The origins of vertebrate adaptive immunity.

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VLR-based adaptive immunity. Annu Rev Immunol (2012) 1.56

Implication of haematophagous arthropod salivary proteins in host-vector interactions. Parasit Vectors (2011) 1.39

Co-dependents: MR1-restricted MAIT cells and their antimicrobial function. Nat Rev Microbiol (2012) 1.30

Evolutionary implications of a third lymphocyte lineage in lampreys. Nature (2013) 1.19

Evolution of Innate Immunity: Clues from Invertebrates via Fish to Mammals. Front Immunol (2014) 1.13

Viral ancestors of antiviral systems. Viruses (2011) 1.11

Evolutionarily conserved features contribute to αβ T cell receptor specificity. Immunity (2011) 1.06

Why does the immune system of Atlantic cod lack MHC II? Bioessays (2012) 1.02

Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding. Sci Rep (2014) 1.00

Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy. PLoS One (2013) 0.98

Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal. Proc Natl Acad Sci U S A (2011) 0.96

Evolution of the immune system influences speciation rates in teleost fishes. Nat Genet (2016) 0.96

IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells. PLoS One (2011) 0.96

Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One (2012) 0.94

Cooperativity of adaptive and innate immunity: implications for cancer therapy. Cancer Immunol Immunother (2011) 0.93

A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions. Proc Natl Acad Sci U S A (2011) 0.92

A review of neosporosis and pathologic findings of Neospora caninum infection in wildlife. Int J Parasitol Parasites Wildl (2015) 0.90

Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos). Immunogenetics (2014) 0.86

A second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapods. J Immunol (2012) 0.83

A Basal chordate model for studies of gut microbial immune interactions. Front Immunol (2012) 0.82

The vigor of defense against non-self: potential superiority of allorestricted T cells in immunotherapy of cancer? Front Oncol (2013) 0.82

The evolution of costly acquired immune memory. Ecol Evol (2013) 0.81

Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics (2011) 0.80

Macroevolutionary Immunology: A Role for Immunity in the Diversification of Animal life. Front Immunol (2012) 0.80

Initiation and regulation of complement during hemolytic transfusion reactions. Clin Dev Immunol (2012) 0.80

The Vγ9Vδ2 T Cell Antigen Receptor and Butyrophilin-3 A1: Models of Interaction, the Possibility of Co-Evolution, and the Case of Dendritic Epidermal T Cells. Front Immunol (2014) 0.80

A prominent role for invariant T cells in the amphibian Xenopus laevis tadpoles. Immunogenetics (2014) 0.80

V(D)J Recombination: Mechanism, Errors, and Fidelity. Microbiol Spectr (2014) 0.79

Genomic analysis offers insights into the evolution of the bovine TRA/TRD locus. BMC Genomics (2014) 0.79

A mouse variable gene fragment binds to DNA independently of the BCR context: a possible role for immature B-cell repertoire establishment. PLoS One (2013) 0.78

A model for the evolution of the mammalian t-cell receptor α/δ and μ loci based on evidence from the duckbill Platypus. Mol Biol Evol (2012) 0.78

Lamprey immunity is far from primitive. Proc Natl Acad Sci U S A (2013) 0.77

Primed immune responses to gram-negative peptidoglycans confer infection resistance in silkworms. J Biol Chem (2014) 0.77

Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles. J Immunol (2013) 0.77

Immune related genes underpin the evolution of adaptive immunity in jawless vertebrates. Curr Genomics (2012) 0.77

Inflammatory risk factors, biomarkers and associated therapy in ischaemic stroke. Nat Rev Neurol (2016) 0.77

Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response. Front Immunol (2015) 0.77

Memory and Specificity in the Insect Immune System: Current Perspectives and Future Challenges. Front Immunol (2017) 0.76

New insights into the evolutionary origins of the RAG proteins and V(D)J recombination. FEBS J (2016) 0.76

Evolution of V genes from the TRV loci of mammals. Immunogenetics (2015) 0.76

Improving immunity in the elderly: current and future lessons from nonhuman primate models. Age (Dordr) (2011) 0.76

Precambrian origins of the TNFR superfamily. Cell Death Discov (2016) 0.76

The immunological contribution to heterotopic ossification disorders. Curr Osteoporos Rep (2015) 0.76

