Published in Eur J Cell Biol on April 02, 2011
Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein. Biochemistry (2013) 1.07
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase. J Am Chem Soc (2013) 0.93
Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging. Exp Brain Res (2011) 0.93
Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina. PLoS One (2012) 0.86
APP Receptor? To Be or Not To Be. Trends Pharmacol Sci (2016) 0.85
Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One (2012) 0.81
Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells. Int J Oncol (2012) 0.80
Proteomic analysis of the presynaptic active zone. Exp Brain Res (2012) 0.79
Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix. Biophys J (2014) 0.79
Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration. J Neurosci (2016) 0.78
Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization. J Biol Chem (2014) 0.77
Combined immunotherapy with "anti-insulin resistance" therapy as a novel therapeutic strategy against neurodegenerative diseases. NPJ Parkinsons Dis (2017) 0.75
Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus. Front Mol Neurosci (2016) 0.75
APP-A Novel Player within the Presynaptic Active Zone Proteome. Front Mol Neurosci (2017) 0.75
Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell (2016) 0.75
Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences. Front Mol Neurosci (2017) 0.75
Backbone hydrogen bond strengths can vary widely in transmembrane helices. J Am Chem Soc (2017) 0.75
De novo determination of peptide structure with solid-state magic-angle spinning NMR spectroscopy. Proc Natl Acad Sci U S A (2002) 2.66
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J (2007) 2.61
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proc Natl Acad Sci U S A (2004) 1.83
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. EMBO J (2011) 1.80
A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade. J Neurochem (2004) 1.68
Ultrahigh resolution in proton solid-state NMR spectroscopy at high levels of deuteration. Angew Chem Int Ed Engl (2006) 1.58
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol (2004) 1.56
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat Chem Biol (2011) 1.54
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A (2010) 1.47
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice. Proc Natl Acad Sci U S A (2003) 1.46
Solid-state NMR of proteins sedimented by ultracentrifugation. Proc Natl Acad Sci U S A (2011) 1.38
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem (2003) 1.38
Proton-detected solid-state NMR spectroscopy of fibrillar and membrane proteins. Angew Chem Int Ed Engl (2011) 1.36
Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity. J Neurosci (2009) 1.34
Characterization of chemical exchange between soluble and aggregated states of beta-amyloid by solution-state NMR upon variation of salt conditions. Biochemistry (2005) 1.32
A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Mol Cell Biol (2006) 1.30
Determination of multiple torsion-angle constraints in U-(13)C,(15)N-labeled peptides: 3D (1)H-(15)N-(13)C-(1)H dipolar chemical shift NMR spectroscopy in rotating solids. J Am Chem Soc (2002) 1.30
Structure calculation from unambiguous long-range amide and methyl 1H-1H distance restraints for a microcrystalline protein with MAS solid-state NMR spectroscopy. J Am Chem Soc (2011) 1.29
Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP. J Biol Chem (2008) 1.29
Characterization of membrane proteins in isolated native cellular membranes by dynamic nuclear polarization solid-state NMR spectroscopy without purification and reconstitution. Angew Chem Int Ed Engl (2011) 1.28
Large protein complexes with extreme rotational correlation times investigated in solution by magic-angle-spinning NMR spectroscopy. J Am Chem Soc (2009) 1.28
Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. J Biol Chem (2010) 1.22
Sensitivity enhancement using paramagnetic relaxation in MAS solid-state NMR of perdeuterated proteins. J Magn Reson (2007) 1.22
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. J Neural Transm (Vienna) (2009) 1.22
Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif. J Biol Chem (2010) 1.21
Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem (2010) 1.18
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease. Acta Neuropathol (2006) 1.16
Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers. J Mol Biol (2012) 1.16
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. J Cell Sci (2009) 1.14
Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc. Nucleic Acids Res (2006) 1.14
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. J Lipid Res (2002) 1.13
Protein side-chain dynamics as observed by solution- and solid-state NMR spectroscopy: a similarity revealed. J Am Chem Soc (2008) 1.13
1H detection in MAS solid-state NMR spectroscopy of biomacromolecules employing pulsed field gradients for residual solvent suppression. J Am Chem Soc (2003) 1.12
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice. Brain Pathol (2002) 1.11
High resolution 1H detected 1H,13C correlation spectra in MAS solid-state NMR using deuterated proteins with selective 1H,2H isotopic labeling of methyl groups. J Am Chem Soc (2006) 1.09
In support of the BMRB. Nat Struct Mol Biol (2012) 1.09
The Mechanism of nucleotide-assisted molybdenum insertion into molybdopterin. A novel route toward metal cofactor assembly. J Biol Chem (2006) 1.09
IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways. J Biol Chem (2007) 1.09
Optimum levels of exchangeable protons in perdeuterated proteins for proton detection in MAS solid-state NMR spectroscopy. J Biomol NMR (2009) 1.08
Proton-detected solid-state NMR spectroscopy at aliphatic sites: application to crystalline systems. Acc Chem Res (2013) 1.07
Proton-detected scalar coupling based assignment strategies in MAS solid-state NMR spectroscopy applied to perdeuterated proteins. J Magn Reson (2008) 1.06
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. J Biol Chem (2004) 1.05
The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species. J Biol Chem (2012) 1.05
Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene. J Biol Chem (2004) 1.04
Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies. J Biol Chem (2003) 1.04
The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators. Biochemistry (2011) 1.03
Residual methyl protonation in perdeuterated proteins for multi-dimensional correlation experiments in MAS solid-state NMR spectroscopy. J Magn Reson (2008) 1.03
Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein. J Biol Chem (2003) 1.03
An asymmetric dimer as the basic subunit in Alzheimer's disease amyloid β fibrils. Angew Chem Int Ed Engl (2012) 1.03
Detection of dynamic water molecules in a microcrystalline sample of the SH3 domain of alpha-spectrin by MAS solid-state NMR. J Biomol NMR (2005) 1.02
Yeast prion-protein, sup35, fibril formation proceeds by addition and substraction of oligomers. Chembiochem (2006) 1.02
Bacterial inclusion bodies of Alzheimer's disease β-amyloid peptides can be employed to study native-like aggregation intermediate states. Chembiochem (2011) 1.01
Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease. J Biol Chem (2004) 1.00
NMR spectroscopy of soluble protein complexes at one mega-dalton and beyond. Angew Chem Int Ed Engl (2013) 0.98
Microsecond time scale mobility in a solid protein as studied by the 15N R(1rho) site-specific NMR relaxation rates. J Am Chem Soc (2010) 0.98
High resolution 1H-detected solid-state NMR spectroscopy of protein aliphatic resonances: access to tertiary structure information. J Am Chem Soc (2010) 0.98
Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation. J Biol Chem (2002) 0.97
Accurate determination of order parameters from 1H,15N dipolar couplings in MAS solid-state NMR experiments. J Am Chem Soc (2009) 0.96
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem (2009) 0.96
Methyl rotation barriers in proteins from 2H relaxation data. Implications for protein structure. J Am Chem Soc (2007) 0.96
Interaction kinetics of the copper-responsive CopY repressor with the cop promoter of Enterococcus hirae. J Biol Inorg Chem (2004) 0.95
Structure and orientation of peptide inhibitors bound to beta-amyloid fibrils. J Mol Biol (2005) 0.95
Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. J Neurosci (2002) 0.94
Differential line broadening in MAS solid-state NMR due to dynamic interference. J Am Chem Soc (2007) 0.94
Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain. J Mol Biol (2012) 0.93
Proteome of metastatic canine mammary carcinomas: similarities to and differences from human breast cancer. J Proteome Res (2010) 0.93
Human BACE forms dimers and colocalizes with APP. J Biol Chem (2004) 0.92
The conformation of cyclo(-D-Pro-Ala4-) as a model for cyclic pentapeptides of the DL4 type. J Am Chem Soc (2006) 0.92
Importance of low-oligomeric-weight species for prion propagation in the yeast prion system Sup35/Hsp104. Proc Natl Acad Sci U S A (2003) 0.92
Periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter is sufficient to bind the maltose binding protein MalE. Biochemistry (2009) 0.92
Protein-RNA interfaces probed by 1H-detected MAS solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2013) 0.92
The proton-pump inhibitor lansoprazole enhances amyloid beta production. PLoS One (2013) 0.91
Combined analysis of (15)N relaxation data from solid- and solution-state NMR spectroscopy. J Am Chem Soc (2007) 0.91
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment. Neurobiol Dis (2003) 0.91
alphaB-crystallin competes with Alzheimer's disease beta-amyloid peptide for peptide-peptide interactions and induces oxidation of Abeta-Met35. FEBS Lett (2006) 0.91
Comparison of solid-state dipolar couplings and solution relaxation data provides insight into protein backbone dynamics. J Am Chem Soc (2010) 0.91
The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo. J Biol Chem (2005) 0.91
Measurement of 15N-T1 relaxation rates in a perdeuterated protein by magic angle spinning solid-state nuclear magnetic resonance spectroscopy. J Chem Phys (2008) 0.90
Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial. J Neural Transm (Vienna) (2008) 0.89
Direct observation of millisecond to second motions in proteins by dipolar CODEX NMR spectroscopy. J Am Chem Soc (2009) 0.88
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases. J Biol Chem (2010) 0.88
MAS solid-state NMR studies on the multidrug transporter EmrE. Biochim Biophys Acta (2007) 0.88
Cryogenic solid state NMR studies of fibrils of the Alzheimer's disease amyloid-β peptide: perspectives for DNP. J Biomol NMR (2013) 0.87
Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease. J Alzheimers Dis (2005) 0.87
Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions. J Biol Chem (2013) 0.87
Probing surface accessibility of proteins using paramagnetic relaxation in solid-state NMR spectroscopy. J Am Chem Soc (2009) 0.86
Structural and mechanistic implications of metal binding in the small heat-shock protein αB-crystallin. J Biol Chem (2011) 0.86
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cell Mol Life Sci (2011) 0.86
Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial. J Neural Transm (Vienna) (2008) 0.85
Involvement of amyloid beta precursor protein (AbetaPP) modulated copper homeostasis in Alzheimer's disease. J Alzheimers Dis (2005) 0.85
Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation. J Biol Chem (2011) 0.85
Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels. J Mol Med (Berl) (2007) 0.85
Dynamics in the solid-state: perspectives for the investigation of amyloid aggregates, membrane proteins and soluble protein complexes. J Biomol NMR (2014) 0.85
Optimal degree of protonation for ¹H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency. J Biomol NMR (2012) 0.84
Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers. EMBO Mol Med (2012) 0.84
Quantitative analysis of backbone motion in proteins using MAS solid-state NMR spectroscopy. J Biomol NMR (2009) 0.84
High-resolution double-quantum deuterium magic angle spinning solid-state NMR spectroscopy of perdeuterated proteins. J Am Chem Soc (2009) 0.83