.04
Glucose metabolism and proliferation in glia: role of astrocytic gap junctions. J Neurochem (2006) 1.04
Stimulation of lens cell differentiation by gap junction protein connexin 45.6. Invest Ophthalmol Vis Sci (2003) 1.02
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol (2013) 1.02
Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells. Am J Physiol Cell Physiol (2009) 1.02
Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. J Immunol (2007) 1.01
Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes. Glia (2008) 1.01
Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats. Brain Res (2002) 1.01
Lysosomes are the major vesicular compartment undergoing Ca2+-regulated exocytosis from cortical astrocytes. J Neurosci (2008) 1.01
Connexin-based intercellular communication and astrocyte heterogeneity. Brain Res (2012) 1.00
In vivo differentiation of mouse embryonic stem cells into hepatocytes. Cell Transplant (2002) 1.00
Gap junction proteins on the move: connexins, the cytoskeleton and migration. Biochim Biophys Acta (2012) 1.00