Transcriptome profiling reveals higher vertebrate orthologous of intra-cytoplasmic pattern recognition receptors in grey bamboo shark. PLoS One (2014) 0.75

The piggyBac transposon-derived genes TPB1 and TPB6 mediate essential transposon-like excision during the developmental rearrangement of key genes in Tetrahymena thermophila. Genes Dev (2016) 0.75

A comprehensive analysis of the germline and expressed TCR repertoire in White Peking duck. Sci Rep (2017) 0.75

Update on Chlamydia trachomatis Vaccinology. Clin Vaccine Immunol (2017) 0.75

Fish Immunoglobulins. Biology (Basel) (2016) 0.75

African Lungfish Reveal the Evolutionary Origins of Organized Mucosal Lymphoid Tissue in Vertebrates. Curr Biol (2015) 0.75

Exploring the Homeostatic and Sensory Roles of the Immune System. Front Immunol (2016) 0.75

Primer on the Immune System. Alcohol Res (2015) 0.75

Crystallization and preliminary X-ray diffraction analysis of a single variable domain of the immunoglobulin superfamily in amphioxus, Amphi-IgSF-V. Acta Crystallogr F Struct Biol Commun (2014) 0.75

Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut. Crit Rev Biochem Mol Biol (2016) 0.75

The Immune Syntax Revisited: Opening New Windows on Language Evolution. Front Mol Neurosci (2016) 0.75

An inhibitory receptor of VLRB in the agnathan lamprey. Sci Rep (2016) 0.75

Sepsis in the burn patient: a different problem than sepsis in the general population. Burns Trauma (2017) 0.75

Evolution of innate-like T cells and their selection by MHC class I-like molecules. Immunogenetics (2016) 0.75

Quantitative analysis and clonal characterization of T-cell receptor β repertoires in patients with advanced non-small cell lung cancer treated with cancer vaccine. Oncol Lett (2017) 0.75

Somatic generation of antibody diversity. Nature (1983) 28.06

Innate immune recognition. Annu Rev Immunol (2001) 26.65

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80

Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00

Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem (2007) 6.92

Gene regulatory networks and the evolution of animal body plans. Science (2006) 6.42

V(D)J recombination: RAG proteins, repair factors, and regulation. Annu Rev Biochem (2001) 5.44

Retroviral restriction by APOBEC proteins. Nat Rev Immunol (2004) 5.00

The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell (1996) 4.93

High-throughput sequencing of the zebrafish antibody repertoire. Science (2009) 4.46

Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature (2004) 4.37

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35

The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell (2010) 3.88

A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity (2007) 3.54

RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons. PLoS Biol (2005) 3.50

Diversity and function of adaptive immune receptors in a jawless vertebrate. Science (2005) 3.39

Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase. Nat Immunol (2007) 3.14

Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nat Rev Genet (2009) 3.11

The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res (2008) 3.04

Reconstructing immune phylogeny: new perspectives. Nat Rev Immunol (2005) 2.95

Dual nature of the adaptive immune system in lampreys. Nature (2009) 2.53

AID in somatic hypermutation and class switch recombination. Curr Opin Immunol (2006) 2.48

The immune gene repertoire encoded in the purple sea urchin genome. Dev Biol (2006) 2.43

The evolution of adaptive immunity. Annu Rev Immunol (2006) 2.32

Identification of a DNA nonhomologous end-joining complex in bacteria. Science (2002) 2.27

Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate. Nat Immunol (2002) 2.26

The DNA-dependent protein kinase: the director at the end. Immunol Rev (2004) 2.20

Genomic insights into the immune system of the sea urchin. Science (2006) 2.20

Comparative analyses of immunoglobulin genes: surprises and portents. Nat Rev Immunol (2002) 2.03

Variable lymphocyte receptors in hagfish. Proc Natl Acad Sci U S A (2005) 1.99

Evolution of antigen binding receptors. Annu Rev Immunol (1999) 1.99

An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nat Immunol (2004) 1.98

Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity. Genome Res (2008) 1.92

Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus. Nat Immunol (2006) 1.92

Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice. Nat Immunol (2006) 1.89

