Published in Crit Care on April 06, 2011
How wasting is saving: weight loss at altitude might result from an evolutionary adaptation. Bioessays (2014) 1.45
Insulin in the brain: there and back again. Pharmacol Ther (2012) 1.25
Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci (2013) 1.21
Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease. Front Endocrinol (Lausanne) (2014) 0.98
N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation. Front Neuroenergetics (2013) 0.97
Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague-Dawley rats. Nutr Metab (Lond) (2016) 0.96
Brain resuscitation in the drowning victim. Neurocrit Care (2012) 0.93
Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity. Aging Dis (2016) 0.88
Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis. Neurochem Int (2013) 0.80
Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications. Biochem Insights (2016) 0.79
Prevalence of ketosis, ketonuria, and ketoacidosis during liberal glycemic control in critically ill patients with diabetes: an observational study. Crit Care (2016) 0.78
Metabolomic profiling in perinatal asphyxia: a promising new field. Biomed Res Int (2015) 0.77
Regulation of Ketone Body Metabolism and the Role of PPARα. Int J Mol Sci (2016) 0.76
A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome. Proc Natl Acad Sci U S A (2016) 0.75
Sweet taste receptor signaling network: possible implication for cognitive functioning. Neurol Res Int (2015) 0.75
Ketone Body Infusion With 3-Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study. J Am Heart Assoc (2017) 0.75
The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J (1967) 12.40
Brain metabolism during fasting. J Clin Invest (1967) 6.48
Hormone-fuel interrelationships during fasting. J Clin Invest (1966) 6.44
The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver. Biochem J (1969) 3.57
Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial. JAMA (2004) 3.54
Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues. Biochem J (1971) 3.48
Liver and kidney metabolism during prolonged starvation. J Clin Invest (1969) 3.47
The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids (2004) 2.96
D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. J Clin Invest (2003) 2.25
D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci U S A (2000) 2.11
Ketone bodies, potential therapeutic uses. IUBMB Life (2001) 1.98
Control of glucose utilization in working perfused rat heart. J Biol Chem (1994) 1.97
Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock. Crit Care Med (2000) 1.83
Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging (2004) 1.81
Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience (2007) 1.76
Use of hypertonic (3%) saline/acetate infusion in the treatment of cerebral edema: Effect on intracranial pressure and lateral displacement of the brain. Crit Care Med (1998) 1.72
Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab (2007) 1.70
Mitochondrial function in sepsis: acute phase versus multiple organ failure. Crit Care Med (2007) 1.68
The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics (1998) 1.65
Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol (2006) 1.65
Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc Natl Acad Sci U S A (1998) 1.56
Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Prostaglandins Leukot Essent Fatty Acids (2004) 1.51
Ketone body production and disposal: effects of fasting, diabetes, and exercise. Diabetes Metab Rev (1989) 1.42
Cerebral ketone body metabolism. J Inherit Metab Dis (2005) 1.38
Hepatic ketogenesis and gluconeogenesis in humans. J Clin Invest (1974) 1.37
Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury. J Neurosci Res (2005) 1.35
Ketone body synthesis in the brain: possible neuroprotective effects. Prostaglandins Leukot Essent Fatty Acids (2004) 1.30
A multicenter trial for resuscitation of injured patients with 7.5% sodium chloride. The effect of added dextran 70. The Multicenter Group for the Study of Hypertonic Saline in Trauma Patients. Arch Surg (1993) 1.24
Fatty acid oxidation and ketogenesis by astrocytes in primary culture. J Neurochem (1991) 1.22
Ketones: metabolism's ugly duckling. Nutr Rev (2003) 1.22
The fasting test in paediatrics: application to the diagnosis of pathological hypo- and hyperketotic states. Eur J Pediatr (1990) 1.21
Equilibrium relations between pyridine nucleotides and adenine nucleotides and their roles in the regulation of metabolic processes. Adv Enzyme Regul (1969) 1.20
Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem Int (2001) 1.20
Ketogenic diet, amino acid metabolism, and seizure control. J Neurosci Res (2001) 1.20
Beta-hydroxybutyrate, a cerebral function improving agent, protects rat brain against ischemic damage caused by permanent and transient focal cerebral ischemia. Jpn J Pharmacol (2002) 1.20
Is there an astrocyte-neuron ketone body shuttle? Trends Endocrinol Metab (2001) 1.19
Brain hydroxyl radical generation in acute experimental head injury. J Neurochem (1993) 1.16
The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones. J Child Neurol (2000) 1.16
Beta-hydroxybutyrate transport in rat brain: developmental and dietary modulations. Am J Physiol (1976) 1.15
Ketone bodies are selectively used by individual brain regions. Science (1979) 1.15
Regional ketone body utilization by rat brain in starvation and diabetes. Am J Physiol (1986) 1.15
Lipoproteins in the central nervous system. Ann N Y Acad Sci (2000) 1.15
Rapid intravenous sodium acetoacetate infusion in man. Metabolic and kinetic responses. J Clin Invest (1973) 1.15
How astrocytes feed hungry neurons. Mol Neurobiol (2005) 1.14
Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats. Jpn J Pharmacol (2001) 1.13
The metabolism of acetone in rat. J Biol Chem (1984) 1.12
Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Physiol (1996) 1.11
Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats. J Neurochem (2004) 1.11
D,L-3-hydroxybutyrate treatment of multiple acyl-CoA dehydrogenase deficiency (MADD). Lancet (2003) 1.10
The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice. Epilepsy Res (2003) 1.09
Induction processes in blood-brain transfer of ketone bodies during starvation. Am J Physiol (1975) 1.08
Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats. Dev Neurosci (2006) 1.08
Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis. J Cereb Blood Flow Metab (2000) 1.07
D-beta-hydroxybutyrate is neuroprotective against hypoxia in serum-free hippocampal primary cultures. J Neurosci Res (2005) 1.06
Beneficial effects of ketogenic diet in obese diabetic subjects. Mol Cell Biochem (2007) 1.06
Ketone-body production and oxidation in fasting obese humans. J Clin Invest (1974) 1.06
Prehospital resuscitation of hypotensive trauma patients with 7.5% NaCl versus 7.5% NaCl with added dextran: a controlled trial. J Trauma (1993) 1.06
The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Initial management. J Neurotrauma (2000) 1.03
Brain metabolism during short-term starvation in humans. J Cereb Blood Flow Metab (1994) 1.03
Persistent hyperglycemia in severe traumatic brain injury: an independent predictor of outcome. Am Surg (2009) 1.01
Ketogenic diet increases glutathione peroxidase activity in rat hippocampus. Neurochem Res (2003) 1.00
D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease. J Neurosci Res (2006) 1.00
Acetoacetate and glucose as lipid precursors and energy substrates in primary cultures of astrocytes and neurons from mouse cerebral cortex. J Neurochem (1986) 1.00
Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition. Neuroscience (2003) 0.99
Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans. Am J Physiol (1995) 0.99
Failure of infused beta-hydroxybutyrate to decrease proteolysis in man. Diabetes (1983) 0.98
Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. J Biol Chem (2004) 0.96
Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain. J Neurochem (2001) 0.93
Head injury and hemorrhagic shock: studies of the blood brain barrier and intracranial pressure after resuscitation with normal saline solution, 3% saline solution, and dextran-40. Surgery (1988) 0.93
Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile rats. Ann Clin Lab Sci (2009) 0.91
Fasting prior to transient cerebral ischemia reduces delayed neuronal necrosis. Metab Brain Dis (1990) 0.91
Neurocardiac toxicity of racemic D,L-lactate fluids. Integr Physiol Behav Sci (1995) 0.90
A review of the efficacy and safety of 7.5% NaCl/6% dextran 70 in experimental animals and in humans. J Trauma (1994) 0.90
Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients. Am J Physiol Endocrinol Metab (2002) 0.88
Evaluation of a carbohydrate-free diet for patients with severe head injury. J Neurotrauma (1996) 0.88
Comparison between hypertonic saline and mannitol in the reduction of elevated intracranial pressure in a rodent model of acute cerebral injury. J Neurosurg Anesthesiol (2000) 0.87
