PubRank

Takashi Tsukamoto

Author PubWeight™ 60.24‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 2012 4.80
2 The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab 2012 3.81
3 Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res 2010 3.30
4 Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+. Plant J 2006 2.82
5 Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES). Biochem J 2007 2.52
6 High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen. Mol Imaging 2005 1.97
7 Rice metal-nicotianamine transporter, OsYSL2, is required for the long-distance transport of iron and manganese. Plant J 2010 1.66
8 Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer. EMBO J 2006 1.55
9 Mutational reconstructed ferric chelate reductase confers enhanced tolerance in rice to iron deficiency in calcareous soil. Proc Natl Acad Sci U S A 2007 1.54
10 Biosynthesis and secretion of mugineic acid family phytosiderophores in zinc-deficient barley. Plant J 2006 1.41
11 Synthesis and biological evaluation of D-amino acid oxidase inhibitors. J Med Chem 2008 1.29
12 Recent advances in the discovery of D-amino acid oxidase inhibitors and their therapeutic utility in schizophrenia. Curr Pharm Des 2011 1.28
13 Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine. Biol Psychiatry 2009 1.27
14 Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J Med Chem 2012 1.27
15 Deoxymugineic acid increases Zn translocation in Zn-deficient rice plants. Plant Mol Biol 2008 1.22
16 Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol 2014 1.21
17 Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc Natl Acad Sci U S A 2003 1.18
18 Glutamate production by HIV-1 infected human macrophage is blocked by the inhibition of glutaminase. J Neurochem 2007 1.13
19 Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem 2003 1.12
20 Multivalent scaffolds for affinity maturation of small molecule cell surface binders and their application to prostate tumor targeting. J Med Chem 2009 1.10
21 Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. J Med Chem 2007 1.08
22 Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. J Neurosci 2011 1.06
23 Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction. Mol Cancer Ther 2013 1.05
24 Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice. Drug Metab Dispos 2012 1.02
25 Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs. J Mol Biol 2008 1.01
26 Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase. ACS Med Chem Lett 2012 0.94
27 Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem 2006 0.93
28 Inhibition of xc⁻ transporter-mediated cystine uptake by sulfasalazine analogs. Bioorg Med Chem Lett 2011 0.92
29 The dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase from Haemophilus influenzae is a dinuclear metallohydrolase. J Am Chem Soc 2003 0.91
30 Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy. Adv Exp Med Biol 2006 0.91
31 Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors. Biochem Biophys Res Commun 2013 0.89
32 Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors. Cancer Res 2013 0.87
33 Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett 2003 0.86
34 Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase. Bioorg Med Chem Lett 2013 0.86
35 Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice. Brain Res 2010 0.83
36 Expression of salinarum halorhodopsin in Escherichia coli cells: solubilization in the presence of retinal yields the natural state. Biochim Biophys Acta 2011 0.83
37 Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds. J Med Chem 2012 0.81
38 The orally active glutamate carboxypeptidase II inhibitor E2072 exhibits sustained nerve exposure and attenuates peripheral neuropathy. J Pharmacol Exp Ther 2012 0.80
39 Converting a light-driven proton pump into a light-gated proton channel. J Am Chem Soc 2015 0.80
40 The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett 2010 0.79
41 Structural and functional roles of the N- and C-terminal extended modules in channelrhodopsin-1. Photochem Photobiol Sci 2015 0.78
42 Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). J Pharm Biomed Anal 2013 0.78
43 Facile synthesis of alpha-substituted acrylate esters. J Org Chem 2002 0.78
44 Reversible disulfide formation of the glutamate carboxypeptidase II inhibitor E2072 results in prolonged systemic exposures in vivo. Drug Metab Dispos 2012 0.77
45 δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors. J Med Chem 2013 0.76
46 Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J Med Chem 2014 0.76
47 Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity. J Med Chem 2016 0.76
48 Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine. Anal Biochem 2011 0.75
49 Direct detection of the substrate uptake and release reactions of the light-driven sodium-pump rhodopsin. J Am Chem Soc 2020 0.75
50 Discovery of a para-acetoxy-benzyl ester prodrug of a hydroxamate-based Glutamate Carboxypeptidase II inhibitor as oral therapy for neuropathic pain. J Med Chem 2017 0.75