Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.

PubWeight™: 1.06‹?› | Rank: Top 15%

🔗 View Article (PMC 3302726)

Published in J Neurosci on April 13, 2011

Authors

Mohamed H Farah1, Bao Han Pan, Paul N Hoffman, Dana Ferraris, Takashi Tsukamoto, Thien Nguyen, Philip C Wong, Donald L Price, Barbara S Slusher, John W Griffin

Author Affiliations

1: Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Articles citing this

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J (2012) 1.61

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush. Exp Neurol (2014) 1.43

Wallerian degeneration: the innate-immune response to traumatic nerve injury. J Neuroinflammation (2011) 1.41

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J Neurochem (2014) 1.37

Animal models of Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.18

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. J Biol Chem (2012) 1.13

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond. Front Physiol (2012) 1.09

Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination. Glia (2011) 1.04

The role of neuregulin-1 in the response to nerve injury. Future Neurol (2011) 1.03

Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system. PLoS One (2012) 0.89

A protective mutation against Alzheimer disease? Commun Integr Biol (2012) 0.87

BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice. Exp Neurol (2012) 0.83

Molecular Mechanisms Involved in Schwann Cell Plasticity. Front Mol Neurosci (2017) 0.80

MicroRNAs in the axon locally mediate the effects of chondroitin sulfate proteoglycans and cGMP on axonal growth. Dev Neurobiol (2015) 0.80

Can BACE1 inhibition mitigate early axonal pathology in neurological diseases? J Alzheimers Dis (2014) 0.80

The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury. Front Mol Neurosci (2016) 0.79

Changes in the Foxj1 expression of Schwann cells after sciatic nerve crush. J Mol Histol (2013) 0.77

Temporal-spatial expressions of Spy1 in rat sciatic nerve after crush. Cell Mol Neurobiol (2012) 0.77

Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury. Brain Res (2014) 0.76

Paclitaxel causes degeneration of both central and peripheral axon branches of dorsal root ganglia in mice. BMC Neurosci (2016) 0.75

BACE1 RNAi Restores the Composition of Phosphatidylethanolamine-Derivates Related to Memory Improvement in Aged 3xTg-AD Mice. Front Cell Neurosci (2016) 0.75

Transplanted human glial-restricted progenitors can rescue the survival of dysmyelinated mice independent of the production of mature, compact myelin. Exp Neurol (2017) 0.75

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling. Mol Neurodegener (2016) 0.75

Differential roles of Aβ processing in hypoxia-induced axonal damage. Neurobiol Dis (2015) 0.75

Spatiotemporal Expression of Poly(rC)-Binding Protein PCBP2 Modulates Schwann Cell Proliferation After Sciatic Nerve Injury. Cell Mol Neurobiol (2015) 0.75

Articles cited by this

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron (2000) 22.02

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature (2009) 6.17

Axonal neuregulin-1 regulates myelin sheath thickness. Science (2004) 6.09

Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat Rev Neurosci (2003) 4.60

Control of peripheral nerve myelination by the beta-secretase BACE1. Science (2006) 4.55

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54

Neuregulin-1 type III determines the ensheathment fate of axons. Neuron (2005) 4.19

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci (2001) 3.85

Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci (2006) 3.85

Axon regeneration requires a conserved MAP kinase pathway. Science (2009) 3.48

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci (2005) 3.23

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature (1997) 3.14

Cutting edge: TREM-2 attenuates macrophage activation. J Immunol (2006) 3.07

Peripheral regeneration. Annu Rev Neurosci (2007) 2.94

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet (2001) 2.76

TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med (2007) 2.62

Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration. J Neurosci (2007) 2.51

ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J Neurosci (2007) 2.40

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem (2009) 2.37

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci U S A (2008) 2.25

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem (2003) 1.99

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J Biol Chem (2007) 1.91

Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels. J Neurosci (1995) 1.88

Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. Eur J Immunol (2007) 1.88

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1). J Med Chem (2004) 1.87

The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves. BMC Neurosci (2005) 1.84

Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation. J Neurocytol (1989) 1.79

Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest (1997) 1.71

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proc Natl Acad Sci U S A (2001) 1.63

