Antibiotics as signalling molecules.

Bacterial competition: surviving and thriving in the microbial jungle. Nat Rev Microbiol (2010) 5.63

Biofilms. Cold Spring Harb Perspect Biol (2010) 3.10

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A (2009) 2.86

Going back to the roots: the microbial ecology of the rhizosphere. Nat Rev Microbiol (2013) 2.73

Redox-active antibiotics control gene expression and community behavior in divergent bacteria. Science (2008) 2.70

Regulation of fungal secondary metabolism. Nat Rev Microbiol (2012) 2.45

Biofilm Formation As a Response to Ecological Competition. PLoS Biol (2015) 2.42

Nonoptimal microbial response to antibiotics underlies suppressive drug interactions. Cell (2009) 2.27

Molecular regulation of antibiotic biosynthesis in streptomyces. Microbiol Mol Biol Rev (2013) 2.24

Identifying producers of antibacterial compounds by screening for antibiotic resistance. Nat Biotechnol (2013) 2.02

Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli. J Bacteriol (2008) 2.01

Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. ISME J (2009) 1.94

The role of natural environments in the evolution of resistance traits in pathogenic bacteria. Proc Biol Sci (2009) 1.94

The neglected intrinsic resistome of bacterial pathogens. PLoS One (2008) 1.82

Chemical decay of an antibiotic inverts selection for resistance. Nat Chem Biol (2010) 1.80

Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. Eukaryot Cell (2008) 1.73

Symbiotic Streptomycetes provide antibiotic combination prophylaxis for wasp offspring. Nat Chem Biol (2010) 1.66

Resolution of gene regulatory conflicts caused by combinations of antibiotics. Mol Cell (2011) 1.65

Bacterial conversations: talking, listening and eavesdropping. An introduction. Philos Trans R Soc Lond B Biol Sci (2007) 1.64

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. PLoS Pathog (2010) 1.63

The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes. Chem Biol (2015) 1.57

Microbial metabolic exchange--the chemotype-to-phenotype link. Nat Chem Biol (2011) 1.55

Antibiotics as signal molecules. Chem Rev (2011) 1.54

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A (2011) 1.41

Exit from dormancy in microbial organisms. Nat Rev Microbiol (2010) 1.35

The natural history of antibiotics. Curr Biol (2009) 1.32

Antibiotic resistance shaping multi-level population biology of bacteria. Front Microbiol (2013) 1.22

Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures. Biochemistry (2008) 1.22

Acyl-homoserine lactone-dependent eavesdropping promotes competition in a laboratory co-culture model. ISME J (2012) 1.21

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters. Proc Natl Acad Sci U S A (2014) 1.20

Selective advantage of resistant strains at trace levels of antibiotics: a simple and ultrasensitive color test for detection of antibiotics and genotoxic agents. Antimicrob Agents Chemother (2011) 1.19

Evolutionary consequences of antibiotic use for the resistome, mobilome and microbial pangenome. Front Microbiol (2013) 1.17

The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. J Bacteriol (2008) 1.11

The spectral networks paradigm in high throughput mass spectrometry. Mol Biosyst (2012) 1.11

Concentration-dependent activity of antibiotics in natural environments. Front Microbiol (2013) 1.06

Sympatric inhibition and niche differentiation suggest alternative coevolutionary trajectories among Streptomycetes. ISME J (2013) 1.05

The intrinsic resistome of bacterial pathogens. Front Microbiol (2013) 1.05

Extracellular signaling and multicellularity in Bacillus subtilis. Curr Opin Microbiol (2011) 1.04

Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. Proc Natl Acad Sci U S A (2011) 1.04

Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope. BMC Genomics (2011) 1.03

Natural antibiotic resistance and contamination by antibiotic resistance determinants: the two ages in the evolution of resistance to antimicrobials. Front Microbiol (2012) 1.03

The roles of RNA in the synthesis of protein. Cold Spring Harb Perspect Biol (2011) 1.03

The genome sequence of Streptomyces lividans 66 reveals a novel tRNA-dependent peptide biosynthetic system within a metal-related genomic island. Genome Biol Evol (2013) 1.02

