Published in PLoS One on April 20, 2011
AID targeting is dependent on RNA polymerase II pausing. Semin Immunol (2012) 1.01
Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences. PLoS Biol (2014) 0.95
Identification of core DNA elements that target somatic hypermutation. J Immunol (2012) 0.88
Generation and repair of AID-initiated DNA lesions in B lymphocytes. Front Med (2014) 0.81
A critical context-dependent role for E boxes in the targeting of somatic hypermutation. J Immunol (2013) 0.79
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Immunoglobulin gene transcription is activated by downstream sequence elements. Cell (1983) 15.53
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell (2000) 9.99
Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32
Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell (1994) 3.06
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science (2002) 3.04
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92
AID in somatic hypermutation and class switch recombination. Curr Opin Immunol (2006) 2.48
The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. EMBO J (1989) 2.48
Targeting of somatic hypermutation. Nat Rev Immunol (2006) 2.42
Light chain gene conversion continues at high rate in an ALV-induced cell line. EMBO J (1990) 2.28
Mutant loxP vectors for selectable marker recycle and conditional knock-outs. BMC Biotechnol (2001) 2.09
Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation. Nat Immunol (2002) 1.63
Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. PLoS Biol (2004) 1.56
A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation. PLoS Genet (2009) 1.24
Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. J Immunol (2008) 1.22
Chromatin structural analyses of the mouse Igkappa gene locus reveal new hypersensitive sites specifying a transcriptional silencer and enhancer. J Biol Chem (2002) 1.08
Attracting AID to targets of somatic hypermutation. J Exp Med (2010) 1.03
Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation. J Immunol (2006) 1.00
Targeting of AID-mediated sequence diversification by cis-acting determinants. Adv Immunol (2007) 0.98
The Downstream Transcriptional Enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutation. J Immunol (2008) 0.98
Hijacked DNA repair proteins and unchained DNA polymerases. Philos Trans R Soc Lond B Biol Sci (2009) 0.96
NF-kappaB family of transcription factor facilitates gene conversion in chicken B cells. Mol Immunol (2009) 0.90
Transcription-coupled mutagenesis by the DNA deaminase AID. Genome Biol (2004) 0.89
Evolution and the molecular basis of somatic hypermutation of antigen receptor genes. Philos Trans R Soc Lond B Biol Sci (2001) 0.89
AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene. Mol Immunol (2007) 0.86
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
The immune gene repertoire encoded in the purple sea urchin genome. Dev Biol (2006) 2.43
The origins of vertebrate adaptive immunity. Nat Rev Immunol (2010) 1.81
A coming-of-age story: activation-induced cytidine deaminase turns 10. Nat Immunol (2009) 1.68
Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination. Int Immunol (2004) 1.41
Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. J Biol Chem (2005) 1.25
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. J Cell Biol (2005) 1.22
Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. J Immunol (2008) 1.22
A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol (2003) 1.21
Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J Exp Med (2006) 1.14
Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain (2002) 1.13
Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells. Immunity (2003) 1.05
Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography. Anal Biochem (2013) 0.96
Separation of mutational and transcriptional enhancers in Ig genes. J Immunol (2011) 0.90
The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination. Mol Cell Biol (2007) 0.90
AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene. Mol Immunol (2007) 0.86
Targeting of AID-mediated sequence diversification to immunoglobulin genes. Curr Opin Immunol (2011) 0.83
Modulation of specific protein expression levels by PTEN: identification of AKAP121, DHFR, G3BP, Rap1, and RCC1 as potential targets of PTEN. Oncogene (2005) 0.82
Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. J Biol Chem (2007) 0.81
The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tails. Dev Comp Immunol (2008) 0.80
RNA AIDS DNA. Nat Immunol (2003) 0.80
Transcription, splicing, and release: are we there yet? Cell (2012) 0.79
DNA repair: breaking the seal. Nature (2002) 0.78
Immunology. UNGstoppable switching. Science (2004) 0.77
Characterizing somatic hypermutation and gene conversion in the chicken DT40 cell system. Methods Mol Biol (2011) 0.75