ATP is required and advances cytokine-induced gap junction formation in microglia in vitro.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 3655668)

Published in Mediators Inflamm on April 23, 2013

Authors

Pablo J Sáez1, Kenji F Shoji, Mauricio A Retamal, Paloma A Harcha, Gigliola Ramírez, Jean X Jiang, Rommy von Bernhardi, Juan C Sáez

Author Affiliations

1: Departamento de Fisiología, Pontificia Universidad Católica de Chile, Alameda 340, 6513677 Santiago, Chile. pjsaez@uc.cl

Articles cited by this

Molecular physiology of P2X receptors. Physiol Rev (2002) 13.61

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J (2006) 8.12

Physiology of microglia. Physiol Rev (2011) 6.99

Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol (2009) 6.79

Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett (2004) 4.73

Microglia as a source and target of cytokines. Glia (2002) 4.48

Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett (2005) 3.89

Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem (2005) 3.87

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci U S A (2001) 3.17

Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J Exp Med (1997) 2.52

Connexin 43 hemichannels are permeable to ATP. J Neurosci (2008) 2.46

Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem (2006) 2.27

Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol (2005) 2.09

Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci (2007) 2.06

Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav Immun (1995) 1.91

Evolution of gap junction proteins--the pannexin alternative. J Exp Biol (2005) 1.88

The P2X7 purinergic receptor: from physiology to neurological disorders. FASEB J (2009) 1.71

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP. J Immunol (1996) 1.60

IFN-gamma receptor signaling mediates spinal microglia activation driving neuropathic pain. Proc Natl Acad Sci U S A (2009) 1.57

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. J Neurochem (2001) 1.56

Functional implications of calcium permeability of the channel formed by pannexin 1. J Cell Biol (2006) 1.56

Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading. J Biol Chem (2008) 1.52

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J Neurochem (2011) 1.52

Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission. PLoS One (2011) 1.49

TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunol (2003) 1.46

Long-range Ca2+ waves transmit brain-damage signals to microglia. Dev Cell (2012) 1.46

Microglial activation by purines and pyrimidines. Glia (2002) 1.45

Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome. J Gen Physiol (2010) 1.45

The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore. J Neurosci (2009) 1.40

ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma. J Immunol (2001) 1.36

Transformation of mouse bone marrow cells by transfection with a human oncogene related to c-myc is associated with the endogenous production of macrophage colony stimulating factor 1. J Cell Physiol (1985) 1.35

Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal (2009) 1.34

Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha. Proc Natl Acad Sci U S A (2001) 1.34

ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle. J Biol Chem (2009) 1.31

FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels. Proc Natl Acad Sci U S A (2010) 1.30

Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons. J Immunol (1994) 1.30

Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function. J Neurosci (2003) 1.29

Amyloid β-induced death in neurons involves glial and neuronal hemichannels. J Neurosci (2011) 1.28

Astrocyte Ca2+ waves trigger responses in microglial cells in brain slices. FASEB J (2001) 1.27

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders. J Neurochem (2009) 1.25

Activation of microglia by amyloid {beta} requires P2X7 receptor expression. J Immunol (2009) 1.23

Ca(2+) regulation of connexin 43 hemichannels in C6 glioma and glial cells. Cell Calcium (2009) 1.20

Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J Neurochem (2001) 1.19

Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Mol Biol Cell (2008) 1.15

Purinergic systems in microglia. Cell Mol Life Sci (2008) 1.13

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci (2010) 1.12

Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. PLoS One (2011) 1.08

Autocrine activation of microglia by tumor necrosis factor-alpha. J Neuroimmunol (2005) 1.07

The effects of IL-6 on cell adhesion and e-cadherin expression in breast cancer. Cytokine (1998) 1.05

Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons. J Neurosci Res (2005) 1.05

Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization. Am J Physiol Cell Physiol (2010) 1.05

Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors. Life Sci (2008) 1.03

P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells. J Neurochem (2003) 1.02

Functional role of calcium signals for microglial function. Glia (2006) 1.02

Interferon gamma gene expression in rat central nervous system glial cells. Cytokine (1998) 1.02

P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia. Mediators Inflamm (2013) 1.02

Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. J Immunol (2007) 1.01

Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats. Brain Res (2002) 1.01

Connexon-mediated cell adhesion drives microtissue self-assembly. FASEB J (2010) 1.01

Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia. J Neurochem (2005) 1.00

Mouse microglial cell lines differing in constitutive and interferon-gamma-inducible antigen-presenting activities for naive and memory CD4+ and CD8+ T cells. J Neuroimmunol (1995) 0.98

Modulation of the ATP-lnduced release and processing of IL-1beta in microglial cells. Crit Rev Immunol (2009) 0.97

ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion. Exp Mol Med (2007) 0.96

Understanding risk factors for Alzheimer's disease: interplay of neuroinflammation, connexin-based communication and oxidative stress. Arch Med Res (2012) 0.95

Calcium signaling in microglial cells. Glia (2002) 0.95

Opening hemichannels in nonjunctional membrane stimulates gap junction formation. Biophys J (2004) 0.92

Interleukin-10 expression in lipopolysaccharide-activated microglia is mediated by extracellular ATP in an autocrine fashion. Neuroreport (2004) 0.91

Purinergic mediated changes in Ca2+ mobilization and functional responses in microglia: effects of low levels of ATP. J Neurosci Res (2005) 0.88

Calcium and connexin-based intercellular communication, a deadly catch? Cell Calcium (2011) 0.88

Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion. J Neurosci (2012) 0.87

Activation of human polymorphonuclear cells induces formation of functional gap junctions and expression of connexins. Med Sci Monit (2002) 0.86

Connexin- and pannexin-based channels in normal skeletal muscles and their possible role in muscle atrophy. J Membr Biol (2012) 0.85

Functional significance of the negative-feedback regulation of ATP release via pannexin-1 hemichannels under ischemic stress in astrocytes. Neurochem Int (2010) 0.85

Injury of skeletal muscle and specific cytokines induce the expression of gap junction channels in mouse dendritic cells. J Cell Physiol (2007) 0.82

Up-regulation of Na(+)-Ca2+ exchange activity by interferon-gamma in cultured rat microglia. J Neurochem (2004) 0.82

Acute actions of tumor necrosis factor-alpha on intracellular Ca(2+) and K(+) currents in human microglia. Neuroscience (2001) 0.81

AGEs-RAGE mediated up-regulation of connexin43 in activated human microglial CHME-5 cells. Neurochem Int (2012) 0.79

Interferon-gamma acutely induces calcium influx in human microglia. J Neurosci Res (2002) 0.78

Production of interleukin-1 receptor antagonist isoforms by microglia in mixed rat glial cells stimulated by lipopolysaccharide. Eur Cytokine Netw (2000) 0.77

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci U S A (2001) 3.17

Gating and regulation of connexin 43 (Cx43) hemichannels. Proc Natl Acad Sci U S A (2003) 2.79

Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell (2005) 2.75

New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci (2003) 2.25

Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta (2005) 2.16

Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci (2007) 2.06

S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proc Natl Acad Sci U S A (2006) 1.74

Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev (2004) 1.54

Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading. J Biol Chem (2008) 1.52

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J Neurochem (2011) 1.52

Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways. J Bone Miner Res (2010) 1.47

TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunol (2003) 1.46

Biological role of connexin intercellular channels and hemichannels. Arch Biochem Biophys (2012) 1.45

Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor. J Biol Chem (2003) 1.39

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A (2012) 1.38

Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal (2009) 1.34

Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp Cell Res (2010) 1.34

Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proc Natl Acad Sci U S A (2007) 1.30

FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels. Proc Natl Acad Sci U S A (2010) 1.30

Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels. Proc Natl Acad Sci U S A (2010) 1.30

Glucocorticoid-induced autophagy in osteocytes. J Bone Miner Res (2010) 1.29

Amyloid β-induced death in neurons involves glial and neuronal hemichannels. J Neurosci (2011) 1.28

Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling. Mol Cell Biol (2010) 1.24

Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J Cell Sci (2004) 1.19

Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid. J Biol Chem (2005) 1.18

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J (2012) 1.17

Developmental regulation of the direct interaction between the intracellular loop of connexin 45.6 and the C terminus of major intrinsic protein (aquaporin-0). J Biol Chem (2005) 1.17

Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Mol Biol Cell (2008) 1.15

Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. Glia (2010) 1.14

The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol (2012) 1.13

Currently used methods for identification and characterization of hemichannels. Cell Commun Adhes (2008) 1.13

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci (2010) 1.12

Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels. Glia (2011) 1.11

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Brain Res (2012) 1.10

Gap junctions and hemichannels in signal transmission, function and development of bone. Biochim Biophys Acta (2011) 1.08