Angucyclines as signals modulate the behaviors of Streptomyces coelicolor. Proc Natl Acad Sci U S A (2014) 1.01

A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1. Proc Natl Acad Sci U S A (2010) 0.97

Tobramycin at subinhibitory concentration inhibits the RhlI/R quorum sensing system in a Pseudomonas aeruginosa environmental isolate. BMC Infect Dis (2010) 0.96

Distinct growth strategies of soil bacteria as revealed by large-scale colony tracking. Appl Environ Microbiol (2011) 0.96

Dynamics of symbiont-mediated antibiotic production reveal efficient long-term protection for beewolf offspring. Front Zool (2013) 0.95

Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. J Am Chem Soc (2011) 0.95

Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants. Environ Microbiol Rep (2009) 0.95

Resource amendments influence density and competitive phenotypes of Streptomyces in soil. Microb Ecol (2008) 0.94

Antibiotics as selectors and accelerators of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases world. Front Microbiol (2013) 0.93

A function of SmeDEF, the major quinolone resistance determinant of Stenotrophomonas maltophilia, is the colonization of plant roots. Appl Environ Microbiol (2014) 0.93

The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes. Curr Opin Microbiol (2011) 0.91

Emergence and spread of antibiotic resistance: setting a parameter space. Ups J Med Sci (2014) 0.90

Carbapenem resistance in Elizabethkingia meningoseptica is mediated by metallo-β-lactamase BlaB. Antimicrob Agents Chemother (2012) 0.89

Intrinsic Antimicrobial Resistance Determinants in the Superbug Pseudomonas aeruginosa. MBio (2015) 0.89

Immunomodulatory and protective roles of quorum-sensing signaling molecules N-acyl homoserine lactones during infection of mice with Aeromonas hydrophila. Infect Immun (2011) 0.88

Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. J Am Chem Soc (2017) 0.86

Functional characterization of bacteria isolated from ancient arctic soil exposes diverse resistance mechanisms to modern antibiotics. PLoS One (2015) 0.86

Biotic acts of antibiotics. Front Microbiol (2013) 0.86

Examining the evolution of the regulatory circuit controlling secondary metabolism and development in the fungal genus Aspergillus. PLoS Genet (2015) 0.85

Quorum sensing influences Vibrio harveyi growth rates in a manner not fully accounted for by the marker effect of bioluminescence. PLoS One (2008) 0.85

Association of fungal secondary metabolism and sclerotial biology. Front Microbiol (2015) 0.84

Pseudomonas aeruginosa syntrophy in chronically colonized airways of cystic fibrosis patients. Antimicrob Agents Chemother (2012) 0.84

Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenal. Front Microbiol (2015) 0.84

The enzymes of bacterial census and censorship. Trends Biochem Sci (2011) 0.83

Beta- lactam antibiotics stimulate biofilm formation in non-typeable haemophilus influenzae by up-regulating carbohydrate metabolism. PLoS One (2014) 0.83

Antibiotic resistance is widespread in urban aquatic environments of Rio de Janeiro, Brazil. Microb Ecol (2014) 0.83

The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species. Microbiol Mol Biol Rev (2016) 0.82

Inhibition of Cell Differentiation in Bacillus subtilis by Pseudomonas protegens. J Bacteriol (2015) 0.82

Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity. PLoS One (2014) 0.81

The freshwater sponge Ephydatia fluviatilis harbours diverse Pseudomonas species (Gammaproteobacteria, Pseudomonadales) with broad-spectrum antimicrobial activity. PLoS One (2014) 0.81

Intraspecies comparison of Streptomyces pratensis genomes reveals high levels of recombination and gene conservation between strains of disparate geographic origin. BMC Genomics (2014) 0.80

Fighting microbial drug resistance: a primer on the role of evolutionary biology in public health. Evol Appl (2015) 0.80

Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery. Antibiotics (Basel) (2014) 0.80

Genomics of sponge-associated Streptomyces spp. closely related to Streptomyces albus J1074: insights into marine adaptation and secondary metabolite biosynthesis potential. PLoS One (2014) 0.79

