Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects.

Regulation of hepatic glucose uptake and storage in vivo. Adv Nutr (2012) 1.44

Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans. Br J Pharmacol (2013) 1.14

Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. FASEB J (2013) 0.96

Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice. J Biol Chem (2013) 0.91

The new biology of diabetes. Diabetologia (2015) 0.89

Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase. Proc Natl Acad Sci U S A (2013) 0.88

Mutational analysis of allosteric activation and inhibition of glucokinase. Biochem J (2011) 0.87

Repair of diverse diabetic defects of β-cells in man and mouse by pharmacological glucokinase activation. Diabetes Obes Metab (2012) 0.85

Making β cells from adult cells within the pancreas. Curr Diab Rep (2013) 0.81

Red carpeting the newer antidiabetics. J Pharmacol Pharmacother (2012) 0.81

Functional characterization of MODY2 mutations highlights the importance of the fine-tuning of glucokinase and its role in glucose sensing. PLoS One (2012) 0.81

Thermal stability of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea. Biochim Biophys Acta (2012) 0.81

Addressing unmet medical needs in type 2 diabetes: a narrative review of drugs under development. Curr Diabetes Rev (2015) 0.79

Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence. Biochem J (2014) 0.79

Something old, something new and something very old: drugs for treating type 2 diabetes. Br J Pharmacol (2014) 0.79

Novel and emerging diabetes mellitus drug therapies for the type 2 diabetes patient. World J Diabetes (2014) 0.77

The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (2002) 5.09

Allosteric activators of glucokinase: potential role in diabetes therapy. Science (2003) 3.97

Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet (2003) 3.91

The initiation of liver development is dependent on Foxa transcription factors. Nature (2005) 3.88

KLF family members regulate intrinsic axon regeneration ability. Science (2009) 3.80

Extracting transcription factor targets from ChIP-Seq data. Nucleic Acids Res (2009) 3.58

Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology (2002) 3.39

Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab (2011) 3.35

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature (2008) 3.23

Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev (2002) 3.22

The evolution of Fox genes and their role in development and disease. Nat Rev Genet (2009) 3.13

Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08

Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55

Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell (2009) 2.55

Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology (2005) 2.53

Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes Dev (2011) 2.53

Epigenomic plasticity enables human pancreatic α to β cell reprogramming. J Clin Invest (2013) 2.38

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev (2008) 2.38

Foxa2 regulates alveolarization and goblet cell hyperplasia. Development (2004) 2.35

The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J (2007) 2.34

Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circ Res (2008) 2.30

Glucocorticoid receptor-dependent gene regulatory networks. PLoS Genet (2005) 2.19

The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol (2004) 2.19

Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev (2011) 2.17

Foxa2 integrates the transcriptional response of the hepatocyte to fasting. Cell Metab (2005) 2.15

Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem (2005) 2.15

Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell (2009) 2.14

The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14

Foxa2 is essential for mouse endometrial gland development and fertility. Biol Reprod (2010) 2.12

Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer. Cell (2012) 2.05

Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology (2006) 2.04

Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell (2012) 2.02

Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Genes Dev (2007) 1.97

MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function. Gastroenterology (2010) 1.95

Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting. Diabetes (2013) 1.90

Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev Biol (2005) 1.90

The transcriptional response of the islet to pregnancy in mice. Mol Endocrinol (2009) 1.89

Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab (2010) 1.88

FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (2010) 1.86

Foxl1 is a marker of bipotential hepatic progenitor cells in mice. Hepatology (2009) 1.82

Expansion of beta-cell mass in response to pregnancy. Trends Endocrinol Metab (2009) 1.81

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes (2006) 1.80

Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell (2013) 1.79

Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology (2007) 1.78

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J Clin Invest (2005) 1.78

Imaging pancreatic beta-cells in the intact pancreas. Am J Physiol Endocrinol Metab (2005) 1.74

Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology (2008) 1.72

Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res (2007) 1.71

The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse. BMC Dev Biol (2009) 1.66

FoxOs function synergistically to promote glucose production. J Biol Chem (2010) 1.66

Foxa2 controls vesicle docking and insulin secretion in mature Beta cells. Cell Metab (2007) 1.66

Defining pancreatic endocrine precursors and their descendants. Diabetes (2007) 1.65

X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. J Am Chem Soc (2008) 1.64

Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. J Biol Chem (2006) 1.64

Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol (2006) 1.63

The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR. Protein Sci (2003) 1.62

Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes (2002) 1.60

Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Dev Cell (2003) 1.60

Comparison of different labeling methods for two-channel high-density microarray experiments. Physiol Genomics (2002) 1.60

Resetting the transcription factor network reverses terminal chronic hepatic failure. J Clin Invest (2015) 1.58

Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci U S A (2004) 1.57

Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nat Med (2008) 1.57

Foxa2 regulates multiple pathways of insulin secretion. J Clin Invest (2004) 1.57

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab (2011) 1.55

CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metab (2009) 1.55

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest (2009) 1.54

Genome-wide analysis of histone modifications in human pancreatic islets. Genome Res (2010) 1.51

An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Dev Cell (2006) 1.50

Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest (2009) 1.50

The nucleosome map of the mammalian liver. Nat Struct Mol Biol (2011) 1.47

Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Mol Endocrinol (2010) 1.47

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. J Clin Invest (2011) 1.46

Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation. Proc Natl Acad Sci U S A (2004) 1.46

Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site. Nucleic Acids Res (2008) 1.46

Identification of transcriptional networks during liver regeneration. J Biol Chem (2004) 1.46

beta-Catenin is critical for early postnatal liver growth. Am J Physiol Gastrointest Liver Physiol (2007) 1.45

Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2. Mol Cell Biol (2005) 1.45

FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. J Biol Chem (2008) 1.44

Foxa1 and Foxa2 regulate bile duct development in mice. J Clin Invest (2009) 1.43

Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3. Diabetes (2005) 1.38

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet (2013) 1.37

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol (2009) 1.36

HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol Med (2004) 1.32

Targeting glucokinase activation for the treatment of type 2 diabetes--a status review. Curr Opin Drug Discov Devel (2005) 1.32

Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology (2009) 1.31

Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (2008) 1.31

DNA methylation is required for the control of stem cell differentiation in the small intestine. Genes Dev (2014) 1.31

Hydrogen bonding and the cryoprotective properties of glycerol/water mixtures. J Phys Chem B (2006) 1.30

Gut endocrine cell development. Mol Cell Endocrinol (2009) 1.29

The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev Biol (2007) 1.29

Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice. Gastroenterology (2009) 1.28

Species-specific strategies underlying conserved functions of metabolic transcription factors. Mol Endocrinol (2011) 1.25

Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations. Diabetes (2009) 1.23

Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes (2002) 1.23

Forkhead transcription factors II. Cell (2007) 1.21

Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice. Hepatology (2006) 1.21

Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev (2010) 1.21

Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem (2007) 1.21