Aquaporin 0 enhances gap junction coupling via its cell adhesion function and interaction with connexin 50. J Cell Sci (2010) 1.07

Interaction of major intrinsic protein (aquaporin-0) with fiber connexins in lens development. J Cell Sci (2004) 1.07

Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation. Biol Res (2005) 1.06

Glucocorticoid dose determines osteocyte cell fate. FASEB J (2011) 1.06

Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization. Am J Physiol Cell Physiol (2010) 1.05

Gap junction and hemichannel functions in osteocytes. Bone (2012) 1.04

Stimulation of lens cell differentiation by gap junction protein connexin 45.6. Invest Ophthalmol Vis Sci (2003) 1.02

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol (2013) 1.02

Prenatal to early postnatal nicotine exposure impairs central chemoreception and modifies breathing pattern in mouse neonates: a probable link to sudden infant death syndrome. J Neurosci (2008) 1.02

Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells. Am J Physiol Cell Physiol (2009) 1.02

Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. J Immunol (2007) 1.01

Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats. Brain Res (2002) 1.01

In vivo differentiation of mouse embryonic stem cells into hepatocytes. Cell Transplant (2002) 1.00

c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice. Neurobiol Aging (2009) 1.00

Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress. J Biol Chem (2013) 0.99

Mechanical loading stimulates expression of connexin 43 in alveolar bone cells in the tooth movement model. Cell Commun Adhes (2006) 0.99

Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo. Am J Physiol Heart Circ Physiol (2008) 0.97

Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner. J Cell Sci (2009) 0.96

Understanding risk factors for Alzheimer's disease: interplay of neuroinflammation, connexin-based communication and oxidative stress. Arch Med Res (2012) 0.95

Connexin43 hemichannels contribute to cadmium-induced oxidative stress and cell injury. Antioxid Redox Signal (2011) 0.95

Aquaporin-0 targets interlocking domains to control the integrity and transparency of the eye lens. Invest Ophthalmol Vis Sci (2014) 0.94

De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy. Proc Natl Acad Sci U S A (2013) 0.92

Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function. Mol Biol Cell (2012) 0.92

Connexin 43 channels are essential for normal bone structure and osteocyte viability. J Bone Miner Res (2015) 0.91

Glial hemichannels and their involvement in aging and neurodegenerative diseases. Rev Neurosci (2012) 0.91

Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation. J Biol Chem (2014) 0.91

Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments. J Neurochem (2009) 0.90

Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. J Membr Biol (2007) 0.90

Cataract-causing mutation of human connexin 46 impairs gap junction, but increases hemichannel function and cell death. PLoS One (2013) 0.90

Transforming growth factor-β stimulates β amyloid uptake by microglia through Smad3-dependent mechanisms. J Neurosci Res (2012) 0.90

Gap junctions are selectively associated with interlocking ball-and-sockets but not protrusions in the lens. Mol Vis (2010) 0.90

Promotion of lens epithelial-fiber differentiation by the C-terminus of connexin 45.6 a role independent of gap junction communication. J Cell Sci (2007) 0.90

The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP. Brain Res Brain Res Rev (2004) 0.89

Gap junction remodeling associated with cholesterol redistribution during fiber cell maturation in the adult chicken lens. Mol Vis (2009) 0.89

Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators. Am J Physiol Gastrointest Liver Physiol (2002) 0.89

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease. Mol Neurodegener (2013) 0.89

Gap junctions at the dendritic cell-T cell interface are key elements for antigen-dependent T cell activation. J Immunol (2009) 0.89

Regulation of renal amino acid transporters during metabolic acidosis. Am J Physiol Renal Physiol (2006) 0.88

Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. Adv Exp Med Biol (2012) 0.88

FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X(7). J Cell Physiol (2013) 0.88

Phosphorylation of connexin 50 by protein kinase A enhances gap junction and hemichannel function. J Biol Chem (2011) 0.88

Nitric oxide signaling in the retina: what have we learned in two decades? Brain Res (2011) 0.87

Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow. J Biomech (2010) 0.87

Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro. Cell Immunol (2007) 0.87

Connexin 43 channels protect osteocytes against oxidative stress-induced cell death. J Bone Miner Res (2013) 0.87

Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species. Biochem Biophys Res Commun (2011) 0.87

Presence and importance of connexin43 during myogenesis. Cell Commun Adhes (2003) 0.87

Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: involvement of ATP released via pannexin 1 channels. Glia (2013) 0.86