PubRank

Lina M Obeid

Author PubWeight™ 160.44‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008 12.34
2 The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 2002 4.52
3 Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell 2012 3.23
4 An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol 2010 2.33
5 Many ceramides. J Biol Chem 2011 2.31
6 Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta 2008 2.25
7 De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem 2002 2.24
8 PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem 2002 2.11
9 The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J 2003 2.10
10 Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem 2004 1.84
11 Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J 2005 1.83
12 Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem 2002 1.79
13 Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J 2008 1.78
14 Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem 2002 1.74
15 A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J 2008 1.71
16 A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta 2006 1.65
17 Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J Biol Chem 2007 1.61
18 Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta 2004 1.61
19 Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J 2005 1.57
20 Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J 2012 1.57
21 Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem 2004 1.52
22 Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. J Histochem Cytochem 2005 1.51
23 The mechanism of membrane targeting of human sphingosine kinase 1. J Biol Chem 2005 1.44
24 Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. J Biol Chem 2006 1.43
25 Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem 2007 1.38
26 Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. J Biol Chem 2007 1.36
27 The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol 2005 1.33
28 Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. J Biol Chem 2003 1.31
29 Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J 2006 1.30
30 Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. Biochem J 2009 1.29
31 A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J 2005 1.28
32 Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. Biochim Biophys Acta 2006 1.28
33 The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther 2007 1.27
34 Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther 2006 1.24
35 Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorg Med Chem 2006 1.24
36 Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem 2003 1.24
37 Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem 2005 1.23
38 Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res 2010 1.23
39 Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. J Invest Dermatol 2007 1.23
40 AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res 2009 1.23
41 Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell 2005 1.21
42 Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul 2002 1.21
43 Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther 2006 1.20
44 Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors. Biochim Biophys Acta 2012 1.20
45 Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood 2011 1.19
46 Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. Biochimie 2010 1.19
47 Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death. Anticancer Agents Med Chem 2012 1.19
48 JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction. J Biol Chem 2007 1.18
49 Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem 2006 1.18
50 Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. FASEB J 2010 1.16
51 Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med 2012 1.16
52 Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. J Immunol 2010 1.16
53 Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. J Biol Chem 2011 1.15
54 Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem 2004 1.15
55 Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther 2006 1.14
56 Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. FASEB J 2007 1.13
57 Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem 2011 1.13
58 Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. J Biol Chem 2008 1.13
59 The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. J Biol Chem 2010 1.12
60 A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J 2007 1.10
61 Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem 2009 1.10
62 Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem 2008 1.09
63 Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. J Biol Chem 2003 1.09
64 Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem 2005 1.08
65 Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem 2006 1.08
66 Combination of C(17) sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism. Methods Enzymol 2007 1.08
67 Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. J Biol Chem 2010 1.07
68 Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem 2010 1.07
69 Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochim Biophys Acta 2007 1.06
70 Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. Prostaglandins Other Lipid Mediat 2007 1.05
71 Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. J Biol Chem 2004 1.05
72 Yeast sphingolipid metabolism: clues and connections. Biochem Cell Biol 2004 1.05
73 A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet 2011 1.05
74 Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2). J Biol Chem 2010 1.03
75 A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prev Res (Phila) 2011 1.03
76 Dihydroceramide-based response to hypoxia. J Biol Chem 2011 1.02
77 Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg 2005 1.02
78 Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. J Biol Chem 2006 1.02
79 Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets 2008 1.01
80 Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. J Biol Chem 2010 1.01
81 Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis. J Immunol 2005 1.01
82 Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. FASEB J 2008 1.00
83 Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. Arch Biochem Biophys 2003 0.99
84 The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. J Biol Chem 2007 0.99
85 Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells. Prostaglandins Other Lipid Mediat 2006 0.98
86 Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem 2011 0.98
87 Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. J Lipid Res 2006 0.98
88 Ceramidases in the regulation of ceramide levels and function. Subcell Biochem 2002 0.98
89 ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae. J Biol Chem 2009 0.97
90 Sphingosine-1-phosphate receptor 2. FEBS J 2013 0.97
91 Sphingosine kinase 1 in cancer. Adv Cancer Res 2013 0.97
92 The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. J Biol Chem 2007 0.96
93 Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem 2011 0.95
94 Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem 2003 0.93
95 Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. Exp Cell Res 2006 0.93
96 De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins Other Lipid Mediat 2008 0.93
97 Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. J Biol Chem 2009 0.92
98 Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J 2013 0.92
99 Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. Crit Rev Biochem Mol Biol 2011 0.91
100 p53 and regulation of bioactive sphingolipids. Adv Enzyme Regul 2010 0.90
101 Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. J Biol Chem 2010 0.90
102 Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore. J Biol Chem 2008 0.90
103 Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. FASEB J 2013 0.89
104 Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes. FASEB J 2010 0.89
105 Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J Lipid Res 2010 0.88
106 Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation. J Biol Chem 2013 0.88
107 Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis. Rheumatol Int 2012 0.88
108 Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease. FEBS Lett 2006 0.86
109 Effect of sphingosine kinase 1 inhibition on blood pressure. FASEB J 2012 0.86
110 Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. PLoS One 2011 0.85
111 Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway. FASEB J 2011 0.85
112 Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis. J Biol Chem 2010 0.85
113 Sphingolipids in vascular biology. Adv Exp Med Biol 2002 0.85
114 Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins Other Lipid Mediat 2012 0.84
115 Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity. J Biol Chem 2013 0.84
116 CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction. J Pathol 2011 0.83
117 Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells. J Lipid Res 2012 0.83
118 Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway. Handb Exp Pharmacol 2013 0.82
119 Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. Mol Endocrinol 2011 0.82
120 Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis. PLoS One 2013 0.81
121 Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. Neurosci Lett 2011 0.80
122 Bcl-xL interrupts oxidative activation of neutral sphingomyelinase. FEBS Lett 2002 0.79
123 Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. J Biol Chem 2012 0.79
124 Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. FASEB J 2013 0.76
125 Impact of sphingosine kinase on inflammatory pathways in fibroblast-like synoviocytes. Inflamm Allergy Drug Targets 2011 0.75