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem (2007) 1.61

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J (2008) 1.60

Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res (2004) 1.59

Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. J Neurosci (2007) 1.57

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol (2010) 1.56

Requirement of myeloid cells for axon regeneration. J Neurosci (2008) 1.52

Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans? Nat Clin Pract Neurol (2006) 1.52

Motor axons preferentially reinnervate motor pathways. J Neurosci (1993) 1.47

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci (1997) 1.46

Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochem Biophys Res Commun (1991) 1.45

Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge. Trends Pharmacol Sci (2004) 1.41

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain (2008) 1.38

Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway. J Neurosci (2010) 1.37

Delayed macrophage responses and myelin clearance during Wallerian degeneration in the central nervous system: the dorsal radiculotomy model. Exp Neurol (1994) 1.36

Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury. Proc Natl Acad Sci U S A (2010) 1.34

Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice. J Neurosci Methods (2004) 1.32

Disruption of the gene for the myelin-associated glycoprotein improves axonal regrowth along myelin in C57BL/Wlds mice. Neuron (1996) 1.29

Axonal protective effects of the myelin-associated glycoprotein. J Neurosci (2009) 1.29

Dynamics of axonal mRNA transport and implications for peripheral nerve regeneration. Exp Neurol (2009) 1.21

Measuring nerve regeneration in the mouse. Exp Neurol (2010) 1.20

Accelerating axon growth to overcome limitations in functional recovery after peripheral nerve injury. Neurosurgery (2009) 1.17

Contributions of pathway and neuron to preferential motor reinnervation. J Neurosci (1998) 1.15

Cell birth and death in the mouse retinal ganglion cell layer. J Comp Neurol (2005) 1.11

Proteolytic shedding of ST6Gal-I by BACE1 regulates the glycosylation and function of alpha4beta1 integrins. J Biol Chem (2008) 1.09

Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease. Med Res Rev (2009) 1.01

The effect of a conditioning lesion on the regeneration of motor axons. Brain Res (1978) 0.99

Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons. Exp Neurol (2009) 0.99

Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors. J Med Chem (2010) 0.96

Roles of channels and receptors in the growth cone during PNS axonal regeneration. Exp Neurol (2009) 0.92

Antibodies to myelin-associated glycoprotein accelerate preferential motor reinnervation. J Peripher Nerv Syst (2003) 0.88

Acceleration of axonal outgrowth in rat sciatic nerve at one week after axotomy. J Neurobiol (1993) 0.87

GAP-43 as a marker for structural plasticity in the mature CNS. Prog Brain Res (1990) 0.87

Effect of conditioning lesion on axonal sprout formation at nodes of Ranvier. J Comp Neurol (1985) 0.86

The anterograde and retrograde transport of neurobiotin in the central nervous system of the rat: comparison with biocytin. J Neurosci Methods (1991) 0.79

Effect of a conditioning lesion on regeneration of goldfish optic axons: ultrastructural evidence of enhanced outgrowth and pinocytosis. Brain Res (1980) 0.78

Intra-axonal Neurobiotin injection rapidly stains the long-range projections of identified trigeminal primary afferents in vivo: comparisons with HRP and PHA-L. J Neurosci Methods (1993) 0.77

Cumulative labeling of embryonic mouse neural retina with bromodeoxyuridine supplied by an osmotic minipump. J Neurosci Methods (2004) 0.76

Articles by these authors

The development of the first catalyzed reaction of ketenes and imines: catalytic, asymmetric synthesis of beta-lactams. J Am Chem Soc (2002) 6.08

Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature (2012) 4.95

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab (2012) 4.80

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab (2012) 3.81

DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4). Am J Hum Genet (2004) 3.72

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res (2010) 3.30

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci (2005) 3.23

Spinal axon regeneration induced by elevation of cyclic AMP. Neuron (2002) 3.09

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat Neurosci (2002) 3.09

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron (2004) 2.94

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem (2004) 2.85

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci (2006) 2.85

A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron (2007) 2.83

Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+. Plant J (2006) 2.82

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J Neurosci (2009) 2.80

Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neurosci (2009) 2.71

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES). Biochem J (2007) 2.52

Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci (2011) 2.47

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc Natl Acad Sci U S A (2005) 2.45

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci (2007) 2.31

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities. Neurobiol Dis (2005) 2.22