Antibody responses of variable lymphocyte receptors in the lamprey. Nat Immunol (2008) 1.87

New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity (1995) 1.84

B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities. Nat Immunol (2006) 1.81

An ancient evolutionary origin of the Rag1/2 gene locus. Proc Natl Acad Sci U S A (2006) 1.79

Development and function of B-1 cells. Curr Opin Immunol (2000) 1.78

Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: "waiting for Godot". Immunogenetics (2003) 1.75

Diverse organization of immunoglobulin VH gene loci in a primitive vertebrate. EMBO J (1988) 1.70

Evolution of innate and adaptive immunity: can we draw a line? Trends Immunol (2004) 1.67

The acquired immune system: a vantage from beneath. Immunity (2004) 1.64

Antigen recognition by variable lymphocyte receptors. Science (2008) 1.61

Programmed loss of millions of base pairs from a vertebrate genome. Proc Natl Acad Sci U S A (2009) 1.58

Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol (2009) 1.55

Isolation and characterization of lymphocyte-like cells from a lamprey. Proc Natl Acad Sci U S A (2002) 1.50

IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates. Proc Natl Acad Sci U S A (2006) 1.46

alpha, beta, gamma, and delta T cell antigen receptor genes arose early in vertebrate phylogeny. Immunity (1997) 1.43

Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Nat Immunol (2009) 1.43

Evolution of genetic networks underlying the emergence of thymopoiesis in vertebrates. Cell (2009) 1.42

Soluble receptors in human disease. J Leukoc Biol (1998) 1.38

High-affinity lamprey VLRA and VLRB monoclonal antibodies. Proc Natl Acad Sci U S A (2009) 1.35

The evolution of the immune response. VII. Antibody to human "O" cells and properties of the immunoglobulin in lamprey. J Immunol (1970) 1.32

Novel genes dramatically alter regulatory network topology in amphioxus. Genome Biol (2008) 1.32

Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc Natl Acad Sci U S A (2004) 1.30

Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis. Proc Natl Acad Sci U S A (2006) 1.29

The evolutionary history of lymphoid organs. Nat Immunol (2007) 1.28

Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytes. Proc Natl Acad Sci U S A (2002) 1.28

Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol (2004) 1.24

An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks. Proc Natl Acad Sci U S A (2006) 1.18

Immunoglobulin diversity, B-cell and antibody repertoire development in large farm animals. Rev Sci Tech (1998) 1.16

Phylogeny of lower vertebrates and their immunological structures. Curr Top Microbiol Immunol (2000) 1.16

Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum. Eur J Immunol (2005) 1.16

A unique T cell receptor discovered in marsupials. Proc Natl Acad Sci U S A (2007) 1.14

Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradox. Proc Natl Acad Sci U S A (2003) 1.10

Individual protochordates have unique immune-type receptor repertoires. Curr Biol (2004) 1.08

The origins of the Rag genes--from transposition to V(D)J recombination. Semin Immunol (2009) 1.07

Highly diversified innate receptor systems and new forms of animal immunity. Semin Immunol (2009) 1.06

gammadelta T cell subsets: a link between TCR and function? Semin Immunol (2010) 1.04

Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions. Immunity (2002) 1.04

Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity. J Exp Med (1993) 1.03

Regulation of antigen-receptor gene assembly in hagfish. EMBO Rep (2010) 1.03

A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Immunity (2008) 0.98

Complex expression patterns of lymphocyte-specific genes during the development of cartilaginous fish implicate unique lymphoid tissues in generating an immune repertoire. Int Immunol (2001) 0.98

Immunoglobulin superfamily virus receptors and the evolution of adaptive immunity. PLoS Pathog (2009) 0.98

Co-evolution of a primordial peptide-presentation system and cellular immunity. Nat Rev Immunol (2006) 0.98

Expression of individual immunoglobulin genes occurs in an unusual system consisting of multiple independent loci. Eur J Immunol (2004) 0.98

Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers. Proc Natl Acad Sci U S A (1998) 0.97

Antibodies of sharks: revolution and evolution. Immunol Rev (1998) 0.97

Origins of lymphocyte developmental programs: transcription factor evidence. Semin Immunol (2004) 0.96