Multifaceted Interfaces of Bacterial Competition. J Bacteriol (2016) 0.79

Prescreening bacterial colonies for bioactive molecules with Janus plates, a SBS standard double-faced microbial culturing system. Antonie Van Leeuwenhoek (2012) 0.79

Leveraging ecological theory to guide natural product discovery. J Ind Microbiol Biotechnol (2015) 0.78

Antidiabetic effect of Sida cordata in alloxan induced diabetic rats. Biomed Res Int (2014) 0.78

Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle. BMC Genomics (2016) 0.78

Quantitative proteome profiling of C. burnetii under tetracycline stress conditions. PLoS One (2012) 0.78

Genomic analysis reveals distinct concentration-dependent evolutionary trajectories for antibiotic resistance in Escherichia coli. DNA Res (2014) 0.77

Developmental plasticity of bacterial colonies and consortia in germ-free and gnotobiotic settings. BMC Microbiol (2012) 0.77

Mechanisms of resistance in bacteria: an evolutionary approach. Open Microbiol J (2013) 0.77

Natural products from microbes associated with insects. Beilstein J Org Chem (2016) 0.77

Theory of the origin, evolution, and nature of life. Life (Basel) (2011) 0.76

Sublethal Concentrations of Antibiotics Cause Shift to Anaerobic Metabolism in Listeria monocytogenes and Induce Phenotypes Linked to Antibiotic Tolerance. Front Microbiol (2016) 0.76

Antibiotics trapping transcription initiation intermediates: To melt or to bend, what's first? Transcription (2011) 0.76

Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes. Bioorg Med Chem Lett (2016) 0.75

Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules. FEMS Microbiol Rev (2016) 0.75

Regulation of Secondary Metabolism by the Velvet Complex Is Temperature-Responsive in Aspergillus. G3 (Bethesda) (2016) 0.75

Novel mechanism of metabolic co-regulation coordinates the biosynthesis of secondary metabolites in Pseudomonas protegens. Elife (2017) 0.75

Protein as chemical cue: non-nutritional growth enhancement by exogenous protein in Pseudomonas putida KT2440. PLoS One (2014) 0.75

Microbiology and ecology are vitally important to premedical curricula. Evol Med Public Health (2015) 0.75

A Decade-Long Commitment to Antimicrobial Resistance Surveillance in Portugal. Front Microbiol (2016) 0.75

Advances in industrial microbiome based on microbial consortium for biorefinery. Bioresour Bioprocess (2017) 0.75

Effect of antibiotics on bacterial populations: a multi-hierachical selection process. F1000Res (2017) 0.75

The evolution of no-cost resistance at sub-MIC concentrations of streptomycin in Streptomyces coelicolor. ISME J (2017) 0.75

Prokaryotes: the unseen majority. Proc Natl Acad Sci U S A (1998) 21.41

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature (2002) 19.35

Computational improvements reveal great bacterial diversity and high metal toxicity in soil. Science (2005) 9.75

Sampling the antibiotic resistome. Science (2006) 7.27

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature (2005) 7.19

Bacteriocins: developing innate immunity for food. Nat Rev Microbiol (2005) 5.77

Aminoglycoside antibiotics induce bacterial biofilm formation. Nature (2005) 4.93

Communication in bacteria: an ecological and evolutionary perspective. Nat Rev Microbiol (2006) 4.44

Look who's talking: communication and quorum sensing in the bacterial world. Philos Trans R Soc Lond B Biol Sci (2007) 4.24

The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol (2000) 4.10

The bacterial ribosome as a target for antibiotics. Nat Rev Microbiol (2005) 3.27

Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proc Natl Acad Sci U S A (2002) 3.25

Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa. Mol Microbiol (2003) 3.06

The world of subinhibitory antibiotic concentrations. Curr Opin Microbiol (2006) 2.89

The ecological role of bacteriocins in bacterial competition. Trends Microbiol (1999) 2.42

Small molecules: the missing link in the central dogma. Nat Chem Biol (2005) 2.40