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem (2004) 2.08

Pharmacological mechanisms of 5-HT₃ and tachykinin NK₁ receptor antagonism to prevent chemotherapy-induced nausea and vomiting. Eur J Pharmacol (2012) 2.07

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci U S A (2010) 2.05

Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci (2005) 2.04

High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord. Brain (2007) 2.03

Biodistribution, tumor detection, and radiation dosimetry of 18F-DCFBC, a low-molecular-weight inhibitor of prostate-specific membrane antigen, in patients with metastatic prostate cancer. J Nucl Med (2012) 2.00

High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen. Mol Imaging (2005) 1.97

Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. Proc Natl Acad Sci U S A (2010) 1.92

The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain (2004) 1.90

Palonosetron triggers 5-HT(3) receptor internalization and causes prolonged inhibition of receptor function. Eur J Pharmacol (2009) 1.81

Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomy. J Neurosci (2009) 1.79

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest (2015) 1.67

Rice metal-nicotianamine transporter, OsYSL2, is required for the long-distance transport of iron and manganese. Plant J (2010) 1.66

Diabetes and driving. Diabetes Care (2012) 1.66

Genetically engineered mouse models of neurodegenerative diseases. Nat Neurosci (2002) 1.66

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity. J Biol Chem (2008) 1.65

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nat Neurosci (2013) 1.63

Cyclic AMP elevates tubulin expression without increasing intrinsic axon growth capacity. Exp Neurol (2004) 1.59

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiol Dis (2003) 1.59

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. J Neurosci (2003) 1.58

Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer. EMBO J (2006) 1.55

Mutational reconstructed ferric chelate reductase confers enhanced tolerance in rice to iron deficiency in calcareous soil. Proc Natl Acad Sci U S A (2007) 1.54

An overview of APP processing enzymes and products. Neuromolecular Med (2010) 1.54

Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell (2011) 1.52

The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J Pharmacol Exp Ther (2010) 1.48

Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron. J Neurosci (2002) 1.48

Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J Neurosci (2008) 1.45

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Neurosci (2008) 1.44

In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016. Clin Cancer Res (2009) 1.44

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. J Neurosci (2005) 1.43

Progress in the discovery and development of glutamate carboxypeptidase II inhibitors. Drug Discov Today (2007) 1.42

Biosynthesis and secretion of mugineic acid family phytosiderophores in zinc-deficient barley. Plant J (2006) 1.41

Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J Neurosci (2002) 1.41

Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects. Eur J Pharmacol (2012) 1.39

Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons. Ann Neurol (2003) 1.39

Glial cell line-derived neurotrophic factor alters axon schwann cell units and promotes myelination in unmyelinated nerve fibers. J Neurosci (2003) 1.38

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J Neurochem (2014) 1.37

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. J Biol Chem (2005) 1.37

Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents. J Neurosci (2002) 1.36

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem (2008) 1.34

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS One (2008) 1.34

Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice. Exp Neurol (2005) 1.32

Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. J Neurosci (2004) 1.31

Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). J Neurosci (2007) 1.29

Synthesis and biological evaluation of D-amino acid oxidase inhibitors. J Med Chem (2008) 1.29

Axonal protective effects of the myelin-associated glycoprotein. J Neurosci (2009) 1.29

Recent advances in the discovery of D-amino acid oxidase inhibitors and their therapeutic utility in schizophrenia. Curr Pharm Des (2011) 1.28

Diabetes and employment. Diabetes Care (2013) 1.28

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice. J Neurochem (2006) 1.27

Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine. Biol Psychiatry (2009) 1.27

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J Med Chem (2012) 1.27

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J Neurosci (2005) 1.26

BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. J Neurosci (2008) 1.25

Rodent models of TDP-43: recent advances. Brain Res (2012) 1.24

Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis (2007) 1.24

Deoxymugineic acid increases Zn translocation in Zn-deficient rice plants. Plant Mol Biol (2008) 1.22

The etiopathogenesis of Parkinson disease and suggestions for future research. Part I. J Neuropathol Exp Neurol (2007) 1.21

Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies. Brain (2007) 1.21

Comparison of neuropathy-inducing effects of eribulin mesylate, paclitaxel, and ixabepilone in mice. Cancer Res (2011) 1.21