D-beta-hydroxybutyrate prevents glutamate-mediated lipoperoxidation and neuronal damage elicited during glycolysis inhibition in vivo. Neurochem Res (2006) 0.87
Nephrolithiasis associated with the ketogenic diet. J Urol (2000) 0.87
Induction of brain D(--)-beta-hydroxybytrate dehydrogenase activity by fasting. Science (1969) 0.87
Ketogenic diet protects the hippocampus from kainic acid toxicity by inhibiting the dissociation of bad from 14-3-3. J Neurosci Res (2006) 0.86
Uptake of ketone bodies by rat brain in vivo. Biochem J (1971) 0.86
Generation of ketone bodies from leucine by cultured astroglial cells. J Neurochem (1995) 0.85
The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats. Brain Inj (2009) 0.84
KTX 0101: a potential metabolic approach to cytoprotection in major surgery and neurological disorders. CNS Drug Rev (2005) 0.84
Malignant cerebral edema in patients with hypertensive intracerebral hemorrhage associated with hypertonic saline infusion: a rebound phenomenon? J Neurosurg Anesthesiol (1998) 0.83
Metabolic control of the expression of mitochondrial D-beta-hydroxybutyrate dehydrogenase, a ketone body converting enzyme. Biochim Biophys Acta (1990) 0.83
Protective effect of fasting upon cerebral hypoxic-ischemic injury. Metab Brain Dis (1988) 0.82
Adaptation to chronic hypoxia during diet-induced ketosis. Adv Exp Med Biol (2005) 0.82
Mitochondrial redox state in the critically ill. Br J Anaesth (1999) 0.81
The effect of treatment with albumin, hetastarch, or hypertonic saline on neurological status and brain edema in a rat model of closed head trauma combined with uncontrolled hemorrhage and concurrent resuscitation in rats. Anesth Analg (2001) 0.80
Effect of 3-hydroxybutyrate on posttraumatic metabolism in man. Surgery (1991) 0.79
Effects of chemical pretreatment on posttraumatic cortical edema in the rat. Am J Emerg Med (1996) 0.77
7.2% NaCl/10% dextran 60 versus 20% mannitol for treatment of intracranial hypertension. Acta Neurochir Suppl (Wien) (1994) 0.77
Effect of small-volume resuscitation on intracranial pressure and related cerebral variables. J Trauma (1997) 0.77
Superoxide production by liver macrophages in a septic rat model--relation to arterial ketone body ratio. Eur Surg Res (1992) 0.76
Real-time assessment of hepatic function is related to clinical outcome in critically ill patients after polytrauma. Clin Biochem (2007) 0.76
Crystalloid strong ion difference determines metabolic acid-base change during in vitro hemodilution. Crit Care Med (2002) 2.47
Epidemiology and 12-month outcomes from traumatic brain injury in australia and new zealand. J Trauma (2008) 2.39
Applications of transcranial Doppler in the ICU: a review. Intensive Care Med (2006) 1.65
Plasma-Lyte 148 vs 0.9% saline for fluid resuscitation in diabetic ketoacidosis. J Crit Care (2012) 1.56
Interruption management in the intensive care unit: Predicting resumption times and assessing distributed support. J Exp Psychol Appl (2010) 1.15
Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies. Anesth Analg (2005) 1.08
Disagreement between ion selective electrode direct and indirect sodium measurements: estimation of the problem in a tertiary referral hospital. J Crit Care (2012) 1.01
Plasma acetate, gluconate and interleukin-6 profiles during and after cardiopulmonary bypass: a comparison of Plasma-Lyte 148 with a bicarbonate-balanced solution. Crit Care (2011) 0.91
Crystalloid strong ion difference determines metabolic acid-base change during acute normovolaemic haemodilution. Intensive Care Med (2004) 0.88
Evaluation of the P-POSSUM mortality prediction algorithm in Australian surgical intensive care unit patients. ANZ J Surg (2002) 0.82
Effect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status. Intensive Care Med (2013) 0.80
Granulometric analysis of spots in DNA microarray images. Genomics Proteomics Bioinformatics (2004) 0.75
Intensive Care Medicine Training in Australia and New Zealand: A Clarification. Crit Care Med (2015) 0.75
Sample introduction mode: another source of error in saline PCO2 measurement. Intensive Care Med (2002) 0.75
Sodium crocetinate does not alter gut hypercapnic responses or renal energy stores during transient sub-diaphragmatic ischaemia. Intensive Care Med (2003) 0.75
Emergency medical equipment storage: benefits of visual cues tested in field and simulated settings. Hum Factors (2014) 0.75