Published in PLoS One on April 04, 2011
Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression. Arterioscler Thromb Vasc Biol (2012) 0.98
Involvement of heparanase in atherosclerosis and other vessel wall pathologies. Matrix Biol (2013) 0.93
Regulating intestinal function to reduce atherogenic lipoproteins. Clin Lipidol (2013) 0.79
Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. J Am Heart Assoc (2014) 0.76
Diet-induced hypercholesterolemia alters liver glycosaminoglycans and associated-lipoprotein receptors in rats. J Physiol Biochem (2017) 0.75
Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab (2007) 5.04
Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation (2007) 4.62
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med (1999) 4.22
Atherogenesis: a postprandial phenomenon. Circulation (1979) 3.74
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest (2007) 2.53
Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler Thromb (1992) 2.31
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate. Curr Pharm Des (2007) 2.14
Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet. Circ Res (2007) 1.94
Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol (2009) 1.72
Human heparanase. Purification, characterization, cloning, and expression. J Biol Chem (1999) 1.69
Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. Cancer Metastasis Rev (1990) 1.66
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J (2004) 1.64
Molecular processes that handle -- and mishandle -- dietary lipids. J Clin Invest (2008) 1.60
Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Circ Cardiovasc Genet (2010) 1.60
Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J Clin Invest (2009) 1.56
The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro. J Clin Invest (1997) 1.55
Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing. J Clin Invest (2007) 1.54
Cell-surface heparan sulfate proteoglycans: dynamic molecules mediating ligand catabolism. Curr Opin Lipidol (1997) 1.53
12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice. Circulation (2001) 1.45
Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque. Arterioscler Thromb (1994) 1.42
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis. Proc Natl Acad Sci U S A (2005) 1.37
Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation (1999) 1.18
Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism. J Biol Chem (2000) 1.13
Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both. J Biol Chem (1996) 1.12
Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver: in vivo role of heparan sulfate proteoglycans. J Lipid Res (1995) 1.12
Recent insights into factors affecting remnant lipoprotein uptake. Curr Opin Lipidol (2010) 1.06
PI-88: a novel inhibitor of angiogenesis. Expert Opin Investig Drugs (2008) 0.99
Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice. J Clin Invest (2000) 0.98
Postprandial metabolism of apolipoprotein B-48- and B-100-containing particles in type 2 diabetes mellitus: relations to angiographically verified severity of coronary artery disease. Atherosclerosis (2000) 0.98
Liposome-like particles isolated from human atherosclerotic plaques are structurally and compositionally similar to surface remnants of triglyceride-rich lipoproteins. Arterioscler Thromb (1994) 0.96
Lipoprotein lipase bound to apolipoprotein B lipoproteins accelerates clearance of postprandial lipoproteins in humans. Arterioscler Thromb Vasc Biol (2006) 0.95
Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II. Diabetes (2005) 0.94
Hepatic clearance of chylomicron remnants in mice lacking apoprotein E. Biochim Biophys Acta (1994) 0.87
Reduced body fat and increased hepatic lipid synthesis in mice bearing interleukin-6-secreting tumor. Am J Physiol Endocrinol Metab (2001) 0.84
Delayed metabolism of postprandial triglyceride-rich lipoproteins in subjects with echolucent carotid plaques. Lipids (2008) 0.77
Effect of chronic heparin administration on serum lipolytic activity and some aspects of lipid metabolism. Biochim Biophys Acta (1990) 0.77
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol (2006) 3.24
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. J Natl Cancer Inst (2004) 2.52
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis. J Biol Chem (2007) 2.25
Heparanase: busy at the cell surface. Trends Biochem Sci (2009) 2.07
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res (2006) 2.02
A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair. J Am Coll Cardiol (2003) 1.84
Processing and activation of latent heparanase occurs in lysosomes. J Cell Sci (2004) 1.82
Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis. Arterioscler Thromb Vasc Biol (2007) 1.79
Sex differences in giant cell arteritis. J Rheumatol (2002) 1.79
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. FEBS J (2010) 1.78
Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem (2004) 1.78
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest (2009) 1.73
Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Circ Res (2008) 1.64
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J (2004) 1.64
Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development. Semin Cancer Biol (2002) 1.57
Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res (2003) 1.54
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood (2010) 1.53
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting. J Biol Chem (2005) 1.52
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. Blood (2007) 1.49
Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J Biol Chem (2013) 1.49
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PLoS One (2009) 1.46
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. Proc Natl Acad Sci U S A (2002) 1.45
Cardiovascular risk assessment and treatment to target low density lipoprotein levels in hospitalized ischemic heart disease patients: results of the HOLEM study. Isr Med Assoc J (2005) 1.44
Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46. J Immunol (2004) 1.43
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. J Biol Chem (2004) 1.43
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment. J Biol Chem (2008) 1.43
Thoracic manifestations of Behçet disease at CT. Radiographics (2004) 1.43
Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer (2006) 1.42
Non-anticoagulant heparins and inhibition of cancer. Pathophysiol Haemost Thromb (2009) 1.41
Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice. Neurosci Lett (2011) 1.41
Heparanase mediates cell adhesion independent of its enzymatic activity. FASEB J (2003) 1.41
SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis. Clin Cancer Res (2011) 1.40
Echocardiographic manifestations of Adamantiades-Behcet's disease. Eur J Echocardiogr (2006) 1.40
Clinical problem-solving. A fractured diagnosis. N Engl J Med (2005) 1.40
Early treatment with activated protein C for meningococcal septic shock: case report and literature review. Intensive Care Med (2005) 1.40
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development (2007) 1.40
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis. Proc Natl Acad Sci U S A (2005) 1.37
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res (2008) 1.35
Role of endothelial heparanase in delayed-type hypersensitivity. Blood (2005) 1.35
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. Cancer Res (2009) 1.34
Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem (2003) 1.34
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J (2005) 1.32
Heparan sulfate is a cellular receptor for purified infectious prions. J Biol Chem (2005) 1.32
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. J Clin Invest (2011) 1.32
Heparanase induces VEGF C and facilitates tumor lymphangiogenesis. Int J Cancer (2008) 1.31
Heparanase is essential for the development of diabetic nephropathy in mice. Diabetes (2011) 1.29
The heparanase system and tumor metastasis: is heparanase the seed and soil? Cancer Metastasis Rev (2011) 1.28
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival. Neoplasia (2006) 1.28
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase. J Biol Chem (2005) 1.27
Heparin, heparan sulfate and heparanase in inflammatory reactions. Thromb Haemost (2009) 1.27
Function of heparanase in prostate tumorigenesis: potential for therapy. Clin Cancer Res (2008) 1.25
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate. Nat Chem Biol (2007) 1.25
The heparanase/syndecan-1 axis in cancer: mechanisms and therapies. FEBS J (2013) 1.24
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. J Biol Chem (2010) 1.19
Heterodimer formation is essential for heparanase enzymatic activity. Biochem Biophys Res Commun (2003) 1.17
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts. J Immunol (2004) 1.16
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins. FASEB J (2007) 1.14
Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans. PLoS One (2008) 1.14
Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase. J Biol Chem (2005) 1.13
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics. FASEB J (2009) 1.13
Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. J Cell Sci (2002) 1.12
Role of promoter methylation in regulation of the mammalian heparanase gene. Oncogene (2003) 1.12
Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass. J Cell Physiol (2006) 1.11
Familial Mediterranean fever and peritoneal malignant mesothelioma: a possible association? Isr Med Assoc J (2006) 1.10
Tumorigenic and adhesive properties of heparanase. Semin Cancer Biol (2010) 1.10
Regulation of heparanase gene expression by estrogen in breast cancer. Cancer Res (2003) 1.09
Heparanase upregulation by colonic epithelium in inflammatory bowel disease. Mod Pathol (2006) 1.09
Characterization of mechanisms involved in secretion of active heparanase. J Biol Chem (2006) 1.08
Human heparanase is localized within lysosomes in a stable form. Exp Cell Res (2002) 1.07
Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis. Cancer Res (2009) 1.07
Intracardiac mass as initial cardiac manifestation of Behçet's disease: think before you cut. Echocardiography (2014) 1.06
Improvement in cholesterol emboli syndrome after iloprost therapy. BMJ (2002) 1.05
Heparanase levels are elevated in the plasma of pediatric cancer patients and correlate with response to anticancer treatment. Neoplasia (2007) 1.04
Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase. Circ Res (2011) 1.04
Heparanase induces Akt phosphorylation via a lipid raft receptor. Biochem Biophys Res Commun (2007) 1.04
An ELISA method for the detection and quantification of human heparanase. Biochem Biophys Res Commun (2006) 1.03
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis. Proc Natl Acad Sci U S A (2009) 1.02
Pre-clinical and clinical significance of heparanase in Ewing's sarcoma. J Cell Mol Med (2011) 1.02
Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence. Mod Pathol (2006) 1.02
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels. PLoS One (2011) 1.01