Bacterial cell-to-cell communication: sorry, can't talk now - gone to lunch! Curr Opin Microbiol (2002) 2.31

Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals. Proc Natl Acad Sci U S A (2003) 2.26

Circularization of Tn916 is required for expression of the transposon-encoded transfer functions: characterization of long tetracycline-inducible transcripts reading through the attachment site. Mol Microbiol (1998) 2.19

Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa. J Bacteriol (2005) 2.07

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc Natl Acad Sci U S A (2004) 2.05

Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2001) 1.86

Quorum-quenching microbial infections: mechanisms and implications. Philos Trans R Soc Lond B Biol Sci (2007) 1.85

Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens. Philos Trans R Soc Lond B Biol Sci (2007) 1.70

Evolutionary theory of bacterial quorum sensing: when is a signal not a signal? Philos Trans R Soc Lond B Biol Sci (2007) 1.69

Ciprofloxacin and trimethoprim cause phage induction and virulence modulation in Staphylococcus aureus. Antimicrob Agents Chemother (2006) 1.51

The smallest known gene. Nature (1994) 1.38

N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus. Infect Immun (2006) 1.35

sinI- and expR-dependent quorum sensing in Sinorhizobium meliloti. J Bacteriol (2005) 1.27

Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria. Philos Trans R Soc Lond B Biol Sci (2007) 1.25

Transcription modulation of Salmonella enterica serovar Typhimurium promoters by sub-MIC levels of rifampin. J Bacteriol (2006) 1.23

Effect of antibiotics on group A Streptococcus exoprotein production analyzed by two-dimensional gel electrophoresis. Antimicrob Agents Chemother (2005) 1.21

Quorum-sensing regulation in rhizobia and its role in symbiotic interactions with legumes. Philos Trans R Soc Lond B Biol Sci (2007) 1.21

Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A. Antimicrob Agents Chemother (2003) 1.20

Cross-kingdom signalling: exploitation of bacterial quorum sensing molecules by the green seaweed Ulva. Philos Trans R Soc Lond B Biol Sci (2007) 1.19

Small bugs, big business: the economic power of the microbe. Biotechnol Adv (2000) 1.12

Induction of fibronectin adhesins in quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin or by sigma B transcription factor activity is mediated by two separate pathways. Antimicrob Agents Chemother (2005) 1.03

The combinatorial chemistry of nature. Nature (1996) 1.03

Subinhibitory cerulenin inhibits staphylococcal exoprotein production by blocking transcription rather than by blocking secretion. Microbiology (2005) 0.92

Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Microbiol (2010) 4.22

Tackling antibiotic resistance. Nat Rev Microbiol (2011) 3.95

Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proc Natl Acad Sci U S A (2002) 3.25

Molecular characterization of bacterial diversity from British Columbia forest soils subjected to disturbance. Can J Microbiol (2002) 2.61

The truth about antibiotics. Int J Med Microbiol (2006) 1.68

Serum proprotein convertase subtilisin kexin type 9 is correlated directly with serum LDL cholesterol. Clin Chem (2007) 1.58

Catabolism of benzoate and phthalate in Rhodococcus sp. strain RHA1: redundancies and convergence. J Bacteriol (2005) 1.56

Magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. Alcohol Clin Exp Res (2009) 1.52

Molecular characterization of bacterial diversity in Lodgepole pine (Pinus contorta) rhizosphere soils from British Columbia forest soils differing in disturbance and geographic source. FEMS Microbiol Ecol (2002) 1.47

Transcription modulation of Salmonella enterica serovar Typhimurium promoters by sub-MIC levels of rifampin. J Bacteriol (2006) 1.23

Bacterial single-stranded DNA-binding proteins are phosphorylated on tyrosine. Nucleic Acids Res (2006) 1.19

Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus. Antimicrob Agents Chemother (2008) 1.17

Bugs, drugs and chemical genomics. Nat Chem Biol (2011) 1.15

Novel pathway of salicylate degradation by Streptomyces sp. strain WA46. Appl Environ Microbiol (2004) 1.14

Neuropyschological and behavioral outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. Can J Clin Pharmacol (2009) 1.14

