Published in Curr Biol on April 14, 2011
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia. Mol Biol Cell (2011) 1.60
The Angiomotins--from discovery to function. FEBS Lett (2014) 1.07
Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)-ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration. Cell Signal (2013) 1.03
KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis. J Biol Chem (2012) 0.97
Signaling pathways in cell polarity. Cold Spring Harb Perspect Biol (2012) 0.92
aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface. J Biochem (2014) 0.87
Candidate genes in quantitative trait loci associated with absolute and relative kidney weight in rats with Inherited Stress Induced Arterial Hypertension. BMC Genet (2015) 0.87
KIBRA: In the brain and beyond. Cell Signal (2014) 0.85
Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment. Am J Physiol Gastrointest Liver Physiol (2014) 0.84
The KIBRA-aPKC connection: A potential regulator of membrane trafficking and cell polarity. Commun Integr Biol (2012) 0.83
PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity. Mol Biol Cell (2014) 0.81
p120-catenin controls contractility along the vertical axis of epithelial lateral membranes. J Cell Sci (2015) 0.81
Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance. Transl Psychiatry (2013) 0.79
aPKC phosphorylates p27Xic1, providing a mechanistic link between apicobasal polarity and cell-cycle control. Dev Cell (2014) 0.79
KIBRA promotes prostate cancer cell proliferation and motility. FEBS J (2016) 0.79
aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Dev Cell (2016) 0.78
Creation of trophectoderm, the first epithelium, in mouse preimplantation development. Results Probl Cell Differ (2012) 0.78
The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond. Genes (Basel) (2016) 0.76
Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro. Front Neuroanat (2015) 0.75
Nuclear fallout provides a new link between aPKC and polarized cell trafficking. BMC Biol (2016) 0.75
KIBRA attains oncogenic activity by repressing RASSF1A. Br J Cancer (2017) 0.75
Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway. J Exp Clin Cancer Res (2017) 0.75
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature (2011) 5.84
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
The PAR-aPKC system: lessons in polarity. J Cell Sci (2006) 4.73
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys. Thyroid (2012) 2.78
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature (2002) 2.68
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature (2007) 2.48
Junctional adhesion molecules (JAMs): more molecules with dual functions? J Cell Sci (2004) 2.47
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr Biol (2004) 2.40
Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol (2003) 2.38
Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. J Biochem (2003) 2.32
Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J Clin Invest (2012) 2.26
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19
Evaluation of F-18 fluorodeoxyglucose (FDG) PET scanning for pulmonary nodules less than 3 cm in diameter, with special reference to the CT images. Lung Cancer (2004) 2.17
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci (2002) 2.04
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci (2003) 1.84
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development (2006) 1.81
Isolation of mouse pancreatic ductal progenitor cells expressing CD133 and c-Met by flow cytometric cell sorting. Gastroenterology (2006) 1.74
The effect of periocular warming on accommodation. Ophthalmology (2005) 1.74
The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. Science (2009) 1.65
Fluorine 18-tagged fluorodeoxyglucose positron emission tomographic scanning to predict lymph node metastasis, invasiveness, or both, in clinical T1 N0 M0 lung adenocarcinoma. J Thorac Cardiovasc Surg (2004) 1.62
Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin. Cancer Res (2002) 1.55
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res (2011) 1.55
Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells. Genes Cells (2002) 1.54
ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol (2010) 1.54
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metab (2009) 1.51
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene (2003) 1.50
The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism (2008) 1.50
The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta (2005) 1.49
Prevalence and persistence of depression in patients with implantable cardioverter defibrillator: a 2-year longitudinal study. Pacing Clin Electrophysiol (2010) 1.48
Epoxycarotenoid-mediated synthesis of abscisic acid in Physcomitrella patens implicating conserved mechanisms for acclimation to hyperosmosis in embryophytes. New Phytol (2014) 1.48
CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. Blood (2011) 1.46
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J (2009) 1.46
Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci (2009) 1.45
Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly. J Gastroenterol (2010) 1.43
Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol (2008) 1.42
The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci (2006) 1.40
Diagnosis and Detection of Myocardial Injury in Active Cardiac Sarcoidosis - Significance of Myocardial Fatty Acid Metabolism and Myocardial Perfusion Mismatch. Circ J (2015) 1.39
Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn (2002) 1.39
Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. J Biochem (2003) 1.38
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Sci Signal (2010) 1.38
alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. Int J Cancer (2002) 1.36
Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J Cell Sci (2002) 1.35
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep (2006) 1.35
Usefulness and complications of computed tomography-guided lipiodol marking for fluoroscopy-assisted thoracoscopic resection of small pulmonary nodules: experience with 174 nodules. J Thorac Cardiovasc Surg (2006) 1.34
Ocean acidification reduces sperm flagellar motility in broadcast spawning reef invertebrates. Zygote (2010) 1.34
Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity. J Cell Sci (2006) 1.33
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes (2009) 1.33
An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics. Nat Cell Biol (2009) 1.31
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell (2012) 1.28
PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development (2006) 1.25
Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia. Mol Biosyst (2011) 1.24
Coral larvae under ocean acidification: survival, metabolism, and metamorphosis. PLoS One (2011) 1.23
Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. J Neuropathol Exp Neurol (2005) 1.23
Self-association of PAR-3-mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions. J Biol Chem (2003) 1.21
Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth. Front Biosci (2008) 1.21
MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Development (2002) 1.21
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am J Pathol (2004) 1.21
Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol (2005) 1.20
Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. J Biol Chem (2005) 1.19
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest (2010) 1.17
Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts. Mol Ther (2006) 1.17
Interplay between the tumor suppressor p53 and TGF beta signaling shapes embryonic body axes in Xenopus. Development (2003) 1.16
Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2. J Clin Endocrinol Metab (2003) 1.15
High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab (2011) 1.15
aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci U S A (2009) 1.15
The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. Hum Pathol (2008) 1.14
Tear evaporation dynamics in normal subjects and subjects with obstructive meibomian gland dysfunction. Invest Ophthalmol Vis Sci (2003) 1.14
Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease. Ann Neurol (2004) 1.14
Polysialic acid facilitates tumor invasion by glioma cells. Glycobiology (2005) 1.13
PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest (2005) 1.12
Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina. J Neurosci (2005) 1.12
Role of hypothalamic AMP-kinase in food intake regulation. Nutrition (2008) 1.11
Analysis of anatomic variants of mesenteric veins by 3-dimensional portography using multidetector-row computed tomography. Am J Surg (2010) 1.11
Glycogen synthase kinase 3 β-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration. Proc Natl Acad Sci U S A (2011) 1.11
An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms. PLoS One (2009) 1.10
Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J Biol Chem (2007) 1.09
Effects of acidified seawater on coral calcification and symbiotic algae on the massive coral Porites australiensis. Mar Environ Res (2011) 1.09
Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation. Cell Mol Life Sci (2013) 1.08
Retroperitoneal primary mucinous adenocarcinoma with a mural nodule of anaplastic tumor: a case report and literature review. Int J Gynecol Pathol (2003) 1.08