Immunoglobulin heavy chain exclusion in the shark. PLoS Biol (2008) 0.95

The evolution of vertebrate antigen receptors: a phylogenetic approach. Mol Biol Evol (2000) 0.95

Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus. BMC Genet (2008) 0.94

Characterization of arrangement and expression of the T cell receptor gamma locus in the sandbar shark. Proc Natl Acad Sci U S A (2009) 0.94

A role for DNA polymerase mu in the emerging DJH rearrangements of the postgastrulation mouse embryo. Mol Cell Biol (2008) 0.93

Evolution of adaptive immune recognition in jawless vertebrates. Semin Immunol (2010) 0.91

Toll-like receptor genes (TLRs) from Capitella capitata and Helobdella robusta (Annelida). Dev Comp Immunol (2007) 0.86

Transcriptional regulation of NK cell receptors. Curr Top Microbiol Immunol (2006) 0.85

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Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain. Mol Immunol (2007) 0.82

Those other mammals: the immunoglobulins and T cell receptors of marsupials and monotremes. Semin Immunol (2009) 0.80

The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tails. Dev Comp Immunol (2008) 0.80

Blimp-1; immunoglobulin secretion and the switch to plasma cells. Curr Top Microbiol Immunol (2005) 0.77

A genomic regulatory network for development. Science (2002) 9.67

The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41

The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res (2008) 3.04

Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet (2013) 2.76

The immune gene repertoire encoded in the purple sea urchin genome. Dev Biol (2006) 2.43

A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo. Dev Biol (2002) 2.26

An ancient evolutionary origin of the Rag1/2 gene locus. Proc Natl Acad Sci U S A (2006) 1.79

A coming-of-age story: activation-induced cytidine deaminase turns 10. Nat Immunol (2009) 1.68

New early zygotic regulators expressed in endomesoderm of sea urchin embryos discovered by differential array hybridization. Dev Biol (2002) 1.50

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Expression patterns of four different regulatory genes that function during sea urchin development. Gene Expr Patterns (2004) 1.41

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination. Int Immunol (2004) 1.41

Unusual gene order and organization of the sea urchin hox cluster. J Exp Zool B Mol Dev Evol (2006) 1.34

The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanisms. Immunol Rev (2004) 1.25

Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. J Immunol (2008) 1.22

A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol (2003) 1.21

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Alternative mechanisms of immune receptor diversity. Curr Opin Immunol (2007) 1.06

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New insights into alternative mechanisms of immune receptor diversification. Adv Immunol (2005) 0.98

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Echinoderm immunity. Adv Exp Med Biol (2010) 0.92

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The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination. Mol Cell Biol (2007) 0.90

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AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene. Mol Immunol (2007) 0.86

Targeting of AID-mediated sequence diversification to immunoglobulin genes. Curr Opin Immunol (2011) 0.83

Genomic resources for the study of sea urchin development. Methods Cell Biol (2004) 0.83

Classical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells. PLoS One (2011) 0.81

Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. J Biol Chem (2007) 0.81

The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tails. Dev Comp Immunol (2008) 0.80

RNA AIDS DNA. Nat Immunol (2003) 0.80

Transcription, splicing, and release: are we there yet? Cell (2012) 0.79

DNA repair: breaking the seal. Nature (2002) 0.78

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Echinoderms. Curr Biol (2005) 0.77

SpTie1/2 is expressed in coelomocytes, axial organ and embryos of the sea urchin Strongylocentrotus purpuratus, and is an orthologue of vertebrate Tie1 and Tie2. Dev Comp Immunol (2010) 0.76

Biological bulletin virtual symposium: genomics of large marine metazoans. Biol Bull (2008) 0.75

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Characterizing somatic hypermutation and gene conversion in the chicken DT40 cell system. Methods Mol Biol (2011) 0.75

Perturbation of gut bacteria induces a coordinated cellular immune response in the purple sea urchin larva. Immunol Cell Biol (2017) 0.75

Bacterial artificial chromosomes as recombinant reporter constructs to investigate gene expression and regulation in echinoderms. Brief Funct Genomics (2017) 0.75

Corrigendum: Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nat Commun (2017) 0.75