Functional characterization of a catabolic plasmid from polychlorinated- biphenyl-degrading Rhodococcus sp. strain RHA1. J Bacteriol (2004) 1.12

Dual effects of MLS antibiotics: transcriptional modulation and interactions on the ribosome. Chem Biol (2004) 1.12

β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice. Arthritis Rheum (2012) 1.10

Modulation of virulence gene expression by cell wall active antibiotics in Staphylococcus aureus. J Antimicrob Chemother (2011) 1.07

Molecular characterization of class 3 integrons from Delftia spp. J Bacteriol (2007) 1.01

Cladoniamides A-G, tryptophan-derived alkaloids produced in culture by Streptomyces uncialis. Org Lett (2008) 1.01

Enhancing antibiotic activity: a strategy to control Acinetobacter infections. J Antimicrob Chemother (2009) 1.00

Functional magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. J Neurodev Disord (2009) 0.97

Complex integrons containing qnrB4-ampC (bla(DHA-1)) in plasmids of multidrug-resistant Citrobacter freundii from wastewater. Can J Microbiol (2012) 0.96

Magnetic resonance spectroscopy outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. Magn Reson Imaging (2009) 0.95

Cultivation-dependent characterization of bacterial diversity from British Columbia forest soils subjected to disturbance. Can J Microbiol (2002) 0.95

Phenotypic changes in ciprofloxacin-resistant Staphylococcus aureus. Res Microbiol (2009) 0.94

Improved lux reporters for use in Staphylococcus aureus. Plasmid (2009) 0.94

Roles of ring-hydroxylating dioxygenases in styrene and benzene catabolism in Rhodococcus jostii RHA1. J Bacteriol (2007) 0.92

Heterologous production of daptomycin in Streptomyces lividans. J Ind Microbiol Biotechnol (2005) 0.91

Identifying protein kinase inhibitors using an assay based on inhibition of aerial hyphae formation in Streptomyces. J Antibiot (Tokyo) (2002) 0.88

Immunohistochemical application of a highly sensitive and specific murine monoclonal antibody recognising the extracellular domain of the human hepatocyte growth factor receptor (MET). Histopathology (2014) 0.85

Molecular cloning of streptomyces genes encoding vanillate demethylase. Biosci Biotechnol Biochem (2006) 0.85

Actinobacteria: the good, the bad, and the ugly. Antonie Van Leeuwenhoek (2010) 0.84

Antimicrobial resistance gene delivery in animal feeds. Emerg Infect Dis (2004) 0.84

Herbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10. J Nat Prod (2014) 0.82

Coumabiocins A-F, aminocoumarins from an organic extract of Streptomyces sp. L-4-4. J Nat Prod (2010) 0.81

Staphylococcus aureus promoter-lux reporters for drug discovery. J Antibiot (Tokyo) (2010) 0.80

Characterization of a mycothiol ligase mutant of Rhodococcus jostii RHA1. Res Microbiol (2008) 0.78

Class 1 and class 2 integrons in multidrug-resistant gram-negative bacteria isolated from the Salmon River, British Columbia. Can J Microbiol (2011) 0.77

Underappreciated role of regionally poor water quality on globally increasing antibiotic resistance. Environ Sci Technol (2014) 0.77

Isolation and characterization of Streptomyces sp. NL15-2K capable of degrading lignin-related aromatic compounds. J Biosci Bioeng (2006) 0.77

Characterization of two isozymes of coniferyl alcohol dehydrogenase from Streptomyces sp. NL15-2K. Biosci Biotechnol Biochem (2011) 0.77

Proteomic analysis of survival of Rhodococcus jostii RHA1 during carbon starvation. Appl Environ Microbiol (2012) 0.77

Sanitation: Sewage recycles antibiotic resistance. Nature (2012) 0.75

Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers. Emerg Infect Dis (2022) 0.75

Antibiotic Resistance in and from Nature. Microbiol Spectr (2013) 0.75

Rhodococcus jostii: a home for Rhodococcus strain RHA1. Antonie Van Leeuwenhoek (2013) 0.75