Antibiotics trapping transcription initiation intermediates: To melt or to bend, what's first?

Coupling of downstream RNA polymerase-promoter interactions with formation of catalytically competent transcription initiation complex. J Mol Biol (2014) 0.84

The sigma 70 family: sequence conservation and evolutionary relationships. J Bacteriol (1992) 9.07

Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science (2001) 8.92

Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution. Nature (2002) 6.74

Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution. Science (2002) 5.18

Structural basis for transcription elongation by bacterial RNA polymerase. Nature (2007) 5.09

Structural organization of bacterial RNA polymerase holoenzyme and the RNA polymerase-promoter open complex. Cell (2002) 3.21

Antibiotics as signalling molecules. Philos Trans R Soc Lond B Biol Sci (2007) 2.74

Kinetics of open complex formation between Escherichia coli RNA polymerase and the lac UV5 promoter. Evidence for a sequential mechanism involving three steps. Biochemistry (1985) 2.71

Allosteric control of Escherichia coli rRNA promoter complexes by DksA. Genes Dev (2009) 2.59

Topography of intermediates in transcription initiation of E.coli. EMBO J (1990) 2.16

The RNA polymerase "switch region" is a target for inhibitors. Cell (2008) 1.96

Kinetic studies and structural models of the association of E. coli sigma(70) RNA polymerase with the lambdaP(R) promoter: large scale conformational changes in forming the kinetically significant intermediates. J Mol Biol (2002) 1.83

The downstream DNA jaw of bacterial RNA polymerase facilitates both transcriptional initiation and pausing. J Biol Chem (2002) 1.79

Changes in the DNA structure of the lac UV5 promoter during formation of an open complex with Escherichia coli RNA polymerase. Biochemistry (1985) 1.69

DNA footprints of the two kinetically significant intermediates in formation of an RNA polymerase-promoter open complex: evidence that interactions with start site and downstream DNA induce sequential conformational changes in polymerase and DNA. J Mol Biol (1998) 1.64

Transcription inactivation through local refolding of the RNA polymerase structure. Nature (2008) 1.63

Real-time footprinting of DNA in the first kinetically significant intermediate in open complex formation by Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A (2007) 1.44

Intermediates in the formation of the open complex by RNA polymerase holoenzyme containing the sigma factor sigma 32 at the groE promoter. J Mol Biol (1989) 1.28

Evidence for a tyrosine-adenine stacking interaction and for a short-lived open intermediate subsequent to initial binding of Escherichia coli RNA polymerase to promoter DNA. J Mol Biol (2008) 1.17

Probing DNA binding, DNA opening, and assembly of a downstream clamp/jaw in Escherichia coli RNA polymerase-lambdaP(R) promoter complexes using salt and the physiological anion glutamate. Biochemistry (2010) 1.07

One-step DNA melting in the RNA polymerase cleft opens the initiation bubble to form an unstable open complex. Proc Natl Acad Sci U S A (2010) 1.05

The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site. EMBO J (2010) 1.02

Dissection of two hallmarks of the open promoter complex by mutation in an RNA polymerase core subunit. J Biol Chem (2000) 1.02

Remodeling of the sigma70 subunit non-template DNA strand contacts during the final step of transcription initiation. J Mol Biol (2005) 0.99

Promoter melting triggered by bacterial RNA polymerase occurs in three steps. Proc Natl Acad Sci U S A (2010) 0.97

DNA melting by RNA polymerase at the T7A1 promoter precedes the rate-limiting step at 37 degrees C and results in the accumulation of an off-pathway intermediate. Nucleic Acids Res (2009) 0.94

Inhibition by lipiarmycin of bacteriophage growth in Bacillus subtilis. J Virol (1980) 0.94

Multiple roles of the RNA polymerase {beta}' SW2 region in transcription initiation, promoter escape, and RNA elongation. Nucleic Acids Res (2010) 0.92

Frequency and characterisation of spontaneous lipiarmycin-resistant Enterococcus faecalis mutants selected in vitro. Int J Antimicrob Agents (2009) 0.90

Conformational changes in E. coli RNA polymerase during promoter recognition. Nucleic Acids Res (1993) 0.86

[Mutations in beta'-subunit of the Escherichia coli RNA-polymerase influence interaction with downstream duplex DNA in the elongation complex]. Genetika (2002) 0.78

Topography of lacUV5 initiation complexes. Nucleic Acids Res (2001) 0.77